Suresh Kumarasamy

In this study, an endophytic actinomycetes strain of Streptomyces viridodiastaticus strain MGR23 was isolated from the roots of the medicinal plant Centella asiatica. The biosynthesized Ag-NPs were characterized using UV-Vis spectroscopy, Fourier transform infrared (FT-IR), Scanning electron microscopy (SEM), X-ray diffraction (XRD) and Zeta potent...

This systematic review identified various bioactive compounds which have the potential to serve as novel drugs or leads against acute myeloid leukemia. Acute myeloid leukemia is a heterogeneous hematopoietic malignancy that arises from the dysregulation of cell differentiation, proliferation, and cell death. The risk factors associated with the ons...

The tobacco cutworm, Spodoptera litura and cotton bollworm, Helicoverpa armigera (Lepidoptera: Noctuidae) are important pests of various agricultural crops that cause sevier economic loses throughout the world. Indiscriminate and frequent use of insecticide may lead to development of resistance in these pests. Nanotechnology has given an alternativ...

Studies have investigating the detoxification and antioxidant enzymes with melatonin under pesticide stress in many vertebrates, whereas no reports produced in invertebrates. In this study possible role of melatonin and luzindole effect on fipronil toxicity and the detoxification, antioxidant enzymes in H. armigera has been reported. Result showed...

Background: In recent years, biological precursor-based synthesis, particularly plant-based green synthesis, has piqued interest in the field of nanotechnology. The plant-based approach is a promising technique for the biosynthesis of nanoparticles. Aim of the study: Biosynthesis nanoparticles (AgNPs) using the ethanolic extract of a resin exuded f...

The soil and water systems are the significant factors for all the creatures that survive on the earth; they either directly or indirectly depend on these two systems to complete their lifespan. Unfortunately, in recent decades, the global population continuous rise force humankind to enter into modern agriculture practices to get more yields to fu...

In recent decades, our eating has become unhealthy, our lifestyle is sedentary, working is stressful and our living environment is also polluted causing number of diseases which affect the quality of human life. This creates awareness to utilize natural plant products for modern world human problems. In this review article, the most deadly diseases...

The aim of this research was to identify a biopolymer producing potential actinobacteria candidate from polluted soil. The Streptomyces toxytricini D2 was enumerated as potential biopolymer producer, which was isolated and characterized using 16S rRNA sequencing. The S. toxytricini D2 produced polymeric granules were categorized through FTIR, 1H NM...

Insects are a vital component in the world as they do harmful and harmless effects on human beings. The medically and agriculturally essential insects occupy more space for their habitats and better surveillance. Consequently, insects’ population increased and reduced agricultural products’ productivity and served as a vector for many threatening d...

Coronaviruses have caused enough devastation in the last two decades. These viruses have some rare features while sharing some common features. Novel coronavirus disease (nCoV-19) caused an outbreak with a fatality rate of 5%. It emerged from China and spread into many countries. The present research focused on genome analysis of Indian nCoV-19 Iso...

Contamination of aquatic systems with pharmaceuticals, personal care products, steroid hormones, and agrochemicals has been an immense problem for the earth's ecosystem and health impacts. The environmental issues of well-known persistence pollutants, their metabolites, and other micro-pollutants in diverse aquatic systems around the world were col...

The objective of this study was to find a biopolymer producing potential actinobacteria candidate from polluted soil. A biopolymer fabricating Streptomyces toxytricini D2 was isolated and characterized by 16S rRNA sequencing. The S. toxytricini D2 produced polymeric granules were categorized by FTIR, 1H NMR, and 13C NMR analyses and confirmed that...

Enzyme inhibitor from natural origin without any side effects and multi diseases target provide more advantageous over commercial drugs. In present study phytocompound lupeol was isolated from Indian traditional medicinal plant Crateva adansonii leave extracts and its possible applications for treating diabetes and inflammation diseases. Single maj...

The preparation of racemic guaifenesin (3-(2-methoxyphenoxy)-1,2-propanediol by a Williamson ether synthesis reaction was well-suited towards the reaction mechanisms, spectroscopic analysis and pharmaceutical synthesis of enantioselective compound. Analysis of the reaction products includes NMR, HPLC, GC techniques that involve comparison of the re...

