Suraj Manjunath

Suraj Manjunath
St. John's Medical College Hospital, Bangalore, India · Department of Surgical Oncology

MS, MCh

About

67
Publications
5,719
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
429
Citations
Introduction
Additional affiliations
April 2017 - present
Vikram Hospital Bangalore
Position
  • Consultant
September 2013 - August 2014
Dharamshila Cancer Hospital and Research Centre
Position
  • Consultant
October 2006 - March 2017
Vikram Hospital Bangalore
Position
  • Professor and Head

Publications

Publications (67)
Article
Background: An optimal core needle biopsy (CNB) is expected to balance between tissue diagnosis, the accuracy of negative sampling, and concordance with reports from resected specimens to select the appropriate treatment. Though various techniques for CNBs are available, no guidelines exist for processing CNB, with practices varying from lab to la...
Article
In India, for the year 2012, 144,937 women were newly detected with breast cancer and 70,218 women died of it. For every 2 women newly diagnosed with breast cancer, one lady is dying of it. The aim of this study is to evaluate clinical parameters and pathological findings including various Immuno-histochemistry (IHC) markers like ER, PR, HER-2 NEU,...
Article
Full-text available
Purpose To understand the role played by the immediate family in treatment decision and support in patients diagnosed with breast cancer, the influence of demographic factors on psychosocial roles of women within the family. Methods A mixed method design used for data collection on family support, financial arrangement and psychosocial impact of c...
Article
This is a case report of a 61-year-old male patient, presented with fifth recurrence of retroperitoneal liposarcoma and operated for six times. Literature review on retroperitoneal liposarcoma biology, recurrence pattern, role of surgery in primary tumor, and recurrent tumor, adjuvant therapy, role of multivisceral resection, and palliative surgery...
Article
Full-text available
Introduction: In spite of rapid urbanization and modernization the family remains central in the socio-cultural structure of India. The individuals are enmeshed into this unit and tend to be interlinked financially, emotionally and socially. The head of this family unit tends to be a male more often than not. As is well known, despite recent attemp...
Article
Full-text available
The term “collision tumor” implies the occurrence of two or more neoplasms in a single biopsy specimen. This is a rare feature in skin biopsies, with most of the reported combinations involving melanocytic lesions or basal cell carcinomas. Combinations of adnexal tumors are found very sporadically. We report a 67-year-old woman with a scalp nodule,...
Article
Full-text available
Hormone receptor positive (HR+) breast cancers are a heterogeneous class with differential prognosis. Although more than half of Indian women present with advanced disease, many such patients do well. We have attempted identification of biologically indolent tumors within HR+HER2- tumors based on gene expression using histological grade as a guide...
Article
Full-text available
Tuberculosis (TB) is still a major public health problem in the world, with many factors contributing to this burden, including poor living conditions, overcrowding, poverty, malnutrition, illiteracy, and rapid spread of human immunodeficiency virus infection. Cutaneous tuberculosis is a less common form of extrapulmonary tuberculosis, and in this...
Article
Full-text available
Neurofibromatosis 1 (NF1) patients are generally at higher risk of developing common malignant tumors such as brain and soft tissue tumors. These patients are 5-fold increased the risk of developing breast cancer by the age of 50 years after that the risk remains the same. The most common reported cancer is infiltrating duct carcinoma. We report a...
Article
Full-text available
Despite an overall good prognosis, a significant proportion of patients with hormone receptor positive human epidermal growth factor receptor 2 negative breast cancers develop distant metastases. The metastatic potential of epithelial cells is known to be regulated by tumor–stromal interaction and mediated by epithelial-to-mesenchymal transition. H...
Article
Background: MicroRNA mediated molecular alterations are involved in the initiation and progression of cancer. Altered expression of multiple microRNAs is associated with endocrine resistance in hormone receptor positive HER2 negative (HR+/HER2-ve) cancer. The role of miR-221 in inducing epithelial to mesenchymal transition (EMT) is well documented...
Article
Full-text available
