Sven Magnus Carlsen

Sven Magnus Carlsen
Norwegian University of Science and Technology | NTNU · Department of Cancer Research and Molecular Medicine

MD, PhD

About

110
Publications
10,950
Reads
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3,157
Citations
Additional affiliations
January 2009 - October 2015
Norwegian University of Science and Technology
Position
  • Professor (Full)
November 2003 - present
St. Olavs Hospital
Position
  • Consultant
November 2003 - present
St. Olavs Hospital
Position
  • Consultant

Publications

Publications (110)
Article
Full-text available
Patients with diabetes mellitus type 1 depend on exogenous insulin to keep their blood glucose concentrations within the desired range. Subcutaneous bihormonal artificial pancreas devices that can measure glucose concentrations continuously and autonomously calculate and deliver insulin and glucagon infusions is a promising new treatment option for...
Article
Introduction Glucagon and insulin are the two most important hormones for glucose metabolism and have been incorporated in the dual-hormonal artificial pancreas, a device for automated glucose regulation for people with diabetes type 1. Currently the subcutis is the preferred site of hormone delivery for insulin-only as well as dual-hormonal artifi...
Article
Full-text available
Introduction: There is increasing scientific evidence to substantiate using low-dose glucagon as a supplement to insulin therapy in artificial pancreata for diabetes mellitus type 1. The delivery of both these hormones intraperitoneally would mimic normal physiology. However, our knowledge of the pharmacological properties of glucagon after intrap...
Article
Full-text available
Objective Polycystic ovary syndrome (PCOS) is a common endocrine disorder, with potential effects on offspring both genetically and through altered intrauterine environment. Metformin, which ameliorate hormonal disturbances in non-pregnant women with PCOS is increasingly used in pregnancy. It passes the placenta, and the evidence on potential conse...
Article
Full-text available
Polycystic ovary syndrome (PCOS) is characterized by the presence of insulin resistance, and women with PCOS have high prevalence of gestational diabetes (GDM). Both conditions have been associated with increased risk for pregnancy complications such as preterm birth, preeclampsia and increased offspring birth weight. We aimed to estimate the preva...
Article
Full-text available
Background and Objective Artificial pancreases administering low-dose glucagon in addition to insulin have the scope to improve glucose control in patients with diabetes mellitus type 1. If such a device were to deliver both hormones intraperitoneally, it would mimic normal physiology, which may be beneficial. However, the pharmacokinetic propertie...
Article
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The intraperitoneal route of administration accounts for less than 1% of insulin treatment regimes in patients with diabetes mellitus type 1 (DM1). Despite being used for decades, a systematic review of various physiological effects of this route of insulin administration is lacking. Thus, the aim of this systematic review was to identify the physi...
Article
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Introduction The effect of intraperitoneal insulin infusion has limited evidence in the literature. Therefore, the aim of the study was to investigate the pharmacokinetics and pharmacodynamics of different intraperitoneal insulin boluses. There is a lack of studies comparing the insulin appearance in the systemic circulation after intraperitoneal c...
Article
Full-text available
Background To provide age- and sex-specific incidence and case fatality rates for non-traumatic aneurysmal subarachnoid hemorrhage (aSAH) in Norway. We also studied time trends in incidence and case fatality, as well as predictors of death following aSAH.MethodsA nationwide study using discharge data for patients admitted with aSAH between 2008 and...
Article
Full-text available
Glucagon is a pancreatic hormone and increases the blood glucose levels. It may be incorporated in a dual hormone artificial pancreas, a device to automatically and continuously control blood glucose levels of individuals with diabetes. Artificial pancreas systems have been developed for use in the subcutaneous tissue; however, the systems are not...
Article
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Introduction Gestational diabetes mellitus (GDM) is a common disorder of pregnancy and contributes to adverse pregnancy outcomes. Metformin is often used for the prevention and management of GDM; however, its use in pregnancy continues to be debated. The Metformin in Pregnancy Study aims to use individual patient data (IPD) meta-analysis to clarify...
Article
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Background: There is limited evidence on the comparative performance of private and public healthcare. Our aim was to compare outcomes following surgery for lumbar disc herniation (LDH) in private versus public hospitals. Methods: Data were obtained from the Norwegian registry for spine surgery. Primary outcome was change in Oswestry disability...
