Susan Ellen Brien

Susan Ellen Brien
University of Ottawa · Department of Surgery

MD.FRCSC,MED,

About

47
Publications
7,406
Reads
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1,021
Citations
Citations since 2017
9 Research Items
563 Citations
2017201820192020202120222023020406080100120
2017201820192020202120222023020406080100120
2017201820192020202120222023020406080100120
2017201820192020202120222023020406080100120
Additional affiliations
December 2007 - present
Royal College of Physicians and Surgeons of Canada
Position
  • Director of practice, performance and innovation

Publications

Publications (47)
Article
The dynamic response of the human brain subjected to impulsive loading conditions is of fundamental importance to the understanding of traumatic brain injuries. Due to the complexity of such measurements, the existing experimental datasets available to researchers are sparse. However, these measurements are used extensively in the validation of com...
Article
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Purpose This article shares our experience developing an integrated curriculum for the ACES (Acute Critical Event Simulation) program. The purpose of the ACES program is to ensure that health care providers develop proficiency in the early management of critically ill patients. The program includes multiple different types of educational interventi...
Article
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Objective Impacts to the head are the primary cause of concussive injuries in sport and can occur in a multitude of different environments. Each event is composed of combinations of impact characteristics (striking velocity, impact mass, and surface compliance) that present unique loading conditions on the head and brain. The purpose of this study...
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Introduction Evaluation capacity building (ECB) is a topic of great interest to many organizations as they face increasing demands for accountability and evidence-based practices. ECB is about building the knowledge, skills, and attitudes of organizational members, the sustainability of rigorous evaluative practices, and providing the resources and...
Article
Background Falls are a common cause of morbidity and mortality in society, particularly among the aged and young. There has been research to describe the epidemiology of these types of events, but to date there has been few correlations of clinical brain injury outcomes and metrics used in biomechanical research; parameters often used to help devel...
Article
Full-text available
Objectives Conceptual clarity on physician volunteer engagement is lacking in the medical literature. The aim of this study was to present a conceptual framework to describe the elements which influence physician volunteer engagement and to explore volunteer engagement within a national educational programme. Setting The context for this study was...
Article
This research focuses on describing the differences between mild traumatic brain injury (mTBI) and focal traumatic brain injury (fTBI). The purpose of this research was to compare clinical mTBI and fTBI groups who incurred brain injury from falls to hard surfaces to identify clinical and biomechanical factors that may delineate between these two ou...
Article
Much of what is known concerning human brain injury thresholds is based upon impacts to cadavers and animal models that were used to generate the Wayne State Concussion Tolerance Curve (WSTC) and similar curves. These curves are the foundation for predictive metrics used in standard development as well as helmet design. These curves were based upon...
Article
Introduction: Torso bleeding remains the most preventable cause of post-traumatic death worldwide. Remote Damage Control Resuscitation (RDCR) endeavours to rescue the most catastrophically injured, but has not focused on pre-hospital surgical torso haemorrhage control (HC). We examined the logistics and metrics of intra-peritoneal packing in weigh...
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Background: Hemorrhage is the leading cause of preventable posttraumatic death. Many such deaths may be potentially salvageable with remote damage-control surgical interventions. As recent innovations in information technology enable remote specialist support to point-of-care providers, advanced interventions, such as remote damage-control surgery...
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Bleeding to death is the most preventable cause of posttraumatic death worldwide. Despite the fact that many of these deaths are anatomically salvageable with relatively basic surgical interventions, they remain lethal in actuality in prehospital environments when no facilities and skills exist to contemplate undertaking basic damage control surger...
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Traumatic injury is increasing in importance in all settings and environments worldwide. Many preventable deaths are from conditions that are common and treatable. However, as potentially lethal injuries often induce progressive and frequently irreversible physiologic decline, the timing of interventions is critical. Invasive treatments may need to...
Article
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OBJECT Concussions typically resolve within several days, but in a few cases the symptoms last for a month or longer and are termed persistent postconcussive symptoms (PPCS). These persisting symptoms may also be associated with more serious brain trauma similar to subdural hematoma (SDH). The objective of this study was to investigate the head dyn...
Article
Traumatic brain injury (TBI) continues to be a leading cause of morbidity and mortality throughout the world. Research has been undertaken in order to better understand the characteristics of the injury event and measure the risk of injury to develop more effective environmental, technological, and clinical management strategies. This research used...
Article
Background : Transitioning from medical school to residency is difficult and stressful, necessitating innovation in easing this transition. In response, a Canadian neurosurgical Rookie Camp was designed and implemented to foster acquisition of technical, cognitive and behavioral skills among incoming Canadian post graduate year one (PGY-1) neurosur...
