Susana Astiz

Susana Astiz
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria | INIA · Department of Animal Reproduction

PhD, VMD, Dip ECBHM

About

165
Publications
38,604
Reads
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1,529
Citations
Citations since 2017
77 Research Items
1173 Citations
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2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
Introduction
Vet Med, Madrid 1995, Master Biostatistics, Barcelona 2000, PhD, Hannover 1999; Dip ECBHM 2007. Worked as Practitioner in Europe; Technical Manager at pharma-firms; since 2009 Senior Researcher at INIA. Mean research topics: Animal Production, Reproduction in Livestock, Biotechnology, Animal Welfare and Modelling. Near to the agrarian sector and to the Academia Community. Expertise in education and scientific communication. Active Member of ANEMBE (Board), UEECA (Board), SEP, IETS and SEO.
Additional affiliations
November 2009 - present
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
Position
  • Senior Researcher

Publications

Publications (165)
Article
Full-text available
Sperm quality decreases over time, so bull semen may need to be preserved after field collection. However, the effect of handling such semen samples from commercial farms and placing them in very short–term storage has not been elucidated. Therefore, ejaculate from 25 bulls from 1 dairy and 14 beef cattle farms were collected under farm conditions...
Article
A high intramuscular fat content characterizes Wagyu (WY) cattle breed. Our objective was to compare beef from WY, WY-by-Angus, or Wangus (WN) steers with European, Angus-by-Charolais-Limousine crossbred steers (ACL), considering metabolic biomarkers pre-slaughtering and nutritional characteristics, including health-related indexes of the lipid fra...
Article
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Intrauterine growth restriction (IUGR) and later obesity and metabolic disorders have classically been associated with maternal malnutrition, but most cases of IUGR are related to placental insufficiency. The current study, using a swine model for IUGR and obesity, aimed to determine the interaction of birth weight (categorized as low birth weight...
Article
Full-text available
Intrauterine Growth Restriction (IUGR) is a major problem in pig production and different strategies, mainly maternal supplementation with different agents, are currently being studied. The combination of hydroxytyrosol and n3-PUFA seems to be a promising treatment to counteract IUGR, since the combination may help improve n3-PUFA composition and l...
Article
Full-text available
The hypothalamus is implicated in controlling feeding and adiposity, besides many other physiological functions, and thus can be of great importance in explaining productive differences between lean and fatty pig breeds. The present study aimed to evaluate the hypothalamic transcriptome of pure Iberian (IBxIB) and Large White x Iberian crossbreds (...
Article
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Aim of study: To describe veterinary services and farm management practices in cattle dairy farms in São Miguel Island in the Azores and to identify weak points for improvement. Area of study: São Miguel Island, Azores (Portugal). Material and methods: A questionnaire survey was sent to all veterinarians who work in São Miguel Island. It asked ab...
Article
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Japanese Black (Wagyu) cattle produce high-quality beef. However, whether Wagyu steers can be profitably raised under conditions different than the traditional Japanese ones remains unclear. From 2018 to 2020, we raised 262 Wagyu purebred steers, 103 Wagyu-by-Angus (Wangus) crossbred steers, and 43 Angus-by-European (ACL) crossbred steers on a Span...
Article
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This work aimed to review the important aspects of the dairy industry evolution at herd level, interrelating production with health management systems. Since the beginning of the industrialization of the dairy cattle sector (1950s), driven by the need to feed the rapidly growing urban areas, this industry has experienced several improvements, evolv...
Article
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We evaluated the relationship between plasma levels of anti-Müllerian hormone (AMH) and the number of antral follicles at the restart of the follicular wave in crossbred Holstein cows reared under extensive grazing systems over 2500 m above sea level. The study included 140 cows from 15 farms that were in average at the 75.3 ± 2.10 d post partum. A...
Article
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Multiple ovulation and embryo transfer (MOET) systems have been intensively implemented in Japanese Black cattle in Japan and to create Japanese Black herds out of these areas. Environmental conditions influence MOET efficiency. Thus, we describe results of 137 in vivo, non-surgical embryo flushings performed between 2016–2020, in a full-blood Japa...
Article
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The intensification of bovine milk production in the Azores has led farmers to increase farm size and specialization in grasslands, implementing confined and semi-confined production systems. Fixed milking parlours (FMP) have progressively gained more popularity, at the expense of conventional mobile milking systems (MMS). The present study aimed t...
