Syafruddin Ilyas

• PhD
• Professor at University of North Sumatra

Objective: This study seeks to investigate the potential of 36 nanoherbal compounds extracted from senduduk bulu (Miconia crenata (Vahl) Michelang.) as inhibitors of v-akt murine thymoma viral oncogene homolog 1 (AKT1) using molecular docking techniques, pharmacokinetic analysis, safety evaluation, and bioactivity assessment. Methods: Senduduk bulu...

Mentawai taro (Colocasia esculenta var. Mentawai, Araceae) corm is a staple food for local people in Mentawai islands, West Sumatra, Indonesia. This study aimed to determine whether the incorporation of fiber and starch extracted from Mentawai taro corm could improve adiposity and plasma lipid profiles and intestinal microbiota composition in mice...

Context: Doxorubicin, a potent chemotherapy drug, often leads to cardiotoxicity, limiting its clinical use. This study investigates the potential of Vitis gracilis Wall. nanoherbs (VGN) in mitigating doxorubicin-induced heart damage, aiming to provide insights into its therapeutic efficacy as a cardioprotective agent. Aims: To evaluate the therapeu...

Breast cancer is the most prevalent cause of cancer-related deaths worldwide, and mortality rates are on the increase. This study aims to evaluate the potential of bioactive compounds from Clibadium surinamense L. leaves as inhibitors of AKT1 protein interactions, which play a crucial role in tumor growth mechanisms. Leaves of Clibadium surinamense...

Cancer significantly impacts human health, affecting one in five people during their lifetime. While chemotherapeutic agents like doxorubicin are crucial in treating various cancers, they are also associated with severe side effects, including nephrotoxicity. This review examines the renoprotective potential of flavonoids against doxorubicin-induce...

Benign prostate hyperplasia (BPH) is a life-threatening condition that primarily affects geriatric patients, with obesity serving as a major risk factor. Several studies have also reported the role of obesity as a risk factor for other chronic non-communicable diseases, such as cardiovascular disease and type 2 diabetes. Therefore, this study aims...

Excessive intake of a high-fat diet (HFD) is profoundly linked with various diseases, including dyslipidemia, inflammation, obesity, type 2 diabetes mellitus (T2DM), and inflammation. Meanwhile, Mentawai taro, a variety of taro in the Colocasia esculenta species, has traditionally served as a daily staple food for the local people in the Mentawai I...

This study aims to analyze the Expression of Caspase 3 and Caspase 10 in Rat Muscles Post Gagatan Harimau (Paraboea leuserensis B.L.Burtt) Nanoherbal and Exercise. Treatment consists of control group, maximum physical exercise, maximum physical exercise + Vitamin C at a dose of 2 mg/Kg Body Weight, maximum physical exercise + Gagatan Harimau nanohe...

Background/Aims: Traumatic brain injury is a significant public problem with an incidence of 10 million people per year, causing the largest deaths and disabilities worldwide. Head injuries can be classified into primary and secondary head injuries. Secondary head injuries can be caused by several factors such as ischemia, cerebral edema, and neuro...

Cancer refers to the proliferation and multiplication of aberrant cells inside the human body, characterized by their capacity to proliferate and infiltrate various anatomical regions. Numerous biochemical pathways and signaling molecules have an impact on the cancer auto biogenesis process. The regulation of crucial cellular processes necessary fo...

Context: Cellular abnormalities in the ducts and breast tissue cause breast cancer to invade nearby tissues like the liver. The fibroblast growth factor (FGF) signals are sent to its receptor and regulate various cellular processes to maintain liver homeostasis. However, this condition has few and inefficient treatments. Breast cancer is characteri...

Context: Doxorubicin is an anticancer drug that can adversely affect the liver. Therefore, seeking medical attention to manage pain and minimize side effects is crucial. Aims: To evaluate the hepatoprotective potential of Vitis gracilis Wall. nanoherbs against doxorubicin-induced hepatotoxicity. Methods: The study included five treatment groups: T0...

