Sylvia Hartl

Sylvia Hartl
Ludwig Boltzmann Institute for Lung Health · Dep.of Resp.and Crit.Care; Clinic Penzing; Vienna Hospital Trust WiGev

MD, MBA, assoc. Professor
3rd examination of the population based study is ongoing after 8 years of follow up, after 75% completion of visit 2

About

120
Publications
16,221
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3,491
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Introduction
The LEAD study a population based observational longitudinal cohort study in a general population aged from 6-80 yrs; is a health examination survey on spirometry and lung volumes pre-/ post bronchodilation, body composition by DXA scan, skin prick test, whole blood samples from fasting blood and biobank samples , extensive questionnaires on environmental and life style risk factors as well as disease specific questionaires; subsets of asthma and COPD specific measurements.
Additional affiliations
March 2020 - present
Ludwig Boltzmann Institue for Lung Health
Position
  • Head of Department
Description
  • Research is focusesd on the LEAD longitudinal health study , a population based cohort study of >14.000 participants with a basic exam and 1 follow up visit exam, and respiratory oncology ( Phase 1-3 medication studies) www.lunghealth.lbg.ac.at
May 2015 - present
Wiener Gesundheitsverbund
Position
  • Head of Department
Description
  • I am Head of Department and Head of the Research Institute at the Vienna Hospital trust. Iam affiliated to the Sigmund Freud medical University as associate Professor and to the Paracelsus Medical University of Salzburg for collaborating research Programmes. The Department is full medical training centre for respiratory medicine and critical care ffor>2000admissions/y. and >15.000 outpatients . We provide traing for 11 Trainees in respiratory medicine and 2 for Critical Care Medicine.

