Swapnil P Borse

Swapnil P Borse
Savitribai Phule Pune University | University of Poona · AYUSH - Center of Excellence, Center for Complementary and Integrative Health, Pune.

PhD-Pharmacology & Toxicology

About

45
Publications
15,859
Reads
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418
Citations
Citations since 2016
40 Research Items
416 Citations
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Introduction
With experience in drug-herb-disease interactions, drug metabolism and pharmacokinetics, toxicokinetics, animal model development, pharmaco-toxicological evaluations, scientific/medical writing and presentations, augmented with equal expertise in Ayurveda based natural products drug discovery and development; aim is to innovate and be a scientist with entrepreneurial skills of par excellence.
Additional affiliations
October 2014 - present
Nirma University
Position
  • Doctoral Research Scholar
October 2013 - April 2016
B.V. Patel Pharmaceutical Education & Research Development (PERD) Centre
Position
  • Researcher
October 2013 - October 2016
B.V. Patel Pharmaceutical Education & Research Development (PERD) Centre
Position
  • Doctoral Research Scholar
Education
August 2011 - August 2013
Symbiosis School of Biomedical Sciences; Symbiosis International University; Lavale Pune- 411 042
Field of study
  • Drug Interaction, Integrative Pharmacokinetics
August 2007 - July 2011
JSPM's Charak Collge of Pharmacy & Research, Wagholi, Pune
Field of study
  • Pharmacy.

