Svitlana Drozdovska

National University of Physical Education and Sport of Ukraine · biomedical department

Athletic performance is a polygenic trait influenced by both environmental and genetic factors. To investigate individually and in combination the association of common gene polymorphisms with athlete status in Ukrainians. A total of 210 elite Ukrainian athletes (100 endurance-oriented and 110 power-orientated athletes) and 326 controls were genoty...

In the vast majority of sports, muscle activity is dynamic in nature, however, recently sports physiologists have been paying considerable attention to static exercises. The deep mechanisms of the phenomenon of static efforts have been studied since its discovery, but there are still many gaps in biological knowledge regarding the issue of the impa...

Non-communicable diseases (NCDs), including coronary heart disease, stroke, hypertension, type 2 diabetes, dementia, depression and cancers, are on the rise worldwide and are often associated with a lack of physical activity (PA). Globally, the levels of PA among individuals are below WHO recommendations. A lack of PA can increase morbidity and mor...

Metabolic syndrome (MS) is characterized by disorders of carbohydrate and fat metabolism, which can lead to the development of cardiac autonomic neuropathy (CAN). Heart rate variability (HRV) analysis is used to assess the state of autonomic regulation. A decrease in HRV indicates unfavourable changes in autonomic regulation and the development of...

Metabolic syndrome (MS) is characterized by disorders of carbohydrate and fat metabolism, which can lead to the development of cardiac autonomic neuropathy (CAN). Heart rate variability (HRV) analysis is used to assess the state of autonomic regulation. A decrease in HRV indicates unfavourable changes in autonomic regulation and the development of...

This chapter reviews the issue of overweight management, which is one of the major challenges faced by most countries today. The causes of obesity include genetic and epigenetic factors, a lack of physical activity, eating disorders, and gut microbiota status. Physical exercise is the main means of prevention and management of overweight and obesit...

The objective of this study was to identify informative anthropometric and functional indicators for design- ing self-training exercise programs for middle-aged obese women. The study involved 105 women with an average age of 38.9 and was conducted at the Scientific Research Institute of NUPESU. The physical fitness profile of the middle-aged overw...

Skeletal muscles as an endocrine regulator of metabolic syndrome development Abstract. Metabolic syndrome is a combination of metabolic disorders that occur against the background of obesity, insulin resistance, hypertension, dyslipidemia and are accompanied by disorders of lipid, purine and carbohydrate metabolism. Objective. Analyze the role of s...

The purpose of this study was to evaluate the effectiveness of a combined exercise program focused on the improvement of young women’s physical condition. Materials and methods. The study involved 62 healthy women (an average age of 29.4 years). More than 50 parameters were assessed (anthropometric indicators, physical capacity and motor abilities...

Sports hernias are diagnosed in over 80% of athletes presenting with chronic groin pain. The genotype distributions of the examined polymorphisms were studied in 95 football players, all males, using the Copenhagen Hip and Groin Outcome Score (HAGOS) questionnaire. DNA extracted from buccal epithelium. Statistical calculations were performed in the...

Metabolic syndrome is a cluster of cardiometabolic risk factors. They include obesity, dyslipidemia, hypertension, and insulin resistance. Central obesity and resistance to insulin, in particular, are recognized as causative factors, which form the development of metabolic syndrome. Metabolic syndrome is a progressive and genetically determined con...

Obesity is a widespread problem within modern society, serving to increase the risk of cardiovascular, metabolic, and neu-rodegenerative disorders. Peroxisome proliferator-activated receptor gamma (PPARγ) and PPARγ coactivator 1 α (PGC1α) play a key role in the regulation of cellular energy metabolism and is implicated in the pathology of these dis...

Aim. Peroxisome proliferator activated receptor gamma (PPARG) and PPARG coactivator 1α (PPARGC1A) is a key regulator of energy metabolism. This study examines the influence of PPARG and PPARGC1A gene polymorphisms on the PPARG expression, obesity risk, lipoprotein profile and effectiveness of the physical activity intervention for improvement of th...

The study was focused on the substantiation of a personalized approach to designing health-promoting exercise programs for young women based on the genetic factors. To achieve the defined objectives the following methods were used: theoretical analysis and generalization of the data of scientific and methodological literature; surveys and questionn...

A well-maintained skeletal muscle is important for the overall people’s health and their physical capacity. Although the role of heredity and genetic determinants of muscle mass was recognized several decades ago, the modern scientific studies have established numerous new genetic and epigenetic factors affecting the state of muscular tissue. This...

Skeletal muscle mass is an important indicator of human health and physical performance. Representing about 50% of body weight, skeletal muscles play a key role not only in motor activity, but also in maintaining the body’s metabolic status. The muscle mass is an important factor as the physical human qualities that underlie its sporting achievemen...

The aim of this study was to investigate the association between the MCT1 (monocarboxylate transporter 1) A1470T polymorphism and positional roles in a large cohort of professional football players from five different countries. We compared genotype distributions of the MCT1 A1470T polymorphism between football players (n=694) and non-athlete contr...

MOLECULAR GENETIC MARKERS IN UKRAINIAN ATHLETES

The mTOR (mammalian target of rapamycin) enzyme plays an important role in extracellular signal transduction, phosphorylates various protein metabolism enzymes, transcription and translation factors and in this way regulate metabolism in skeletal muscles [1]. mTOR is encoded by the mTOR (FRAP1) gene, which contains 8189 single nucleotide polymorphi...

: Molecular mechanisms of adaptation to exercise despite a large number of studies remain unclear. One of the crucial factors in this process is hypoxia inducible factor (HIF) that regulates transcription of many target genes encoding proteins that are implicated in molecular adaptation to hypoxia. Experiments were conducted on 24 adult male Fisher...

The adaptation of an athlete to systematic physical exercise has been shown to be determined by a combination of great many genes. The aim of our study was to investigate the dependence of the aerobic capacity parameters in sport on the set of gene polymorphisms. Cardio-respiratory system (CRS) adaptation reactions to exercise of 72 endurance athle...

The feature of cardiorespiratory system responses to physical load has been investigated in athletes with different genotypes. The influence of АСЕ, eNOS, PPARA, PPARG, HIF-1α, PPARGC1B gene polymorphisms on gas analysis indices have been analyzed. The association of I/D АСЕ, Т/С eNOS G/C PPARA gene polymorphisms with various characteristics of aer...

Analyzes of the methods used in sports genetics, and molecular genetics of muscle activity in particular are considered. The historical retrospective review of sports genetics methods was created. Contemporary level sports genetics methods were determined by the scientific literature analysis. The most common molecular genetics techniques that are...

The role of HIF-3α in response to intermittent hypoxia and physical exercise was investigated in Fisher rats using reverse transcription, real-time PCR and RNA interference. Under acute hypoxia (12% O(2), 2h), the level of HIF-1α, HIF-2α, and HIF-1β mRNA did not significantly change in the heart, lung, kidney and muscle tissues, but HIF-3α mRNA exp...

Background: The aim of the study is to define the possibility of usage of the gene eNOS polymorphisms as molecular-genetic markers of athletes' resistance to exercise-induced hypoxia. Material/Methods: 127 highly qualified athletes were examined (30 persons are underwater finswimmers, 41 – rowers and 56 sportsmen who practice speed and power track...