Suresh Kumar

Suresh Kumar
Guru Gobind Singh Indraprastha University | GGSIPU · School of Bio Technology

PhD, Newcastle University

About

45
Publications
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520
Citations

Publications

Publications (45)
Article
Full-text available
Citation: Malhi, G.S.; Rana, M.C.; Kumar, S.; Rehmani, M.I.A.; Hashem, A.; Abd_Allah, E.F. Efficacy, Energy Budgeting, and Carbon Footprints of Weed Management in Blackgram (Vigna mungo L.). Sustainability 2021, 13, 13239. https://doi. Abstract: Weed management in blackgram is one of the most efficient ways to improve its yield, as uncontrolled wee...
Article
The assigned goals of the study were examined to HMG-CoA reductase inhibition and antioxidants potential of the small molecule phytochemicals of petroleum ether pod extract of Prosopis cineraria (L.) Druce by in-vitro, in-vivo, and in-silico assessments. The phytochemical fingerprinting of the extract was done by LC-MS analysis, and compounds were...
Article
COVID-19 (CoronaVirus disease 2019) is caused by the SARS-CoV-2 virus (severe acute respiratory syndrome corona virus 2). SARS-CoV-2 virus is highly contagious and affects the human respiratory tract resulting in symptoms such as high fever, body ache, cough, dysfunctions of tastebuds and smelling sense of body. The objective of the present study i...
Article
Full-text available
Context Withania coagulans (Stocks) Dunal fruits are used in the therapeutics of several ailments due to possessing of potent phytoconstituents which is also used traditionally for curing the diabetes. Objective The present study was assessing the amelioration potential of the phytochemicals of an ethanol fruit extract of W. coagulans (Stocks) Dun...
Preprint
Full-text available
Background: The HMG-CoA inhibitor are used to control adverse cardiovascular event caused by Hypercholesterolemia and dyslipidaemia. The current study was aimed to evaluate the ability of phytoconstituents of an aqueous seed extract of Acacia senegal (L.) Willd to inhibit HMG-CoA reductase and regress the formation of atherosclerotic plaque. Method...
Article
Full-text available
Amyloidosis is the process of fibril formation responsible for causing several diseases in the human being that involve protein aggregation such as Alzheimer’s, Parkinson’s, Huntington’s disease, and type II diabetes. Natural phytocompounds such as curcumin shown promising anti-amyloidogenic activity. In the present study, selective phytocompounds...
Article
Full-text available
Abstract Alzheimer's disease (AD) is a neurodegenerative disorder, and multiple factors are involved in disease progression. This is why there is an urgent need to develop novel molecules with multi‐target‐directed ligands (MTDLs) potential. The current study explores the active phytoconstituents from traditionally used medicinal spices, namely pip...
Article
Alzheimer’s disease (AD) is a multifactorial disorder characterized by cognitive deficit and memory loss. The pathological feature of the disease involves β-amyloid senile plaques, reduced levels of acetylcholine neurotransmitter, oxidative stress and neurofibrillary tangles formation within the brain of AD patients. The present study aims to scree...
Article
Full-text available
There is accumulating evidence showing that hyperglycemia conditions like diabetes possess a greater risk of impairment to the neuronal system because high glucose levels exacerbate oxidative stress, accumulation of amyloid-beta peptides, and mitochondrial dysfunction, and impair cognitive functions and cause neurodegeneration conditions like Alzhe...
Article
Background: Several human diseases like Parkinson's, Alzheimer's disease, and systemic amyloidosis are associated with the misfolding and aggregation of protein molecules. Objective: The present study demonstrated the comparison of 4-methyl coumarin and 4methylthiocoumarin derivative for their anti-amyloidogenic and disaggregation activity. The...
Article
Background: Coronavirus disease 2019 (COVID-19) playing havoc across the globe caused 585,727 deaths and 13,616,593 confirmed cases so far as per World Health Organization data released till 17th July 2020. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2) is responsible for causing this pandemic across different continents. It is not...
Preprint
Full-text available
Context: Withania coagulans (Stocks) Dunal fruits are used in the therapeutics of several ailments due to possessing of potent phytoconstituents which is also used traditionally for curing the diabetes. Objective: The present study was assessing the amelioration potential of the phytochemicals of an ethanol fruit extract of Withania coagulans (Sto...
Preprint
Full-text available
