Susanne Brander

Susanne Brander
Oregon State University | OSU · Fisheries Wildlife and Conservation Sciences

Ph.D. Toxicology (2011) University of California, Davis (she/her)
Microplastics, nanoplastics, and pesticide toxicity research with a dash of climate change

About

90
Publications
30,158
Reads
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1,668
Citations
Citations since 2016
71 Research Items
1536 Citations
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20162017201820192020202120220100200300400500
20162017201820192020202120220100200300400500
Introduction
Associate Professor at Oregon State University. Research encompasses the fields of toxicology, endocrinology, and ecology; integrating molecular approaches with measurements at the organism and population level. Current work examines the influence of factors such as temperature and salinity on responses to contaminants of emerging concern, and study of the ingestion, trophic transfer, and potential effects of microplastics and nanoplastics. Also active in the group 500 Women Scientists.
Additional affiliations
September 2017 - present
Oregon State University
Position
  • Faculty Member
August 2013 - August 2017
University of North Carolina at Wilmington
Position
  • Professor
September 2006 - December 2011
University of California, Davis
Position
  • PhD Student

Publications

Publications (90)
Presentation
Full-text available
VIDEO: https://vimeo.com/sccwrp/review/480010525/56ec962965 SCCWRP hosted a Microplastics Health Effects Workshop in which an international group of experts convened to identify the primary pathways by which microplastics affect biota, prioritize the microplastics characteristics (e.g., size, shape, polymer) that are of greatest biological concern...
Presentation
Full-text available
Microplastics are an important environmental issue that is very prevalent right now. This panel has both a science side and a policy side. Panelists will talk about microplastics being found throughout the food chain and how they affect the environment, as well as potential concerns for human health. We will also discuss the policy work being done...
Article
Full-text available
Many pollutants cause endocrine disruption in aquatic organisms. While studies of the direct effects of toxicants on exposed organisms are commonplace, little is known about the potential for toxicant exposures in a parental (F0) generation to affect unexposed F1 or F2 generations (multigenerational and transgenerational effects, respectively), par...
Article
Full-text available
Plastic pollution is a defining environmental contaminant and is considered to be one of the greatest environmental threats of the Anthropocene, with its presence documented across aquatic and terrestrial ecosystems. The majority of this plastic debris falls into the micro (1 μm-5 mm) or nano (1-1000 nm) size range and comes from primary and second...
Article
Full-text available
The ubiquitous pollution of the environment with microplastics, a diverse suite of contaminants, is of growing concern for science and currently receives considerable public, political, and academic attention. The potential impact of microplastics in the environment has prompted a great deal of research in recent years. Many diverse methods have be...
Article
In March, the global community agreed to establish a legally binding treaty to end plastic pollution. To deliver on this goal, the treaty needs to cover all issues of plastics chemicals as an inseparable part of the problem.
Article
Full-text available
Acute environmental stressors such as short-term exposure to pollutants can have lasting effects on organisms, potentially impacting future generations. Parental exposure to toxicants can result in changes to the epigenome (e.g. DNA methylation) that are passed down to subsequent, unexposed generations. However it is difficult to gauge the cumulati...
Article
Fourier transform infrared (FTIR) and Raman microspectroscopy are methods applied in microplastics research to determine the chemical identity of microplastics. These techniques enable quantification of microplastic particles across various matrices. Previous work has highlighted the benefits and limitations of each method and found these to be com...
Article
Pyrethroids, a class of commonly used insecticides, are frequently detected in aquatic environments, including estuaries. The influence that salinity has on organism physiology and the partitioning of hydrophobic chemicals, such as pyrethroids, has driven interest in how toxicity changes in saltwater compared to freshwater. Early life exposures in...
Article
Full-text available
There is definitive evidence that microplastics, defined as plastic particles less than 5 mm in size, are ubiquitous in the environment and can cause harm to aquatic organisms. These findings have prompted legislators and environmental regulators to seek out strategies for managing risk. However, microplastics are also an incredibly diverse contami...
Article
Full-text available
Drinking water is one of numerous sources of human exposure to microscale and nanoscale plastic particles. Here, using a mouse model, we tested enteric and hepatic cellular responses to nanoplastic ingestion. At 1.5 or 25.5 h after an oral dose of 70 mg polystyrene nanospheres (PSNS)/kg (nominal diameters of 20 and 200 nm) in aqueous suspension fem...
Article
Full-text available
To assess the potential risk of microplastic exposure to humans and aquatic ecosystems, reliable toxicity data is needed. This includes a more complete foundational understanding of microplastic toxicity and better characterization of the hazards they may present. To expand this understanding, an international group of experts was convened in 2020–...