Publications

Publications (120)
Article
Full-text available
Background: Monitoring of sensitization may become a non-invasive marker of impaired epithelial barrier function related to changing environmental conditions. Objective: To longitudinally evaluate the prevalence and associated factors for positive skin prick tests (SPT) in a general population cohort. Methods: Baseline and 4-year follow-up dat...
Article
Rationale Recent guidelines consider chronic cough to be a unique clinical entity with different phenotypes. We aimed to investigate them in a general population and to describe prevalence, distribution, and characteristics of these phenotypes within the Austrian general population. Methods From the LEAD study, a longitudinal observational populat...
Article
Full-text available
The impact of body composition on the early origin of chronic diseases is an increasingly appreciated phenomenon. Little is known about the characteristics of children with varying body composition. The aim of this study was to investigate serum lipid profiles and other characteristics in relation to body composition. The data of 1394 participants...
Article
Full-text available
Articulating a satisfactory definition of a disease is surprisingly difficult. Despite the alarming individual, societal and economic burden of chronic obstructive pulmonary disease (COPD), diagnosis is still largely based on a physiologically dominated disease conception, with spirometrically determined airflow limitation as a cardinal feature of...
Article
Background: During the past century, socioeconomic and scientific advances have resulted in changes in the health and physique of European populations. Accompanying improvements in lung function, if unrecognised, could result in the misclassification of lung function measurements and misdiagnosis of lung diseases. We therefore investigated changes...
Article
Full-text available
Background The prevalences of obstructive and restrictive spirometric phenotypes, and their relation to early-life risk factors from childhood to young adulthood remain poorly understood. The aim was to explore these phenotypes and associations with well-known respiratory risk factors across ages and populations in European cohorts. Methods We stu...
Article
Background The clinical context for using blood eosinophil (EOS) counts as treatment-response biomarkers in asthma and chronic obstructive pulmonary disease (COPD) requires better understanding of EOS distributions and ranges. We describe EOS distributions and ranges published in asthma, COPD, control (non-asthma/COPD) and general populations. Met...
Article
Full-text available
We analyzed SARS-CoV-2 seroprevalence in a large, well-described representative Viennese cohort after an early governmental lockdown with respect to the occurrence of symptoms and household transmission. Participants of the LEAD Study, a population-based cohort study from Vienna, Austria, were invited along with their household members (April 20th...
Preprint
Background SARS-CoV-2 antibody tests have undergone a remarkable improvement in performance. However, due to the low seroprevalence in several areas, very high demands are made on their specificity. Furthermore, the low antibody-response in some individuals requires high test sensitivity to avoid underestimating true seroprevalence. Optimization of...
Article
Full-text available
Objectives: The Austrian Lung Cancer Audit (ALCA) is a pilot study to evaluate clinical and organizational factors related to lung cancer care across Austria. Materials and methods: The ALCA is a prospective, observational, noninterventional cohort study conducted in 17 departments in Austria between September 2013 and March 2015. Participating...
Conference Paper
Background: European population cohorts continue to expand our understanding of chronic airways disease and inter-study collaboration may help address the inevitable limitations of study size, duration, era and geography. Towards this aim, CADSET has collated data from ten major general population European cohorts: Asklepios; Copenhagen City Heart...
Article
Full-text available
Zusammenfassung Mitglieder der Österreichischen Gesellschaft für Pneumologie (ÖGP) beschreiben die erwartete Entwicklung der respiratorischen Gesundheit und zeigen Wege einer patientenorientierten und kosteneffizienten Versorgung für Österreich auf. Methoden: Im November 2017 trifft sich eine Gruppe von respiratorisch tätigen Ärzten, Pflegekräften...
Article
Background: In the context of the COVID-19 pandemic, numerous new serological test systems for the detection of anti-SARS-CoV-2 antibodies rapidly have become available. However, the clinical performance of many of these is still insufficiently described. Therefore, we compared three commercial, CE-marked, SARS-CoV-2 antibody assays side by side....
Article
Full-text available
Increasing attention has been drawn on the assessment of body composition phenotypes, since the distribution of soft tissue influences cardio-metabolic risk. Dual-energy X-ray absorptiometry (DXA) is a validated technique to assess body composition. European reference values from population-based cohorts are rare. To provide age- and sex-related re...
Article
Background and objective Cardiovascular risk is substantially increased in patients with COPD and can be quantified via arterial stiffness. The PDE‐IV inhibitor roflumilast revealed a potential reduction of COPD‐related cardiovascular risk. We aimed to investigate the effects of roflumilast on arterial stiffness by quantification of pulse wave velo...
Article
Full-text available
Background DXA is a widely used technique to assess body composition. Reference values based on a large general population cohort of European children and adolescents were missing. The aim of this study was to provide age‐ and sex‐specific reference percentiles of body composition parameters for European children and adolescents and to compare them...
Article
Full-text available
Background: COPD patients suffer from respiratory symptoms and limitations in daily life. We aimed to characterize the impact of disease on overall health, daily life, and perceived well-being in COPD outpatients. Methods: We conducted a national, cross-sectional study among pulmonologists and general practitioners (GPs). The St. George's Respir...
Preprint
Full-text available
Background: In the context of the COVID-19 pandemic, numerous new serological test systems for the detection of anti-SARS-CoV-2 antibodies have become available quickly. However, the clinical performance of many of them is still insufficiently described. Therefore we compared three commercial, CE-marked, SARS-CoV-2 antibody assays side by side. Met...
Article
There is growing interest in blood eosinophil counts in the management of chronic respiratory conditions such as asthma and chronic obstructive pulmonary disease [COPD]). Despite this, typical blood eosinophil levels in the general population, and the impact of potential confounders on these levels have not been clearly defined. We measured blood e...
Article
Background: Based on biological and behavioural diversity sex and gender may affect co-morbidities associated with prediabetes and diabetes. Besides evaluating the prevalence of prediabetes and diabetes (using fasting plasma glucose and HbA1c levels), the primary aim of the study is to investigate sex and gender differences in the prevalence of co...
Article
Background: Most patients with small-cell lung cancer (SCLC) have extensive-stage disease at presentation, and prognosis remains poor. Recently, immunotherapy has demonstrated clinical activity in extensive-stage SCLC (ES-SCLC). The CASPIAN trial assessed durvalumab, with or without tremelimumab, in combination with etoposide plus either cisplatin...
Poster
Full-text available
Based on biological and behavioural diversity sex and gender may affect co-morbidities associated with prediabetes and diabetes.
Article
