Surapong Chatpun

Surapong Chatpun
Prince of Songkla University · Faculty of Medicine

PhD in Bioengineering (UCSD)

About

71
Publications
10,455
Reads
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448
Citations
Citations since 2017
34 Research Items
328 Citations
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2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
Education
January 2006 - June 2010
University of California, San Diego
Field of study
  • Bioengineering
October 2001 - September 2003
The University of Tokyo
Field of study
  • Mechanical Engineering
May 1992 - April 1996
Chulalongkorn University
Field of study
  • Mechanical Engineering

Publications

Publications (71)
Article
Full-text available
To reduce the trial and error in a real clinical scenario, the finite element analysis (FEA) can be effectively used to simulate various effective pad designs and a material selection to reduce and redistribute peak plantar pressure in a diabetic foot with neuropathy. The aim of this study was to investigate the effect of pad design and material st...
Article
Full-text available
An abdominal aortic aneurysm (AAA) is an enlargement of the abdominal aorta that can become a life-threatening disease. The pulsatile blood flow exhibits intricate laminar patterns in the abdominal portion of the human aorta under normal resting conditions, whereas secondary flows are caused by adjacent branches and abnormal vessel geometries. If a...
Article
Full-text available
Emerging studies have reported that functional brain networks change with increasing age. Graph theory is applied to understand the age-related differences in brain behavior and function, and functional connectivity between the regions is examined using electroencephalography (EEG). The effect of normal aging on functional networks and inter-region...
Article
Full-text available
Hemagglutination is a critical reaction that occurs when antigens expressed on red blood cells (RBCs) react with the antibodies used for blood typing. Even though blood typing devices have been introduced to the market, they continue to face several limitations in terms of observation by the eye alone, blood manipulation difficulties, and the need...
Article
Background The changes in electroencephalogram (EEG) signals that reflect the changes in physiological structure, cognitive functions, and activities have been observed in healthy aging adults. It is unknown that when the brain aging initiates and whether these age-related alterations can be associated with incipient neurodegenerative diseases in h...
Article
Background: Endoscopic carpal tunnel release is a common treatment for moderate to severe carpal tunnel syndrome. Recently there have been various new techniques which offer improved accuracy and decreased recovery time. In this study, orthopedic surgeons and biomedical engineers from the Faculty of Medicine and Faculty of Engineering, Prince of So...
Article
Objective: The aim of this study was to assess the effect of customized insole (CMI) variations on plantar pressure in diabetic foot with neuropathy, using finite element analysis (FEA). Material and Methods: A three-dimensional foot model was constructed using FEA to study the peak contact pressure between the foot and the CMI. Nora® Lunalastike,...
Article
PurposePostero-anterior (PA) mobilization is widely used to manage low back pain by physiotherapists. The PA load is applied through the spinous process of a vertebra. Low bone density is a counter-indication of PA mobilization, whether PA mobilization may cause fractures in fragile vertebrae is unclear. Therefore, the aim of this study was to quan...
Article
Full-text available
Offloading plantar pressure in a diabetic foot with neuropathy is challenging in conventional clinical practice. Custom-made insole (CMI) materials play an important role in plantar pressure reduction, but the assessment is costly and time-consuming. Finite element analysis (FEA) can provide an efficient evaluation of different insoles on the plant...
Article
This study assessed the hemodynamics of a patient-specific multiple stenosed common carotid artery including its bifurcation into internal and external carotid arteries; ICA and ECA, respectively. A three-dimensional computational model of the common carotid artery was reconstructed using a process of segmentation. Computational fluid dynamics was...
Article
Full-text available
Impact force remains the primary cause of foot injury and general discomfort with regard to footwear. The footwear industry traditionally relies on modified elastomers (including natural rubber) whose properties can be physically adjusted by varying the constituents in the rubber formulations. This work aims to investigate the effect of filler/plas...
Article
Full-text available
Abdominal aortic aneurysm (AAA) is a life-threatening disease when the diameter exceeds its safety margin or the aortic wall reaches its mechanical strength. Both of these potential problems need to be clinically assessed. The geometrical influence on blood flow behavior and hemodynamic changes of AAA are not fully clinically understood. The study...
Article
