Surya Kant TripathiUniversity of North Carolina at Chapel Hill | UNC · School of Medicine
Surya Kant Tripathi
Doctor of Philosophy
Postdoctoral Research Associate
About
28
Publications
4,233
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Introduction
I did PhD under the supervision of Dr. Bijesh K. Biswal form Cancer Drug Resistance Laboratory, Department of Life Science, NIT (Rourkela), Orissa, India. Now, I am doing PostDoctoral at Amelio Lab, Lineberger Comprehensive Cancer Center, School of medicine, University of North Carolina, Cahpel Hill, USA. Interested in, epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) resistance, Drug tolerance, Combination Therapy, and Tumormicroenviornment
Education
July 2011 - July 2013
Publications
Publications (28)
The dysregulated expression of the transcription factor (TF) Sry-related HMG box 9 (SOX9) has been extensively correlated with various biological effects, including the initiation and progression of cancer. Differential expression of SOX9 has been positively correlated with cancer cell growth, invasion, migration, metastasis, and therapy resistance...
The present study fabricates biogenic zinc oxide nanoparticles (ZnO NPs) with the aqueous leaf extract of Annona muricata (Am) plant collected from semi-evergreen forests of Odisha, India. The synthesized Am-ZnO NPs were physicochemically characterized. The ultraviolet/visible spectrum showed the maximum optical absorbance of Am-ZnO NPs at 355 nm....
Bioceramic materials based biological implants have gained enormous attention in research due to their extensive medical application. However, release of wear debris from them limits their clinical relevance due to many health risks in the recipient. Thus, we decided to evaluate the cytotoxicity and genotoxicity of wear debris released from Stronti...
The presence of small subpopulations of cells within tumor cells are known as cancer stem cells (CSCs). These cells have been the reason for metastasis, resistance with chemotherapy or radiotherapy, and tumor relapse in several types of cancers. CSCs underwent to epithelial–mesenchymal transition (EMT) and resulted in the development of aggressive...
Aims
The first-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), gefitinib, continues to be a primary treatment option for lung cancer patients. However, acquisition of resistance to gefitinib is a major obstacle in lung cancer treatment and its cause is poorly understood. The present study aimed to implicate the rol...
The open innovation hub Digital Health and Patient Safety Platform (DHPSP) was recently established with the purpose to invigorate collaborative scientific research and the development of new digital products and personalized solutions aiming to improve human health and patient safety. In this study, we evaluated the effectiveness of a Twitter-base...
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are preferred treatments for non-small cell lung carcinoma (NSCLC) that have EGFR activating mutations. Although the initial responses to first- to third-generation EGFR-TKIs is impressive, these agents become ineffective because of the rapid emergence of resistance mediated by...
Dysregulation of transcription factors is one of the common problems in the pathogenesis of human cancer. SOX9 is one of the critical transcription factors involved in various diseases, including cancer. The expression of SOX9 is regulated by microRNAs (miRNAs), methylation, phosphorylation, and acetylation. Interestingly, SOX9 acts as a proto-onco...
Studies have established the presence of a small subpopulation of cells within tumor cells, known as cancer stem cells (CSCs). These cells have evidently been the reason for metastasis, chemotherapy or radiotherapy resistance and tumor relapses in several types of cancers. CSCs are prone to epithelial-to-mesenchymal transition (EMT), resulting in a...
Background: Lagerstroemia speciosa (L.) Pers is one of the most valuable plants due to its ornamental and pharmacological relevance. It is known for its anti-diabetic activity with proved potent blood sugar-lowering activity. The anti-diabetic activity is due to presence of its biologically active component corosolic acid. Moreover, L. speciosa and...
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) have led to a substantial improvement in the prognosis of lung cancer patients by explicitly targeting the activating mutations within the EGFR. Initially, patients harboring tumors with EGFR mutations show progression free survival and improvement in the response rates toward...