Article
Full-text available
Microplastic particles (MPs) are ubiquitous across a wide range of aquatic habitats but determining an appropriate level of risk management is hindered by a poor understanding of environmental risk. Here, we introduce a risk management framework for aquatic ecosystems that identifies four critical management thresholds, ranging from low regulatory...
Article
Full-text available
Throughout the past decade, many studies have reported adverse effects in biota following microplastic exposure. Yet, the field is still emerging as the current understanding of microplastic toxicity is limited. At the same time, recent legislative mandates have required environmental regulators to devise strategies to mitigate microplastic polluti...
Article
Full-text available
Microplastics have been documented in drinking water, but their effects on human health from ingestion, or the concentrations at which those effects begin to manifest, are not established. Here, we report on the outcome of a virtual expert workshop conducted between October 2020 and October 2021 in which a comprehensive review of mammalian hazard s...
Article
Full-text available
An international group of experts says the production of new plastics should be capped to solve the plastic pollution problem. The authors argue that all other measures won’t suffice to keep up with the pace of plastic production and releases. This letter was published in the journal Science.
Article
Full-text available
Ingestion of microplastics has been documented across marine species, but exposure remains sparsely described in many seabird species. We assess microplastic (between 0.2 and 5.0 mm) ingestion in two Northwestern Atantic - breeding species for which exposure to microplastics is entirely or largely undescribed: Common Terns (Sterna hirundo) and Rose...
Article
Full-text available
While microplastics are a pollutant of growing concern in various environmental compartments, less is known regarding the sources and delivery pathways of microplastics in urban rivers. We investigated the relationship between microplastic concentrations and various spatiotemporal factors (e.g., land use, arterial road length, water velocity, preci...
Article
Full-text available
Each year, over 2,000 new chemicals are added to the tens of thousands that already flood the global market. Of these, an estimated 1% have been assessed adequately for safety, and many more are suspected to be toxic. Individual regulatory agencies lack the resources and political power to tackle this enormous challenge, signaling the need for a ta...
Article
Full-text available
Synthetic rubber emissions from automobile tires are common in aquatic ecosystems. To assess potential impacts on exposed organisms, early life stages of the estuarine indicator species Inland Silverside (Menidia beryllina) and mysid shrimp (Americamysis bahia) were exposed to three tire particle (TP) concentrations at micro and nano size fractions...
Article
Full-text available
Environmental sampling has documented a diversity of microplastics, including high levels of black rubber— generally identified as tire debris. Though organisms have been shown to ingest tire particles (TPs), past research focused on toxicity of leachate alone, overlooking potential effects of particles. To address these gaps, we assessed the toxic...
Article
Full-text available
Anthropogenic debris including microparticles (MP; <5mm) are ubiquitous in marine environments. The Salish Sea experiences seasonal fluctuations in precipitation, river discharge, sewage overflow events, and tourism– all variables previously thought to have an impact on MP transport and concentrations. Our goals are two‐fold: 1) Describe long‐term...
Article
Microplastics are ubiquitous in marine and estuarine ecosystems, and thus there is increasing concern regarding exposure and potential effects in commercial species. To address this knowledge gap, we investigated the effects of microplastics on larval and early juvenile life stages of the Black Sea Bass (Centropristis striata), a North American fis...
Article
Full-text available
Changing salinity in estuaries due to sea level rise and altered rainfall patterns, as a result of climate change, has the potential to influence the interactions of aquatic pollutants as well as to alter their toxicity. From a chemical property point of view, ionic concentration can increase the octanol–water partition coefficient and thus decreas...
Article
Full-text available
Capacity to cope with warming temperatures is a key determining factor of species’ persistence under global climate change. Many successful invasive species have heightened thermal tolerance relative to their native counterparts, which may provide competitive advantages for habitat utilization and resource acquisition under warming scenarios, ultim...
Article
Agglomeration of nanoplastics in waters can alter their transport and fate in the environment. Agglomeration behavior of four nanoplastics differing in core composition (red‐ or blue‐dyed polystyrene (PS)) and surface chemistry (plain or carboxylated poly (methyl methacrylate) (PMMA)) was investigated across a salinity gradient. No agglomeration wa...
Article
Full-text available
Salinity can interact with organic compounds and modulate their toxicity. Studies have shown that the fraction of pyrethroid insecticides in the aqueous phase increases with increasing salinity, potentially increasing the risk of exposure for aquatic organisms at higher salinities. In the San Francisco Bay Delta (SFBD) estuary, pyrethroid concentra...
Article
Global climate change (GCC) significantly affects aquatic ecosystems. Continual use of pyrethroid insecticides results in contamination of these ecosystems and concurrent GCC raises the potential for synergistic effects. Resistance to pyrethroids has been documented in Hyalella azteca, a common epibenthic amphipod and model organism. Resistant H. a...
