Sylvia Brinkman

Sylvia Brinkman
Academisch Medisch Centrum Universiteit van Amsterdam | AMC · Department of Medical Informatics

PhD

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33
Publications
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772
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Publications

Publications (33)
Article
Full-text available
Background To assess trends in the quality of care for COVID-19 patients at the ICU over the course of time in the Netherlands. Methods Data from the National Intensive Care Evaluation (NICE)-registry of all COVID-19 patients admitted to an ICU in the Netherlands were used. Patient characteristics and indicators of quality of care during the first...
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Full-text available
Purpose Describe the differences in characteristics and outcomes between COVID-19 and other viral pneumonia patients admitted to Dutch ICUs. Materials and methods Data from the National-Intensive-Care-Evaluation-registry of COVID-19 patients admitted between February 15th and January 1th 2021 and other viral pneumonia patients admitted between Jan...
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Full-text available
Background Building Machine Learning (ML) models in healthcare may suffer from time-consuming and potentially biased pre-selection of predictors by hand that can result in limited or trivial selection of suitable models. We aimed to assess the predictive performance of automating the process of building ML models (AutoML) in-hospital mortality pred...
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Objectives: Obesity is a risk factor for severe coronavirus disease 2019 and might play a role in its pathophysiology. It is unknown whether body mass index is related to clinical outcome following ICU admission, as observed in various other categories of critically ill patients. We investigated the relationship between body mass index and inhospi...
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Introduction The impact of the care for COVID-19 patients on nursing workload and planning nursing staff on the Intensive Care Unit has been huge. Nurses were confronted with a high workload and an increase in the number of patients per nurse they had to take care of. Objective The primary aim of this study is to describe differences in the planni...
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Background Several instruments have been developed to measure nursing workload. The commonly used Nursing Activities Score (NAS) and Therapeutic Intervention Scoring System (TISS) are applied to all types of ICU patients. Former research showed that NAS explained 59 to 81% of actual nursing time, whereas the Therapeutic Intervention Scoring System...
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Background: Multiple factors contribute to mortality after ICU, but it is unclear how the predictive value of these factors changes during ICU admission. We aimed to compare the changing performance over time of the acute illness component, antecedent patient characteristics, and ICU length of stay (LOS) in predicting 1-year mortality. Methods:...
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Background A range of classification systems are in use for the measurement of nursing workload in Intensive Care Units. However, it is unknown to what extent the measured (objective) nursing workload, usually in terms of the amount of nursing activities, is related to the workload actually experienced (perceived) by nurses. Objectives The aim of...
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Objectives: Assessment of all-cause mortality of intracerebral hemorrhage and ischemic stroke patients admitted to the ICU and comparison to the mortality of other critically ill ICU patients classified into six other diagnostic subgroups and the general Dutch population. Design: Observational cohort study. Setting: All ICUs participating in t...
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Full-text available
OBJECTIVES To develop a scoring system model that predicts mortality within 30 days of admission of patients older than 80 years admitted to intensive care units (ICUs). DESIGN Prospective cohort study. SETTING A total of 306 ICUs from 24 European countries. PARTICIPANTS Older adults admitted to European ICUs (N = 3730; median age = 84 years [in...
Article
A strategy of defining and checking explicitly formulated patient-specific treatments targets or "daily goals" in the intensive care unit has been associated with improved communication. We investigated the effect of incorporation of daily goals into daily care planning on length of stay in the intensive care unit. Furthermore, the type of daily go...
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Purpose: To describe the trends in short-term and long-term mortality in very elderly intensive care unit (ICU) patients between 2008 and 2014. Methods: A retrospective cohort study was conducted using data from the National Intensive Care Evaluation Foundation from 31 Dutch ICUs. Generalized linear mixed-effects models were used to determine th...
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Context: Intoxicated patients are frequently admitted from the emergency room to the ICU for observational reasons. The question is whether these admissions are indeed necessary. Objective: The aim of this study was to develop a model that predicts the need of ICU treatment (receiving mechanical ventilation and/or vasopressors <24?h of the ICU admi...
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The relationship between the number of patients admitted to an intensive care unit (ICU) volume and mortality is currently the subject of debate. After implementation of a national guideline in 2006, all Dutch ICUs have been classified into three levels based on ICU size, patient volume, ventilation days, and staffing. The goal of this study is to...