The crucial challenge in herbal medicine development lies in ensuring the safety, quality, and effectiveness of herbal materials to comply with the regulatory standards in the herbal medicine industry. This research aims to synthesize nano-based herbal medicine by combining two medicinal plants: Bischofia javanica leaves and Phaleria macrocarpa fru...

This research explores a contemporary approach to managing Oral Squamous Cell Carcinoma (OSCC) by integrating nano-technology into herbal production, combining Bischofia javanica leaves and Phaleria macrocarpa fruits. Benzo[a]pyrene (BaP)-induced OSCC rats were treated with nano herbals from Bischofia javanica leaves, Phaleria macrocarpa fruits, a...

Doxorubicin is a potent chemotherapy drug. However, it is known to cause cardiotoxicity via inhibition of sirtuin 1 (SIRT1) and adenosine monophosphate protein kinase (AMPK) activity in the cardiomyocytes. This research aimed to explore the pharmacokinetics, safety, and bioactivity of compounds from Vitis gracilis leaves in their interaction with S...

The prevalence of breast cancer among patients in Indonesia is significant. Indonesian individuals maintain the belief that cancer cannot be cured alone by pharmaceuticals and treatment; herbal remedies must be used in conjunction. Rhodomyrtus tomentosa, also known as Haramonting, is an indigenous Indonesian medicinal plant renowned for its copious...

Inhaling Allethrin (C19H26O3) may induce oxidative stress in lung cells by causing the formation of free radi-cals. Interleukins (IL) are a group of secreted cytokines or proteins and signaling molecules initially produced as an immune response by leukocytes. Rhodomyrtus tomentosa (Aiton) Hassk. (haramonting) contains antioxidants that may prevent...

This research aims to analyse Expression of Caspase 3 in Rat Liver Cells With Maximum Physical Exercise After Administration of Gagatan Harimau Nanoherbal (Paraboea leuserensis B.L.Burtt). The research was conducted in April-June 2023. The research location was the Animal Physiology Laboratory and Experimental Animal House, Department of Biology, F...

Context: With recent biochemical studies, inflammation has been considered a therapeutic target. Mesenchymal stem cells are considered a therapeutic option because of the immunomodulatory effects of their bioactive factors, the secretome. Aims: To systematically review the potential of mesenchymal stem cell secretome therapy on inflammation through...

Objective Dementia is a common aging-related neurodegenerative disease in the elderly worldwide. Alterations in neurogenesis and angiogenesis factors have been linked to cognitive impairment in neurological disorders. However, synthetic drugs to improve memory disorders have uncomfortable side effects. The purpose of this study is to explore the ne...

This study aims to determine the effect of chronic administration of amphetamine-type stimulants at varying doses on inflammation and oxidative stress in Wistar rats. They were given methylphenidate and divided into 4 treatment groups. Furthermore, simple random grouping was carried out to divide the samples into 5 groups, each consisting of 9 rats...

There is a correlation between the occurrence of anxiety and the production of inflammatory mediators, and red ginger rhizome is a well-known herbal product with a high content of phenolic and flavonoid compounds that can be used as anti-inflammatories and antioxidants. The aim of study to evaluate the effect of red ginger as antianxiety in mice (M...

This study explores the chronic toxicity of nano-formulated Bischofia javanica leaves, a plant with pharmacological significance in Indonesia, following OECD guidelines 452. Graded doses (2, 4, 6, and 8 g/kg BW) of nano-formulated Bischofia javanica were administered to the treatment groups for 60 days, while the control group (K-) received only wa...

Diabetes mellitus is profoundly associated with various detrimental outcomes including sexual dysfunction and infertility in males. On the other hand, a medicinal plant namely Vitis gracilis Wall (Vitaceae) has been used as a traditional medicine to enhance vitality. This present study aimed to investigate the protective effect of V. gracilis leaf...