This study aims to develop an eco-friendly method for rapidly synthesizing silver nanoparticles (AgNPs) using Asafoetida ethanol extracts and to validate AgNPs synthesis using UV–vis spectroscopy (absorption spectrum), FTIR (functional groups), XRD (crystallinity), FE-SEM (size of the particles) and SEM-EDAX (Purity). Furthermore, to evaluate the a...

The MCH assimilation Clavispora lusitaniae MGR5 (KY209902) was isolated from sugarcane juice using a screening medium. The preliminary assimilation was exercised with Clavispora lusitaniae MGR5 grown on synthetic medium and assimilation by pH change of the medium was observed. The specific rotation of R-3-Chloro-1,2-propanediol was-6 (c=2.5, in C2H...

Background: Type 2 diabetes (adult onset diabetes) is the most common type of diabetes, accounting for around 90% of all diabetes cases with insulin resistance and insulin secretion defect. The key goal of anti-diabetic therapy is to increase the development of insulin, immunity and/or decrease the amount of blood glucose. While many synthetic com...

The accumulated bauxite mine soil had an acidic pH of 5.52 ± 0.12 and more heavy metals such as Cr, Cd, Zn, and Pb, which can cause severe soil and water pollution to the nearby farmlands and water reservoirs. Hence, the work was designed to find the possibility of reclamation of bauxite mine soil through Crotalaria juncea with the amalgamation of...

Abandoned magnesite mine heap causing pollution to nearby farmland and water reservoir. Thus the intention of this research was to screening metal mobilizing and absorbing bacteria from the rhizosphere section of V. unguiculata from farmland nearby to magnesite mine. Further, studied their stimulus effect on growth, biomass, and phytoextraction pro...

The unavailability of vaccine and medicines raised serious issues during COVID-19 pandemic and peoples from different parts of world relied on traditional medicine for their immediate recovery from COVID-19 and it found effective also. The current research aims to target COVID-19 immunological human host receptors i.e. angiotensin-converting enzyme...

The unavailability of vaccine and medicines raised serious issues during COVID-19 pandemic and peoples from different parts of world relied on traditional medicine for their immediate recovery from COVID-19 and it found effective also. The current research aims to target COVID-19 immunological human host receptors i.e. angiotensin-converting enzyme...

The unavailability of vaccine and medicines raised serious issues during COVID-19 pandemic and peoples from different parts of world relied on traditional medicine for their immediate recovery from COVID-19 and it found effective also. The current research aims to target COVID-19 immunological human host receptors i.e. angiotensin-converting enzyme...

SARS CoV-2 causes a world pandemic disease called COVID-19. In the present study, natural phenol and flavonoid compounds from food sources are used to search for effective drug candidates for treating novel coronavirus 2019. Thirtyfive natural phenolic compounds were taken for our study. Four levels of in silico virtual screening (Drug likeliness,...

Background: The frequent usage of broad-spectrum insecticides like cypermethrin in agriculture activities could lead to the development of resistance in insects like Amsacta albistriga. Objectives: The present study was conducted to understand the toxicity of cypermethrin with and without a combination of three enzyme inhibitors (PBO, DEM, and TPP)...

The prime aim of this study was to enumerate predominant bacteria from polluted lake soil samples, which possess polyhydroxybutyrate (PHB) fabricating potential and identify the suitable growth conditions and nutritional factors for PHB fabrication. From several numbers of bacterial cultures, one culture has the competence to yield PHB, and it was...

Novel Corona Virus (2019 nCoV/COVID-19) emerged from Wuhan city of Hubei Province China in November 2019. Now it causes pandemic disease COVID-19 across the globe in 2020. There is no proper medication and vaccine treatment option available for novel corona virus. There is a global urge set to prepare effective drug and vaccines from various possib...

Novel Corona Virus (2019 nCoV/COVID-19) emerged from Wuhan city of Hubei Province China in November 2019. Now it causes pandemic disease COVID-19 across the globe in 2020. There is no proper medication and vaccine treatment option available for novel corona virus. There is a global urge set to prepare effective drug and vaccines from various possib...

The bacillary white diarrhea disease is one of the most threaten disease in poultry birds especially broilers, caused by Salmonella pullorum. The major sign of this disease are white diarrhea, in appetence, depression, ruffled feathers, closed eyes, loud chirping, vent pasting, gasping, and lameness. The Trichosanthes dioica (family: Cucurbitaceae)...

The aim of this investigation was to find enzymes and metabolites involved in ß Cypermethrin pesticide degradation. The continuous usage of chemical pesticide for rapid agriculture activities leads to the major cause of soil pollution. In this study, Bacillus cereus, a bacterium isolated from the BT cotton cultivated and pesticide contaminated soil...

