Sutiman Sumitro

Brawijaya University · Department of Biology

Mesenchymal stem cells (MSCs) have unique properties, including high proliferation rates, self-renewal, multilineage differentiation ability, wide multipotency, hypoimmunogenicity, noninduction of teratomas, and anticancer properties. MSCs can be isolated from embryonic and extraembryonic tissues as well as adult organs. Human Wharton's jelly stem...

Mesenchymal stem cells (MSCs) from Wharton's jelly have a higher proliferation rate and self-renewal capacity than adult tissue-derived MSCs. A low oxygen level or hypoxic condition is prevalent in the microenvironment of the stem cells in the early stages of development. Hypoxia can influence proliferation and differentiation of various stem/precu...

Background Both cortical and cancellous bone display a complex, porous microstructure whose properties depend on the macrostructure of bone as well as age and health of the individual. The aim of this study was to compare the microstructure and characteristics of mineral atoms in osteoporotic and normal bone. Methods A prospective laboratory expe...

This study aimed to evaluate the level of reactive oxygen species, oxidative stress, and NF-κB and p53 in undifferentiated nasopharyngeal carcinoma. Twenty-four nasopharyngeal carcinoma patients and ten normal subjects were involved in order to compare the level of malondialdehyde (MDA), hydrogen peroxide (H2O2), and peroxidative index (PI). The le...

Clinical research indicates that negative calcium balance is associated with low bone mass, rapid bone loss, and high fracture rates. However, some studies revealed that not only calcium is involved in bone strengthening as risk factor of fracture osteoporosis. Thus, in this report, the difference of metallic and nonmetallic elements in osteoporosi...

The number of people with neurodegenerative disease continues to increase every year. A new perspective is needed in overcoming this disease. In this review, researchers collected information about epigenetics and energy factors of neurodegenerative disease driven by mitochondria. Mitochondrial epigenetic dysregulation can cause damage to the neuro...

Glycated human serum albumin (gHSA) undergoes conformational changes and unfolding events caused by free radicals. The glycation process results in a reduced ability of albumin to act as an endogenous scavenger and transporter protein in diabetes mellitus type 2 (T2DM) patients. Astaxanthin (ASX) in native form and complexed with metal ions (Cu2+ a...

The process of vitrification of the cumulus-oocyte complex (COCs) often results in cold shock. When warming, heat shock occurs which can disrupt the balance of intracellular calcium (Ca 2+) intensity. Drastic changes in temperature cause Reactive Oxygen Species (ROS), affecting changes on Ca 2+ in COCs. The role of calcium is needed for oocyte acti...

Jamu is well known as traditional herbal medicine that has been used by Indonesian for centuries ago. Local people usually consume jamu for maintaining health and therapy diseases because it is cheaper and has less side effects. Scientific approach needs to be done to study the characteristic of the herbals. This research aims to characterize Indon...

Implementing a proper learning model during the post COVID-19 pandemic is fundamental for learning quality enhancement, specifically for students' conceptual mastery. The research aims to develop a Complexity Science- Problem Based Learning (CS-PBL) model assisted by the Sistem Informasi Pengelola Pembelajaran (SIPEJAR) e-learning platform that is...

Cenderawasih Bay has extremely high biodiversity with an enormous amount of endemic species due to geography isolation. Tripneustes gratilla is one of the species that is abundant in the bay. The species has ecological value that is suitable for bio-indicators of the environmental condition. Since the Bay relatively isolated area, then we examined...

Tyramine-Fe complex is predicted present in Brotowali (Tinospora crispa) and play a role in its anti-inflammatory activity. Excessive inflammation in COVID-19 patients can be fatal and can even cause death. Anti-inflammatory drugs such as aspirin and ibuprofen inhibits the reaction of prostaglandin formation from COX 2 and arachidonic acid. This st...

Akway (Drimys piperita Hook f.) was known as an endogenous plant of Indonesia. This plant was investigated as free radical scavenger based on paramagnetic properties. This study aimed to identify the bioactive compound and the role of Fe metals ions to enhance the free radical scavenger capacity as Low molecular weight antioxidant (LWMA) of akway....