Diabetes mellitus is profoundly associated with various detrimental outcomes including sexual dysfunction and infertility in males. On the other hand, a medicinal plant namely Vitis gracilis Wall (Vitaceae) has been used as a traditional medicine to enhance vitality. This present study aimed to investigate the protective effect of V. gracilis leaf...

Context: Swimming is a common form of exercise; however, excessive exercise might reduce sperm count by lowering testosterone levels and increasing the production of free radicals, commonly known as reactive oxygen species (ROS). In Indonesia, Vitis gracilis Wall. is a traditional remedy for increasing stamina. Aims: To assess the concentration of...

Challenges of the medicinal plant agribusiness is free trade. Free trade demands the availability of quality and sustainable products. Improving medicinal plant preparations into nano-extracted forms is a promising method. Furthermore, the use of medicinal plants has a significant impact on plant biodiversity and the sustainability of the environme...

Obesity-related deaths continue to rise, and thus losing weight in overweight and obese patients is critical to prevent complications. Anredera cordifolia (Ten,) Steenis, species of succulent plant of the genus Basellaceae, is widely used in herbal medicine to decrease body weight. This study evaluated the potential benefits of Anredera cordifolia...

In sepsis, simultaneously elevated levels of pro-inflammatory cytokines and interleukin (IL)-10 indicate immune response dysregulation, increasing the mortality of the host. As mesenchymal stem cell (MSC) secretome is known to have immunomodulatory effects, we aim to assess the role of MSC secretome in the inflammatory mediators (NF-κB p65 and p50,...

Extracts of Phaleria macrocarpa have been used for years in traditional medicine and have been evaluated scientifically as well. This study aimed to evaluate the chronic toxicity level of nano herbal Phaleria macrocarpa and its effect on the changes in hematology, biochemistry, electrolytes, and organ histopathology. High Energy Milling (HEM) produ...

Context: The high mortality rate in people with lung disease indicates that this disorder requires immediate attention. It is established that excessive swimming can reduce the ability of lung cells to function and cause respiratory problems. Vitis gracilis Wall. is a traditional medicinal plant used by the Karo people of North Sumatra to improve s...

Context: Excessive swimming can reduce the ability of hippocampus cells and memory function. When hippocampus volume is lost in late adulthood, aerobic exercise can help recover it. This improvement in memory performance is beneficial, but excessive aerobic exercise can harm the hippocampal structure. Vitis gracilis Wall. is a traditional medicinal...

Background: Lower limb peripheral artery disease (PAD) is the main risk of diabetes mellitus which result to high mortality rate. Approximately, 50% of patients who receive several treatments have passed away or lost limbs at a year's follow-up. Secretome of hypoxia mesenchymal stem cells (S-MSCs) contains several active soluble molecules from hyp...

Hyperuricemia is defined as a metabolic syndrome disease with markers characteristic of uric acid production that exceed normal limits. Normal uric acid levels range from 3.4-7.0 mg/dl in adult men and 2.4 -6.0 mg/dl in adult women. So if uric acid levels exceed the normal limit, it will cause uric acid can not be fully metabolized and cause hyperu...

The specific aim to be achieved is the production of salted eggs low-sodium and low cholesterol. Spices for making 30 salted duck eggs are coconut fiber ash 1 kg, green tea in two tablespoons, 15 gram of bay leaves, 15 gram of reed root, 15 gram of leaves of mahkota dewa, 15 gram guava leaves, and 1/2 kg palm sugar. The method in the experiment is...

Kencur drink is one of the traditional drinks that has been known to be popular and has become an icon for daily healthy drinks. Kencur drink is very useful in preventing and treating diarrhea in Indonesia, can prevent colds and flu. Kencur can also prevent cancer, stop vomiting, prevent and treat fungi, lower cholesterol and improve appetite. Ther...

Background Smoking is the leading cause of death in worldwide and is known as one of the risk factors in the development and pathogenesis of several diseases and most are respiratory and cardiovascular diseases. Secondhand smoke (SHS) exposure is associated with negative health consequences including respiratory tract infection, asthma, and cancer....