Objective Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are the major reason for COPD hospitalization and increased risk for readmissions. The organizational structure of Austrian hospitals provides the opportunity to investigate the impact of specialized respiratory care compared to general care on adherence to guidelines a...
Article
Full-text available
Background: The Lung, hEart, sociAl, boDy (LEAD) Study (ClinicalTrials.gov; NCT01727518; http://clinicaltrials.gov) is a longitudinal, observational, population-based Austrian cohort that aims to investigate the relationship between genetic, environmental, social, developmental and ageing factors influencing respiratory health and comorbidities thr...
Article
Full-text available
Background: Non-invasive ventilation (NIV) is used to treat acute hypercapnic respiratory failure (AHRF) in patients with chronic obstructive pulmonary disease (COPD); however, long-term outcomes following discharge are largely unknown. This study aimed to characterize long-term outcomes and identify associated markers in patients with COPD after...
Article
Zusammenfassung Das vorliegende Dokument ist eine Neufassung und Aktualisierung der Leitlinie zur Diagnostik und Therapie von Patienten mit COPD, die die bisherige Version aus dem Jahr 2007 ablöst. Die Fülle an neuen Erkenntnissen zu Risikofaktoren, Diagnostik, Schweregradeinschätzung, Prävention und medikamentösen sowie nicht medikamentösen Therap...
Book
Full-text available
The effects of climate change on health are already being felt today and can be classified as an increasing threat to health in Austria. The most severe and far- reaching effects to be expected are health impacts due to heat. Also changes in ecosystems which influence the distribution, frequency, types and severity of pollen allergies and vector-bo...
Article
Full-text available
Chronic obstructive pulmonary disease: QUESTIONNAIRE FOR PRE-SCREENING POTENTIAL SUFFERERS: Scientists in Austria have developed a brief, simple questionnaire to identify patients likely to have early-stage chronic lung disease. Chronic obstructive pulmonary disease (COPD) is notoriously difficult to diagnose, and the condition often causes irreve...
Article
Background: The European COPD Audit initiated by the European Respiratory Society (ERS) evaluated the management of hospital admissions due to exacerbation of chronic obstructive pulmonary disease (COPD) in several European countries. Data on the treatment of severe acute exacerbations of COPD (AECOPDs) in Switzerland are scarce. Objectives: In...
Article
We thank Ernesto Crisafulli, Monica Guerrero, Alfredo Chetta and Antoni Torres for their differentiated perspective on the topic of hospital readmission of chronic obstructive pulmonary disease (COPD). It is high time for a holistic approach to COPD exacerbation including each suitable intervention to the risk profile
Article
Background: Physical exercise training is an evidence-based treatment in chronic obstructive pulmonary disease (COPD), and patients' peak work rate is associated with reduced COPD mortality. We assessed whether supplemental oxygen during exercise training in nonhypoxemic COPD patients might lead to superior training outcomes, including improved pe...
Data
Understanding variation in length of hospital stay for COPD exacerbation: European COPD audit
Article
Chronic obstructive pulmonary disease (COPD) care across Europe has high heterogeneity with respect to cost and the services available. Variations in length of stay (LOS) may be attributed to patient characteristics, resource and organisational characteristics, and/or the so-called hospital cluster effect. The European COPD Audit in 13 countries in...
Article
The current consensus report was compiled under the patronage of the Austrian Society of Pneumology (Österreichischen Gesellschaft für Pneumologie, ÖGP) with the intention of providing practical guidelines for out-of-hospital ventilation that are in accordance with specific Austrian framework parameters and legal foundations. The guidelines are ori...
Article
Full-text available
Studies report high in-hospital and post-discharge mortality of chronic obstructive pulmonary disease (COPD) exacerbations varying depending upon patient characteristics, hospital resources and treatment standards. This study aimed to investigate the patient, resource and organisational factors associated with in-hospital and 90-day post-discharge...
Article
Full-text available
Background Appropriate use of inhaled therapies for asthma and chronic obstructive pulmonary disease (COPD) is critical to ensuring good patient outcomes, efficient use of healthcare resources and limiting the effects of high-morbidity. The appropriate choice of inhaler and active therapy, incorporating patient preferences, can help improve treatme...
Article
More research is needed to elucidate natural history and underlying pathomechanisms of the most common airway diseases, Asthma and COPD. In the last decade risk factors affecting the natural history of lung function, defined by the decline of lung function over time, have been evaluated. Moreover, scientific methods have been extended and novel bio...
Article
A wide spectrum of non-malignant lung diseases is closely related to active and passive smoking. Obstructive pulmonary diseases like COPD and asthma, restrictive pulmonary diseases like respiratory bronchiolitis associated interstitial lung disease (RB/ ILD), desquamative interstitial pneumonia (DIP), pulmonary Langerhans cell histiocytosis (PLCH)...
Article
Full-text available
Objective: There is controversy regarding the significance of radiological consolidation in the context of COPD exacerbation (eCOPD). While some studies into eCOPD exclude these cases, consolidation is a common feature of eCOPD admissions in real practice. This study aims to address the question of whether consolidation in eCOPD is a distinct clin...
Article
Full-text available
Appropriate use of antibiotics in the management of hospitalised patients with COPD exacerbations is defined within the GOLD strategy. This paper analyses the factors associated with antibiotic prescribing in patients to better understand how prescribing may be improved. The European COPD audit was a study of clinical care in 384 hospitals from 13...
Article
Full-text available
Background Evidence is weak for the ability of long-term non-invasive positive pressure ventilation (NPPV) to improve survival in patients with stable hypercapnic chronic obstructive pulmonary disease (COPD). Previous prospective studies did not target a reduction in hypercapnia when adjusting ventilator settings. This study investigated the effect...
Article
The aim was to study the overall content and organisational aspects of pulmonary rehabilitation programmes from a global perspective in order to get an initial appraisal on the degree of heterogeneity worldwide. A 12-question survey on content and organisational aspects was completed by representatives of pulmonary rehabilitation programmes that h...
Article
To study the overall content and organizational aspects of pulmonary rehabilitation programs from a global perspective to get an initial appraisal on the degree of heterogeneity worldwide.A twelve-question survey on content and organizational aspects was completed by representatives of pulmonary rehabilitation programs that previously participated...
Article
![][1] Chronic obstructive pulmonary disease (COPD) is a significant cause of morbidity and mortality in Europe [1, 2], which has a major resource impact on both primary and secondary healthcare [3]. COPD has a huge impact on people with the condition, causing a gradual decline in functional ability and greater dependence upon health and social...
Article
Full-text available
Der Granulocyten-Stimulierende-Faktor (G-CSF) kann • zu einer höheren Sicherheit hämatotoxischer Chemotherapien (CHT) beitragen • das Risiko einer febrilen Neutropenie reduzieren