Ginger (Zingiber officinale) and meniran (Phyllanthus niruri L.) is a cultural heritage in Madura ethnic, Indonesia. Madurese herbs were traditionally boiled using pottery which is made from clay. Clay consists of Silica (SiO2), Aluminum silicate (Al2O3), Magnesium (MgO), Calcium (CaO),) Iron (Fe2O3) and Potassium (K2O). This component contributes...

21st century learning focuses on problem-solving skills. A higher level of education requires an understanding of a more systematic concept to elaborate problems. Problem-solving skill is one of the fundamental cognitive processes. It involves higher order thinking to discover solutions or ideas. This research aims to analyze the relationship betwe...

In this study, silver nanoparticles (AgNPs) were synthesized using aqueous extract of Piper retrofractum fruits by the sonication-assisted an eco-friendly method. The compounds of Piper retrofractum extract can perform as reducing as well as capping agent in the synthesis process of AgNPs. Silver nitrate was used as a starting material and was reac...

Determinant factors which contribute to the prediction should take into account multivariate analysis for capturing coarse-to-fine contextual information. From the preliminary descriptive analysis, it shows that environmental factor such as UV (ultraviolet) is one of the essential factors that should be considered to observe the COVID-19 epidemic d...

This study aimed was to determine the optimal ratio, duration, and temperature reaction to form the astaxanthin-metal ions complex based on the UV-Vis spectrum profile and confirmation of complex formation using FTIR. The method used consists of the synthesis of the astaxanthin-metal ions (Cu2+ and Zn2+) and the determination of complex formation b...

Background: Mesenchymal stem cells (MSCs) are an appealing source of adult stem cells for cell therapy due to the high rate of proliferation, self-renewal capability, and applicable therapy. Wharton’s jelly (WJ), the main component of the umbilical cord extracellular matrix, comprises multipotent stem cells with a high proliferation rate and self-r...

Ethnopharmacological study of flavonoid compounds in Magnolia champaca (L.) Baill. ex Pierre as anti-inflammatory agents by molecular docking [Estudio etnofarmacológico de compuestos flavonoides en Magnolia champaca (L.) Baill. ex Pierre como agentes antiinflamatorios por acoplamiento molecular] Abstract Resumen Context: Magnolia champaca (L.) Bail...

Context: Magnolia champaca (L.) Baill. ex Pierre has traditionally been used by the culture to prevent and cure the inflammatory disease. Aims: To determine the benefit of M. champaca in the local community, especially in the treatment of tuberculosis, and investigate the potency of the flavonoid content of M. champaca as an anti-inflammatory agen...

Glycated human serum albumin (gHSA) undergoes conformational changes of proteins caused by free radicals. The glycation process results in a reduced ability of albumin as an endogenous scavenger in diabetes mellitus type 2 (T2DM) patients. Astaxanthin (ASX) has been shown to prevent gHSA from experiencing unfolding events and improve protein stabil...

Michelia champaca is used by the community to treat mild diseases in the population. The plant Michelia champaca produces anti-inflammatory com�pounds. Some anti-inflammatory classes of compounds include Phenols and Triterpenoids. In disease prevention and treatment mechanics, COVID 19 in particular, the ability of anti-inflammatory compounds is...

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The use of medicinal plants as the main alternative to solve respiratory disorders is widespread in the Ammatoa Kajang community. However, the Ammatoa Kajang’s knowledge, attitude, and practice of this medicinal plant use have not yet been revealed. This study was conducted to analyze the Ammatoa Kajang’s knowledge, attitude, and practice (KAP) of...

Determinant factors which contribute to the prediction should take into account multivariate analysis for capturing coarse-to-fine contextual information. From the preliminary descriptive analysis, it shows that environmental factor such as UV (ultraviolet) is one of the essential factors that should be considered to observe the COVID-19 epidemic d...

Ethnopharmacological study of flavonoid compounds in Magnolia champaca (L.) Baill. ex Pierre as anti-inflammatory agents by molecular docking [Estudio etnofarmacológico de compuestos flavonoides en Magnolia champaca (L.) Baill. ex Pierre como agentes antiinflamatorios por acoplamiento molecular] Abstract Resumen Context: Magnolia champaca (L.) Bail...

Balur is an integrative topical medication from Indonesia using herbal medicines: Moringa oleifera , Nicotiana tabacum , and Coffea arabica . Balur can be applied to treat various diseases including chronic diseases and autism because it performs to scavenge free radicals and release electron of heavy metals. However, the complexity of the balur me...

