Sylvia Lehmann

RWTH Aachen University · Department of Paediatric and Adolescent Medicine

Background: Drug hypersensitivity reactions of immediate type pose a challenging problem, especially, if standard diagnostic procedures do not lead to conclusive results. The aim of this investigation is to identify, whether basophil activation test (BAT) is able to provide additional benefit in the diagnostic evaluation of immediate type drug hype...

Background: Electrical impedance tomography (EIT) provides information on global and regional ventilation during tidal breathing and mechanical ventilation. During forced expiration maneuvers, the linearity of EIT and spirometric data has been documented in healthy persons. The present study investigates the potential diagnostic use of EIT in pedia...

This paper describes a novel extension of the Forced Oscillation Technique (FOT), namely the volume-dependent Forced Oscillation Technique (v-FOT). This extension is based on the measurement of the respiratory impedance over the whole lung volume. A new measurement protocol was introduced: subjects breathe slowly from residual volume to total lung...

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There is a lack of noninvasive pulmonary function tests which can assess regional information of the lungs. Electrical impedance tomography (EIT) is a radiation-free, non-invasive real-time imaging that provides regional information of ventilation volume regarding the measurement of electrical impedance distribution. Forced oscillation technique (F...

The forced oscillation technique (FOT) is a non-invasive pulmonary function test which is based on the measurement of respiratory impedance. Recently, promising results were obtained by the application of FOT on patients with respiratory failure and obstructive sleep apnea (OSA). By using a nasal mask instead of a mouthpiece, the influences of the...

Electrical impedance tomography (EIT) provides global and regional information about ventilation by means of relative changes in electrical impedance measured with electrodes placed around the thorax. In combination with lung function tests, e.g. spirometry and body plethysmography, regional information about lung ventilation can be achieved. Imped...

Background: Asthma in childhood has a prevalence of 5-10% in Germany and severe asthma accounts for about 5% in this patient group. Positive predictive values for severe asthma are atopy, a positive family history and sensitizations against inhalative allergens. Alternaria is an important inhalative allergen and sensitization is suspected to corre...

Background: Electrical impedance tomography (EIT) delivers information about global and regional ventilation. Linearity of EIT during tidal breathing is known. We investigated the feasibility of EIT during lung function tests in pediatric patients with cystic fibrosis (CF) and healthy controls. Methods: Eleven CF patients and 11 age-matched cont...

Introduction: Electrical Impedance Tomography (EIT) is a tomographic, radiation-free technique based on the injection of a harmless alternating current. Objective: As electrical impedance strictly correlates with the variation of air content, EIT delivers highly dynamic information about global and regional ventilation. We want to demonstrate th...

Introduction: Continuous or episodic allergen exposure is a major risk factor of frequent symptoms and exacerbations for patients with allergic asthma. It has been shown that temperature-controlled laminar airflow (TLA) significantly reduced allergen exposure and airway inflammation and improved quality of life of patients with poorly controlled a...

Background: Allergic bronchopulmonary aspergillosis (ABPA) is a severe complication in patients with cystic fibrosis (CF), resulting in deterioration of lung function and impairment of overall prognosis. Standard therapy consists of high dosage, long-term corticosteroid treatment. This carries the risk of serious side effects such as immune suppre...

Abstract Electrical impedance tomography (EIT) is a radiation-free technique generating cross-sectional images of the lung. EIT visualizes global and regional ventilation by illustrating the distribution of electrical bioimpedance. With an electrode belt around the patient's thorax, rotating injection-couples of a harmless alternating current allow...

Pulmonary function tests are used to assess the severity of obstructive and restrictive lung diseases. These tests provide information on the whole lung considered as one compartment and can be used to globally describe the physical properties of flow resistance R and compliance C, but do not yield regional information. Electrical impedance tomogra...

Food allergens are frequent causes of anaphylaxis. In particular in children and adults they are frequent elicitors of severe allergic reactions, whereas in adults food allergens range among venom and drugs. Since 2006 severe allergic reactions from Germany, Austria and Switzerland are collected in the anaphylaxis registry. Currently 78 hospitals a...

Cellular in vitro tests such as the CD63-based basophil activation test (BAT) have been successfully used to diagnose hymenoptera venom sensitization in adult patients while this has not been investigated in children so far. 15 children (9 male, 6 female; 12.7±3.5 years) with suspected allergy to vespula (VE) or honey bee (HB) venom entered this st...