Objectives: With increasing rates of breast cancer survivors, psychosocial issues surrounding cancer survivorship have been gaining prominence. The following article reports on body image and sexuality‑related issues in aftermath of the diagnosis and its treatment in the Indian context. Materials and Methods: Research design was mixed method, cross...
Article
Lymphadenopathy can be due to multitude of causes. Owing to the high prevalence of infectious diseases in India, and malignancy being a life threatening cause for lymphadenopathy; accurate diagnosis is important in preventing delay or misdiagnosis and in improving patient care, thereby increasing longevity with quality. Fine needle aspiration cytol...
Article
The axillary reverse mapping (ARM) technique has been described as an attempt to map and preserve the upper extremity lymphatic drainage during axillary lymph node dissection (ALND) and/or SLNB. This technique is based on the hypothesis that the lymphatic pathway from the upper extremity is not involved by metastasis from primary breast cancer. The...
Article
Full-text available
Oral cancers in India are very common. SLNB (sentinel lymph node biopsy) for the management of the cN0 neck provides proper staging with less morbidity. The study aims at assessment of the technical feasibility and accuracy of SLNB. Two by two table and Kappa statistic was used to compare SLN and END. In 14 cases out of 16 cases, SLN was identified...
Data
Figure S4. Data analyzed from 93 HER2+ tumors from TCGA dataset with ITGB6 mRNA information. ITGB6 mRNA distribution between ER− and ER+ groups, a P‐value of <0.05 was considered statistically significant.
Data
Figure S6. Data analyzed from 73 HER2+ tumors from TCGA dataset with both ITGB6 mRNA and RPPA data available. Correlation plots between ITGB6 mRNA and ERBB2, EGFR, and PXN proteins. Pearson's correlation coefficient, r indicates the strength of correlation and a P‐value of <0.05 was considered statistically significant.
Data
Table S2. Primer sequences used for gene expression analysis.
Data
Figure S1. Distribution of ITGB6 mRNA in the two case series—KMIO and Nadathur‐CS. The dynamic ranges of ITGB6 ARNU in both the CS were similar and ranged from 0 to 14. ITGB6 mRNA expression followed a normal distribution in both the case series.
Data
Figure S3. In‐silico data analysis from the TEX trial dataset. The distribution of ITGB6 transcripts was plotted across the PAM50 subtypes and intergroup variability was analyzed using the Kruskal–Wallis test. A P‐value of <0.05 was considered significant.
Data
Figure S5. Data analyzed from 93 HER2+ tumors from TCGA dataset with mRNA information available. Distribution of RHOV, RAC3, and MMP15 between ITGB6‐L and –H groups.
Data
Table S1. Clinicopathological characteristics of 446 and 269 patients in the Nadathur‐CS.
Data
Figure S2. Representative tissue microarray sections. (A) Images of the Hematoxylin & Eosin‐stained sections of a complete block (90 cores) and at a higher magnification, (B) immunohistochemistry staining of integrin αvβ6 on multiple TMA cores and a complete 1.5 mm core (1.75 sq. mm). TMA cores with less than 100 invasive tumor cells were considere...
Article
Full-text available
Integrin αvβ6 is involved in the transition from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) of the breast. In addition, integrin β6 (ITGB6) is of prognostic value in invasive breast cancers, particularly in HER2+ subtype. However, pathways mediating the activity of integrin αvβ6 in clinical progression of invasive breast can...
Article
Full-text available
The experience of diagnosis and treatment of cancer leads to significant changes within an individual. In the course of survivorship trajectory, very often cancer survivors are left with the sense, improvements could be done to enhance the quality of cancer care. This article focuses on experiences of breast cancer survivors with oncology setting i...
Article
Full-text available
Purpose: Apart from germ-line BRCA1-mutated breast cancers, a significant proportion of women with sporadic triple negative breast cancer (TNBC) sub-type are known to harbour varying levels of BRCA1-dysfuction. There is currently no established diagnostic method to identify these patients. Methods: The analysis was performed on 183 primary breas...
Data
Correlation of MIR182 to BRCA1 protein. (DOCX)
Data
Comparison of clinical characteristics of the BRCA1 deficient and adequate groups in the 55 TNBC samples. (DOCX)
Data
Images- Immunohistochemistry. (DOCX)
Data
Histograms depicting distributions of transcript levels of—A. BRCA1 and B. ID4. (DOCX)
Data
KaplanMeir Curves for survival analysis. (DOCX)
Article
Full-text available