Extracts of B. javanica have been used for years in traditional medicine and have been evaluated scientifically as well. Nano-sized drugs have a high ability to penetrate cells and can be manufactured without the use of heat. This study compared the physiological effect of nano herbal Sikkam leaves (NSL) to an ethanol extract of Sikkam leaves (EESL...

Background Hyperglycemia conditions in diabetes mellitus (DM) can turn on pro-inflammatory cytokines like IL-6 and TNF-α. These cytokines play a role in insulin resistance and the development of DM complications. People in Indonesia have used Phaleria macrocarpa to treat diabetes, but the leaf of this plant has not been studied to see if it can red...

Background Immunosuppression in sepsis is hypothesized to result from the increased expression of the immune checkpoint molecules programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1). PD-1 and PD-L1 blockade therapies have been reported to increase survival in septic animals. Currently, the interleukin (IL)-10 within mesenchymal stem cel...

Background: Sickle Garlic (Allium sativum L.) is known as a spice native to western Asia has a strong antioxidant effect and revealed it functions as an antioxidant by increasing ROS-capture activity, cellular antioxidants, SOD, CAT, and GSH levels in cells. Cigarette smoke is very dangerous because it can cause serious illness and death. Cigarette...

Background: Physiological aging and due to oxidative stress in long term will have an impact on cellular response disorders, can caused aging of hippocampus and senility. Brain weight is known to decrease with age and p16INK4a as aging biomarkers have been investigated. Andaliman is one of typical herbal plants from North Sumatra has been widely u...

Immunostimulatory effect of Pirdot (Saurauia vulcani) has been reported previously. However, molecular interactions tend to be involved in mechanism of immunostimulatory activity has not been clarified. Our previous study indicated that ethanol extract of Pirdot leaves affected significantly the number of erythrocyte and spleen histological structu...

Context: HIF1α and VEGF are proteins marker oxidative stress and a decrease in placental growth factor (PlGF). Decreasing of HIF1α and VEGF in rats displayed poor trophoblast differentiation, placental abnormalities, and fetal mortality. Rhodomyrtus tomentosa is a flowering plant in the Myrtaceae family that has the potential to be a source of heal...

Background and Objective: Herbs have the potential to be used in molecular therapy to treat inflammation and apoptosis. It has been demonstrated that the Indonesian native Vitris gracilis inhibits cytochrome c as a precursor to apoptosis. When body tissues are injured, infected with bacteria, exposed to toxins or exposed to heat that causes cell de...

Background and Objective: Natural herbs and molecular therapy can be used to treat cervical cancer. The Myc and Wee1 control tumour cell fate and microenvironmental changes like angiogenesis activation and host immune response suppression. The study aims to know about the correlation of Myc and Wee1 expressions as a molecular therapy given by Zanth...

Background and Objective: Hepatitis is a liver illness caused by a viral infection, autoimmune conditions or the use of certain medicines. In molecular hepatitis treatment, cytochrome c can be used as a potential predictor of the severity of liver impairment. In Asia, particularly in Indonesia, antioxidant-rich plants include Ficus carica and Olea...

The Asian Featherback Fish Or Ikan Belida Is One Of The Most Important Species Of Fish In Indonesia That Is Utilised By Locals As A Food Ingredient. Unfortunately, One Of The Species (Chitala Lopis) Has Already Been Reported Extinct By The IUCN. Nevertheless, Many Publications After That Still Claimed That Chitala Lopis Is Extant. We Study 28 COI P...

There are two species diversity of Asian elephants in Indonesia, namely: Sumatran elephant (Elephas maximus sumatranus) and Borneo elephant (Elephas maximus borneensis). This literature study aims to identify and analyze the diversity of Asian elephants in Indonesia, namely: Sumatran elephants (Elephas maximus sumatranus) and Borneo elephants (Elep...

Oral squamous cell carcinoma (OSCC) is a malignancy that occurs on keratinocyte cells that have the potential to spread through lymphatic tissue or blood vessels. These carcinomas develop as a result of a series of molecular factors, which are influenced by individual genetic factors as well as environmental exposure to carcinogens. The evaluation...