Jamu is a traditional medicine based on the wisdom of the local community can be used as an alternative to the treatment of several symptoms of the disease, one of which is pain, fever. The purpose of the research is to know the type and use of medicinal plants, the content of active compounds as well as prospective traditional herbal medicine for...

Traditional medicine using plants, animal materials, mineral substances, serian (generic) preparations, or mixtures of these ingredients that have been used from generation to generation for treatment based on experience and applied by the prevailing norms in society are called jamu. The research objective was to determine the types of medicinal pl...

Tyramine-Fe complex is a bioinorganic complex that is formed in brotowali. The complex is thought to play a role in the anti-inflammatory activity of brotowali. The mechanism of anti-inflammatory drugs such as aspirin and ibuprofen is to inhibit the reaction of prostaglandin formation from COX2 and arachidonic acid. In this study, a docking simulat...

Azis S, Zubaidah S, Mahanal S, Batoro J, Sumitro SB. 2020. Local knowledge of traditional medicinal plant use and education system on their young Ammatoa Kajang tribe in South Sulawesi, Indonesia. Biodiversitas 21: 3989-4002. Kajang tribal community in Indonesia has been using plants as traditional medicine for long periods of time; however, this t...

The copper nanoparticles (CuNPs) have attracted much attention due to their application in diverse fields. The applications of CuNPs depend on their physical and chemical properties. This study presents the first report for the use of medicinal fruit extract of Piper retrofractum Vahl as an eco-friendly reagent in the synthesis of CuNPs using coppe...

Mangosteen has several important elements for biological activities such as anti-oxidant, anti-inflammatory, anti-bacterial and anti-cancer. There are γ-mangostin, α-mangostin, flavonoids, saponins, and tannins which could stimulate the collagen deposition and accelerate wound healing process. Burn injury cause deep wound in the skin and often caus...

This study aims to predict the degradation mechanism of cellulose substrate in silico from the results of isolation and test the potential of cellulolytic bacteria from rice fields in Greater Malang in producing cellulolytic enzymes, among others: β-1, 4 exoglunase, β-1, 4 endoglucase and β - glucosidase, identified isolates that have high potentia...

This research aims to computationally characterize HSA 4K2C protein and describe as well as its ability to bind transition metal ions. Data mining is performed to obtain HSA 4K2C from PDB and transition metal ions such as Cu2+ (ID: 27099), Fe2+ (ID: 27284), Mn2+ (ID: 27854), Mn3+ (ID: 105130) and Fe3+ (ID: 29936) from PubChem. The analysis consists...

Introduction: Breast cancer is one of the leading cause of cancer deaths in women. Metastasis in BC is caused by immunosurveillance deficiency, such NK cell maturation, low NK activity and decreasing cytotoxicity. This study was performed to improve activating receptors and cytotoxicity of NK cells using interleukins (ILs). Methods: Human recomb...

UV (ultraviolet) light is an important factor should be considered to predict coronavirus epidemic growth pace. UV is different from weather temperature since UV is electromagnetic wavelength from 10 nm to 400 nm in size, shorter than of visible lights. For some people, UV light can lead to cancer from unprotected sun exposure, however, for tropica...

Background We investigated whether 10-gingerol is able to induce oxidative stress in cumulus cells. Methods For the in-vitro research, we used a cumulus cell culture in M199, containing 10-gingerol in various concentrations (0, 12, 16, and 20 µM), and detected oxidative stress through superoxide dismutase (SOD) activity and malondialdehyde (MDA) c...

Spodoptera litura is classified as a plant-disturbing organism. Efforts to control S. litura by using chemical insecticides have a detrimental impact on the environment and the potential to harm non-target organisms. Bioinsecticides provide a safe alternative for reducing the agricultural pest problem. The purpose of this study was to investigate t...

Breast cancer (BC) is the most prevalent type of cancer among women and one of the major causes of cancer mortality in women. Metastasis in breast cancer (BC) occurs due to immunosurveillance deficiency, including impairment of natural killer (NK) cell maturation. Conditioned medium (CM) from human Wharton’s jelly mesenchymal stem cells (hWJMSC-CM)...