Context: Withania coagulans (Stocks) Dunal fruits are used in the therapeutics of several ailments due to possessing of potent phytoconstituents which is also used traditionally for curing the diabetes. Objective: The present study was assessing the amelioration potential of the phytochemicals of an ethanol fruit extract of Withania coagulans (Sto...
Preprint
Full-text available
Background and objectives: The pod of Prosopis cineraria traditionally used in several ailments and key component of traditional food recipe of the Panchkuta of western Rajasthan, India. The current study was targeted to assess ability of phytoconstituents of aqueous pod extract of Prosopis cineraria to inhibit HMG-CoA reductase activity and regres...
Article
Full-text available
Alzheimer’s disease (AD) is characterized by depositions of amyloid β (Aβ) peptides aggregates resulting in plaques formation in the central nervous system (CNS). This study evaluates the disease-modifying potential of scopoletin against multiple factors associated with AD such as cholinesterase enzymes, Aβ peptides, and neuroprotective properties...
Article
Alzheimer's disease (AD), is a multifactorial neurodegenerative disorder characterized by memory loss and cognitive deficit. Various drug targets implicated in AD are β-amyloid (Aβ) peptides, cholinesterase enzymes, and free radicals. Plants derived phytoconstituents provides a vast pool of diverse compounds as a source of novel drugs. In view of t...
Article
Full-text available
Alzheimer's disease (AD) is a multifactorial disorder characterized by exponential loss of memory and cognitive deficit involving several disease modifying targets (amyloid beta, beta-secretase, monoaminoxidase-B, and cholinesterase). The present study explores multi-target directed ligand approach using secondary metabolite reserpine (RES) and ajm...
Article
Full-text available
Background: The HMG-CoA reductase is key enzyme of cholesterol biosynthesis which potentially contributes in management of hypercholesterolemia. The present study was designed to assess the inhibitory effect of phytoconstituents of an ethanolic extract of Prosopis cineraria pods on HMG - CoA reductase and regression potential of atherosclerotic pl...
Article
Full-text available
Background Insulin resistance causes decreased uptake of glucose which promotes susceptibility of type 2 associated neurological impairments. Methods The study was aimed to evaluate inhibition potential of an ethanolic extract of Prosopis cineraria (EPC) pods against DPP-4 and cholinesterase enzymes by in-vitro, in-vivo and in-silico assessments....
Article
Full-text available
The current study was aimed to evaluate amelioration in insulin resistance, β-cell function and pancreas protection by DPP-4 inhibition potential of Trigonella foenum (TF) seed extract in corticosteroid induced type-2 diabetic rats by in slilico, in vitro and in vivo assays. The corticosteroid induced diabetic status of animal model was considered...
Article
Full-text available
Amyloidogenesis is the process in which amyloid beta (Aβ) peptide aggregation results in plaque formation in central nervous system (CNS) are associated with many neurological diseases such as Alzheimer’s disease. The peptide aggregation initiated from peptide monomers results in formation of dimers, tetramers, fibrils, and protofibrils. The abilit...
Article
Full-text available
Background: Alzheimer's disease (AD) is an irreversible neurodegenerative disease associated with memory loss and cognition deficit. At present, the drugs which are available in the markets only provide symptomatic relief to patients; there is no permanent cure for this disease. Several hypotheses have been proposed by various researchers, one of t...
Conference Paper
Full-text available
Alzheimer’s disease (AD) is a neurodegenerative disease, which is pathologically characterized by production and deposition of amyloid plaques. The plaques are formed by extracellular deposition of amyloid-b peptide (Ab). The b-secretase (b-site amyloid precursor protein cleaving enzyme, BACE1) is the principle enzyme responsible for the initiatory...
Article
Full-text available
Background Alzheimer’s disease (AD) is the most prevalent form of dementia and represents one of the highest unmet requirements in medicine today. There is shortage of novel molecules entering into market because of poor pharmacokinetic properties and safety issues. Drug repurposing offers an opportunity to reinvigorate the slowing drug discovery p...
Conference Paper
N-methyl-d-aspartate receptor (NMDAR) play key role in glutamatergic neurotramission which is critical for synaptic plasticity and survival of neurons. However, ‘slow excitotoxicity’ at post- synaptic neurons promotes gradual neurodegeneration as occurred in Alzheimer’s disease (AD). In view of this natural and synthetic compounds that act as antag...