Article
Since the introduction of head protection, a decrease in sports-related traumatic brain injuries has been reported. The incidence of concussive injury, however, has remained the same or on the rise. These trends suggest that current helmets and helmet standards are not effective in protecting against concussive injuries. This article presents a lit...
Article
Head impact direction has been identified as an influential risk factor in the risk of traumatic brain injury (TBI) from animal and anatomic research; however, to date, there has been little investigation into this relationship in human subjects. If a susceptibility to certain types of TBI based on impact direction was found to exist in humans, it...
Article
Objective Update on simulation-based education and its evolution in North America. Data sources Main articles including those published within the last five years and indexed in Medline, and unpublished data from the Royal College of Physicians and Surgeons of Canada have been analyzed. Data synthesis After a review of historical development of s...
Article
Update on simulation-based education and its evolution in North America. Main articles including those published within the last five years and indexed in Medline, and unpublished data from the Royal College of Physicians and Surgeons of Canada have been analyzed. After a review of historical development of simulation in North America, this article...
Article
To prevent brain trauma, understanding the mechanism of injury is essential. Once the mechanism of brain injury has been identified, prevention technologies could then be developed to aid in their prevention. The incidence of brain injury is linked to how the kinematics of a brain injury event affects the internal structures of the brain. As a resu...
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Full-text available
Object: The purpose of this study was to examine how the dynamic response and brain deformation of the head and brain-representing a series of injury reconstructions of which subdural hematoma (SDH) was the outcome-influence the location of the lesion in the lobes of the brain. Methods: Sixteen cases of falls in which SDH was the outcome were re...
Article
Purpose: The purpose of this article is to review the role of technical and nontechnical skills in routine and crisis situations. We discuss the role of different simulation modalities in addressing these skills and competencies to enhance patient safety. Principal findings: Human and system errors are a recognized cause of significant morbidity...
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Traumatic brain injuries contribute to a high degree of morbidity and mortality in society. To study traumatic brain injuries researchers reconstruct the event using both physical and FE models. The purpose of these reconstructions is to correlate the brain deformation metric to the type of injury as a measure for prediction. These reconstructions...
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Purpose: To quantify the effects of graded head rotation and elevation on intracranial pressure (ICP) in neurosurgical patients, before and after induction of general anesthesia. Methods: Patients with supratentorial tumours (n=12), scheduled for craniotomy with planned ICP monitoring, underwent baseline ICP measurements awake and supine (0 degr...
Article
We review the relationship between science, testing standards, and helmet design to provide an understanding of how helmets protect the brain. Research describing the mechanisms of injury, resulting types of brain injuries, and characteristics of helmet protection are reviewed. The article is designed to describe the state of the relationship betwe...
Article
Excision repair cross-complementing rodent repair deficiency genes (ERCC) are human genes implicated in nucleotide excision repair. ERCC-2 has been implicated in the repair of DNA damaged by chemotherapeutic agents, and may thus play an important role in anticancer drug resistance. ERCC-2 gene expression is low in primary tumor samples rendering it...
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We have developed a method to quantitate ERCC-2 gene expression in tumor cell lines. A mutant ERCC-2 DNA fragment (1-bp mutation) is used as a competitive DNA template in a coamplification PCR reaction with cDNA obtained by reverse transcribing DNase-free total RNA from six human tumor cell lines. The PCR products are separated on agarose gel by vi...
Chapter
More than 20 years ago, Judah Folkman envisioned a time when “antiangiogenesis” would be applied clinically to treatment of human cancer, but one fundamental problem remained: how could the growth of microvascu-lature, and its inhibition, be scientifically (i.e. quantitatively) assessed, and avoid the subjective and confusing terms of “highly vascu...
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Microvascular proliferation, a hallmark of malignant brain tumors, represents an attractive target of anticancer research, especially because of the quiescent nonproliferative endothelium of the normal brain. Cerebral neoplasms sequester copper, a trace metal that modulates angiogenesis. Using a rabbit brain tumor model, normocupremic animals devel...
Article
The application of a monoclonal antibody to bromodeoxyuridine (BUdR) provides a rapid, reproducible, nontoxic, immunohistochemical method to measure cellular kinetics of intracerebral tumor angiogenesis. The rabbit brain tumor model of angiogenesis consists of tumor and endothelial cell populations with high proliferative rates that demonstrate the...
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Full-text available
A case of musicogenic epilepsy is reported in which the seizures were precipitated by singing voices. It was found that some singers' voices were particularly epileptogenic and that some of their songs, but not others, would precipitate a seizure. A study of the "offending" songs and singers did not reveal a common key, chord, harmonic interval, pi...

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