The petrochemical-based non-degradative polymers are causing severe environmental pollution that resulting in acute or chronic toxicity in living organisms. Hence emerging of biological polymers is significant to replace traditional polymers. Therefore, the present study aimed to isolate efficient PHAs producing bacteria from municipal sludge soil,...

Chemical efficiency and medium formulation was the essential step for design highly demands laboratory experiments for the yield enhancement and productivity of phytase by two strains of Hanseniaspora guilliermondii S1 MG663578 and Pichia fermentans S2 MG663579.The SSF experimental model showed maximum phytase production of 365 U/ml appearing g/100...

Our interest has been focused on the production of chiral compounds by the method of enantioselective microbial transformations of prochiral starting material with yeast. The preliminary assimilation was exercised with Wickerhamomyces anomalous MGR6 grown on synthetic medium and observed assimilation by pH change of the medium.The specific rotation...

The phytase-producing Pichia membranifaciens S3 (MG663581) was isolated from sugarcane juice using phytase screening medium. The predicted and experimental model showed maximum phytase production of 364 U/ml appearing g/100ml: Jack fruit seed (1.5), peptone (0.15), dextrose (0.50), yeast extract (0.05), malt extract (0.05) pH 5.5 and 280C) used OVA...

The quantitative analysis of acetone and ethanol extract of Aloe barbadensis were studied, the total flavonoid content was determined as 13 µg/ml in the acetone extracts of gel of the plant whereas in the ethanol extract, it was 30 µg/ml followed by total phenol content which was almost same in the extracts but found higher in acetone extract as 34...

The cloned E. coli cell containing Murine IFN -γ inserted pRSET A vector system was effectively expressed in this study. The induction of the clones was done using IPTG in E.coli and induces mRNA generation and synthesis protein. It has shown an expression of protein with 18 kda in SDS PAGE and western blotting and their size was determined by GENE...

Isolation of yeasts from natural resources is the most successful technique to obtain yeast isolates that have abilities to utilize and ferment various compounds. Racemic monochlorohydrin assimilation and degradation yeast were screened from sugar cane mills using synthetic medium composed of 0.5% (v/v) racemic monochlorohydrin, 0.5% (NH4)2SO4, 0.1...

This study acquired the microbial consortium of 4 sugar cane samples collected from different location in Tamilnadu. A total of 18 isolates dominative 4 isolates of Candida sp MGR1 KY209900, Candida sp MGR7 KY209904, Candida sp MGR8 KY209905 and Candida sp MGR1KY2099011 were identified by biochemical, morphological and molecular techniques. The hig...

The Asian Society of Gynecologic Oncology (ASGO) was founded in 2008 with the aim of scientific exchange and collaboration, provision of educational opportunities, deepening friendship between members and ultimately improving care of women with gynecological cancer in Asia [1]. ASGO has an important role as almost half of all gynecologic cancer dea...

The Asian Society of Gynecologic Oncology International Workshop 2014 on gynecologic oncology was held in Asan Medical Center, Seoul, Korea on the 23rd to 24th August 2014. A total of 179 participants from 17 countries participated in the workshop, and the up-to-date findings on the management of gynecologic cancers were presented and discussed. Th...

Young docters who gained travel award to participate the 3rd ASGO workshop.

Counsil members of ASGO, speakers, and chairpersons of the 3rd ASGO workshop.

Program of the 3rd ASGO International Workshop on Gynecolgic Oncology

Rauvolfia serpentina (L.) Benth. called Sarpagandha (the snake root) in Hindi, belongs to family Apocynaceae. This plant is listed in earliest Ayurvedic medicinal text the Charaka Samhita (c. 700 B.C.) and has been used since in olden days for the treatment of mental illness and insomnia. The roots of R. serpentina contain numerous alkaloids. Its i...

Rauvolfia serpentina (L.) Benth. called Sarpagandha (the snake root) in Hindi, belongs to family Apocynaceae. This plant is listed in earliest Ayurvedic medicinal text the Charaka Samhita (c. 700 B.C.) and has been used since in olden days for the treatment of mental illness and insomnia. The roots of R. serpentina contain numerous alkaloids. Its i...