Article
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Objective The Finnish Diabetes Risk Score (FINDRISC) is a recommended tool for type 2 diabetes prediction. There is a lack of studies examining the performance of the current 0–26 point FINDRISC scale. We examined the validity of FINDRISC in a contemporary Norwegian risk environment. Research design and methods We followed 47 804 participants with...
Article
Full-text available
Background In classical approaches for an artificial pancreas, continuous glucose monitoring (CGM) is the only measured variable used for insulin dosing and additional control functions. The CGM values are subject to time delays and slow dynamics between blood and the sensing location. These time lags compromise the controller's performance in main...
Article
The artificial pancreas requires fast and reliable glucose measurements. The peritoneal space has shown promising results, and in one of our studies we detected glucose changes in the peritoneal space already at the same time as in the femoral artery. The peritoneal lining is highly vascularised, covered by a single layer of mesothelial cells and t...
Article
Closed-loop glucose control has the potential to improve the glycemic control in patients with diabetes mellitus type 1. Such an artificial pancreas (AP) should keep the user safe despite all disturbances and faults. The objective of this paper is to analyze those perturbations according to their effects on the glycemic status, and thereby supporti...
Article
Background: Metformin is increasingly used to treat gestational diabetes and type 2 diabetes in pregnancy, and in attempts to improve pregnancy outcomes in polycystic ovary syndrome and obesity. It passes across the placenta with possible long-term consequences for the offspring. We previously explored the effect of metformin, given to women with...
Poster
Full-text available
Background Aim: Investigate the effect of intraperitoneal (IP) insulin boluses with respect to insulin absorption and the effect on blood glucose levels.
Article
Background: Women with polycystic ovary syndrome (PCOS) have an increased risk of pregnancy complications. Epi-analysis of two previous randomised controlled trials that compared metformin with placebo during pregnancy in women with PCOS showed a significant reduction in late miscarriages and preterm births in the metformin group. The aim of this...
Article
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Objective Among individuals at high risk for diabetes identified through a population survey, we performed an intervention study with basic lifestyle advice aiming to prevent diabetes. Research design and methods Among 50 806 participants in the HUNT3 Survey (2006–2008), 5297 individuals with Finnish Diabetes Risc Score (FINDRISC ≥15 were invited...
Presentation
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Comparison of Flash Glucose Monitor (FGM) measurements to frequent Self Monitor Blood Glucose measurements (SMBG) in the first day of use. Investigation of bias and lag.
Article
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Introduction Patients with diabetes type 1 (DM1) struggle daily to achieve good glucose control. The last decade has seen a rush of research groups working towards an artificial pancreas (AP) through the application of a double subcutaneous approach, i.e., subcutaneous (SC) continuous glucose monitoring (CGM) and continuous subcutaneous insulin inf...
Article
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Context: Increased Anti-Mullerian Hormone in polycystic ovary syndrome, may be due to overactive follicles rather than reflect antral follicle count. Objective: Does Anti-Mullerian Hormone reflect antral follicle count similarly in women with or without polycystic ovary syndrome or polycystic ovarian morphology? Design: Cross-sectional, case-c...
Article
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Background A wide range of antithrombotic medications can be used in the prevention and treatment of thrombosis. Among hemorrhagic complications of antithrombotic drugs, intracranial hemorrhage may have particularly devastating consequences with high morbidity, disability and mortality rates. The incidence and risks of intracranial hemorrhage in pa...
Article
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In acromegaly, high GH/IGF-1 levels associate with abnormal glucose metabolism. Somatostatin analogs (SSAs) reduce GH and IGF-1 but inhibit insulin secretion. We studied glucose homeostasis in de novo patients with acromegaly and changes in glucose metabolism after treatment with SSA and surgery. In this post hoc analysis from a randomized controll...
Article
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Background: Anti-Müllerian hormone (AMH) has a positive linear relationship to antral follicle count (AFC) in healthy women. However, studies of intra-follicular AMH-levels indicate a non-linear relation to AFC. It is speculated whether high AMH in polycystic ovary syndrome (PCOS) women is due to overactive follicles rather than directly reflect AF...
Article
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Context: Metformin is used to reduce pregnancy complications in women with polycystic ovary syndrome (PCOS), although it is not approved for this indication and solid evidence is lacking. Midpregnancy Doppler ultrasound is one of the best methods for prediction of adverse pregnancy outcome. Objective: The objectives of the study were to investig...
