Sunita Shailajan

Sunita Shailajan
Ramnarain Ruia College · Botany

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85
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Publications

Publications (85)
Article
The article is a brief review on certain important aspects of tuberculosis. A good number of medicinal plants and their chemical constituents are reported to have antimycobacterial activity comparable to the existing antitubercular drugs or sometimes even better in efficacy. The present review covers the literature published concerning medicinal pl...
Article
Background: Ayurvedic medicines show great promise due to their holistic approach in the treatment of diseases. But proper standardization is necessary for their integration into mainstream medicine. One such well-known formulation is Pushyanuga Churna. As safety and efficacy of a multiherbal formulation is dependent on the authenticity of the ingr...
Article
The family Orchidaceae is one of the largest groups of angiosperms having a wide range of implication owing to its pharmacological as well as horticultural attributes. In the recent past it has been observed that the biological diversity of the orchid resources are on the verge of facing extinction due to various anthropogenic pressures. Dendrobium...
Article
Objectives: Standardization of traditional medicine is a multidimensional approach that ensures the quality and concentration of chemical constituents for their bio-potency. Pushyanuga churna is a traditional ayurvedic formulation prescribed for the treatment of various female reproductive disorders leucorrhoea, menorrhagia etc. As per AFI, the for...
Article
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Objective: Symplocos racemosa Roxb. is traditionally used in various ailments like leprosy, diarrhoea, dysentery, menorrhagia and uterine disorders etc. The plant exhibits these therapeutic effects due to the presence of different biologically active phytoconstituents like ellagic acid, symplocoside, betulin, oleanolic acid, β-sitosterol, betulinic...
Article
Ethnopharmacological relevance: Saraca asoca (Roxb.) de Wilde, Ashok, is a popular traditional plant used for gynecological disorders. In India, the juice of Ashok flowers is traditionally consumed as a tonic by women in case of uterine disorders. But despite the use, its estrogenic potency is not yet evaluated and thus lacks the scientific recogn...
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Background: Mangifera indica L.; the largest fruit-tree found in India, is an important component of indigenous medical systems. Mangifera indica L. leaves (MIL) have been reported to possess various biological activities and thus, can be a useful source of substances for drug development. Although the leaves have been traditionally used as antibac...
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Introduction: Mimusops elengi L. (Sapotaceae), known as Bakul in Ayurveda, is an evergreen tree found throughout India. M. elengi flowers (MEF) are reported to possess immunomodulatory, hepatoprotective, skin whitening, anti-anxiety and wound healing activities which may be attributed to its phytochemical constituents including triterpenoids, alkal...
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Background: The present study was aimed to evaluate the traditionally reported wound healing potential of Chrysophyllum cainito leaves. Methods: The ethanolic extract of C. cainito leaves was standardized in terms of its gallic acid content (a phenolic compound with wound healing properties) using a validated HPTLC technique. The antioxidant activi...
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Introduction: Eclipta alba Linn. (Asteraceae) is an important ingredient of several Ayurvedic formulations. The monograph on different parts of plant like flowers, leaves, roots are listed in Ayurvedic pharmacopeia of India. The plant is reported to be effective for broad range maladies like inflammation, reproductive problems of females etc. It is...
Article
Background: Cuscuta campestris Yuncker (Cuscutaceae), is a rootless obligate stem holoparasite that subsists on various plant species worldwide, including economically important crops and reduces their yields substantially causing damage in agriculture. Cuscuta campestris has been reported for its analgesic, anthelminthic, antipyretic, anti-inflamm...
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Objective: This study investigates the potential estrogenic activity of the ethanolic extract of Flemingia vestita Benth tubers using ovariectomized rat model. Materials and Methods: The ethanolic extract of F. vestita tubers has been standardized using validated HPLC method in terms of its genistein content (8.43 ± 0.05 mg/g of extract). Three to...
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Introduction: Acorus calamus Linn. ( A. calamus ) has been found use in medicines to cure fevers, for asthma, bronchitis and as an all-round sedative. β-asarone is an important phytochemical compound present richly in the rhizomes of Acorus calamus that imparts several therapeutic properties to the plant by the virtue of which the plant has occupie...