Fluid replacement or plasma expander (PE) is fluid administered to instantly restore intravascular volume following massive blood loss by enhancing the volume of blood plasma. PEs can be prepared from various types of polymers such as gelatin, dextran, albumin and starch derivatives. In case of starch‐based PEs, their properties depend on sources o...
Article
Previously, satiated animals or human subjects can still be motivated to eat by palatable food-associated cues. However, neural circuitries of hedonic hunger have not been well investigated. This study identified neural network connectivities between major brain areas in response to chocolate-associated cues following repeated exposures to chocolat...
Article
Background: Abnormal peak plantar pressure in neuropathic diabetic foot during walking activities is well managed through the use of appropriate design and material selection for the fabrication of custom made insoles (CMI). The redistribution of plantar pressure is possible by selecting an appropriate material for the fabrication of CMI. The walk...
Article
Full-text available
span lang="EN-US">Cell counting is a required procedure in biomedical experiments and drug testing . Manual cell counting performed with a hemocytometer is time consuming and individual dependence . This study reported the development of a computer - assisted program for trypan blue stained - cell counting using digital image analysis . Images of t...
Article
Food deprivation is known to trigger hunger sensation and motivation to eat for energy replenishing. However, brain mechanisms associated with hunger and neural circuitries that mediate hunger driven responses remained to be investigated. To understand neural signaling of hunger, local field potentials (LFPs) in the lateral hypothalamus (LHa), nucl...
Article
Full-text available
Hemodynamics in highly proximal neck of abdominal aortic aneurysm (AAA) was investigated in an idealized case by using computational fluid dynamics (CFD) technique. The steady and pulsatile flow simulations were carried out and compared. The three-dimensional model was constructed using CAD software and boundary conditions were adopted from the lit...
Article
Full-text available
The name of the third author was incorrect in the initial online publication. The original article has been corrected.
Article
Full-text available
Aneurysms are considered as a critical cardiovascular disease worldwide when they rupture. The clinical understanding of geometrical impact on the flow behaviour and biomechanics of abdominal aortic aneurysm (AAA) is progressively developing. Proximal neck angulations of AAAs are believed to influence the hemodynamic changes and wall shear stress (...
Article
Full-text available
Computer-assisted image analysis can be employed to reduce the time consumed in the routine task such as cell counting. This study aimed to establish a method to perform this routine task based on an image analysis to automatically count live and dead cells after staining with trypan blue dye. Gray scale conversion and morphological operation were...
Article
Full-text available
Development of numerical technique would be benefited to diagnose the biological structure especially in femoropopliteal artery. Blood circulatory system and heart hemodynamic performance can be simulated by applying lumped parameter method. Thus, this study aims to develop numerical modelling in femoropopliteal artery by constructing an electric a...
Article
Full-text available
An abdominal aortic aneurysm (AAA) is considered a deadly cardiovascular disease that defined as a focal dilation of blood artery. The healthy aorta size is between 15 and 24 mm based on gender, bodyweight, and age. When the diameter increased to 30 mm or more, the rupture can occur if it is kept growing or untreated. Moreover, the proximal angular...
Article
Eating motivation is induced not only by negative energy balance but also food related cues. However, neural processing for acquisition of learned food preference remains to be established. This study aimed to identify hippocampal neural signaling in response to olfactory cue (chocolate scent) after completion of repetitive chocolate sessions. Male...
Article
Background: Using a total contact orthosis (TCO) is an effective method to offload in diabetic patients with foot neuropathy. However, the redistribution of peak plantar pressure is mostly observed during level walking, which may differ from other walking activities. The aim of this study was to investigate the plantar pressure from 4 regions of t...
Article
Background: Total-contact orthosis (TCO) is one kind of foot orthosis (FO) that is used to adjust biomechanics in flexible flatfoot. Objective: To determine the effects of a TCO on the MLA moment, MLA deformation angle and lower limb biomechanics. Study design: Cross-sectional study. Methods: Seven-flatfoot and thirteen-normal foot subjects...
Article
Full-text available
This study aimed to develop and characterize pectin beads loaded with self-emulsifying curcumin (SE-Cur) or a solid dispersion of curcumin (SD-Cur) in polyvinyl pyrrolidone for colon targeting. The pectin beads were prepared by the ionotropic gelation technique and contained 5% w/v SE-Cur or 1% w/v SD-Cur (equivalent to curcumin 222 mg). The optimi...
Article
