Sutapa Majee

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Verified

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• Ph. D.
• Professor at NSHM Knowledge Campus

Objective: Stable pharmaceutical disperse systems are defined as heterogeneous, biphasic systems as suspensions and emulsions, stabilized by third agent or stabilizer. The aim of the present investigation was to extract mucilage from the leaves of Hibiscus rosa-sinesnsis L. and explore its ability to function as stabiliser for adult (10%w/v) and pa...

Background: Oleogel is a thermo-reversible, viscoelastic, semi-solid self-assembled preparation in which an apolar phase gets immobilized within a 3-D networked structure formed via physical or chemical interaction with different organogelators. Objective: The objective of the present investigation was to develop drug-loaded (paracetamol) Span 40/T...

Background: “Oleohydrogel hybrid”is a combination of two different components, the oleogel phase formed by apolar lipophilic phase consisting of soybean oil and non-ionic surfactants andhydrogel component consisting of gelling agent in aqueous base[1]. The hybridpossesses the characteristics and benefits of both the phases [2]. Objective:The main...

BACKGROUND: Bigels are novel formulations composed of biphasic structured systems obtained by mixing hydrogel and oleogel. Such systems can overcome the major drawbacks of either of the single phases and possess the advantages of both [1]. Variables affecting the characteristics of bigels and drug release includeconcentrations of organogelators in...

The occurrence of hypertension is increasing slowly among urban and rural segments of the Indian population, irrespective of gender. It can affect quality of life and also lead to mortality under serious circumstances. Although several oral anti-hypertensive medications are available in the Indian market, the management of hypertension is reported...

Buccal films for anti-hypertensive drugs like losartan potassium can avoid hepatic first-pass metabolism, improve bioavailability, and enhance patient compliance. Objective: The purpose of this study was to develop and characterize buccal films of losartan potassium, to achieve sustained and complete release and permeation of the drug over a reason...

Infectious diseases are illnesses caused by pathogenic microorganisms, including viruses, bacteria, fungi, and parasites. These diseases can be transmitted from one individual to another, as well as through contaminated food, water, and insect bites, infectious agents invade the body, multiply, and disrupt normal bodily functions, leading to variou...

In mediaeval ages, the word 'spices' was associated with a variety of exotic foods. Indian history has a special place for spices and herbs because of their long traditional usage, culinary usage, medical benefits, and uses as flavourings. Currently, one of the greatest health issues facing the globe today is diabetes, whose prevalence and related...

Herbs and spices, which may originate from various parts of the plants, are utilized in cooking for their aroma, flavor, and preservative qualities, as well as its therapeutic advantages. Herbs come in a wide variety, and many of them have medical properties, such as antihypertensive, antidiabetic, antioxidant, antibacterial, and anti-inflammatory...

Incidences of Cardio Vascular Diseases (CVDs) are increasing in an alarming proportion in India. Conventional oral dosage forms cannot be retained in the stomach for long owing to gastric emptying. Moreover, drugs which are commonly employed in management of chronic CVDs either have reduced solubility at alkaline pH, undergo colonic degradation, ex...

Phospholipases are ubiquitously distributed across mammalian, insect, bacterial and fungal species. They play crucial role in lipid metabolic pathways, signalling networks and hence in progression of cancers, inflammation, infection, atherosclerosis and several other pathological conditions. Overexpression on surface of several cancer cells, broad-...

Beneficial Health Effects of 20 Exotic Spices focuses on individual spices and their uses in treating various diseases.

The first volume contains Introduction, Therapeutic Properties and Commercial Products has been divided into four segments, beginning with an introduction to the history of use of spices in Indian culture.

Hydrophilic swellable polymers can be well used for the fabrication of matrix formulations. The present investigation aimed to develop controlled release matrix formulations of Amoxicillin trihydrate with different concentration of gum karaya, without changing the other factors. The matrix granules, prepared by wet granulation process were first...

Among the various strategies employed to enhance solubility, dissolution and bioavailability of poorly soluble drugs in vivo, formulation of solid dispersion using hydrophilic and/or water-soluble carriers with varying physicochemical characteristics seems to be a developable, economically viable and easy option. The present study is aimed to use s...