Article
Full-text available
CASA kinetic parameters are often evaluated in a diagnostic centre. How storage conditions affect ejaculates up to evaluation is unclear. We assessed, in 25 commercial bulls electroejaculated in the field, the impact of time until evaluation (0–2 h, 4–6 h, and 24 h post-ejaculation), holding temperature (5 °C vs. room temperature), and extender (An...
Article
Full-text available
Seminal parameters can be evaluated in situ, or samples can be delivered to a diagnostic centre. How storage conditions affect ejaculates up to evaluation is unclear. We assessed, in 25 commercial bulls electroejaculated in the field, the impact of time until evaluation (0–2 h, 4–6 h, and 24 h post-ejaculation), holding temperature (5 °C vs. room t...
Article
Full-text available
Maternal supplementation with antioxidants and n-3 PUFAs may be a promising strategy to reduce the risk of intrauterine growth restriction and preterm delivery, which may diminish the appearance of low-birth-neonates. A previous studies showed beneficial outcomes of the combination of hydroxytyrosol and linoleic acid, but there is no data of its pr...
Article
The objective of this randomized, controlled study was to evaluate the reproductive and economic performance of dairy Holstein heifers managed for first to third artificial inseminations (AIs) with or without an intravaginal progesterone device (IPD) under different temperature-humidity indexes (THI) and combined with AI after observed estrus. A to...
Article
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The use of amino acids during pregnancy, such as glutamine (Gln), seems to be a promising strategy in selected swine breeds to improve the offspring prenatal development. The main goal of the current study was to assess the development of the offspring from parity 1–3 sows of a traditional breed, which were supplemented with 1% glutamine after Day...
Article
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In beef herds, increasing animal welfare, improving reproductive performance and easing animal management are key goals in farm economics. We explored whether delaying the removal of the intravaginal progesterone device by 24 h in heifers synchronized with a 5d Co-synch 72-h protocol could improve reproductive efficiency of fixed-time artificial in...
Preprint
Full-text available
Background In beef herds, increasing animal welfare, improving reproductive performance and easing animal management are key goals in farm economics. This study explored whether delaying the removal of the intravaginal progesterone device by 24 h in heifers synchronized with a 5d Co-synch 72 h protocol could improve reproductive efficiency of fixed...
Article
Full-text available
The present study aimed to assess the importance of offspring genotype on postnatal development, independently of confounding factors related to prenatal environment and postnatal lifestyle, using a translational model of obesity and metabolic syndrome (the Iberian pig). Hence, we compared two genotypes (purebred Iberian and crossbreds Iberian × La...
Article
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Researchers have contributed by increasing our understanding of the factors affecting reproduction in beef, mainly physical health and nutrition aspects, which have been main concerns during decades. Animal welfare is of outmost relevance in all animal production systems and it is strongly associated to stress. Stress responses involve endocrine, p...
Article
Full-text available
Metformin is currently used to improve pregnancy outcome in women affected by polycystic ovary syndrome (PCOS) or diabetes. However, metformin may also be useful in pregnancies at risk of intrauterine growth restriction (IUGR) since it improves placental efficiency and the fetuses’ developmental competence. There is no data on the duration of the e...
Article
Full-text available
Maternal supplementation with antioxidants and n3 PUFAs may be a promising strategy to reduce the risk of intrauterine growth restriction and preterm delivery, which may diminish the appearance of low-birth-weight neonates. The present study aimed to determine benefits and risks of a dietary supplementation combining hydroxytyrosol, a polyphenol fr...
Article
Understanding the physiology of penile spicules in guinea pigs (Cavia porcellus) may improve their management in large-scale production guinea systems. Here we examined whether penis spicule development depends on testosterone and whether exogenous testosterone can reverse penile spicule atrophy in castrated guinea pigs. The relationship between to...
Article
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Menopause strongly increases incidence and consequences of obesity and non-communicable diseases in women, with recent research suggesting a very early onset of changes in lipid accumulation, dyslipidemia, and insulin resistance. However, there is a lack of adequate preclinical models for its study. The present trial evaluated the usefulness of an...
Article
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The present study assessed the relationship between obesity induced by lifestyle and systemic oxidative stress and possible modulations by oral metformin treatments in young individuals, by using a translational swine model of obesity and associated cardiometabolic disorders (Iberian pig). The results indicate the existence of an age-related increa...
Article
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The objective of this retrospective study was to investigate the prevalence of pregnancy loss (PL; between 28–110 pregnancy days) and its relationship with factors: farm, year (2015–2018), season, artificial insemination (AI)-rank, parity, AI-type (fixed-time vs. oestrus-AI), previous PL, days in milk (DIM), fixed-time-AI protocol, AI-technician, b...