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Objective: To investigate the anti-androgenic properties of Symplocos racemosa Roxb. (S. racemosa) in the treatment of hyperandrogenemia associated polycystic ovary syndrome (PCOS) in a letrozole induced PCOS rat model. Methods: The testosterone levels were used to evaluate the anti-androgenic effect of S. racemosa in letrozole induced PCOS rats fo...
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Northeast India represents a rich floristic wealth of India. Orchids form a very noticeable feature of this vegetation. Amongst orchids, the genus Dendrobium forms a very important group of plants which are used by the locals for the treatment of various ailments. A through literature survey revealed that there is a paucity of data on the phytochem...
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Jawarish‑e‑Amla Sada (JAS); a polyherbal Unani formulation, is claimed as a potential hepatoprotective agent in traditional Unani medicine treatise. Aims and Objectives: Though, JAS has its composition recorded in ancient Unani texts, there have been minimal attempts to scientifically validate its hepatoprotective potential. The present work is an...
Article
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Background: Jawarish‑e‑Amla Sada (JAS) is a traditional Unani formulation commonly used for the clinical treatment of Zof‑e‑Meda (weakness of the stomach), Zof‑e‑Kabid (weakness of the liver), Zof‑e‑Qalb (weakness of the heart), Khafqan (palpitation), Nafkh‑e‑Shikam (flatulence in the stomach) and Is‑Hal‑e‑Safrawi (biliary diarrhoea). It is a semis...
Article
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Ursolic acid (UA), a hydroxyl pentacyclic triterpenoic acid found in Carissa carandas Linn., a folk medicine used for the treatment of various diseases and also an important component of plant based medicine. In the present work, a precise, accurate and reproducible densitometric HPTLC method is developed and validated in terms of sensitivity, line...
Article
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Background: Mimusops elengi L. (Sapotaceae, Bakul) is an integral part of many Ayurvedic formulations. Flowers of M. elengi have been traditionally used for their therapeutic activities like antiulcer, wound healing, antioxidant, etc. Flowers are also reported as a brain tonic, expectorant and have been used for the treatment of asthma. Materials a...
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Background: Flemingia vestita Benth (Fabaceae) is a much-branched trailing herb with tuberous roots, found throughout the Himalayas and Khasi Hills up to an elevation of 8,000 ft. Formononetin, pseudobaptigenin, diadzein and genistein are major isoflavones present in the tuberous root of F. vestita. Materials and Methods: In this research work, tub...
Article
The phenolic compound, 2-hydroxy-4-methoxy benzoic acid (HMBA), is one of the major phytoconstituents of Decalepis arayalpathra (Joseph & Chandra.) Venter, a rare and endemic medicinal plant found in the Western Ghats of India. HMBA has been attributed to possess several biological effects including anti-inflammatory, anti-pyretic, anti-oxidant and...
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The leaf bud of Ficus benghalensis L. (Moraceae) is commonly known as Vatankur. It is traditionally used in the treatment of diarrhoea, skin disorders, female reproductive disorders and as a hair vitalizer. In the present study macroscopic, microscopic, proximate, phytochemical and safety profile of Vatankur has been evaluated and discussed. Findin...
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Urtica dioica L. (Urticaceae, leaves) is commonly used in traditional systems of medicine for the treatment of a wide range of disorders. The present work emphasizes on a validated HPTLC method for estimation of ursolic acid from U. dioica leaves and its available formulation. Chromatographic separation was achieved on silica gel 60 F254 TLC plate...
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Taverniera cuneifolia (Roth) Ali is commonly called as jethimadh (Licorice). High - Performance Thin - Layer Chromatographic analysis wa s carried out for the regional variation of different regions of India, seasonal variation and species variation. The root powder was extracted with Methanol and further analysis was performed. Quantitat ion of β...