Objective: Among the various strategies employed to enhance solubility, dissolution, and bioavailability of poorly soluble drugs in vivo, formulation of solid dispersion (SD) using hydrophilic and/or water-soluble carriers with varying physicochemical characteristics seems to be a developable, economically viable and easy option. The goal of the pr...

In recent years, there has been increasing interest in the use of formulations containing lipid-based excipients that comprise combinations of synthetic or semisynthetic lipids with surfactants, co-surfactants or co-solvents. This review is generally focussed on lipid-based excipients in pharmaceutical formulations which improves the oral bioavaila...

In vitro dissolution study should ideally be designed to predict in vivo performance precisely, providing key information on the bioavailability and establishing IVIVC. Development of discriminatory in vivo predictive dissolution model and the establishment of IVIVC is difficult to achieve with BCS Class 2 drugs as they exhibit variable absorption...

Organic nano carriers (e.g. polymeric micelles and vesicles, liposomes, dendrimers, and hydrogels) and inorganic nano carriers (e.g. quantum dots, gold and mesoporous silica nanoparticles) used in therapy are designed to show enhanced pharmacokinetic and pharmacodynamic profiles and reduced side effects over conventional formulations due to their n...

Recent advances in the field of conversion of solid dispersions of poorly water-soluble drugs in a wide range of hydrophilic or water-soluble carriers into solid dispersion tablets have shown great promise in improving solubility, dissolution rate and oral bioavailability of such drugs. Moreover, proper choice of tablet excipients during tableting...

Transdermal drug delivery is the administration of therapeutic agents through intact skin for systemic effect. Polymers are the backbone of the matrix-type transdermal patches. Based on the nature of origin, these polymers can be Natural, Semi-synthetic, and Synthetic polymers. Several experimental results have revealed the fact that in the case of...

The work aimed to prepare super porous hydrogels (SPHs) of Amoxicillin trihydrate to release the drug in a sustained manner in the gastric environment and study the polymeric ratio and pore effect formers on the physicomechanical properties and drug release kinetics of the formulations. Fourier Transform Infra-Red (FTIR) studies were done to check...

Pulmonary dosage forms constitute an important route of drug delivery for systemic absorption of drugs in management of respiratory diseases as well as diseases such as diabetes, migraine, osteoporosis, and cancer. Performance of different pulmonary dosage forms is greatly influenced by aerodynamic particle size distribution of inhalable particles,...

Organogelators induce 3-D networked structures in apolar solvent molecules via cross-linking of non-covalent self-assembled aggregates below the gelation temperature. The objective of the present investigation was to evaluate the effects of different Span 40 concentrations on gelation kinetics and drug release behaviour of topical soybean oleogels....

Objective: The objective of this study was to evaluate the protective effect of Erdosteine on complete freund’s adjuvant (CFA) induced arthritic rats. Methods: Wistar Albino rats of 100–250 g were divided into five groups (n=6) and administered with 0.1 ml of CFA subcutaneously into the left hind paw except the negative control group. The standard...

Meningitis, a serious communicable inflammatory disease continues to be a worldwide threat especially in sub-Saharan Africa affecting millions of people with high death rates every year. Strains from six serogroups of the principal causative organism Neisseria meningitidis are found to be responsible for the majority of infections. Incidences of an...

Objective: Oral disintegrating films consisting of hydrophilic polymer are designed to be quickly hydrated by saliva, adhere to the mucosa and disintegrate rapidly to release the drug. The aim of the present study was to prepare stable, flexible swellable rapid release oral films with hydroxypropyl methylcellulose E15 LV (HPMC) and polyvinyl alcoho...

Stilbenoids constitute a major class of plant-derived secondary metabolites occurring in abundance across several families and are well-known for their nutritional and health-promoting benefits. Several investigations have established their therapeutic potential in the management of different types of cancer, neuroinflammation, arthritis, disorders...

Oleohydrogel hybrid, a novel combination of lipophilic oleogel and hydrophilic hydrogel phases is assumed to achieve the benefits of both the gel phases and exhibit pseudo plastic flow behavior with an excellent drug release profile thereby providing an unique topical base. The present study deals with the development and characterization of olive...