Tuberculosis (TB) is one of the leading infectious diseases in the world. The disease is commonly caused by Mycobacterium tuberculosis (Mtb) bacteria which are capable of rapidly spreading through droplet transmission. In developing countries, poverty and malnutrition cause immunodeficiency which is considered as the main risk factor for the incide...

Objectives: Albumin in diabetes mellitus undergoes conformational changes that affect the ability as an endogenous scavenger. Treatment with astaxanthin (ASX) expected to improve the function of albumin in case of diabetes mellitus. The objectives of this study are to compare the capability of ASX and metformin to prevent conformational changes on...

This research aims to investigate the magnetic character of complex compounds from akway bark (Drimys piperita Hook f.) as a free radical scavenger. This research uses several analytical methods. Polarization microscopy used to characterize the birefringence of the crystals phenomenon. Inductively coupled plasma-Optical Emission Spectrometry (ICP-O...

This research aimed to prove the ability of extracted freeze-dried java plum fruit applied with a cigarette filter to decrease the intensity of free radicals in the cigarette smoke. It was reported that there was a difference in the spectrum infrared (IR) pattern, leading to a wavelength shift in the smoke burning from a cigarette after the applica...

Hyaluronic acid (HA) is a glycosaminoglycan with a straight-chain polymer arrangement defined as the extracellular matrix constituent. High molecular weight HA has normal physicochemical, biological, and physiological properties whereas low molecular weight has the property of angiogenesis, inflammation, and suppresses apoptosis. This study occupie...

Spodoptera litura is folifagus agricultural pest with a tendency of resistance towards chemistry compound. This becomes a reason in the efforts to overcome it. The use of botanical material becomes one of the alternatives in controlling its population. The plant of Mirabilis jalapa has the active biopesticide compound that becomes its alternative p...

Introduction: The involvement of mucin, lectin, and apoptosis in colitis is still unclear. This study aimed to investigate changes in MUC2 expression, inflammation, and changes in lectin expression in colitis patients. Methods: A total of 17 patients were divided into two groups including 11 hemorrhoid patients as a control group and 6 colitis p...

Albumin is not native phase, but it physiologically-binding with another compound which conclude the functions as transporter and scavenger. The general non-enzymatic reaction within proteins, which has a significant impact on their physical and functional properties by reducing sugar, known as glycation. The study investigated the effective compos...

This study aims to reveal the anticancer mechanism of the bioactive compound of Pisangulin angulata and to assess the feasibility of that results as teaching material. This research includes descriptive explorations. In the first stage, an in silico analysis was performed by molecular docking method between physalin compounds and GLI1 protein. The...

Ekstrak sirih diketahui mampu menurunkan pertumbuhan sejumlah bakteri penyebab mastitis. Namun, informasi tentang protein target dan aktivitas seluler senyawa aktif daun sirih dalam menekan bakteri patogen belum diketahui. Penelitian ini bertujuan untuk mengungkap molekul protein target dari senyawa aktif ekstrak sirih dan potensi aktivitasnya aksi...

Background: Mangosteen (Garcinia mangostana Linn.) is tropical fruit that known to contain bioactive compounds which has particular function as antioxidant, anti-inflammatory and antibacterial. Mangosteen rind extract is known to have high contents of xanthone compounds which have antioxidant and free radical scavenging activities. This study was d...

Introduction: Tuberculosis (TB) is one of the leading infectious diseases in the world. It is commonly infected by Mycobacterium tuberculosis (TB) and can rapidly spread through droplet transmission. Poverty and malnutrition cause immunodeficiency, and thus, it increases the risk factor for TB. Indonesia traditional herbal medicine, jamu, has been...

Objectives: The objective of this study was to analyze the estrogenic compounds in pigeon pea seeds and the effect of the plant seeds to rat ovaries development. Materials and Methods: The Cajanus cajan seeds were extracted, and to elucidate its content, liquid chromatography-mass spectrometry (LC-MS), and gas chromatography (GC)-MS analysis were e...

The aim of this research was to (1) compare the effectiveness of OIDDE (Orientation, Identify, Discussion, Decision, and Engage in Behavior) learning model and conventional learning models in improving bioethics knowledge; (2) compare the effectiveness of OIDDE learning model and conventional learning models in improving ethical decision-making abi...

Curcuma xanthorrhiza Roxb and Tamarindus indica L. have been used for a