Presentation
Full-text available
Maintaining good water quality in nearshore regions is important to our well-being, economy, and diverse coastal ecosystems. Unfortunately, nearshore waters are threatened by increasing pollutants, pathogens, and contaminants associated with a range of geophysical and human pressures including, but not limited to warming temperatures, rising sea le...
Article
Background: A critical challenge in genomic medicine is identifying the genetic and environmental risk factors for disease. Currently, the available data links a majority of known coding human genes to phenotypes, but the environmental component of human disease is extremely underrepresented in these linked data sets. Without environmental exposur...
Article
Full-text available
Pyrethroid and organophosphate pesticides are two of the most commonly used classes of insecticide worldwide. At sublethal concentrations, permethrin (a pyrethroid) and chlorpyrifos (an organophosphate) impact behavior in model fish species. We investigated behavioral effects of environmentally relevant concentrations of permethrin or chlorpyrifos...
Article
Full-text available
Microplastics (MPs) are anthropogenic contaminants found in coastal and marine environments worldwide. Pacific razor clams (Siliqua patula), important for local indigenous culture, economy, gastronomy and food security along the United States West Coast, are subjected to myriad environmental stressors including predation, storm events, disease, tox...
Article
Bifenthrin is a pyrethroid insecticide commonly used in agricultural and urban sectors, and is found in watersheds worldwide. As a sodium channel blocker, at sublethal concentrations it causes off-target effects, including disruption of calcium signaling and neuronal growth. At the whole organism level, sublethal concentrations of bifenthrin cause...
Preprint
Full-text available
Plastic pollution is a defining environmental contaminant and is considered to be one of the greatest environmental threats of the Anthropocene, with its presence documented across aquatic and terrestrial ecosystems. The majority of this plastic debris falls into the micro (1 μm - 5 mm) or nano (1 - 1000 nm) size range and comes from primary and se...
Article
This study investigated the sensitivity of two deepsea species using mortality of northern shrimp (Pandalus borealis) and polyp activity of stony coral (Lophelia pertusa) to dispersant, Corexit 9500 and aromatic hydrocarbons (toluene, 2-methylnaphthalene, phenanthrene) in 96-h tests. Resulting hydrocarbon toxicity data were fit to the Target Lipid...
Article
Full-text available
The inland silverside, Menidia beryllina, is a euryhaline fish and a model organism in ecotoxicology. We previously showed that exposure to picomolar (ng/L) levels of endocrine disrupting chemicals (EDCs) can cause a variety of effects in M. beryllina, from changes in gene expression to phenotypic alterations. Here we explore the potential for earl...
Chapter
Pyrethroids are one of the most heavily used insecticide classes globally because they have low mammalian toxicity. However, they are highly toxic to arthropods. Pyrethroids are ubiquitous in the aquatic environment as a result of urban (landscaping, structural pest control, home, and garden) and agricultural runoff and spray drift, often at levels...
Article
Full-text available
Microplastics are of increasing concern as they are readily ingested by aquatic organisms. This study investigated microplastic trophic transfer using larval inland silversides (Menidia beryllina) (5 d posthatch) and unicellular tintinnid (Favella spp.) as a model food chain relevant to North American estuaries. Low‐density polyethylene microsphere...
Article
Full-text available
Legacy and current-use contaminants enter into and accumulate throughout the San Francisco Bay−Delta (Bay−Delta), and are present at concentrations with known effects on species important to this diverse watershed. There remains major uncertainty and a lack of focused research able to address and provide understanding of effects across multiple bio...
Article
Full-text available
Commercial fisheries yield essential foods, sustain cultural practices, and provide widespread employment around the globe. Commercially harvested species face a myriad of anthropogenic threats including degraded habitats, changing climate, overharvest, and pollution. Microplastics are pollutants of increasing concern, which are pervasive in the en...
Article
Delta smelt (Hypomesus transpacificus) is a critically endangered species endemic to the San Francisco Bay Delta (SFBD). Important for the conservation of this species is understanding the physiological and ecological impacts contributing to their population decline, and current studies lack information on embryonic development. Changes in patterns...
Article
Full-text available
Aquatic organisms inhabiting polluted waterways face numerous adverse effects, including physiological disruption by endocrine disrupting compounds (EDCs). Little is known about how the temperatures associated with global climate change may influence the response of organisms exposed to EDCs, and the effects that these combined stressors may have o...
Chapter
Full-text available
Exposures to environmentally relevant concentrations of endocrine disrupting compounds(EDCs) in aquatic ecosystems are long established to be a threat to ecological health (Brander, 2013; Colborn and Thayer, 2000; Schug et al., 2016; Windsor et al., 2018). Numerous studies published over the past several decades demonstrate that EDCs, which include...