Aims: The objective of the present investigation was to develop and characterise soybean oil-HPMCK15M based oleohydrogel hybrid to achieve controlled and improved drug release. Method: Paracetamol loaded oleohydrogel hybrid was prepared by dispersing soybean oil-Span 40 based oleogel into hydrogel developed with varying concentrations of HPMCK15M a...

Nanotechnology is going to revolutionize the world. According to the National Nanotechnology Initiative (NNI), nanotechnology refers to the study of all particles in the range of 100 nanometers or less. One of the most important advantages of the smaller particle size is the ratio of surface atoms or molecules to the total number increases. That me...

The buccal patches of Atenolol were designed in such a way that the mucoadhesive layers was incorporated along with the circumference of the circular patch. The major ingredients selected for the matrix layer were the drug and control release polymer (either HPMC K15M or HPMC K4M) while the Mucoadhesive layer was predominantly comprised of gum kara...

Objective: Super porous hydrogels (SPHs), a novel drug delivery system can be developed to retain drugs in the gastric medium. The aim of the present investigation was to prepare superporous hydrogels (SPHs) of Atenolol to release the drug in sustained manner in the gastric environment and study the effect of two grades of hydroxyl methyl cellulose...

Aims: The objective of the present investigation was to develop and characterise soybean oil-HPMCK15M based oleohydrogel hybrid to achieve controlled and improved drug release. Method: Paracetamol loaded oleohydrogel hybrid was prepared by dispersing soybean oil-Span 40 based oleogel into hydrogel developed with varying concentrations of HPMCK15M a...

Objective: The objective of the present investigation was to develop olive and soybean oil-based oleogels with Span 40 and/or Tween 80 (as gelator and/or surfactant) and determine the critical gelator concentration (CGC), characterise and compare the rheological, thermal properties and drug release profile of the gels formed for topical delivery. M...

Objective: Hydrogels with scope for utilization in numerous fields possess limited applications due to problems in incorporating wide range of drugs and crossing the lipophilic barrier of the skin. Attempts to overcome these problems by developing organogel hold drawbacks. Challenges posed by drug lipophilicity or skin permeation can be solved by d...

Objective: Gums and mucilages are of immense significance as excipients owing to their renewable natural sources, cheapness, ready availability, biodegradability, non-toxicity, ability to undergo hydration and swelling rapidly. To satisfy the ever-increasing demand for highly specific and functional excipients, sweet basil (Ocimum basilicum L.) has...

Objective: Hydrogels or emulgels are recommended for topical application to elicit a local effect. However, they suffer from stability problems. The present study deals with the formulation and comparison of thermally stable soybean oil-based novel topical organogels (soy-gels) using two different gelators (Span 40 and Span 60) for controlled drug...

Objective: Stable pharmaceutical disperse systems are defined as heterogeneous, biphasic systems as suspensions and emulsions, stabilized by third agent or stabilizer. The aim of the present investigation was to extract mucilage from the leaves of Hibiscus rosa-sinesnsis L. and explore its ability to function as stabiliser for adult (10%w/v) and pa...

Objective: Gums and mucilages are of immense significance as excipients owing to their renewable natural sources, cheapness, ready availability, biodegradability, non-toxicity, ability to undergo hydration and swelling rapidly. To satisfy the ever-increasing demand for highly specific and functional excipients, sweet basil (Ocimum basilicum L.) has...

Objective: The objective of the investigation was to isolate mucilage from sweet basil seeds and explore its physicochemical properties for the development of pharmaceutical suspensions and surfactant-free stable emulsions.Methods: Possible applications of sweet basil seed mucilage in the pharmaceutical field for dosage form development are being e...

Background: Oleogel is a thermo-reversible, viscoelastic, semi-solid self-assembled preparation in which an apolar phase gets immobilized within a 3-D networked structure formed via physical or chemical interaction with different organogelators. Objective: The objective of the present investigation was to develop drug-loaded (paracetamol) Span 40/T...