Article
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Fatty pigs are characterized by a thrifty genotype, adapted to harsh environments based on changes in metabolism and energy saving. Thus, we hypothesized that feto-maternal energy partitioning in large litters might have postnatal effects that might be independent of intrauterine growth restriction (IUGR) processes. Hence, the current work reported...
Article
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Identifying metabolite signatures associated with obesity and related diseases might represent a valuable preventive and therapeutic tool to predict subjects at risk, establish an accurate prognosis, and monitor treatment success. The current cross-sectional study is aimed to evaluate the metabolite profile of diet-induced obesity in a porcine mode...
Article
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The pathogenesis of renal disease in the context of overweight/obesity, metabolic syndrome, and insulin resistance is not completely understood. This may be due to the lack of a definitive animal model of disease, which limits our understanding of obesity-induced renal damage. We evaluated the changes in renal histology and lipid deposits induced b...
Article
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Growth is dependent on genotype and diet, even at early developmental stages. In this study, we investigated the effects of genotype, sex, and body weight on the fetal muscle transcriptome of purebred Iberian and crossbred Iberian x Large White pigs sharing the same uterine environment. RNA sequencing was performed on 16 purebred and crossbred fetu...
Article
Full-text available
This study aimed to determine the effects of piglet birthweight (BIW) and sex, and within-litter BIW variation,on postnatal growth traits and meat quality in fatty breeds of pig. In total, 406 crossbred piglets (half male, half female)born to Iberian sows were studied during their postnatal development until slaughter. After birth, piglets were cla...
Article
Full-text available
Maternal supplementation with the polyphenol hydroxytyrosol in a swine model of intrauterine growth restriction (IUGR) improves the fetal oxidative status, decreases the appearance of low birth-weight neonates and favors growth during early postnatal stages (lactation). The current study aimed to determine whether hydroxytyrosol supplementation can...
Conference Paper
Western diet is deficient in omega-3 (ω-3) fatty acids (FA) while being abundant in omega-6 (ω-6) ones. Health-related concerns imply an increasing interest in improving the consumption of ω-3 FA and studying its metabolic implications. Pork is greatly consumed worldwide, and its FA composition can be easily changed. Also, maternal nutrition is ess...
Conference Paper
Swine production is mostly based on highly-efficient commercial breeds, but traditional local breeds (such as Iberian pig) are also used. Despite lower overall efficiency, recent studies have evidenced a major growth potential of Iberian piglets during early developmental stages, especially in females. The aim of this study was to determine the mol...
Presentation
The population of giraffes (Giraffa camelopardalis) in the wild has dramatically decreased over the last 20 years. For this reason, ex situ breeding and management has become necessary for conservation and knowledge of the species. This study was carried out at the Bioparc Valencia (Spain) in March and April 2017, on a group of 6 giraffes (1 male a...
Article
Right displaced abomasum (RDA) and abomasal volvulus (AV) are common diseases in cattle. However, presently there is no consensus regarding the pathogenesis and nomenclature of the different positions that the abomasum can adopt in the right side of the cow. Therefore, the objective of this study was to describe the etiopathogenesis of the right di...
Poster
Full-text available
In swine production, both commercial and traditional breeds (such as Iberian pig), are used, with commercial pigs being more efficient in reproductive and productive traits. However, recent studies have suggested a major growth potential in Iberian piglets during early developmental stages. The aim of this study was to determine the molecular event...
Article
Full-text available
Maternal supplementation with hydroxytyrosol, a polyphenol present in olive leaves and fruits, is a highly promising strategy to improve the oxidative and metabolic status of fetuses at risk of intrauterine growth restriction, which may diminish the appearance of low-birth-weight neonates. The present study aimed to determine whether hydroxytyrosol...
Article
Full-text available
Pregnancy and lactation, especially when concurrent, create a rather metabolically demanding situation in dairy ruminants, but little is known about their effects on offspring phenotype and milk yield. Here, we evaluated the impact of pregnancy and lactation on the metabolic traits and productive performance of Lacaune dairy sheep and their offspri...
Article
Full-text available
Metformin is an anti-hyperglycemic drug widely used for the treatment of insulin resistance and glucose intolerance and is currently considered for preventing large-for-gestational-age (LGA) offspring in pregnant women affected by obesity or diabetes. Our hypothesis was the opposite—metformin may be used for improving the development of offspring a...