The effect of non-Newtonian blood flow on the value of wall shear stress (WSS) of an intracranial aneurysm was investigated using computational fluid dynamics. For cerebral arteries, blood is often assumed to behave as a Newtonian fluid, though the effects of non-Newtonian flow on the prediction of areas of low WSS associated with aneurysm rupture...
Article
Full-text available
Plasma expanders (PEs) are administered fluids to replace blood volume when massive blood loss has occured. Maltodextrin from tapioca starch was selected as a study candidate to prepare a colloid PE due to an uncomplicated production process. The formulations of mixture between tapioca maltodextrin and 0.9 % sodium chloride solution were prepared a...
Article
The lateral hypothalamus plays an important role in homeostasis. It is sensitive to negative energy balance and believed to interact with other brain regions to mediate food seeking behavior. However, no neural signaling of hunger in the lateral hypothalamus has been studied. Male Swiss albino mice implanted with intracranial electrodes into the la...
Article
Valroic acid (VPA) mouse model of autism spectrum disorder (ASD) has been characterized mostly by impaired ultrasonic vocalization, poor sociability and increased repetitive self-grooming behavior. However, its neural signaling remained unknown. This study investigated the local field potentials (LFPs) in the dorsal hippocampal CA1 and the olfactor...
Article
Plasma expanders (PEs) such as hydroxyethyl strach are widely used for volume replacement. The plantation and production of tapioca in Thailand is abundant which may provide a new source for PEs starch with novel properties. This work investigated the properties and circulatory effects of native tapioca starch-based PE (TPE). Various formulations o...
Article
Full-text available
This study aimed to assess the plantar pressure and the gait characteristics in patients with hemiplegia compared with normal subjects. Plantar pressure was measured and evaluated by the Pedar-x system®. Twenty healthy Thai volunteers and 10 Thai patients with hemiplegia were recruited for this study. Patients with hemiplegia had significant differ...
Article
Purpose: Medial longitudinal arch (MLA) strengthening has been considered an important part of successful flatfoot treatment. But, to date, the biomechanical loading behavior of the medial arch in flatfoot has not been evaluated. This study aimed to evaluate the MLA moment, MLA deformation angle, foot kinematics and ground reaction forces (GRF) in...
Article
Full-text available
Background: Endothelial nitric oxide synthase (eNOS) is generally expressed in endocardial cells, vascular endothelial cells and ventricular myocytes. However, there is no experimental study elucidating the relationship between cardiac eNOS expression and elevated plasma viscosity in low oxygen delivery pathological conditions such as hemorrhagic s...
Article
Full-text available
Increased vascular wall shear stress by elevated plasma viscosity significantly enhances the endothelial nitric oxide synthase (eNOS) activity during an acute isovolemic hemodilution. Also the modulation of plasma viscosity has effects on the cardiac function that were revealed if a left ventricular (LV) pressure-volume (PV) measurement was used. T...
Conference Paper
Full-text available
Computational fluid dynamic (CFD) model is used to evaluate cardiovascular hemodynamics and the model is useful to predict the blood flow pattern and the wall shear stress (WSS) in various conditions. This study used the CFD model to assessment the influence of varied blood conditions and geometries on changing of velocity ratio at the internal car...
Conference Paper
Valvular heart disease is considered as an important problem of heart. The mechanical heart valve replacement is one of the methods used to treat valvular heart disease. There are many designs of mechanical heart valves including bileaflet and trileaflet valves. As the heart valve operates under the blood pressure conditions, it might be damaged or...
Conference Paper
This study focused on the step of preprocessing in the part of edge detection techniques to detect red blood cells (RBCs) boundaries. The objectives of the study were to make a comparison between gradient based edge detection and zero-crossing based edge detection and to find out the appropriate operator to use for edge detection of RBCs in capilla...
Conference Paper
The optimal feature is necessary for the reach of electromyography (EMG) control or human-machine interface. This study aimed to find the optimal feature of time-domain features. Five oral muscles movements were performed in five volunteers. The oral activities were open mouth, protrude mouth, broad smile, straight tongue, and up tongue which were...
Article
We review the dorsal skinfold chamber technique as used in microvascular studies, focusing on hemodynamics, tumor angiogenesis and inflammation. We discuss dorsal skinfold chamber implantation, intravital microscopy and microvascular visualization. Implications of vascular diameter, blood flow velocity and functional capillary density are discussed...
Conference Paper
Death cells and living cells counting after cancer drug treatment is a mandatory process for in vitro study to evaluate the effectiveness of the treatment in cancer research. The conventional process using trypan blue dye staining requires expertise and it is time-consumed and tedious work. The aim of this study was to develop a computer-assisted p...