Children should be considered different from adults in terms of pharmacodynamic and pharmacokinetic effects associated with administered drugs. There is still a paucity of robust data in children on safety and efficacy of medicines giving rise to either sub-optimum therapeutic effect or unknown harmful side effects. Strict governance by regulatory...

The emergence of multi-drug resistant pathogenic bacteria, coupled with a decline in discovery of new drugs, has gradually steered the world to the doorstep of post-antibiotic era as trivial infections often become untreatable with the existing antibiotics. Therefore, design and development of new therapeutic strategies would be of paramount im...

Sulfated polysaccharides extracted from marine algae and bacteria constitute an important class of biomacromolecules as they are characterized by biocompatibility, biodegradability and low immunogenicity. Recent advances in bionanotechnology are attributed to identification of marine sulfated polysaccharides of unique composition and functional pro...

Plant pectin constitutes an important class of naturally occurring polysaccharides and are widely distributed in various fruits and vegetables consumed on a regular basis. These biomolecules are reported to exhibit a vast array of biological activities including effects on digestive system, chemopreventive effect in colon cancer, regulation of bloo...

Protein and peptide based pharmaceuticals are a predominant class in the field of therapeutic and clinical application. Parenterals are an orthodox choice for this which has some drawback related to patient acquiescence and formulation. The evolution of new macromolecule drugs, i.e. proteins and peptides can be registered by non-invasive technology...

The most common instability problem of gelatin capsules arises from negative impact of extremes of temperature and especially atmospheric relative humidity on the mechanical integrity of the capsule shells with adverse effect extended even to the fill material. Moreover, choice of fill materials is highly restricted either due to their specific che...

Over the last few decades, numerous bacterial exopolysaccharides have been extensively studied for their composition, structure, biosynthesis and functional properties, owing to their unique properties over traditional plant-derived gums and synthetic polysaccharides. They have been employed in food processing industries as rheology modifiers, gell...

Over the last few decades, numerous bacterial exopolysaccharides have been extensively studied for their composition, structure, biosynthesis and functional properties, owing to their unique properties over traditional plant-derived gums and synthetic polysaccharides. They have been employed in food processing industries as rheology modifiers, gell...

The most common instability problem of gelatin capsules arises from negative impact of extremes of temperature and especially atmospheric relative humidity on the mechanical integrity of the capsule shells with adverse effect extended even to the fill material. Moreover, choice of fill materials is highly restricted either due to their specific che...

Design and delivery of protein-based biopharmaceuticals needs detailed planning and strict monitoring of intermediate processing steps, storage conditions and container-closure system to ensure a stable, elegant and biopharmaceutically acceptable dosage form. Selection of manufacturing process variables and conditions along with packaging specifica...

Design and delivery of protein-based biopharmaceuticals needs detailed planning and strict monitoring of intermediate processing steps, storage conditions and container-closure system to ensure a stable, elegant and biopharmaceutically acceptable dosage form. Selection of manufacturing process variables and conditions along with packaging specifica...

Cancer is one of the major causes of death worldwide, including developing and underdeveloped nations. Mortality and morbidity data suggest that incidences are higher than those of the cardiovascular diseases. High cost and occurrence of numerous side and adverse effects associated with conventional anticancer regimes has necessitated shifting the...

Topical hydrogel preparations are applied on skin to obtain local or systemic action. NSAID’s are non-steroidal drugs having excellent anti-inflammatory and analgesic activity but it produces GIT ulceration when used orally. To overcome that problem with oral formulations, many NSAID’s are preferred to be administered by topical route. The present...

Efficient delivery and accumulation of gene into solid tumors via physical and chemical methods is restricted by lack of tissue selectivity, host cell tropism, immunogenicity and several other factors. Magnetofection shows great promise in external magnetguided delivery of different types of nucleic acids, non-viral transfection systems and viruses...

Polysaccharides of natural, synthetic or semi-synthetic origin have been used from time immemorial in the development of drug delivery systems designed to achieve tailored and site-specific drug release. Starch-based polysaccharides derived from plants have been extensively studied in this regard. Natural polymeric excipients are preferred over the...

