Suzanne Abbring

Suzanne Abbring
Wageningen University & Research | WUR · Division of Human Nutrition

Doctor of Philosophy

About

17
Publications
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280
Citations

Publications

Publications (17)
Article
The allergy-protective capacity of raw cow's milk was demonstrated to be abolished after heat treatment. The heat-sensitive whey protein fraction of raw milk is often implied to be the source of this allergy-protective effect, but a direct link between these proteins and the protection against allergic diseases is missing. This study therefore aime...
Article
Arabinoxylans of various structures and sources have shown to possess the ability to induce a range of immune responses in different cell types in vitro and in vivo. Although the underlying mechanisms remain to be fully established, several studies point towards the involvement of activation of pattern recognition receptors (PRRs). Activation of sp...
Article
Full-text available
The mechanism underlying the allergy-protective effects of raw cow’s milk is still unknown, but the modulation of the gut microbiome may play a role. The effects of consuming raw cow’s milk or processed milk on fecal microbial communities were therefore characterized in an experimental murine model. C3H/HeOuJ mice were treated with raw milk, pasteu...
Article
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Specific and adequate nutrition during pregnancy and early life is an important factor in avoiding non-communicable diseases such as obesity, type 2 diabetes, cardiovascular disease, cancers, and chronic allergic diseases. Although epidemiologic and experimental studies have shown that nutrition is important at all stages of life, it is especially...
Article
Full-text available
The mechanisms underlying the allergy-protective effects of raw cow’s milk are poorly understood. The current focus is mainly on the modulation of T cell responses. In the present study, we investigated whether raw cow’s milk can also directly inhibit mast cells, the key effector cells in IgE-mediated allergic responses. Primary murine bone marrow-...
Article
Full-text available
Epidemiological studies identified raw cow’s milk consumption as an important environmental exposure that prevents allergic diseases. In the present study, we investigated whether raw cow’s milk has the capacity to induce tolerance to an unrelated, non-milk, food allergen. Histone acetylation of T cell genes was investigated to assess potential epi...
Article
Full-text available
Raw cow’s milk was previously shown to suppress allergic symptoms in a murine model for food allergy. In the present study, we investigated the contribution of fat content and heat-sensitive milk components to this allergy-protective effect. In addition, we determined the potency of alkaline phosphatase (ALP), a heat-sensitive raw milk component, t...
Article
Full-text available
Background Several studies demonstrated the adverse effect of milk processing on the allergy‐protective capacity of raw cow's milk. Whether milk processing also affects the allergenicity of raw milk is hardly investigated. Objective To assess the allergenicity of raw (unprocessed) and processed cow's milk in a murine model for food allergy as well...
Article
The prevalence of allergic diseases has increased significantly in Western countries in the last decades. This increase is often explained by the loss of rural living conditions and associated changes in diet and lifestyle. In line with this ‘hygiene hypothesis’, several epidemiological studies have shown that growing up on a farm lowers the risk o...
Article
Full-text available
Epidemiological studies show an inverse relation between raw cow’s milk consumption and the development of asthma. This protective effect seems to be abolished by milk processing. Evidence for a causal relationship is however lacking and direct comparisons between raw and heat treated milk are hardly studied. This study therefore investigated the p...
Article
Enhanced mechanistic target of rapamycin (mTOR) signaling in the brain has been implicated in the pathogenesis of autism spectrum disorder (ASD). Inhibition of the mTOR pathway improves behavior and neuropathology in mouse models of ASD containing mTOR-associated single gene mutations. The current study demonstrated that the amino acids histidine,...
Poster
In this study the sensitizing capacity of raw and processed cow’s milk was compared in a murine sensitization model for food allergy. Conclusion: In contrast to processed milk, raw milk is hardly able to induce sensitization. Allergic symptoms and IgE levels were reduced and this coincided with reduced Th2 cytokine responses. What it is in raw milk...
Data
Figure S1. The effect of the synbiotic diet containing scFOSlcFOS and B. breve (FF + Bb) if fed before and during sensitization and challenge period (Preventive setting) on the (A) acute allergic skin response assessed upon intradermal challenge (delta ear swelling in µm) and (B) anaphylactic shock symptoms upon intradermal challenge.
Data
Figure S2. The effect of scFOSlcFOS (FF), B. breve (Bb), and the synbiotic diet containing scFOSlcFOS + B. breve (FF + Bb) on galectin‐9 concentrations in serum 18 h after oral challenge.
Article
Full-text available
To support dietary management of severe cow's milk allergic infants, a synbiotic mixture of non-digestible oligosaccharides and Bifidobacterium breve M-16V (B. breve) was designed from source materials that are completely cow's milk-free. It was investigated whether this specific synbiotic concept can reduce an established food allergic response in...

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