Abstract Context: Histological quantification of osteoclasts and osteoblasts can evaluate biological responses to orthodontic tooth movement. Histological analysis of bone samples can be technically challenging. Aims: To evaluate the differences between hematoxylin and eosin (HE) staining and immunohistochemistry (IHC) in quantifying osteoblast and...

Wounds of diabetic patients cause damage to skin tissue for a long time. Increased glucose levels affect angiogenesis which triggers the wound to heal. This study was to determine IL-1β expression in diabetic wound healing after being given nano herbal of Zanthoxylum acanthopodium and Rhodomyrtus tomentosa. This study consisted of 4 treatment group...

Context: Hyperglycemia causes diabetes mellitus (DM), abnormal metabolism, oxidative stress, and chronic complications such as impotence. Hyperglycemia causes testicular atrophy and stromal cell, seminiferous tubular damage, and spermatogenic cells. Bischofia javanica Blume is a plant that is used for the treatment of various chronic conditions and...

Context: Physical exercise with maximum intensity to fatigue can cause impaired immunity. Gastrocnemius muscle damage is found in eccentric activities in sports. Vitis gracilis has been proven as a healing agent for degenerative diseases. Aims: To determine whether the V. gracilis Wall extract can recovery of gastrocnemius muscle cells of Mus musc...

Aim Allergic rhinitis (AR) is a heterogeneous condition that has been associated with inflammatory responses and is characterized by clinical typical symptoms of nasal itching, sneezing, watery discharge and congestion. Mesenchymal stem cells (MSCs) are multipotent stem cells that have the immunoregulatory ability by secreting various cytokines whi...

Background: A Erectile dysfunction (ED) is one of the well-known comorbidities in males with diabetes mellitus (DM), whose pathogenesis might be induced by dysregulation of corpus cavernosum smooth muscle cells. UC-MSCs are multipotent cells that attract considerable interest due to immunoregulatory properties and might be a potential strategy to...

Pebriani MA, Barus TA, Ilyas S. 2021. Fish diversity and heavy metal accumulation of Pb, Cu and Zn after Mount Sinabung Eruption in Benuken River, North Sumatra, Indonesia. Biodiversitas 23: 187-194. The Benuken River is a river that has been affected by the volcanic ash eruption of Mount Sinabung, one of the active volcanoes in Indonesia. This stu...

AIM: The hepatoprotective activities of bioactive compounds Pirdot were investigated in vivo and in silico. METHODS: In this study, the completely randomized design non-factorial was experimentally to assess the value of SGPT and SGOT and twenty four adult male rats were divided into four groups : group G0, control group; group G1, a treated group...

Background and Objective: Cervical cancer is the leading cause of death for women in the world and Indonesia. This disease originates from a malignant tumour of squamous epithelial cells caused by infection with the Human Papilloma Virus (HPV). Antioxidants can reduce oxidative stress in and there are plants from Indonesia that have high antioxidan...

Cervical cancer is a disease from the Human papillomavirus (HPV) through transmission, virus persistence, clone development until infecting the cells in the cervical. This study is to determine CDK4 expression in cervical cancer cells after being given Zanthoxylum acanthopodium methanol extract (ZAM) and the histological description of cervical can...

This study investigated the therapeutic role of mesenchymal stem cells (MSCs) on erectile function in a diabetes mellitus erectile dysfunction (DMED) rat model by analyzing the expression of endothelial nitric oxide synthetase (eNOS), vascular endothelial growth factor (VEGF), and the 70 kilodalton heat shock proteins (HSP70). MSCs were isolated fr...

BACKGROUND: Diabetes mellitus (DM) is a chronic and progressive metabolic disease characterized by hyperglycemia due to impaired insulin secretion associated with a lack of phosphoinositide 3-kinase (PI3K) and glucose transporter-4 (GLUT-4) expression in the skeletal muscle membrane. AIM: The aim of the study is to understand the effect of coffee A...