Therapeutic advantage can be achieved to the maximum in the management of topical fungal infections by enhancing the skin retention time of antifungal agents without necessitating frequent application and thereby, minimizing the risk of patient non-compliance. The ultimate objective of any topical dosage form is to minimize skin irritation, maintai...

Drug release kinetics from matrix dosage form is governed by polymer swelling and erosion, drug dissolution/diffusion and polymeric combination. For the preparation of controlled release dosage form, hydrophilic, swellable polymers in optimum combination are essential. The major objective of the current study is to prepare Amoxicillin trihydrate-lo...

The aim of the current investigation is to study the kinetics of drug release pattern from buccal swellable, controlled release tablets of amoxicillin trihydrate. Buccal tablets were prepared with modified gum karaya in 5-20% concentration. Drug release from the formulated amoxicillin trihydrate loaded buccal tablets followed Zero order kinetics re...

ABSTRACT With the advent of biopharmaceuticals into the market, lyophilisation or freeze-drying forms an essential step in their manufacturing technique. Stability and sterility are achieved more easily with the process than with other conventional techniques. Design, development, control, optimisation and scale-up of the process requires considera...

Mathematical modeling involves construction of a set of equations or description of a stochastic process closely mimicking a real phenomenon of practical significance and biological or physiological relevance. This paper reviews some specific pathological conditions of the skin and permeation of drugs across the skin during topical administration a...

Abstract Staging of colorectal cancer constitutes an important part of its diagnosis and prognosis. However, both invasive and non-invasive techniques prevail with their own advantages and disadvantages. The present review focuses on the existence of complementarity between the information obtained from computerized tomography and radioimmunoscinti...

Staging of colorectal cancer constitutes an important part of its diagnosis and prognosis. However, both invasive and non-invasive techniques prevail with their own advantages and disadvantages. The present review focuses on the existence of complementarity between the information obtained from computerized tomography and radioimmunoscintigraphy in...

For the preparation of buccal controlled release patches hydrophilic, swellable, porous polymeric material alone or in optimum combination and optimum mucoadhesive strength is essential. The use of naturally occurring biocompatible polymers has been the area of interest of recent research activity for designing controlled release dosage forms. Dicl...

Drug release mechanism from matrix dosage form is governed by polymer swelling, polymer erosion, drug dissolution/diffusion, drug distribution inside the matrix and drug/polymer ratio. Thus for the preparation of controlled release dosage form , hydrophilic , swellable, porous polymeric material alone or in optimum combination is essential. Here a...

Psyllium husk, a hydrophilic, gel-forming and swellable polysaccharide, is a plant-derived mucilloid. These characteristics can be utilized to design controlled-release, expandable and gastroretentive drug delivery systems, in a synergistic manner, when combined with suitable grade of cellulosic polymer like hydroxypropylmethyl cellulose (HPMC). Ma...

The role of widely used disintegrant, L-HPC LH-11, in modulating the dissolution behavior of poorly water-soluble BCS Class 2 drug remains to be explored. The objective of the present study is to promote fast disintegration, rapid and complete release of Carvedilol from tablets by including low substituted hydroxypropyl cellulose. To improve aqueou...

Hydrophilic swellable polymers are widely used to control the release of drugs from matrix formulations. The natural polymers are biodegradable and nontoxic, which hydrate and swell on contact with aqueous media. The present investigation is aimed to formulate the sustained release matrix granules of Amoxicillin trihydrate with different concentrat...

Formulation of safe and effective delivery system for induction of strong, effective and long-lasting immune response against pathogens poses a major challenge to modern non-invasive vaccination strategies. Intranasal route is being exploited as a viable alternative for mass-scale immunisation because it can gain acceptance by a wider section of th...

To get successful buccal controlled release dosage form hydrophilic, swellable polymeric material alone or in optimum combination is essential. This dosage form should get stuck to the oral cavity and release the drug at a controlled rate under the conditions prevailing in the mouth. Here a natural gum (Gum karaya) has been selected to prepare bucc...

