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Syed Shahid Musvi

Syed Shahid Musvi
Tal Tech university · Chemistry and Biotechnology

Phd
Studying DNA Replication Initiation

About

3
Publications
1,155
Reads
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14
Citations
Citations since 2017
3 Research Items
14 Citations
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Introduction
Develop therapeutics against Fibrosis
Skills and Expertise

Publications

Publications (3)
Chapter
Platelet-derived growth factor (PDGF)-Tyrosine kinase has become a popular pharmacological target for different disorders. Platelet-derived growth factor (PDGF)-Tyrosine kinase inhibitors have recently been recommended as cancer treatments; nevertheless, selectivity and efficacy remain notable hurdles. PDGFs are a family of four cysteine-loop-like...
Article
Pituitary adenylate cyclase-activating polypeptide (PACAP), a neu-roendocrine hormone of the secretin peptide superfamily, is mainlyproduced in hypothalamus. PACAP shows diverse effects on CNS, per-ipheral organs, and some hematopoietic cells by VPAC1 and 2 receptorsignaling [1]. Megakaryocytes (MKs) express the stimulatory G protein(Gs)-coupled PA...
Article
Full-text available
Megakaryocytes (MKs), the largest cells in the bone marrow, are generated from hematopoietic stem cells (HSCs) in a sequential process called megakaryocytopoiesis in which HSCs undergo MK-progenitor (MP) commitment and maturation to terminally differentiated MK. Megakaryocytopoiesis is controlled by a complex network of bone marrow niche factors. T...

Questions

Questions (8)
Question
I have been trying to get the luminescence of my desired cell line which is transfected with luciferase gene and GFP via Varioskan Lux Plate reader. I get a GFP reading but when I use the D-luciferin (1mg/ml in DMSO), working 100ug/ml) on live cells luminescence value is the same as wells which are empty. My queries are:
1. Is it right to dissolve the D-luciferin in DMSO
2. Why there is luminescence in empty wells, is there any way to put it at zero in software or luminescence should is enough high and then subtract the base level lumnisence.
Please suggest the troubleshoot and protocol.
Question
When we design primer at the end we get 4 pair of primers. On what basis we should choose which one.
Question
During Bone Marrow isolation ,how to bring down the cells to single cell suspension . if there are some clumps and we grow them like that ,will it affect the Macrophage differentiation .
Question
What is the difference between miR-126-3p.1 & miR-126-3p.2 . i am not getting it .
Question
What is difference between mir-126 3p and mir-126 3p.1
Question
I identified a new protein I suspect that it is a kinase how we can prove?
Question
In Downs Syndrome we have extra Chromosome present , how we can treat this syndrome .Any technique which can be used in this regard.
Question
since in  ovarian somatic cells, the Rhi is absent, so there may be some any other factor for single-stranded piRNA

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Projects

Project (1)
Project
Identification of Novel replication initation proteins in human cells using Turbo-ID.