Susana Iraola Guzmán

Susana Iraola Guzmán
IMPPC Institute of Predictive and Personalized Cancer Medicine | IMPPC · Cancer Genome Biology

PhD

About

21
Publications
1,317
Reads
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566
Citations
Citations since 2016
0 Research Items
293 Citations
201620172018201920202021202201020304050
201620172018201920202021202201020304050
201620172018201920202021202201020304050
201620172018201920202021202201020304050
Additional affiliations
January 2008 - December 2012
Centre for Genomic Regulation
Position
  • PhD Student
Education
September 1999 - September 2004
School of Pharmacy, Universidad de Navarra
Field of study
  • Bio-Sanitaria

Publications

Publications (21)
Article
Iraola-Guzmán S, Estivill X, Rabionet R. DNA methylation in neurodegenerative disorders: a missing link between genome and environment? The risk of developing neurodegenerative disorders such as Alzheimer's disease or Parkinson's disease is influenced by genetic and environmental factors. Environmental events occurring during development or later i...
Data
Table S2. Table of cross platform GSEA enrichment scores and significance values (provided as word file).
Data
Figure S6. Pathway analysis based on the Ingenuity Pathway Knowledge base. The three best ranked networks derived from EGF-regulated genes as determined by the RankProd test were (A) Cell Death, Embryonic Development, Renal and Urological Disease (B) Amino Acid Metabolism, Post-Translational Modification, Small Molecule Biochemistry and (C) Cell Cy...
Data
Table S5. Table of 20322 RefSeq genes analyzed by RankProd analysis of microarrays and DGE (provided as excel file).
Data
Table S6. Table of 1164 genes found significant by RankProd analysis of microarrays and tag ultrasequencing (provided as excel file).
Data
Table S8. List of primers used in this study.
Data
Figure S1. Activation of signaling pathways in HeLa cells after EGF stimulation. Serum-starved HeLa cells were stimulated with EGF at the indicated times in the presence or absence of kinase inhibitors. Total cell extracts were prepared as indicated in Materials and Methods and samples were subjected to SDS-PAGE and immunoblotting using the indicat...
Data
Table S4. Table of reads generated by the DGE pipeline for each of the runs. Summary table of read mapping statistics generated by the DGE pipeline for each of the runs.
Data
Figure S2. Time course RT-qPCR analysis of potential EGF-regulated mRNAs. Total RNA samples from serum-starved HeLa cells stimulated with EGF at the indicated times (15 min to 24 h) were subjected to quantitative real-time PCR (see Methods for details). Data represent mean fold induction of at least two independent experiments. SFA3 was used as the...
Data
Figure S3. Correlation plot between DGE and microarray log2ratio values. Comparison of estimated log2ratios from DGE (Y-axis) and the average of all three microarray platforms (X-axis). We consider only genes that were interrogated using all platforms and genes with a mean number of counts across lanes greater than 0. Genes with counts greater than...
Data
Figure S4. Heat maps of genes found regulated at 6 h after EGF treatment of HeLa cells in our study and known to be related to EGF signaling. Some genes detected in a subset of all platforms are also included for the sake of completion. (A) Modulators of EGF signaling; (B) non-EGF agonists of EGFR and cytokines linked to the EGF family locus on chr...
Data
Table S7. Significantly regulated genes associated to regulated KEGG cellular functions as determined by GlobalAncova (supplied as word).
Data
Table S1. Gene lists of SAM test overlap by Venn Diagram of 3 microarray platforms and DGE (provided as word file).
Data
Table S3. Table of 20192 genes analyzed by RankProd analysis of microarray data (provided as excel file).
Data
Figure S5. Metallothionein gene expression after EGF treatment. Log2ratio of EGF-treated versus untreated heat maps of metallothionein gene expression after EGF treatment in (A) HeLa cells at 6 h as determined in this study using Agilent, Operon, and Illumina microarrays, and DGE sequencing; (B) RT-qPCR for 6 metallothionein family members, (C) met...
Article
Full-text available
Epidermal Growth Factor (EGF) is a key regulatory growth factor activating many processes relevant to normal development and disease, affecting cell proliferation and survival. Here we use a combined approach to study the EGF dependent transcriptome of HeLa cells by using multiple long oligonucleotide based microarray platforms (from Agilent, Opero...
Article
Full-text available
MicroRNAs (miRNAs) are post-transcriptional gene expression regulators, playing key roles in neuronal development, plasticity and disease. Parkinson's disease (PD) is the second most common neurodegenerative disorder, characterized by the presence of protein inclusions or Lewy bodies and a progressive loss of dopaminergic neurons in the midbrain. H...
Article
Toxicity risk assessment for chemical-induced human health hazards relies mainly on data obtained from animal experimentation, human studies and epidemiology. In vitro testing for acute toxicity based on cytotoxicity assays predicts 70-80% of rodent and human toxicity. The nervous system is particularly vulnerable to chemical exposure which may res...
Article
Neurotoxicology considers that chemicals perturb neurological functions by interfering with the structure or function of neural pathways, circuits and systems. Using in vitro methods for neurotoxicity studies should include evaluation of specific targets for the functionalism of the nervous system and general cellular targets. In this review we pre...
Article
Lingo-1 (also known as Lern1) is a component of the Nogo receptor complex that mediates intracellular signaling in response to myelin associated inhibitors (MAIs): NogoA, MAG, and Omgp. Signaling through Nogo receptor extends to more than its well known role in preventing axon regeneration after lesion in the CNS, being implicated in neuronal funct...

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