Superdisintegrant absorbs water by wicking or capillary action undergoes swelling, induces hydrodynamic pressure in the tablet core causing rupture and disintegration to finer particles of higher specific surface area available for interaction with dissolution medium. Disintegrant efficiency and its performance in dissolution improvement is markedl...

Superdisintegrant absorbs water by wicking or capillary action undergoes swelling, induces hydrodynamic pressure in the tablet core causing rupture and disintegration to finer particles of higher specific surface area available for interaction with dissolution medium. Disintegrant efficiency and its performance in dissolution improvement is markedl...

To get successful buccal controlled release dosage form hydrophilic, swellable polymeric material alone or in optimum combination is essential. This dosage form should get stuck to the oral cavity and release the drug at a controlled rate under the conditions prevailing in the mouth. Here a natural gum (Gum karaya) has been selected to prepare bucc...

Multi-dimensional characteristics of infectious diseases is a matter of great concern for the health professionals in the developing countries because of lack of infrastructural facilities, teeming population and poor database management and handling. Mathematical modeling of transmission dynamics of infectious diseases requires a thorough understa...

In vitro dissolution testing s hould discriminate betw een the impact of excipients on relea se profile of B iopharmaceutics C lassification S ystem class 2 drugs. Among the four batches of carvedilol solid dispersion tablets , SDT - 2 - L cont aining 30% w/w mannitol and 2.5 % w/w L - hydroxypropyl cellulose LH - 11 exhibit ed least mean dissoluti...

In vitro dissolution testing should discriminate between the impact of excipients on release profile of Biopharmaceutics Classification System class 2 drugs. Among the four batches of carvedilol solid dispersion tablets, SDT-2-L containing 30% w/w mannitol and 2.5% w/w L-hydroxypropyl cellulose LH- 11 exhibited least mean dissolution time in gastri...

Drug release from matrix dosage form is affected by polymer swelling, it’s erosion, drug distribution inside the matrix and polymeric combination. To prepare buccal controlled release patches hydrophilic, swellable, porous polymeric material alone or in optimum combination along with their buccoadhesive strength is essential. Here a plant derived g...

Poor aqueous solubility and low oral bioavailability of Carvedilol, a novel third generation anti-hypertensive drug necessitates exploration of formulation strategies to achieve quick onset of action and prolonged drug release from a dosage form. In the present study, disintegration-accelerated solid dispersion-based matrix tablet of Carvedilol has...

Formulation of safe and effective delivery system for induction of strong, effective and long-lasting immune response against pathogens poses a major challenge to modern non-invasive vaccination strategies. Intranasal route is being exploited as a viable alternative for mass-scale immunisation because it can gain acceptance by a wider section of th...

Plant lectins are bioactive glycoproteins possessing carbohydrate-recognition domain which exhibit regiospecific, cell-surface specific and reversible interactions with glycoconjugates. Since, they can decode biological information, lectins play a pivotal role in mediating and triggering diverse cellular phenomena. They serve as powerful tools in i...

Long-term infection by Human Immunodeficiency Virus produces a multitude of clinical symptoms resulting in total suppression of the immune system dominated by depletion in CD4+ T cell count and reduction in density of Human Immunodeficiency Virus specific Cytotoxic T-Lymphocyte immune responses. Since the dynamics between viral infection and replic...

Formulation of optimized delivery system for induction of strong, effective and long-lasting immune response against pathogens poses a major challenge to modern vaccination. Intranasal route is being exploited as a viable alternative for mass-scale immunisation because it can offer comfort to the population. Furthermore, the route is capable of eli...

Drug release kinetics from matrix dosage form is dominated by polymer swelling, polymer erosion, drug dissolution/diffusion, drug distribution inside the matrix and drug/polymer ratio. Thus for the preparation of controlled release dosage form hydrophilic, swellable, porous polymeric material alone or in optimum combination is essential. Here a pla...

Long-term infection by Human Immunodeficiency Virus produces a multitude of clinical symptoms resulting in total suppression of the immune system dominated by depletion in CD4 + T cell count and reduction in density of Human Immunodeficiency Virus specific Cytotoxic T-Lymphocyte immune responses. Since the dynamics between viral infection and repli...