Article
Altered transcription of calcium-dependent signaling cascades involving the ryanodine receptor (RyR) and mechanistic target of rapamycin (mTOR) in response to environmental exposures have been described in model vertebrates, including zebrafish, while the relevance for wild fishes remains unknown. To address this knowledge gap, we exposed the euryh...
Thesis
Full-text available
Microplastics, which pose an environmental hazard because they are readily ingested and accumulated by aquatic organisms, are of increasing global concern in the aquatic environment. The surface of plastic attracts lipophilic compounds, such as the legacy pollutant DDT, that may leach into the tissues of organisms upon ingestion. This study used la...
Article
Full-text available
A predominant concern following oil spills is toxicity to aquatic organisms. However, few data are available on effects in deep‐sea cold water fishes. This study had three major objectives. First, investigate the relative sensitivity of the deep‐sea species Anoplopoma fimbria (sablefish) to acute effects of three aromatic compounds (toluene, 2‐meth...
Article
Over the last few decades, the pyrethroid insecticide bifenthrin has been increasingly employed for pest control in urban and agricultural areas, putting humans and wildlife at increased risk of exposure. Exposures to nanomolar (nM) concentrations of bifenthrin have recently been reported to alter calcium oscillations in rodent neurons. Neuronal ca...
Article
Full-text available
Understanding the combined effects of anthropogenic impacts such as climate change and pollution on aquatic ecosystems is critical. However, little is known about how predicted temperature increases may affect the activity of endocrine disrupting compounds (EDCs), particularly in species with plasticity in sex determination. We investigated the eff...
Article
Full-text available
Over the past decade, the field of molecular biology has rapidly incorporated epigenetic studies to evaluate organism–environment interactions that can result in chronic effects. Such responses arise from early life stage stress, the utilization of genetic information over an individual's life time, and transgenerational inheritance. Knowledge of e...
Article
Assessing how endocrine disrupting compounds (EDCs) affect population dynamics requires tracking males and females (and sex-reversed individuals) separately. A key component in any sex-specific model is the ‘mating function’ (the relationship between sex ratio and reproductive success) but this relationship is not known for any fish species. Using...
Poster
Objectives: • Determine the LC50s of three petroleum hydrocarbons to the Sablefish based on the static renewal test. • Assess if sablefish exhibit sensitivity within the observed range for pelagic species Conclusions: • Results show, that of the three chemicals, phenanthrene was most toxic followed by 2-methylnaphthalene and toluene • Observed LC50...
Poster
Objectives: • Determine the LC50s of three petroleum hydrocarbons to the Sablefish based on the static renewal test. • Assess if sablefish exhibit sensitivity within the observed range for pelagic species Conclusions: • Results show, that of the three chemicals, phenanthrene was most toxic followed by 2-methylnaphthalene and toluene • Observed LC50...
Poster
Objectives: • Determine the LC50s of three petroleum hydrocarbons to the Sablefish based on the static renewal test. • Assess if sablefish exhibit sensitivity within the observed range for pelagic species Conclusions: • Results show, that of the three chemicals, phenanthrene was most toxic followed by 2-methylnaphthalene and toluene • Observed LC50...
Poster
Objectives: • Determine the LC50s of three petroleum hydrocarbons to the Sablefish based on the static renewal test. • Assess if sablefish exhibit sensitivity within the observed range for pelagic species
Poster
Objectives: • Determine the LC50s of three petroleum hydrocarbons to the Sablefish based on the static renewal test. • Assess if sablefish exhibit sensitivity within the observed range for pelagic species Conclusions: • Results show, that of the three chemicals, phenanthrene was most toxic followed by 2-methylnaphthalene and toluene • Observed LC50...
Poster
Full-text available
Objectives: • Determine the LC50s of three petroleum hydrocarbons to the Sablefish based on the static renewal test. • Assess if sablefish exhibit sensitivity within the observed range for pelagic species Conclusions: • Results show, that of the three chemicals, phenanthrene was most toxic followed by 2-methylnaphthalene and toluene • Observed LC50...
Article
Full-text available
Fishes in estuarine waters are frequently exposed to treated wastewater effluent, among numerous other sources of contaminants, yet the impacts of these anthropogenic chemicals are not well understood in these dynamic and important waterways. Inland silversides (Menidia beryllina) at an early stage of development [12 days posthatch (dph)] were expo...
Article
Full-text available
Pyrethroids are now the fourth most used group of insecticides worldwide. Employed in agriculture and in urban areas, they are detected in waterways at concentrations that are lethally and sub-lethally toxic to aquatic organisms. Highly lipophilic, pyrethroids accumulate in sediments and bioaccumulate in fishes. Additionally, these compounds are de...