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Pongamia pinnata L. (fabaceae) is a small evergreen tree reported in traditional literature as ‘Karanj’. Seeds of this plant have been used in the management of skin diseases, ulcer, piles, bronchitis; leprosy etc. Seeds are reported to possess phytoconstituents like pongapin, pongamol, pongaglabrone, kanjone, karanjin etc. The therapeutic activiti...
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Marmelosin is one of the major phytochemical constituents of Aegle marmelos (L.) Corr. (Rutaceae). Till date, there are no methods reported for the estimation of marmelosin in plasma matrix using high-performance thin-layer chromatography (HPTLC) which is a versatile analytical technique promoting shorter analysis time and less consumption of solve...
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Many plants have been claimed to possess liver protecting activity. But, due to scarcity of potent modern medicine to treat severe liver diseases, many folk remedies of plant origin have been scientifically evaluated for their potential hepatoprotective activity in experimental animal models. Parmelia perlata (Huds.) Ach. (lichen, Parmeliaceae), co...
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Vitex negundo L. (Verbenaceae) fruits are reported to possess a wide range of therapeutic properties. The present work is an attempt to evaluate the impact of regional variation on the content of β-sitosterol in V. negundo fruits using validated HPTLC method. Chromatographic separation was achieved on TLC plate pre-coated with silica gel 60 F 254 u...
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The physicochemical and phytochemical analysis of medicinal plants is an important quality control tool in medicinal plants research. The present study involves physicochemical and phytochemical evaluation of six different medicinal important plants namely Aegle marmelos (L.) Correa (fruit pulp), Asteracantha longifolia Nees. (seeds), Salmalia mala...
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HPTLC and HPLC are two most widely accepted methods for determination of natural products. Present research work envisages microwave assisted extraction of quercetin from hydroethanolic extract of Cuscuta reflexa Roxb. (Cuscutaceae), an unusual parasitic vine. Further, chromatographic characterization of hydroethanolic extract of C. reflexa was car...
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Chrysophyllum cainito L. (Sapotaceae); commonly known as Star Apple is a tropical tree native to lowland of Central America and West Indies and exotic to the warmer parts of India. Leaves of C. cainito are reported to possess antidiabetic and antioxidant properties as well as have been used against articular rheumatism. A decoction of leaves is tak...
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Background Infestation with the head louse, Pediculus humanus capitis, is one of the most common parasitic infestations of human worldwide. Traditionally, the main treatment for control of head lice is chemical control that includes wide variety of neurotoxic synthetic insecticides. The main difficulty posed in controlling the head louse infestatio...
Conference Paper
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Despite several publications concerning mangrove forests, a clear understanding of the dynamics in mangrove ecosystems is just beginning to emerge. Mangroves have been a source of several bioactive compounds, they have been used in folklore medicines and the extracts have proven activity against human, animal and plant pathogens too. Avicennia mari...
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Cassia fistula L. (Fabaceae) fruits are reported to possess a wide range of therapeutic properties. In the present work, an HPTLC method has been developed and validated for estimation of β-sitosterol content in C. fistula fruit collected from different geographical regions in and outside India and its polyherbal formulation. Chromatographic separa...
Article
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The aim of the current study was to evaluate pharmacognostic characters of leaves of Parkia biglandulosa Wight & Arn. The evaluation was carried out in terms of macroscopic, microscopic, physicochemical, phytochemical and chromatographic analysis.Leaves of P. biglandulosa showed the presence of circular dark brown gland at its base on either side o...
Article
Several methods are used to evaluate the inflammatory changes. Measurement of edema is the most commonly used method for evaluating artificially induced inflammation in rat model. In this context, we present a method for the measurement of volume of rat paw, in which two glass columns containing fluid are connected by a glass tube. Paw is immersed...
Article
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Carissa carandas Linn. is an evergreen, diffuse and spiny shrub grown in different parts of India for its edible fruits. Fruits of C. carandas are used as potential analgesic, anti-inflammatory and anti-diabetic agent. An HPTLC method has been developed and validated for estimation of β-sitosterol content in C. carandas fruits collected from differ...