Article
Full-text available
Pregnancy and lactation are challenging states that affect maternal and lamb health. In Lacaune dairy sheep, we evaluated the impact of parity, pregnancy rank, and body condition on body weight and the condition of ewes and lambs in mid-pregnancy (75 ± 5 d), in late pregnancy (142 ± 4d), and postpartum (52 ± 5d pp). Maternal age was associated with...
Article
Full-text available
The use of polyphenols is a promising strategy for preventing or alleviating intrauterine growth restriction (IUGR) because polyphenol supplementation increases plasma antioxidant capacity and improves oxidative stress at the feto-placental unit; which are recognized as main issues in IUGR. However, there is a scarcity of experimental data on both...
Article
Full-text available
The present study indicates that short-term progestagen-based protocols for synchronization of estrus and ovulation in sheep involving 7 days of progestagen insertion with administration of prostaglandin F2α at either insertion or removal of the progestagen sponge resulted in 80–90% fertility during the breeding season, while a classical long-term...
Article
Full-text available
Abstract Background The aim of this study was to determine how maternal undernutrition during pregnancy and offspring birth-weight can affect the postnatal development of offspring under farm conditions, which may lead to consequences in its meat and carcass quality. The current study involved a total of 80 litters from Iberian sows fed a diet fulf...
Article
The present study supports that short‐term (7‐days) protocols based on progestagen‐impregnated sponges and progesterone‐loaded CIDRs are equally effective to induce ovulatory response in sheep. There were no significant differences in the onset of estrus behavior (32.0±6.0 and 33.8±4.0h after device withdrawal for sponges and CIDRs, respectively; p...
Article
We recorded conception rates and estimated pregnancy rates following second and later timed artificial inseminations (TAI) after hormonal resynchronization on commercial dairy farms, using the so–called G6G protocol (PGF day‐0; GnRH 2, 8d; PGF 15, 16d, GnRH 17d; TAI 18d), and the 5 day Ovsynch protocol or 5DO (GnRH day 0; PGF 5, 6d; GnRH 7d; TAI 8d...
Poster
Full-text available
Objectives. In order to reduce non-productive days in dairy ewe production, the “accelerated sheep mating systems” can be used. One example is the STAR system, which involves up to 5 lambings/ewe in 3 years (1.2 to 1.4 lambing/ewe/year) through 5 concurrent annual breeding and lambing seasons (5LY). Despite its feasibility, a major disadvantage to...
Article
In the present study, there was a comparison among classical long-term progestagen (fluorogestone acetate) protocols for synchronization of estrus and ovulation (14 days; group FGA14, n = 9 ewes) and short-term protocols based on 7 days of progestagen treatment plus a dose of prostaglandin F2α at either insertion (PG-FGA7, n = 11) or removal (FGA7-...
Article
Full-text available
Background: Leptin resistance is associated with lower reproductive efficiency, with deficiencies in embryo viability and growth leading to low prolificacy and high incidence of intrauterine growth restriction. Objective: We aimed to investigate the underlying mechanisms of the leptin-resistance, evaluating the antioxidant homeostasis of leptin-res...
Article
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Dairy farms need to improve their competitiveness through decisions that are often difficult to evaluate because they are highly dependent on many economic and technical factors. The objective of this project was to develop a stochastic and dynamic mathematical model to simulate the functioning of a dairy farm to evaluate the effect of changes in t...
Article
Full-text available
Sarcopenia and sarcopenic obesity are currently considered major global threats for health and well-being. However, there is a lack of adequate preclinical models for their study. The present trial evaluated the suitability of aged swine by determining changes in adiposity, fatty acids composition, antioxidant status and lipid peroxidation, develop...
Article
Full-text available
El presente artículo revisa diversos aspectos de la programación prenatal en el cerdo ibérico. La investigación sobre los factores que condicionan el fenotipo adulto y la homeorresis en diferentes especies ha abordado tanto la predisposición genética como el papel determinante de la nutrición durante el período prenatal. Tanto la sobrenutrición com...
Article
Full-text available
El crecimiento intrauterino retardado (CIR) es debido a un inadecuado aporte de oxígeno y/o nutrientes durante el desarrollo prenatal. La respuesta adaptativa de la descendencia es tiempo dependiente, pero además están aumentando las evidencias de que el sexo fetal ejerce un fuerte efecto modulador sobre dicha respuesta. El presente estudio pretend...
Article
Full-text available
There is no simple method to measure glomerular filtration rate (GFR) in swine, an established model for studying renal disease. We developed a protocol to measure GFR in conscious swine by using the plasma clearance of iohexol. We used two groups, test and validation, with eight animals each. Ten milliliters of iohexol (6.47 g) was injected into t...