Heavy metals are easy to bind organic matter and settle to the bottom of the waters and unite with sediments, which is cadmium. Cadmium (Cd) is found from volcanic eruptions, from various human activities, and is carcinogenic. This study aims to analyze the concentration of cadmium in water and sediment in Lake Lau Kawar. Water samples were collect...

Lake Lau Kawar is one of the exposed areas in North Sumatra by the volcanic ash originating from Mount Sinabung eruption. The lake has been utilized as a tourism site and fish resources for consumption by the local community. Keperas ( Cyclocheilichthys apogon Val. 1842) is one of the native fish commonly caught by the community. The aim of this st...

Background Orthodontic tooth movement is mediated by the inflammation process. Inflammation induces pain and increases the level of cortisol hormone as it triggers stress. The aim of this research was to observe the effects of vitamin E (VE) supplementation in reducing stress levels from orthodontic force in Wistar rats (Rattus norvegicus). Method...

BACKGROUND: Cisplatin (CIS) is an important chemotherapy agent which is widely used for the treatment of many types of solid tumors, which can cause decreased ovarian function. Nigella sativa has been shown to have an anti-inflammatory and anti-oxidant activity that might protect the ovaries from damage due to CIS. AIM: This study aims to understan...

Background: Allergic Rhinitis (AR) is the most common immunological disease that has been associated with inflammatory responses and is characterized by sneezing. Previous studies found that AR's allergen exposure significantly induces plasma cells and reduces regulatory T (Treg) cells, a population that contributes to control AR. Therefore, upreg...

This study aims to investigate the potential of bioactive secondary metabolites contained in Sphagneticola trilobata (L.) J.F Pruski leaves as novel plant-derived anticancer agent. Qualitative bioactive compound contents in the methanolic extract of S. trilobata leaves were screened using phytochemical method. Antioxidant evaluation was carried out...

BACKGROUND: Coffee arabica gayo leaf extract (Coffea arabica L.) contains polyphenols (chlorogenic acid), flavonoids, saponins, tannins, and steroids which improved PI3K serum levels in rats type 2 diabetic rat. AIM: The purpose of the study was to determine the effect of Coffee Arabica Gayo Leaf Extract (C. arabica L.) on increased PI3K serum leve...

BACKGROUND: One of alternative medicine in stroke therapy is Ophiocephalus striatus sp. extract. The nutrients contained in the O. striatus sp. extract, namely amino acids, fatty acids, cuprum, and zinc, are useful for the process of angiogenesis in poststroke patients through increased endothelial nitric oxide synthase. AIM: We hypothesized that t...

BACKGROUND: Diabetes mellitus (DM) continues to increase with currently more than 463 million people in the world live with DM. One of the causes of Type 2 DM (T2DM) is insulin resistance. Determining laboratory-based tests for early identification of T2DM is important. One of the tests developed was the detection of homeostatic model assessment –...

Context: Gallic acid and quercetin in sikkam leaves (Bischofia javanica) have scientific potential as antidiabetic agents. Quercetin suppresses hyperglycemia by inhibiting active glucose transport. Meanwhile, gallic acid acts as an antidiabetic is closely related to its antioxidant properties. Antioxidant compounds neutralize cells that experience...

The number of people with diabetes mellitus (DM) is increasing alarmingly from year to year. Efforts to find cheap, safe and effective natural ingredients for DM are becoming increasingly important. This study was aimed to study the antidiabetic and immunostimulant properties of bosibosi ( Timonius flavescens ) leaves ethanol extract (LEE) in allox...

Diabetes Mellitus is a metabolic disease characterized by hyperglycemia, occurring due to abnormal insulin secretion or insulin action. Alloxan induces diabetes by damaging pancreatic cells and initiating hyperglycemia. One of the plants that has the potential to decrease blood sugar is leaves of sikkam ( Bischofia javanica ), because it contains q...