Article
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Shadbindu Taila (ST) is an Ayurvedic formulation used as a remedy for loosening of tooth, weakness of the eyesight, loss of hair, diseases of head, etc., Present study is an attempt to develop some newer approaches for the quality control and standardization of ST. Standardized operating procedure for the preparation of ST was developed in accordan...
Article
Eugenol is an important phytochemical bioactive compound of ayurvedic and other marketed herbal formulations. It shows anti-inflammatory, anti-bacterial and anti-tubercular activity. Thus, it is a suitable bioactive biomarker to establish the quality of commercial drug and its formulation. The aim is to develop and validate an efficient and effecti...
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Bilvadileha; an Ayurvedic semi-solid formulation, is prescribed for the treatment of digestive impairment, tastelessness, emesis and excessive salivation. Though the formula composition and therapeutic claims of Bilvadileha are part of the Ayurvedic Formulary of India, the scientific methods for its quality and safety evaluation are yet to be docum...
Article
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Background: Rhein is the major anthraquinone found in Cassia fistula Linn, which is traditionally used as an important component of plant based medicine. Aims and Objective: To develop and validate -a High Performance Thin Layer Chromatographic method for the estimation of Rhein from C. fistula Linn. Materials and Methods: Chromatographic separatio...
Article
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The present work is an attempt to evaluate the impact of regional variation on lupeol content in Carissa carandas Linn. fruits collected from different geographical regions of India using a validated HPTLC method. Chromatographic separation was achieved on TLC plates pre-coated with silica gel 60 F 254 using toluene: methanol (8:1, v/v) as a mobile...
Article
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Background: Seeds of Asteracantha longifolia Nees. (Acanthaceae) are an important ingredient in many traditional/herbal formulations used in the management of a wide range of reproductive disorders. They are reported to posses various therapeutically active phytochemical constituents like asteracanthine, lupeol, asterol, β-sitosterol etc. Materials...
Article
Full-text available
Cassia fistula L. (Fabaceae) fruits are reported to possess a wide range of therapeutic properties. In the present work, an HPTLC method has been developed and validated for estimation of β-sitosterol content in C. fistula fruit collected from different geographical regions in and outside India and its polyherbal formulation. Chromatographic separa...
Article
Asiatic acid (AA), a pentacyclic triterpene from Centella asiatica (L.) Urban, has shown numerous therapeutic activities. However, none of the published works to date has used high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS) for determination of AA from biological fluids. Therefore, the present paper describes a sensitiv...
Article
β-Asarone (BAS), a phenylpropanoid from Acorus calamus Linn., has shown biological effects in the management of cognitive impairment conditions such as Alzheimer's disease. The present paper describes a selective and sensitive liquid chromatography-tandem mass spectrometric method (HPLC-MS/MS) using electrospray ionization source (ESI) for quantifi...
Article
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Background : Carissa carandas L. (Apocynaceae), an important fruit of tropical and subtropical arid region, has a great potential for the development of a new phytotherapeutic medicine. Due to an increase in commercial products of this fruit in the global market, an extensive phytochemical comparison seems imperative to understand its internal qual...
Article
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Background: Psoralea corylifolia L. (Fabaceae, seeds) is used in many formulations for the treatment of a wide range of ailments. Aims and Objective: To develop a reverse phase high-performance liquid chromatography-photodiode array detector (RP-HPLC-DAD) method for quantitation of psoralen from P. corylifolia and its related formulations. Material...
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Sufoof -e -Ziabetes -Dulabi (SZD) is an Unani formulation, used for diabetes and renal disorders since ancient times. In the present work, quality of the raw material and the final product SZD was assessed by modern bioanalytical techniques. Quality of the ingredients of SZD was evaluated prior to its preparation. Values of proximate analysis for t...
Article
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Jawarish-e-Bisbasa, an Unani polyherbal formulation, is used traditionally in the clinical treatment of stomach ulcers, weakness of digestion, piles, flatulence, nausea, gastritis and as an energy enhancer for stomach. In the current work; phytochemical, safety and pharmacokinetic profile of Jawarish-e-Bisbasa has been evaluated. Phytochemical cons...
