Susanne Max Radke- Northeastern University
Susanne Max Radke
- Northeastern University
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24
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Publications (24)
Zusammenfassung
Die Resistenzbildung gegenüber der 1. und 2. Generation von Tyrosinkinase-Inhibitoren (TKIs) des epidermalen Wachstumsfaktors (EGFR) stellt bei der Behandlung von Patienten mit nicht kleinzelligem Lungenkarzinom, die eine aktivierende Mutation im EGFR aufweisen, ein großes Problem dar. Drittgenerations-EGFR-TKIs richten sich sowohl...
Ziel der Studie: Prüfung klinischer Faktoren auf das progressionsfreie (PFS) und das Gesamtüberleben (OS) von NSCLC-Patienten (Pt.) im Stadium IV, mit Mutation des epidermalen Wachstumsfaktorrezeptors (EGFRm+), die im Praxisalltag mit Gefitinib (Gef) bzw. mit Chemotherapie (CT) behandelt wurden.
Methodik: 285 EGFRm+-Pt. der REASON-Studie, die first...
PURPOSE:
To analyze the influence of the localization of mutations in the epidermal growth factor receptor (EGFR) gene on progression-free (PFS) and overall survival (OS) in patients (pts) with locally advanced or metastatic non-small cell lung cancer (NSCLC) treated with gefitinib (gef) or chemotherapy (CT) under real world conditions within the R...
Einleitung: TKI-sensitive Mutationen des EGF-Rezeptors (EGFR-M) sind Voraussetzung fur eine wirksame Behandlung des NSCLC mit TKI. REASON umfasst den derzeit grosten Datensatz zu EGFR-M in kaukasischen Patienten mit NSCLC IIIB/IV und enthalt Informationen zu klinisch-pathologischen Charakterisitika, systemischen Therapien und klinischen Wirksamkeit...
Endocytosis of activated growth factor receptors regulates spatio-temporal cellular signaling. In the case of the EGF receptor, sorting into multivesicular bodies (MVBs) controls signal termination and subsequently leads to receptor degradation in lysosomes. Annexin A1, a Ca(2+)-regulated membrane binding protein often deregulated in human cancers,...
Inhibition of cancer cell growth by histone deacetylase (HDAC) inhibitors has been observed in a number of malignancies. Multiple mechanisms have been proposed to explain the cancer-specific cytotoxic effect of HDAC inhibition, including transcriptional activation of pro-apoptotic and differentiation programs that become epigenetically silenced dur...
The HER2 antibody trastuzumab is the first biological therapy that has proven the value of HER2 blockade in breast cancer. However, not all patients respond to trastuzumab and relapses occur after this treatment. Histone deacetylase inhibitors (HDACIs) are active in HER2-amplified breast cancer but the role of HDACIs in trastuzumab-resistant breast...
#3060
Introduction: The Her2 antibody trastuzumab (T) is the first biological therapy that has proven the value of Her2 blockade in breast cancer. However, not all patients respond to trastuzumab and relapses occur after this treatment. Several studies suggest that histone deacetylase inhibitors (HDACis) are active in Her2-amplified breast cancer b...
We report here that blocking the activity of the 26 S proteasome results in drastic changes in the morphology of the mitochondria and accumulation of intermembrane space (IMS) proteins. Using endonuclease G (endoG) as a model IMS protein, we found that accumulation of wild-type but to a greater extent mutant endoG leads to changes in the morphology...
Skp2B, an F-box protein of unknown function, is frequently overexpressed in breast cancer. In order to determine the function
of Skp2B and whether it has a role in breast cancer, we performed a two-hybrid screen and established transgenic mice expressing
Skp2B in the mammary glands. We found that Skp2B interacts with the repressor of estrogen recep...
Annexin A1 (ANX-A1) is a calcium-dependent membrane-binding protein involved in the modulation of apoptosis and phagocytosis (FASEB J.2003;17:1544). We have previously reported that HDAC inhibitor depsipeptide (FK228) caused marked growth inhibition and apoptosis in t(8;21) Kasumi-1 AML cells with up-regulation of 123 genes (by cDNA array) includin...
Skp2 is an F-box protein involved in the ubiquitination and subsequent degradation of the cyclin-dependent kinase (Cdk) inhibitor p27. Skp2 has been reported to be overexpressed in a variety of cancer types and to correlate with poor prognosis. We have identified a novel isoform of Skp2 we named Skp2B, which differs from Skp2 only in the C-terminal...
Phosphorylation of the Ca2+ and membrane-binding protein annexin 1 by epidermal growth factor (EGF) receptor tyrosine kinase has been thought to be involved in regulation of the EGF receptor trafficking. To elucidate the interaction of annexin 1 during EGF receptor internalization, we followed the distribution of annexin 1-GFP fusion proteins at si...
The t(8;21) translocation, found in 12% of AML, creates the chimeric fusion protein, AML-ETO, which recruits the HDAC complex to AML-1-dependent promoters resulting in transcription repression. Here, we studied the effects of HDAC inhibitor FK228 in the AML1-ETO positive AML cell line, Kasumi-1 and investigated molecular mechanisms of apoptosis ind...
The human Golgi-associated PR-1-related protein (GAPR-1) is closely related to plant pathogenesis-related (PR-1) proteins, which are upregulated in response to pathogen attack. Family members have been identified in a variety of organisms, together constituting the superfamily of PR-1 proteins. GAPR-1 is found within lipid-enriched microdomains on...
Annexins are widely distributed and have been described in lung as well as in other cells and tissues. Annexin I (ANX AI) is a member of the calcium-dependent phospholipid binding protein family. Besides its anti-inflammatory function, ANX AI has been involved in several mechanisms such as the Erk repression pathway or apoptosis. To investigate the...
Recently, we reported that, in contrast to protein kinase C (PKC)α and βII, PKCδ does not require phosphorylation of a specific threonine (Thr505) in the activation loop for catalytic competence (Stempka et al. (1997) J. Biol. Chem. 272, 6805–6811). Here, we show that the acidic residue glutamic acid 500 (Glu500) in the activation loop is important...
ANX A1 ist ein Mitglied der Annexin-Proteinfamilie, die in Kalzium-abhänginger Weise mit Phospholipiden interagieren kann. Annexine bestehen aus einem hochkonservierten Proteinkern, der über Kalziumbrücken an Membranen bindet und aus einer Domäne am aminoständigen Proteinende,? die hohe Variabilität betreffend Aminosäuresequenz und Peptidlänge aufz...
Text engl. Düsseldorf, University, Diss., 2003. Computerdatei im Fernzugriff.