Article
Full-text available
Depletion of acetylcholine in the central nervous system (CNS) is responsible for memory loss and cognition deficit. Enzyme acetylcholinesterase (AChE) is responsible for destruction of acetylcholine (Ach) in the brain. Many herbal plant extracts have been investigated for their potential use in the treatment of Alzheimer’s disease (AD) by inhibiti...
Chapter
Full-text available
“Fermentation” is employed in the production of foods through the application of microorganisms or their enzymes (Geis, 2006). Such foods are an intricate part of the diet of people all over the world, and it is the diversity of the raw materials used as substrates, the methods of preparation, and the sensory qualities of the finished prod-ucts tha...
Article
Full-text available
Aim: Methanolic extract of a Fraxinus micrantha (MeFM) was evaluated for antiproliferative activity in vitro using Michigan Cancer Foundation-7 (MCF-7) breast carcinoma cell line. This plant was selected and studied for naturally available bioactive compound as different synthetic drugs available for cancer treatment has certain limitations and si...
Article
Full-text available
This study identifies the efficacy of an ethyl acetate extract of Garcinia mangostana as a potent inhibitor of nitric oxide (NO) production. Crude extract in the range from 0.906µg/ml to 15.625µg/ml significantly decreased nitrite production in LPS-stimulated RAW 264.7 cells in vitro in a concentration dependent manner (11 μmol to 2.5 μmol) (p<0.01...
Article
Full-text available
Objective: According to cholinergic hypothesis, cholinesterase inhibitors are the only drugs approved for symptomatic treatment of Alzheimer's disease. The present study, evaluates the in-vitro butyrylcholinesterase (BChE) inhibitory activity and mode of inhibition by an aqueous extract of Cuminum cyminum using Ellman's method. Method: Ellman's ass...
Article
Full-text available
The cholinergic hypothesis of Alzheimer’s disease (AD) has provided the rationale for the current pharmacotherapy of this disease. Acetylcholinesterase (AChE) inhibitors are currently the only approved therapy for the symptomatic treatment of AD. The current drugs available in the market has shown various side effect which prompted scientist to sea...
Article
Amyloid-β (Aβ) fibrillogenesis and associated cyto/neurotoxicity are major pathological events and hallmarks in diseases such as Alzheimer's disease (AD). The understanding of Aβ molecular pathogenesis is currently a pharmacological target for rational drug design and discovery based on reduction of Aβ generation, inhibition of Aβ fibrillogenesis a...
Article
The Indian spices are known for their medicinal properties from ages apart from adding taste to the Indian cuisines. In this study, traditional Indian spices such as Cuminum cyminum, Cinnamomum zeylanicu, Eletteria cardamom, Eugenia caryophyllus and Piper nigrum were assessed for inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (...
Article
The ability of an aqueous extract of W. somnifera L. Dunal (Family: Solanaceae) roots to inhibit fibril formation by the amyloid-β peptide in vitro was investigated. W. somnifera is used extensively in traditional Ayurvedic medicine as a nerve tonic with reputed memory enhancing properties. Inhibition of fibrillogenesis measured by transmission ele...
Article
Withania somnifera L. Dunal (Family: Solanaceae) is extensively used in traditional Indian medicine as a nerve tonic and is thought to improve memory. We assessed the acetylcholinesterase (AChE) inhibitory activity and kinetics of an aqueous extract of W. somnifera root, in the context of its potential role in regulating the levels of acetylcholine...
Article
There is mounting evidence that the deposition and aggregation of β-amyloid peptides (Aβ) in the brain play a significant role in the development and pathogenesis of Alzheimer's disease. There is further evidence that free radical species such as hydrogen peroxide (H(2)O(2)) mediate Aβ induced toxicity. Previous studies have demonstrated that green...
Article
Withania somnifera L. Dunal (Solanaceae), also known as 'ashwagandha' in Sanskrit and as 'Indian ginseng', is used widely in Ayurvedic medicine as a nerve tonic and memory enhancer, with antiaging, antistress, immunomodulatory and antioxidant properties. There is a paucity of data on the potential neuroprotective effects of W. somnifera root, as tr...

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Projects

Projects (3)
Project
To ensure medication safety
Project
Indian subcontinent having their own conventional therapeutic remedies for diabetes and other metabolic syndromes.