Publications

Publications (45)
Article
Consuming botanical dietary supplements or herbal drugs along with prescription drugs may lead to potential pharmacokinetic-pharmacodynamic (PK-PD) herb-drug interactions (HDI). The present study focuses on the importance of and novel approach for assessing HDI in integrative medicine with case examples of two frequently-used Ayurvedic Rasayana bot...
Article
Full-text available
Introduction: Progress in management of Nonsteroidal anti-inflammatory drug (NSAID) induced gastrointestinal toxicity requires the availability of appropriate experimental animal models that are as close to humans as feasible. Our objective was to develop a rat model for NSAID-induced gastroenteropathy and also to simulate the common clinical scena...
Article
Full-text available
The pathogenesis of Nonsteroidal anti-inflammatory drug (NSAID) enteropathy is still unclear and consequently there is no approved therapeutic strategy for ameliorating such damage. On the other hand, molecular treatment strategies targeting tumour necrosis factor (TNF) exerts beneficial effects on NSAID-induced intestinal lesions in rodents and rh...
Article
Full-text available
Ayurvedic medicines Withania somnifera Dunal ( ashwagandha ) and AYUSH-64 have been used for the prevention and management of COVID-19 in India. The present study explores the effect of Ashwagandha and AYUSH-64 on important human CYP enzymes (CYP3A4, CYP2C8, and CYP2D6) to assess their interaction with remdesivir, a drug used for COVID-19 managemen...
Poster
Full-text available
Ayurveda therapeutics focuses on strengthening homeostatic mechanisms. Rasayana, a specialty of Ayurveda, deals with tissue nourishment, longevity, and immunomodulation. Rasayana botanicals maintain an immune-homeostasis instead of unidirectional immune-boosting or immune-suppression. Recent studies in cancer and COVID-19 provide important clues on...
Article
Full-text available
Introduction: Vaccines have emerged as the most effective tool in the fight against COVID-19. Governments all over the world have rolled out the COVID-19 vaccine program for their populations. Oxford-AstraZeneca COVID-19 vaccine (COVISHIELDTM) is widely used in India. A large number of Indian people have been consuming various traditional medicines...
Preprint
Full-text available
Aim Withania somnifera Dunal (WS), known as Ashwagandha and AYUSH-64, a polyherbal formulation are repurposed for the management of COVID-19. The extensive use of these botanicals as home remedy along with other drugs for managing multifarious disease conditions is increasing over nations. This raises high chances of herb-drug interactions (HDIs) w...
Preprint
Full-text available
Introduction The government of India has rolled out COVID-19 vaccine program for individuals who are 18 years of age and above and priority is being given to the elderly, and individuals with morbidity. Oxford-AstraZeneca COVID-19 vaccine (COVISHIELD) is most widely used in India. A large number of Indian people have been consuming various traditio...
Article
Full-text available
The Coronavirus disease (COVID-19) caused by the virus SARS-CoV-2 has become a global pandemic in a very short time span. Currently, there is no specific treatment or vaccine to counter this highly contagious disease. There is an urgent need to find a specific cure for the disease and global efforts are directed at developing SARS-CoV-2 specific an...
Article
Full-text available
Recent reports on COVID-19 suggest, the susceptibility to COVID-19 and its progression have a genetic predisposition. Majorly associated genetic variants are found in human leukocyte antigen (HLA), angiotensin convertase enzyme (ACE; rs1799752: ACE2; rs73635825), transmembrane protease serine 2 (TMPRSS-2; rs12329760) genes. Identifying highly prone...
Article
Full-text available
As the COVID-19 pandemic is progressing, the therapeutic gaps in conventional management have highlighted the need for the integration of traditional knowledge systems with modern medicine. Ayurvedic medicines, especially Ashwagandha (Withania somnifera (L.) Dunal, WS), may be beneficial in the management of COVID-19. WS is a widely prescribed Ayur...
Chapter
Glioblastoma (GBM) is considered a severe tumor compared to other existing ones. The recommended approaches used for the treatment of GBM are invasive and suffering from their limitations. In addition to this, the blood-brain barrier (BBB) is considered as one of the major hurdles in the successful treatment of GBM. Therefore, various drug delivery...
Chapter
Full-text available
Turmeric (Curcuma longa), from the Zingiberaceae family, is an important herb. Its rhizomes are widely used throughout the world as a principal spice and drug. Turmeric is taken as a therapeutic adjuvant assuming that it is fully safe with different drugs and/or herbal formulations. However, this may or may not always be the case. This depends on t...
Article
Full-text available
Type-2 diabetes mellitus (T2DM) accounts for more than 90 percent cases of diabetes in adults. Resistance to insulin action is the major cause that leads to chronic hyperglycemia in diabetic patients. T2DM is the consequence of activations of multiple pathways and factors that are involved in insulin resistance and β-cells dysfunction. Also, the et...
Conference Paper
Full-text available
Abstract Purpose Diabetes is a complex multifactorial disease. The prevalence of diabetes throughout the world is increasing, nearly half (46%, 415 million) of the adult population is living with diabetes and the majority of them are with Type 2 Diabetes Mellitus (T2DM). T2DM-mediated alterations in the pharmacokinetics-pharmacodynamics (PK-PD) of...
Article
Full-text available
Background Identifying ways to reduce the burden of prostate cancer (Pca) or benign prostatic hyperplasia (BPH) is a top research priority. It is a typical entanglement seen in men which is portrayed by trouble in micturition. It stands as a significant problem in our society. Different molecular biomarker has high potential to treat Pca or BPH but...
Preprint
Full-text available
The Coronavirus disease (COVID-19) caused by the virus SARS-CoV-2 has become a global pandemic in a very short time span. Currently, there is no specific treatment or vaccine to counter this highly contagiousdisease. Presently, existing anti-virals and disease-modifying agents are being repurposed to manage COVID-19. There is an urgent need to find...
Data
Several extracts and phytoconstituents of Withania somnifera (WS) have shown the potential to address cancer hallmarks. The inner circle depicts the classical hallmarks of cancer. The outer circles illustrate the anti-cancer activities of WS that have the potential to address the respective hallmarks of cancer with the specific molecular targets li...
Article
Ethnopharmacological relevance Withania somnifera (L.) Dunal (WS) is one of the most-studied Rasayana botanicals used in Ayurveda practice for its immunomodulatory, anti-aging, adaptogenic, and rejuvenating effects. The botanical is being used for various clinical indications, including cancer. Several studies exploring molecular mechanisms of WS s...
Article
Abstract Cancer and diabetes are the two major disorders that affect a large proportion of the world’s population. Results from multiple epidemiological studies have concluded that diabetes and cancer are linked, and diabetic patients live at much higher risks of developing cancer and diabetic complications at the later phase of disease. Inflammat...
Article
Full-text available
The type 2 diabetes is one of the major global health issues that affects millions of people. This study evaluated the antidiabetic activity of aqueous extracts (AECP) and methanol extracts (MECP) from Ceiba pentandra trunk bark on an experimental model of type 2 diabetes (T2D). This model was induced in rats by the combination of a high‐fat diet (...
Article
Full-text available
Integrative medicine refers to the blending of conventional and evidence-based complementary medicines and therapies with the aim of using the most appropriate of either or both modalities for ultimate patient benefits. One of the major hurdles for the same is the chances of potential herb-drug interactions (HDIs). These HDIs could be beneficial or...
Article
Quercetin (QCT) is a flavonoid, abundantly present in plants and has gained considerable interest for its antioxidant property and chemo preventive activity. Bioavailability of QCT is very low due to its poor aqueous solubility and instability. Researchers are working on the application of nanotechnology to target chemotherapeutic drugs to the tumo...
Article
Full-text available
Hypertension (HTN) has become a common chronic medical condition which affects ≥20% of adult population worldwide. HTN is assumed to be a major contributing factor for increasing complication of metabolic syndrome by adding one or more comorbidities such as heart disease, stroke, chronic renal failure, myocardial infarction, blindness, and dementia...
Conference Paper
Full-text available
Introduction: Progress in management of Nonsteroidal anti-inflammatory drug (NSAID) induced gastrointestinal toxicity in diabetes requires search of novel therapeutic management. Objective: To develop a rat model for NSAID-induced gastroenteropathy in diabetes and check the multi-targeted potential of insulin plant to treat the same. Materials and...
Article
There is a need to find/discover novel leads to treat complex and/or multi-factorial-pathogenic disease(s). Curcumin (CUR) is one of the promising lead molecules which need its further evaluation against NSAID-induced gastroenteropathy. Hence, the aim of the present study was to explore the pharmaco-mechanistic efficacy of CUR against NSAID-induced...
Article
There is a need to find/discover novel leads to treat complex and/or multi-factorial-pathogenic disease(s) like Nonsteroidal anti-inflammatory drugs (NSAID)-induced gastroenteropathy or gastrointestinal (GI) toxicity as it has emerged as an important medical and socioeconomic problem. There is no approved therapeutic strategy to prevent NSAID-induc...
Article
Management of Nonsteroidal anti-inflammatory drug (NSAID)-induced gastroenteropathy has emerged as a major medical and socioeconomic problem mainly because the highly efficacious gastroprotective drugs i.e. proton pump inhibitors (PPIs) like pantoprazole sodium (PTZ), worsen the NSAID-induced enteropathic damage and lack of approved therapeutic str...
Conference Paper
Full-text available
Management of Nonsteroidal anti-inflammatory drug (NSAID)-induced gastroenteropathy is a challenge for the clinicians mainly because antisecretory drugs like proton pump inhibitors although prevent the NSAID-induced gastro-duodenal damage; they rather worsen the enteropathic damage. Importantly, pathogenesis of the disease remains ill defined and t...
Research
Full-text available
Trademark: Ayurnization TM (Application No.: 3281488-92; Class 3,5,9,16,42)_It is define as evaluation and development of any non Ayurvedic substance as per Ayurvedic principles, for its use in Ayurveda and/or drug discovery and development process
Conference Paper
Full-text available
Management of NSAID-induced gastrointestinal toxicity is a challenge and requires the availability of appropriate experimental animal models that are as close to humans as feasible and a proper understanding of its etiopathogenesis. Our first objective was to develop a rat model for NSAID-induced gastroenteropathy and also to explore if co-administ...
Conference Paper
Full-text available
Concurrent consumption of botanicals as dietary supplement or herbal drug with prescription drugs (PDs) may lead to potential pharmacokinetic-pharmacodynamic (PK-PD) herb-drug interactions (HDIs). In present work, we studied effect of aqueous extract of Asparagus racemosus (ARE) on cytochrome 3A4 P450 (CYP3A4) isoenzyme; major hepatic isoenzyme res...
Conference Paper
Full-text available
S w a p n i l B o r s e S y m b i o s i s I n t e r n a t i o n a l U n i v e r s i t y , I n d i a Abstract Gairic is an Ayurvedic formulation, commonly prescribed as an anti-anemic, anti-inflammatory, antacid and used as base for many ayurvedic formulations. It is prepared by frying of Red ocher with the help of Cow's ghee in the ratio of 10:1. T...
Article
Full-text available
The leaves of Calotropis procera R.Br was undertaken for evaluation of antidiarrhoeal activity in Albino mice (male) weighing between 40-50gm was used in this study. The selected and authenticated plant extract was prepared by maceration with using a methanol as a solvent for 7 days. From the toxicity study; it was observed that plant extract is no...
Conference Paper
Full-text available
The present study deals with the Antidiabetic effect of aqueous extract of Salacia oblanga on Alexon induced diabetic Albino rats. The Salacia oblanga is use in ayurveda as hypoglycemic food. It contents various Phytochemical; the Salacinol as glucosidase inhibitor as that of Acarabose. And also prevents absorption of monosaccharide’s & there by re...