Zanthoxylum acanthopodium has several biological activities, such as antimicrobial, anti-inflammatory, and antioxidant properties. This strong antioxidant herb can be used as a drug for hypertension. FasL and cytochrome c expression play roles in the apoptotic pathway in the placenta. This study focused on the histological change in apoptosis via c...

Background and objective: Haramonting (Rhodomyrtus tomentosa) is an alternative herb to improve health because it has many biological activities and antioxidant. HSP-70 levels as biomarkers of preeclampsia affected the anti-apoptosis of damaged cells in the placenta. This study aimed to evaluate the role of HSP-70 expressions by investigating whet...

Context: Diabetes mellitus (DM) is a metabolic hyperglycemia disease caused by abnormalities in insulin secretion and the highest increase in diabetes sufferers that occurred in Southeast Asian countries, including Indonesia. The sikkam leaf (Bischofia javanica) ethanolic extract contains many secondary metabolites, and some of them are quercetin a...

Introduction: Rhodomyrtus tomentosa (haramonting), a typical plant of North Sumatera, Indonesia, contains important medicinal ingredients. Nano sized drugs have high loading capacities and can be given at high concentrations. This study aimed to determine the components and toxicity of nanoherbal haramonting. It also aimed to determine the effect o...

Background and objective: Andaliman fruit (Zanthoxylum acanthopodium) is a well-known spice antioxidant in Northern Sumatera (Indonesia). The cellular activity requires antioxidants in counteracting free radicals. The cellular proteins that play a role in development, proliferation, differentiation and embryonic processes in the human placenta are...

Background and objective: The andaliman fruits have anti-inflammatory, antioxidant activity and a strong inhibition in antitumor activity. The purpose of this study was to analyze the effect of extract andaliman on rat's kidney and liver histology induced by benzopyrene. Materials and methods: The rats model of cancer-induced benzopyrene. This r...

Cadmium is a metal that has high toxic effects in high and low concentrations. The presence of cadmium will adversely affect the biological processes of aquatic organisms, mainly carp, which can threaten the sustainability of their lives, including humans, through the food network. Lau Kawar Lake was formed several thousand years ago when lava flow...

The ability to regenerate tissue is different for each organism. Mice (Mus musculus) able to regenerate the 3rd phalange of a digit. The tissue regeneration process has four phases are the wound-healing phase, the blastema phase, the regeneration phase, and the maturation phase. Each phase has a different process and different activity of cells. Hi...

Bacterial cellulose (BC), chitosan (Chi), and collagen (Col) are known as biopolymers which have met some properties that are required as wound dressing. This study focused on investigating the fabrication of BC-based wound dressing with chitosan and collagen, since chitosan has red blood cells binding and anti-bacterial properties, while collagen...

Ethanolic leaf extract of Saurauia vulcani Korthor pirdot in Indonesia was evaluated to improve the number of erythrocytes in laboratory rats after being immunized with sheep red blood cells (SRBC). This study was conducted in an experimental manner using a non-factorial Completely Randomized Design (CRD) with four treatments and six replications....

BACKGROUND: Trichuris trichiura is a soil-transmitted parasitic worm commonly found in humid, tropical to subtropical areas, as well as poor sanitation area. These worms are cosmopolitan, especially in tropical and humid countries like Indonesia. This worm infection is more common in developing countries and more in children than adults due to poor...

Aim Vulvovaginal candidiasis (VVC) is a disease mostly caused by Candida albicans and affects the quality of life of women especially in the form of chronic recurrent vulvovaginal candidiasis (RVVC). Nigella sativa is known to have several effects such as antimicrobial, anti-inflammatory, immune stimulation and anticancer properties. The aim of th...

Aim Senduduk fruit (Melastoma malabathricum L) is native to Indomalaya and is believed to possess anticancer activity. This study investigated antiangiogenic and anti-inflammation effects of an ethanolic extract of Senduduk fruit (EESF) on HeLa cells. Methods Cytotoxicity was assayed in HeLa cell cultures exposed to a concentration series of 500–7....