Atopic dermatitis (AD) has been sub-classified into extrinsic and intrinsic types according to the presence or not of allergen-specific IgE antibodies. Although total serum IgE levels are frequently elevated in AD, their potential to predict allergen-specific IgE (asIgE) has rare ly been studied. We investigated 103 children with AD and suspected a...

Immediate-type hypersensitivity to glucocorticosteroids is rare but well known among allergists. Surprisingly, very few reports of glucocorticosteroid hypersensitivity in children exist although glucocorticosteroid treatment is particularly common in this age group. We report the case of a 2-year-old boy who developed generalized urticaria, facial...

Anaphylaxis represents a severe, systemic and potentially fatal hypersensitivity reaction that severely impairs the life of affected children and their caregivers. With an estimated life time prevalence of 0.05% to 2%, it is not a rare disease. Therefore every physician caring for children at risk for anaphylaxis should be familiar with this diseas...

Anaphylaxis represents a severe, systemic and potentially fatal hypersensitivity reaction that severely impairs the life of affected children and their caregivers. With an estimated life time prevalence of 0.05% to 2%, it is not a rare disease. Therefore every physician caring for children at risk for anaphylaxis should be familiar with this diseas...

A 5 1/2-year-old boy revealed symmetric erythematous plaques on both arms and legs as well as in the face. Additionally, contractions of several digital joints were noted. We diagnosed a progressive symmetric erythrokeratoderma and initiated a topical therapy with tretinoin. Here we discuss the etiology, differential diagnoses, and therapeutic opti...

Shortly after birth, a five-week-old female infant developed small blisters and erythema that followed the lines of Blaschko on the upper and lower extremities as well as the abdomen. Histological examination confirmed the clinical presumptive diagnosis of incontinentia pigmenti. We discuss the dinical features, diagnosis, and the molecular genetic...

Two siblings of African origin presented with multiple scaling patches and alopecia on the scalp four weeks after returning from a vacation in Eritrea. Direct KOH examination revealed fungal elements; Trichophyton mentagrophytes and Trichophyton terrestre were identified in the fungal culture. We discuss the putative pathogenic role of both microor...

Ein 5 Wochen alter weiblicher Säugling entwickelte seit Geburt den Blaschko-Linien folgende Bläschen und Erytheme an den oberen und unteren Extremitäten sowie am Abdomen. Eine feingewebliche Untersuchung bestätigte die klinische Verdachtsdiagnose einer Incontinentia pigmenti. Nachfolgend werden die Klinik und Diagnostik sowie die molekulargenetisch...

Wir berichten über Geschwisterkinder afrikanischer Herkunft, die sich mit multiplen erythematosquamösen Effloreszenzen und einer Alopezie der Kopfhaut vorstellten. Die Hautveränderungen waren 4 Wochen nach der Rückkehr aus einem Urlaub in Eritrea aufgetreten. Bereits in der nativmikroskopischen Untersuchung zeigten sich Pilzelemente, kulturell konn...

Hintergrund: Die Borreliose ist die häufigste Vektor-übertragene Infektion im Kindesalter. Ungefähr 80 % der Patienten weisen ein Erythema chronicum migrans auf, dieses tritt jedoch nur in 2-18 % multilokulär auf. Differenzialdiagnostisch vom Erythema chronicum migrans abzugrenzen sind das Erysipel, die persistierende Insektenstichreaktion und das...

In the course of a connatal pneumonia, a 7-day-old female newborn developed symmetrical subcutaneous nodules on her back, shoulders, and upper arms. These skin lesions were accompanied by hypercalcemia. Histological examination confirmed the putative clinical diagnosis of subcutaneous fat necrosis of the newborn. We discuss the differential diagnos...

Eine 7 Tage altes weibliches Neugeborenes entwickelte unter einer konnatalen Pneumonie symmetrisch ausgebildete subkutane Knoten am Rücken, den Schultern und Oberarmen. Die Hautveränderungen waren von einer Hyperkalzämie begleitet. Eine feingewebliche Untersuchung bestätigte die klinische Verdachtsdiagnose einer Adiponecrosis subcutanea neonatorum....

Extrahepatic bile duct disease is a rare finding in infancy and early childhood. However, there is an increasing number of patients operated at this age reported in the literature. This increase may have multifactorial reasons, e.g. real increase, better ability of detection as a result of better diagnostic techniques and knowledge of predisposing...

Borreliosis is the most common vector transmitted disease in childhood. Although the disease manifests with an erythema migrans in 80 % of the patients, multilocular skin manifestations are only observed in 2-18 % of these. Differential diagnoses of erythema migrans include erysipelas, persistent insect bite reaction, and fixed drug eruption, in pa...