Aim: The aim of the study was to understand the phenomenon of posttraumatic growth (PTG) in women survivors of breast cancer from an Indian perspective. Settings and Design: It was a mixed method, cross-sectional, and exploratory design wherein in-depth qualitative data covering a broader area of experiences were gathered from a sub-section of the...
Article
Full-text available
In India, Breast cancer is now the most common cancer in urban and 2nd most common in rural areas [1]. The incidence is rising, more younger women are getting affected and due to increase in survival rates there is an increase in the total number of women suffering from breast Cancer. So far there are no studies evaluating the pattern of breast pro...
Article
Full-text available
Ascariasis is a common problem in developing countries with poor hygiene and sanitation. It is endemic in India and usually seen in the northern states. Biliary ascariasis is an uncommon cause of obstructive jaundice. We present a case of carcinoma of hepatic flexure of colon in which the patient developed biliary ascariasis and posed a diagnostic...
Article
Expedience of conventional radiotherapy in locally advanced cervix cancer: A retrospective analysis Hypertriglyceridemia-induced acute pancreatitis: Yet to be explored Fracture-embolization of peripherally inserted central catheter Patent vitellointestinal duct with inverted ileal loop prolapse: A rare presentation A rare presentation of a necrotic...
Article
Full-text available
Peripherally inserted central catheter (PICC) is a drug delivery system frequently utilized in modern oncology practice. Though generally safe and easy to handle, it may be associated with complications. We present an uncommon case of fracture of PICC and subsequent embolization to pulmonary vessels
Article
Full-text available
A central venous access device is an intravenous device whose internal tip lies in a large central vein. Chemoport is a central venous device which serves various purposes in oncology practice apart from optimum delivery of chemotherapy. Various early and late complications have been frequently reported with the use of these devices. Fracture-embol...
Article
Full-text available
Peripherally inserted central catheter (PICC) is a modern drug delivery system utilised in oncology practice. The purpose of this study was to determine the complications associated with PICCs within a one year study period. PICCs inserted in patients registered at Dharamshila Cancer Hospital and research centre from 1st July 2012 to 30th June 2013...
Article
Full-text available
Theoretical advantages of use of Ultrasonic shears include less tissue damage and better sealing of lymphatic vessels. This may play a role in reducing prolonged drainage following axillary dissection for breast cancer. We conducted a prospective randomized controlled study to evaluate efficacy of ultrasonic shears over cautery for axillary dissect...
Article
Well-differentiated thyroid cancers can present with nodal metastasis that have undergone cystic degeneration. Rarely, mediastinal nodes may undergo cystic changes and pose a diagnostic dilemma, especially if the primary lesion is occult. We describe the case of a patient who presented with a large mediastinal cystic lesion which turned out to be m...
Article
Full-text available
Introduction: Breast cancer is the leading cancer diagnosed in urban Indian women. Historically the proportion of women presenting with advanced disease has been in excess of 50% at most regional cancer centres. The past 20 years has witnessed rapid economic growth and urbanization with significant gains in women's education and access to health. H...
Article
Dedifferentiated chondrosarcomas are a rare and aggressive subtype of chondrosarcoma with a bimorphic pattern on histopathology. Rib is a rare site of dedifferentiated chondrosarcoma. Diagnosis of this subtype preoperatively can be challenging. Treatment options for dedifferentiated chondrosarcoma are limited because they are chemoresistant, and th...
Article
Full-text available
Background: The 2010 guidelines by ASCO-CAP have mandated that breast cancer specimens with ≥1% positively staining cells by immunohistochemistry should be considered Estrogen Receptor (ER) positive. This has led to a subclass of low-ER positive (1-10%) breast cancers. We have examined the biology and clinical behavior of these low ER staining tumo...
Article
We report a case of recurrent squamous cell carcinoma (SCC) of the skin in a post-renal transplant recipient occurring 5 years after transplantation. The purpose of reporting is not for its rarity or uniqueness, but to re-emphasize the fact that skin malignancies could be lethal. The SCC in our patient was aggressive, recurrent and metastasized ear...
