Suresh Babu Donka- Doctor of Philosophy
- Ph.D at Sri Venkateswara University
Suresh Babu Donka
- Doctor of Philosophy
- Ph.D at Sri Venkateswara University
About
7
Publications
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Introduction
Ph.D. in Organic Chemistry and M.Sc. in Medicinal Chemistry from Dept. of Chemistry, Sri Venkateswara University, Tirupati. I have 15+ years of experience in Research and development of Medicinal Chemistry and many drug discovery Programs (in vitro and in vivo studies of various anticancer drugs), inhibitors and PROTACS-degraders, CRO, and synthetic organo heterocyclic chemistry. worked in AVRA labs and Syngene intl ltd, BIOCON.
Current institution
Publications
Publications (7)
A series of novel N-aryl-4-[6-(2-fluoropyridin-3-yl)quinazolin-2-yl]-piperazine-1-carboxamide or -carbothioamide derivatives was synthesized by cyclization of 5-bromo-2-fluorobenzaldehyde and guanidine carbonate in the presence of dimethylacetamide followed by treatment with isoamylnitrite and diiodomethane in the presence of copper iodide to affor...
Alzheimer’s disease is a progressive neurodegenerative condition marked by cognitive deterioration, memory deficits and behavioural changes, underscoring the pressing need for innovative therapeutic strategies. While acetylcholinesterase (AChE) inhibitors remain a cornerstone in managing cholinergic dysfunction in AD, the multifaceted nature of the...
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Abstract
A series of thiazole-piperazine sulfonamide hybrids (8a-k) were synthesized, characterized and subsequently tested on Alzheimer's disease (AD) targets, including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and the ABTS radical, to assess their effectiveness. Three of the target analogues 8c, 8e and 8g exhibited augmen...
Novel antimicrobial drugs are required to fight the serious global health challenge of antibiotic resistance. In this study, 12 hybrids ofdiarylsulfide (DAS) piperazine-amide 8a-l were synthesized. All the 12 compounds were assessed for the antibacterial study againstGram-positive and Gram-negative bacteria. Antibacterial structure-activity relatio...
In pursuit of a biodynamically potent molecule, we have attempted to synthesize derivatives of piperazine by incorporating them into the Rosuvastatin intermediate. The reason behind this is that heterocyclic compounds with nitrogen atoms in their ring structure, such as pyrimidine, have great potential as drug design scaffolds. By doping piperazine...
Aim: Cholinesterase inhibitors and radical scavengers have been recognized as powerful symptomatic anti-Alzheimer's disease agents. Hence, the present study aimed to develop new triazineamides as potent anticholinesterase and antioxidant agents. Methods: Triazineamide (7a–i) derivatives were synthesized using cyanuric chloride via nucleophilic subs...