Plumbagin (PL) is a natural naphthoquinone compound, isolated from Plumbago zeylanica that has cytotoxic and antimigratory potential in many cancer. However, the cytotoxic mechanism of plumbagin in drug resistant lung cancer is poorly understood. To reveal the mechanism, we studied the anticancer effect of plumbagin in both gefitinib-sensitive and...
Piperlongumine, a white to beige biologically active alkaloid/amide phytochemical, has high pharmacological relevance as an anticancer agent. Piperlongumine has several biological activities, including selective cytotoxicity against multiple cancer cells of different origins at a preclinical level. Several preclinical studies have documented the an...
Prognosis of pancreatic cancer patients remains extremely poor thus, the need for the development of new therapeutic options is crucial. Plumbagin, a naphthoquinone derivative from Plumbago indica has been found to possess various pharmacological properties including anticancer activity. The present study was designed to investigate the inhibitory...
Plumbagin is a naturally-derived phytochemical which exhibits promising medicinal properties, including anticancer activities. In the present study, the anticancer potential of plumbagin has been demonstrated in lung cancer cells by targeting reactive oxygen species (ROS) and the intrinsic mitochondrial apoptotic pathway. Plumbagin showed impressiv...
Lung cancer is the most difficult types of cancer to treat. Overexpression of Epidermal Growth Factor Receptor (EGFR) is main causative agent in almost all lung cancer types. All the drugs used for lung cancer treatment have targeted to EGFR mutation. Earlier, first-and second-generation Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors (...
Synthesis of polymeric nanoparticle from Poly (Lactic-co-Glycolic) Acid (PLGA) using plant extract as a reducing agent is known as green approach. The objectives of this study were to synthesize and characterize Alstonia scholaris leaf extract encapsulated PLGA (ASPL) nanoparticle as well as evaluated the antimicrobial effect of ASPL on Gram-positi...
Lung cancer is the most common cancer-related death worldwide. Natural compounds have shown high biological and pharmaceutical relevance as anticancer agents. Retinoids are natural derivatives of vitamin A having many regulatory functions in the human body, including vision, cellular proliferation and differentiation, and activation of tumour suppr...
Plants have many medicinal properties including anticancer activity due to the presence of several secondary metabolites. Current cancer treatment policies are not much effective because of side effects and resistance development. Therefore, the discovery of new phytotherapeutics with no or fewer side effects is highly needed. Pterospermum acerifol...
Phytotherapy has provided a new direction to the treatment of many cancers over conventional chemotherapeutic agents. Pterospermum acerifolium plant has many medicinal properties. Despite, anticancer potential of P. acerifolium is not well known. In our study, we have checked the cytotoxic effect of bark extract on lung (A549) and pancreatic (PANC1...
There are small highly conserved 19-25 mer long non-coding RNAs molecules called miRNAs having a great impact on cell survival and proliferation. Aberrant expression of miRNA has been documented in almost all types of human cancers including lung cancer and works as a regulator of cancer development and progression. Studies showed that approximatel...
There are nineteen secreted glycoproteins in Wnts family which regulate several functions and biological output in humans. It is increasingly confirmed that Wnt signalling is highly conserved signal transduction pathway which acts as intracellular switches and controlling cell proliferation, cell migration, cell polarity and organogenesis. Wnt sign...
Projects
Projects (2)
Cancer remains the most devastating and life-threatening disease worldwide. Current treatment modalities for cancer include chemotherapy, radiotherapy, surgery, and immunotherapy. However, all treatment modalities (except surgery) are associated with serious side effects and resistance within several months of treatment. Therefore, there is an increasing need to discover novel anticancer agents with the potential to target multiple factors in cancer with nominal side effects.
To date, many plant-based products have shown promising therapeutic anti-cancer potential alone or in combination with conventional anticancer therapeutics.
Study on regulatory effect of altered signaling pathways in cancer drug resistance and reprogramming them.