Article
Adamantinoma is a rare primary tumor of the bone of unknown origin [1]. They are low grade malignant tumors which are capable of distant metastases especially to the lung [2]. Distant metastases have been described to occur many years after the presentation of the primary [4]. We describe our experience with a patient of adamantinoma of the tibia...
Article
The proportion of estrogen receptor (ER)-negative and triple-negative (TN) breast cancer in Indian women is higher than that reported in the West, and this difference persists even after their migration to the West. The causes for this significant difference are not entirely clear. Hypermethylation of the ER promoter, an epigenetic alteration, is k...
Article
Full-text available
Extraocular sebaceous carcinomas are rare cutaneous malignancies that account for only about 25% of all sebaceous carcinomas. The most common site of occurrence is the head/neck region. They are aggressive neoplasms that possess metastatic potential to regional or distant sites. Wide local excision of the lesion with removal of regional lymph nodes...
Article
Full-text available
Patients with breast cancer and positive sentinel node biopsy usually require axillary dissection. Different instruments are used for axillary dissection like regular scalpel,monopolar cautery, bipolar cautery etc. All these instruments are having its advantages and disadvantages. Our dept did a pilot study to know the efficacy of ultrasonic shears...
Article
Full-text available
ER negative and Triple negative breast cancers carry a poorer prognosis and are not amenable to hormone therapy. It has been previously observed that Indian patients with breast cancer have a higher tendency to have these tumours. Whether this is due to inherent biological differences in the tumours of our patients is a matter of much debate. We ha...
Article
Full-text available
The lack of either a nationalized health care structure or widespread health insurance in most developing nations is at the root of many of our health care challenges. Amongst them is the loss to follow-up of a majority of patients treated at tertiary care centers. As a consequence, outcomes data from such countries are notoriously non representati...
Article
Full-text available
Background: The incidence of Estrogen Receptor alpha (ER) negative breast cancer and triple negative cases in India is twice that of Western Caucasians. The underlying causes for this two fold difference are unclear. DNA methylation of the ER promoter is one of the mechanisms of gene silencing. Recent data from the West indicate that the ER promote...
Article
Full-text available
Ameloblastoma is a true neoplasm of odontogenic epithelial origin. It is the second most common odontogenic neoplasm, and only odontoma outnumbers it in reported frequency of occurrence. Its incidence, combined with its clinical behavior, makes ameloblastoma the most significant odontogenic neoplasm. Unicystic ameloblastoma (UA) refers to those cys...
Article
Full-text available
Breast cancer presenting as parotid tumour is very rare. This is the first reported case in which parotid tumour was the presenting complaint of the patient. Since the patient was estrogen and progesterone receptor positive - was put on hormone therapy and responded well.
Article
Pedicled anterolateral thigh flap has been well described for ipsilateral groin defects. Its versatility depends on the intact femoral vessels. When the external iliac and the femoral vessels are absent, especially secondary to wide surgical tumour ablations in the groin region, ipsilateral ALT flap is not an option. Free flaps also are difficult b...
Article
Full-text available
Pedicled anterolateral thigh flap has been well described for ipsilateral groin defects. Its versatility depends on the intact femoral vessels. When the external iliac and the femoral vessels are absent, especially secondary to wide surgical tumour ablations in the groin region, ipsilateral ALT flap is not an option. Free flaps also are difficult b...
Article
Many patients with renal cell carcinoma (RCC) present with disease involving the adjacent viscera. Although survival in such patients is poor, surgery remains the only proven modality of treatment. We describe our experience with radical nephrectomy for locally invasive RCC over a five-year period. A retrospective analysis of the records of all pat...
Article
A 7-year-old boy with mixed exocrine-endocrine pancreatic cancer is presented. This may be the second reported case of such a tumor in childhood.

Network

Cited By

Projects

Projects (2)