Conference Paper
Nitric oxide (NO) is known as an important mediator in vasorelaxation and blood pressure regulation. NO is produced from nitric oxide synthase (NOS) by converting amino acid L-arginine to amino acid L-citruine and NO. The reduction of NO synthesis by inhibiting NOS activities causes vasoconstriction and hypertension and affects on microvascular blo...
Article
Background: Plasma expander (PE) based on polyethylene glycol (PEG) conjugated to albumin has shown positive results maintaining blood volume during hemodilution and restoring blood volume during resuscitation from hemorrhagic shock. Polyethylene glycol conjugation to human serum albumin (HSA), PEG-HSA, increases size, weight, and colloidal osmoti...
Article
Full-text available
We investigated the effects of reduced oxygen-carrying capacity on cardiac function during acute hemodilution, while the plasma viscosity was increased in anesthetized animals. Two levels of oxygen-carrying capacity were created by 1-step and 2-step hemodilution in male golden Syrian hamsters. In the 1-step hemodilution (1-HD), 40% of the animals'...
Article
This study evaluated the hypothesis that exogenous nitric oxide (NO) supplementation during acute hemodilution with plasma expander (PE) provides beneficial effects on cardiac function. Acute hemodilution in golden Syrian hamsters was induced by a 40% of blood volume exchange with dextran 70 kDa. Intravascular NO supplementation after hemodilution...
Article
Plasma expanders have become increasingly advantageous when compared to blood transfusion, due to their long shelf-life and cost-effectiveness. A new generation of plasma expander based on polyethylene glycol (PEG) conjugated to human serum albumin (PEG-HSA) has shown positive microvascular effects during extreme hemodilution and fluid resuscitatio...
Article
Full-text available
Hemorrhagic shock results from massive blood loss, leading to hypotension, ischemia, heart failure and multi­ organ dysfunction. The analysis of cardiac function in vivo is complex and even more challenging during hemorrhagic shock, especially in small animals. Cardiac function measurements require animals to be under anesthesia. Sodium pentobarbit...
Article
During hemorrhagic shock and after resuscitation, the left ventricular pressure (LVP) and volume (LVV) vary over time. This study investigates and characterizes the LVP and LVV signals in the frequency and time domains in a hemorrhagic shock-resuscitation model. 40% of blood volume was withdrawn from anesthetized hamsters to induce moderate hemorrh...
Article
Full-text available
Small animal model has not been available to study cardiac pathophysiology during hemorrhagic shock. The main purpose of this study, therefore, was to establish earlier differences in left ventricle functional disturbances during hypovolemia comparable in survival and nonsurvival animals. Ventricular pressure-volume relationships have become well e...
Article
Cerebrovascular disease or stroke is a common problem found in hemiplegic patients. The balance disorder causes a gait pattern of hemiplegic patients in different to normal persons. The Pedar® system, an in-shoe measurement, was used to measure plantar pressure. Two groups of subject were involved in this study; normal person and stroke patient gro...
Article
Previous studies have found that increasing plasma viscosity as whole blood viscosity decrease has beneficial effects in microvascular hemodynamics. As the heart couples with systemic vascular network, changes in plasma and blood viscosity during hemodilution determine vascular pressure drop and flow rate, which influence cardiac function. This stu...
Article
Full-text available
The purpose of this study was to investigate how plasma viscosity affects cardiac and vascular function during moderate hemodilution. Twelve anesthetized hamsters were hemodiluted by 40% of blood volume with two different viscosity plasma expanders. Experimental groups were based on the plasma expander viscosity, namely: high viscosity plasma expan...
Article
In this work, two patterns of cavity arrangement, inline pattern and triangular pattern, with various cavity spacing were experimental studied on a silicon heated surface with micro-machined triple artificial cavities at low heat flux range in pool boiling. It aims to investigate the effects of cavity arrangement on the characteristics of pool boil...
Article
The experiment of pool nucleate boiling of water was performed on a heated silicon surface with triple artificial cavities. The existence and the significance of three effect factors, the bubble coalescence factor `C', the thermal interaction factor `T' and the hydrodynamic interaction factor `H', in the mechanism of nucleation site interaction is...

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Projects

Project (1)
Archived project
The aim of this project is to emphasis in investigating the prediction principles and demonstrating their reliability for that issues and answering the following research questions, based on patient-specific reconstructed model and parameters. • what are the characteristics of an aneurysm pulsatile flow? • How to adjust the appropriate parameters for input and output