Article
Introduction: Some pregnancy complications are characterized by increased levels of cell-free fetal (cffDNA) and maternal DNA (cfmDNA), the latter may also be elevated during physical strain. This study aims at assessing the impact of exercise and metformin intervention in pregnancy, and to compare the levels of cell free DNA in pregnant women wit...
Article
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Background: Gestational diabetes mellitus (GDM) is associated with both maternal and offspring adverse effects. The World Health Organization (WHO) has recently adopted novel GDM criteria. The aim of this study was to evaluate the former WHO and a simplified version of the new International Association for Diabetes in Pregnancy Study Group (IADPSG...
Article
Full-text available
Metformin is suggested to reduce pregnancy complications in women with polycystic ovary syndrome (PCOS). Metformin crosses the placenta and therapeutic concentrations are measured in the fetal circulation. Whether metformin treatment in pregnant PCOS women affects maternal and fetal insulin concentrations at birth is not clarified. To investigate t...
Article
Full-text available
This observational study is designed to test the equivalence between the clinical effectiveness of microdecompression and laminectomy in the surgical treatment of central lumbar spinal stenosis. Lumbar spinal stenosis is the most frequent indication for spinal surgery in the elderly, and as the oldest segment of the population continues to grow its...
Article
Full-text available
Objective The consequences of the recently proposed International Association of Diabetes in Pregnancy Study Group (IADPSG) criteria for gestational diabetes mellitus (GDM) in women with polycystic ovary syndrome (PCOS) are not known. We compared prevalence rates and risk factors for GDM in PCOS women according to both the WHO and modified IADPSG c...
Article
Lung cancer has the highest mortality of all cancers. Patients with early stage disease have the best cure rates and that emphasizes the importance of early detection. About half of all non-small cell lung cancers (NSCLC) are estrogen receptor positive. The impact of estrogen and its receptors for NSCLC carcinogenesis has been studied but is still...
Article
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Background: The insulin tolerance test (ITT) is considered the gold standard test for evaluating the ACTH–cortisol axis in patients with pituitary disease. However, the test requires time and personnel resources, and has clear contraindications. Therefore, an ACTH stimulation test is often performed instead. Objective: The objective was to compare...
Article
Our aim was to re‐evaluate whether metformin may reduce late miscarriage/preterm delivery, pre‐eclampsia and gestational diabetes in women with polycystic ovary syndrome (PCOS). We performed an epi‐analysis of two randomized controlled trials. The participants were 313 women aged 18–42 years with PCOS who had singleton pregnancies. They were random...
Article
Full-text available
Background: The impact of metformin medication in pregnant women with polycystic ovary syndrome on weight gain during pregnancy and after delivery and the impact on growth of the offspring are essentially unexplored. Methods: This is a follow-up study of a randomized controlled trial (The Metformin treatment in pregnant PCOS women study), conduc...
Article
Objectives: To investigate the possible long-term effects of metformin exposure on growth and development of the offspring born to mothers with polycystic ovary syndrome (PCOS). The drug passes through the placenta and can potentially influence the fetus. Patients and methods: This is a follow-up study of a randomized, controlled trial on PCOS w...
Article
Objective: To assess whether 4 week’s use of a continuous glucose monitoring (CGM) system improves glucose control, treatment satisfaction or health status, as compared to intensified conventional finger-prick measurements (ICFM) in patients with type 1 diabetes mellitus (DM1). Method: Thirty patients suffering from DM1 for more than three years an...
Article
Please cite this paper as: Vanky E, Nordskar J, Leithe H, Hjorth-Hansen A, Martinussen M, Carlsen S. Breast size increment during pregnancy and breastfeeding in mothers with polycystic ovary syndrome: a follow-up study of a randomised controlled trial on metformin versus placebo. BJOG 2012;119:1403–1409. Objective To study the significance of breas...
Article
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STUDY QUESTION Can anti-Müllerian hormone (AMH) level replace the morphologic description in the diagnosis of polycystic ovary syndrome (PCOS) and what is the relationship between AMH and different diagnostic criteria of PCOS?
Article
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To assess whether exercise during pregnancy can prevent gestational diabetes and improve insulin resistance. A total of 855 women in gestational week 18-22 were randomly assigned to receiving a 12-week standard exercise program (intervention group) or standard antenatal care (control group). The exercise program followed standard recommendations an...