2 Abstract: 10 yeast strains from 4 genera and 10 species were evaluated for cell-free production of (R)-phenylacetylcarbinol (PAC), the chiral precursor in the manufacture of the pharmaceuticals ephedrine and pseudoephedrine. Carboligase activity of pyruvate decarboxylase (PDC), forming PAC from benzaldehyde and pyruvate, was found in extracts of...

Rauvolfia tetraphylla L. is an endangered woody shrub belongs to the family Apocynaceae. It is an endangered plant species of medicinal importance. An optimal micropropagation procedure was achieved using nodal segments with two axillary buds as explants. A concentration of 0.5 mM kinetin in Murashige and Skoog liquid basal medium was found to be o...

This study was concentrated on the production of reserpine in embryogenic suspension cultures of Rauwolfia serpentina by exposing them to different concentrations (50-500 µM) of methyl jasmonate (MJ) during the culture period. In the bioreactor cultures, reserpine content increased significantly by elicitation of MJ, however, the fresh weight, dry...

Identification and characterization of germplasm is an important link between the conservation and utilization of plant genetic resources. The present investigation was undertaken for identification and genetic variation within eight high yielding varieties of ginger through RAPD markers. A total of 55 distinct DNA fragments ranging from 0.5-2.4 Kb...

Indian medicinal plants (Rauwolfia serpentina and Ephedra vulgaris) were analyzed for their chemical composition, vitamins and minerals. The results revealed the presence of bioactiv e constituents comprising alkaloids (1.24 to 1.48 m g/100 g), saponins (1.46 to 1.72 m g/100 g), flavonoids (1.46 to 1.86 m g/100 g), phenols (0.06 m g/100 g) and tann...

Rauwolfia serpentina (Apocynaceae) is used among rural Indian communities to treat arthritis, skin cancer, burns, eczema, psoriasis, digestive problems, high blood pressure, sedative and diabetes, despite very little supporting scientific evidence. Due to increased interest by both the scientific community and industry regarding the medicinal uses...

An optimal feeding strategy with a 1:1.2 molar ratio of benzaldehyde: pyruvate has been developed to maximize the enzymatic production of the pharmaceutical intermediate R-Phenylacetylcarbinol (PAC) based on a previously published model for this intermediate. The results of the simulation indicate with pyruvate decarboxylase (PDC) at an initial car...

This study was concentrated on the production of apigenin in embryogenic suspension cultures of Cardiospermum halicacabum by exposing them to different concentrations (50-400 μM) of methyl jasmonate (MJ) during the culture period. In the bioreactor cultures, apigenin content increased significantly by elicitation of MJ, however, the fresh weight, d...

The gram positive bacterium Bacillus cereus has been studied for the production of alkaline protease, an industrially important enzyme. Fermentation was carried out in a shake flask with varying carbon sources (glucose, fructose, sucrose, lactose, mannitol) and nitrogen sources (urea, lysine, ammonium chloride, sodium nitrate, L-glutamic acid) in t...

Carica papaya L., Cynodon dactylon (L.) Pers, Euphorbia hirta L., Melia azedarach L., Psidium guajava L. belong to 5 different families, viz., Caricaceae, Gramineae (Poaceae), Euphorbiaceae, Meliaceae and Myrtaceae. The plant leaves contain a number of medicinally important compounds. In the present study, we evaluated the phytochemical analysis fo...

The present study optimized the regeneration protocol by using half seed explant in Vigna mungo (L.) Hepper organogenesis. Half seed explants were inoculated onto B5 medium supplemented with kinetin (4.7 μM to 23.5 μM), 6- benzyladenine (4.4 μM to 22.2 μM), naphthaleneacetic acid (5.4 μM to 27.0 μM), indolebutyric acid (4.9 μM to 24.5 μM) and 2,4-...

The antimicrobial activity of ethanol extract obtained from Rauvolfia tetraphylla was tested against bacterial species of Escherichia coli, Streptococcus lactis, Enterobacter aerogenes, Alcaligenes faecalis, Pseudomonas aeruginosa, Proteus vulgaris, and fungal species of Fusarium oxysporum, Alternaria helianthii, Curvularia lunata, Aspergillus nige...

2 Abstract: Biotransformation of benzaldehyde and pyruvate to (R)-Phenylace tyl carbinol by Hansenula polymorpha was investigated in two-phase aqueous-organic reaction media. With octonol as organic solvent, maximum biotransformation activity was observed with a moisture content of 10%. Of the organic solvents tested, highest biotransformation acti...