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The incidence of sepsis continues to increase. However, over the past decade marked reductions in sepsis-related in-hospital mortality have been reported. Large variations in the presentation and severity of illness may be encountered in ICU patients with severe sepsis, which might preclude the success of screening and guideline programmes. However...
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Surviving Sepsis Campaign bundles have been associated with reduced mortality in severe sepsis and septic shock patients. Case-mix adjusted mortality evaluations have not been performed to compare hospitals participating in sepsis bundle programs with those not participating. We aimed to achieve an individual bundle target adherence more than 80% a...
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To assess in-hospital and long-term mortality of Dutch ICU patients admitted with an acute intoxication. Cohort of ICU admissions from a national ICU registry linked to records from an insurance claims database. Eighty-one ICUs (85% of all Dutch ICUs). Seven thousand three hundred thirty-one admissions between January 1, 2008, and October 1, 2011....
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To analyze the influence of using mortality 1, 3, and 6 months after intensive care unit (ICU) admission instead of in-hospital mortality on the quality indicator standardized mortality ratio (SMR). A cohort study of 77,616 patients admitted to 44 Dutch mixed ICUs between 1 January 2008 and 1 July 2011. Four Acute Physiology and Chronic Health Eval...
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Objectives: To assess the mortality risk of ICU patients after hospital discharge and compare it to mortality of the general Dutch population. Design: Cohort study of ICU admissions from a national ICU registry linked to administrative records from an insurance claims database. Setting: Eighty-one Dutch ICUs. Patients: ICU patients (n = 91,2...
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Objectives: First, to conduct a literature review on the long-term mortality of ICU patients and its determinants. Second, to assess the influence of the found determinants at 3, 6, and 12 months mortality after hospital discharge in the Dutch ICU population. Design: Combination of a literature review to evaluate determinants of long-term mortal...
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Clinical registries are frequently used to monitor and analyze the quality of health care by assessing the in-hospital mortality. However, long-term mortality is often ignored as it is rarely recorded in such clinical registries. In this study linkage of a clinical registry and administrative database is used to assess the longterm mortality of a l...
Article
Introduction: It appears that enteral nutrition is more likely to produce hypoglycemia during intensive insulin therapy than is total parenteral nutrition. Point of View: Although this consequence may in part be the result of frequent discontinuation of feeding or to variability of gastrointestinal absorption of nutrients, there are also distinct p...
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It has been postulated that prognostic models based on administrative data can provide valid adjusted mortality rates in specific patient populations. In this study we compared the performance and robustness of a model based on administrative data (customized hospital standardized mortality ratio) and a model based on clinical data (customized Simp...
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The aim of this study was to validate and compare the performance of the Acute Physiology and Chronic Health Evaluation (APACHE) IV in the Dutch intensive care unit (ICU) population to the APACHE II and Simplified Acute Physiology Score (SAPS) II. This is a prospective study based on data from a national quality registry between 2006 and 2009 from...
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Full-text available
Previous studies have shown that patients admitted to the intensive care unit (ICU) after "office hours" are more likely to die. However these results have been challenged by numerous other studies. We therefore analysed this possible relationship between ICU admission time and in-hospital mortality in The Netherlands. This article relates time of...
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Following two randomized controlled trials that demonstrated reduced mortality and better neurological outcome in cardiac arrest patients, mild therapeutic hypothermia was implemented in many intensive care units. Up to now, no large observational studies have confirmed the beneficial effects of mild therapeutic hypothermia. Internet-based survey c...
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Goal: To describe the case mix and severity of illness of Dutch ICU patients and outcome of treatment as expressed by the standardized mortality ratio (SMR). Methods: At the time of the analysis 61 ICUs were participating in the Dutch National Intensive Care Evaluation (NICE) registry. Reasons for admission, baseline characteristics, severity of il...

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Project
Can we predict the outcome of intoxicated patients admitted to the Emergency department (ED) and the Intensive Care Unit (ICU)? The goal is to look at variables associated with "poor outcome" (defined as prolonged ICU stay or death) in as many EDs/ICUs in the world. For more details, please see our website: www.toxicstduy.org We are still recruiting centers that are willing to participate! Join us for some exiting research.
Project