Article
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Yashtimadhuka Taila (YMT) is an ancient Ayurvedic oil based formulation prescribed for Palita (graying of hair), Keshpatana (falling of hair) and Smasru Patana (falling of beard and moustache). Though YMT is an age old formulation, not much attempt has been made towards its standardization. The current work aims to standardize YMT using modern bioa...
Article
The present communication evaluates the physicochemical and preliminary phytochemical properties of Taverniera cuneifolia (Roth.) Arn. The roots of T. cuneifolia has been considered as a potential substitute of Glycyrrhiza glabra, popularly known as Indian Licorice. However, there is no detailed standardized work done so far. The results revealed t...
Article
Eladi Gutika (EG), a traditional Ayurvedic polyherbal formulation is used as a remedy for Kasa (Cough), Svasa (Asthma), Bhrama (Vertigo), Raktapitta (Bleeding disorders), Jvara (Fever), Amvata (Rheumatism) etc. In the present work, an attempt has been made to develop pharmacognostic standards for EG. The raw materials of EG were subjected to proxim...
Article
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Microwave-assisted extraction (MAE) of phytochemicals has grown as a promising technique in recent years. MAE method was developed for extraction of Lupeol from Cuscuta reflexa Roxb. growing on different hosts. An open vessel modified microwave system has been used for extraction of Lupeol. Various critical parameters such as use of solvent, solv...
Article
In traditional Indian medicinal treatise there are several Ayurvedic formulations mentioned which have been claimed as potential wound healing agents like Madhu Ghrita and Jatyadi Taila. Jatyadi Taila (JT) is a medicated oil formulation (Taila) popularly used in the treatment of various topical wounds. Though JT has its composition recorded in anci...
Article
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Trigonella foenum-graecum (L.) (Fabaceae, Fenugreek) is an important ingredient of Ayurvedic and other marketed herbal formulations. Fenugreek seeds are employed in many traditional systems as an antibacterial and antidiabetic agent, gastric stimulant and galactogogue. Trigonelline, a major phytoconstituent found in fenugreek seeds, shows estrogeni...
Article
Jawarish-e-Bisbasa (JEB) is a traditional Unani medicine commonly used for clinical treatment of stomach ulcers, weakness of digestion, piles, flatulence, nausea, gastritis and as energy enhancer for stomach. It is a polyherbal preparation containing 10 ingredients which are mainly used as a remedy for many gastric disorders. Though this Unani semi...
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Trikatu Churna (TC) is an ancient traditional Ayurvedic preparation prescribed for a wide range of disorders. Though TC is an age old formulation, there are very few references on its quality control and standardization. In this work, an attempt has been made to standardize TC by qualitatively evaluating the preliminary phytochemicals. Piperine con...
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Cuscuta reflexa Roxb. (Cuscutaceae, Amarvel) is a golden yellow parasite commonly found throughout India. Cuscuta reflexa (CR) has been widely used for curing many diseases. CR has been reported as antibacterial, immunomodulatory, hepatoprotectant etc. In the present work a precise, accurate and reproducible densitometric HPTLC method is developed...
Article
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Hingvadi Taila (HT) is an Ayurvedic formulation which is used for Karnashoola (ear-ache) since ancient times. In the present study, the quality of raw materials, intermediates obtained during the preparation of Hingvadi Taila and the final product was assessed by modern scientific procedures. Values of proximate analysis of the raw materials used w...
Article
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A rapid, sensitive and accurate liquid chroma-tographic tandem mass spectrometric method is described for the determination of Mimosine in Mimosa pudica Linn. whole plant powder. Mi-mosine was extracted from the plant using 1.0% HCl in water. The chromatographic separation was achieved using a Thermo Hypurity C18 (50 x 4.6 mm) 5.0 μ column interfac...
Article
Betasitosterol is one of the major phytoconstituents in cornsilk (style and stigma of Zea mays Linn.). This study is an attempt to standardize cornsilk as a bioavailable source of Betasitosterol and it reports the pharmacokinetic evaluation of slurry of cornsilk using HPTLC. The study was conducted on male albino rabbits of New Zealand strain. Bloo...