Article
To test the hypothesis that endocrine and metabolic factors predispose to preterm birth. A cross-sectional, case-control study. Namsos Hospital district (Namsos, Norway). Women from the Namsos Hospital district with previous preterm births (n = 114) were compared with matched controls with term births (n = 127). A clinical examination including tra...
Article
To explore the possible effect of metformin on maternal and fetal androgens and antimüllerian hormone (AMH) levels at birth and to study the predictors of maternal and fetal AMH levels. Substudy of a randomized controlled trial (the PregMet study). University hospital. Women with polycystic ovary syndrome (PCOS) and their newborns (n = 132). Metfor...
Article
Patients with lung cancer have a high frequency of comorbidity. Data on the impact of diabetes mellitus, the most frequent endocrine disorder, on the prognosis of lung cancer are conflicting. The aim was to investigate the impact of diabetes mellitus on survival in lung cancer. We analyzed data from a cohort, the Nord-Trøndelag Health Study (HUNT s...
Article
To assess possible associations between androgen, estrogen and insulin levels and blood pressure in pregnant women after term, compared with the effect of other well-known factors. Cross-sectional retrospective study. University Hospital, Trondheim region. Four hundred and eighty-nine post-term women with uncomplicated pregnancies. Blood pressure m...
Article
Treatment with somatostatin analogues is the primary medical treatment of acromegaly. Controversies still exist whether acute octreotide effect predicts long-term biochemical effects, tumour regression or surgical cure. This prospective study investigates effect of 6-month treatment with octreotide long-acting repeatable (LAR) on insulin-like growt...
Article
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To study the effect of metformin before and during assisted reproductive technology (ART) on the clinical pregnancy rate (CPR) in non-obese women with polycystic ovary syndrome (PCOS). A multi-centre, prospective, randomized, double-blind study was conducted in eight IVF clinics in four Nordic countries. We enrolled 150 PCOS women with a body mass...
Article
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To describe patient characteristics according to different diagnostic criteria in early pregnancy, in women with polycystic ovary syndrome (PCOS). Descriptive, cross-sectional study of 257 women with PCOS in the first trimester of pregnancy. Data from a multicenter trial at the time of inclusion. 257 PCOS women with singleton pregnancies. Investiga...
Article
Full-text available
Metformin is widely prescribed to pregnant women with polycystic ovary syndrome (PCOS) in an attempt to reduce pregnancy complications. Metformin is not approved for this indication, and evidence for this practice is lacking. Our objective was to test the hypothesis that metformin, from first trimester to delivery, reduces pregnancy complications i...
Article
Full-text available
Polycystic ovary syndrome (PCOS) tends to run in families and excess intrauterine androgen exposure has been suggested as one possible cause of PCOS. We wanted to study the relationship between maternal and offspring sex hormone levels and the possible effects of metformin treatment in PCOS pregnancies. We performed a post hoc analysis of a trial i...
Article
Breastfeeding depends on endocrine changes during pregnancy. The association between gestational hormones and lactation has been sparsely investigated. Previously, androgens were used for lactation inhibition. We investigated a possible association between second trimester maternal androgen levels and breastfeeding. Prospective observational study....
Article
To investigate pregnancy complications and offspring sex ratio according to mode of conception in women with polycystic ovary syndrome (PCOS). Retrospective, descriptive study. Tertiary, university hospital. A total of 176 women with PCOS diagnosed according to the Rotterdam criteria. Women with PCOS who have participated in one or more clinical st...
Article
Full-text available
The preferred treatment for polycystic ovary syndrome, which affects women of fertile age, is diet and lifestyle interventions - especially in association with overweight. However, an increasing number of studies have shown that metformin has a beneficial effect on many of the syndrome's manifestations. Norwegian physicians should therefore conside...
Article
Full-text available
Current data suggest that excessive androgen exposure can lead to the development of polycystic ovaries and polycystic ovary syndrome (PCOS). Anti-Müllerian hormone (AMH) levels reflect the number of small antral follicles in the ovaries and are elevated in PCOS. We hypothesized that protracted reduction of circulating androgens and/or insulin resi...
Article
Full-text available
Previous non-randomized and uncontrolled studies indicate major metformin effects on glucose homeostasis in pregnant women with polycystic ovary syndrome (PCOS). We investigated metformin effects on glucose homeostasis in a prospective controlled study. Forty pregnant women with PCOS and without known diabetes mellitus were included in the first tr...