Questions

Questions (7)
Question
To reduce the number and suffering of animals, while focusing on drug-disease-drug/herb interaction(s), how much is it logically and/or scientifically accepted to use the same rats for invivo pharmacokinetics and invitro metabolomics experiments?
When invivo pharmacokinetics experimentation involves jugular vein cannulation for frequent blood sampling, this is a kind of major injury with temporary presence of foreign body in rat leading to alteration in immune cascade and/or body homeostasis.
On the other hand, even acute alteration in body homeostasis and/or immune cascade may alter the functional ability of certain drug metabolizing enzyme(s).
Considering these facts, how much is it logically and/or scientifically accepted to use, liver, kidney and/or intestine of the same rats for further invitro metabolomics experimentation after completion of invivo PK experiment.
If you want any additional information, I’ll be happy to provide it promptly.
Thanking you for your time and consideration of my request.
Looking forward for fruitful interactions...
Best regards,
Swapnil
Question
I have induced type 2 diabetes mailitus using high fat diet (45% fat) plus multiple low dose of streptozotocin (30mg). So can any please tell me Which type insulin (Short, log, Intermidiate acting or Biphasic insuline) should be used to carry out Insulin Tolerance Test in type 2 diabetic rats?
Question
Phytoconstituents and herbal extracts are known to act through multiple complex pathways, there may be some phytoconstituents which can act through HPA axis leading to down-regulation of corresponding gene/protein.

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Projects

Projects (7)
Project
This project explores the potential of Ayurveda-based botanicals in prophylaxis and therapeutic management of COVID-19.