Sungyu Yang

Sungyu Yang
Korea Institute of Oriental Medicine

About

96
Publications
13,688
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468
Citations
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November 2014 - present
Korea Institute of Oriental Medicine
Position
  • Researcher

Publications

Publications (96)
Article
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Abstract Osteoporosis affects millions of people worldwide. As such, this study assessed the macrophage-dependent in vitro anti-osteoporosis, phytochemical profile and hepatotoxicity effects in zebrafish larvae of the stem bark extracts of P. africana. Mouse bone marrow macrophages (BMM) cells were plated in 96-well plates and treated with P. afric...
Article
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Rosae Laevigatae Fructus is a traditional medicine derived from the fruit of Rosa laevigata Michx. a member of the family Rosaceae. Rosa laevigata was recently reported as a new alien plant in Jangmok-myeon, Geoje-si, Gyeongsangnam-do. This study aimed to analyze and describe leaf, petiole, sepal, and petal epidermal cell patterns of Rosa laevigata...
Article
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The genus Philadelphus (Hydrangeaceae) in South Korea is critically revised based on macro- and micro-morphological characteristics from over 1,000 herbarium specimens, and fresh material from wild populations. Findings show that: (1) The presence/absence and the density of the hairs on the disk, pistil, calyx, leaves, and petiole and the degree of...
Article
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The pollen and orbicule morphology of the Korean Piperales (Aristolochia, Asarum, Houttuynia, Piper, and Saururus) were investigated via scanning electron microscopy. Piperales pollen is a monad, its size ranging from very small to large (P = 7.78–51.4 μm, E = 6.68–43.1 μm), and having a mainly circular to sub-circular shape. The aperture type is c...
Article
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Sasang constitution (SC) medicine, an aspect of traditional Korean medicine, originated from the theory that individual types present different responses to specific medicinal plants. We built a forest trail at Mt. Bori-san in Gapyeong-gun to apply the SC to forest therapy. We achieved plant lists based on Korean medicinal classics such as Dongeuis...
Article
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The medicinal plant, Aspilia africana , has been traditionally used in several African countries to treat many diseases such as tuberculosis, cough, inflammation, malaria, osteoporosis, and diabetes. In this study, we developed a protocol for in vitro propagation of A. africana using indirect shoot organogenesis from leaf and root explants of in vi...
Article
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Sanguisorba, commonly known as burnet, is a genus in the family Rosaceae native to the temperate regions of the Northern hemisphere. Five of its thirty species are distributed in Korea: Sanguisorba officinalis, S. stipulata, S. hakusanensis, S. longifolia, and S. tenuifolia. S. officinalis has been designated as a medicinal remedy in the Chinese an...
Article
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Floral micromorphology and pollen morphology of two Leonurus (Lamiaceae) species were examined and compared using scanning electron microscopy to evaluate the diagnostic value of these features to facilitate future studies on floral biology and taxonomy. Floral epidermal patterns were similar in both species, with the conical to central-conical epi...
Preprint
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Background: The genus Prunus (Family Rosaceae) comprises over 400 plant species and exhibits vast biodiversity worldwide. Due to its wide distribution, its taxonomic classification is important. Anatomical characters are conserved and stable and thus can be used as an important tool in plant taxonomic characterization. Thus, this study aimed at exa...
Article
Ethnopharmacological relevance Gekko gecko is used as a traditional medicine for various diseases including respiratory disorders in northeast Asian countries, mainly Korea, Japan, and China. Aim of the study Allergic asthma is a chronic respiratory disease caused by an inappropriate immune response. Due to the recent spread of coronavirus disease...
Article
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Trichosanthes is a genus in Cucurbitaceae comprising 90-100 species. Trichosanthes species are valuable as herbaceous medicinal ingredients. The fruits, seeds, and roots of species such as T. kirilowii and T. rosthornii are used in Korean traditional herbal medicines. T. rosthornii is only found in China, whereas in South Korea two varieties, T. ki...
Article
Background Taxilli Herba (TH) and Visci Herba (VH), defined as the leaves and branches of the mistletoe species Taxillus chinensis and Viscum coloratum, respectively, are popular herbal medicines in East Asia. However, commercial TH and VH products are frequently adulterated with related inauthentic mistletoe species, posing efficacy and safety con...
Article
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Aspilia africana (Pers.) C. D. Adams is an important medicinal plant, that has been used as traditional medicine in many African countries for the treatment of various health problems, including inflammatory conditions, osteoporosis, tuberculosis, cough, measles, diabetes, diarrhea, malaria, and wounds. We developed an efficient and reproducible pr...
Article
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Objectives : Herbal medicines have been used a lot traditionally in Northeast Asia. In particular, various Apiaceae plants (Umbelliferae) are widely used for medicinal purposes among countries. However, the original species designated in each pharmacopoeia standards, are sometimes different and confuse. In this study, herbal medicines in the pharma...
Article
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Gastroesophageal reflux disease (GERD) is a globally prevalent disease and results from a reflux of gastric contents into the esophagus. Existing synthetic drug‐based treatments for GERD have various drawbacks including refractory symptoms, relapse, or resistance due to long‐term use or may result in mucosal degeneration, polyps, and osteoporosis....
Article
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Allium section Rhizirideum is reviewed for South Korea and neighboring northeastern China based on critical observation of wild populations and herbarium materials. Species delimitations are re-evaluated on the basis of morphological and somatic chromosome numbers, resulting in the recognition of five species. Allium dumebuchum from Ulleungdo Islan...
Article
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The genera Arnebia and Lithospermum (Lithospermeae-Boraginaceae) comprise 25-30 and 50-60 species, respectively. Some of them are economically valuable, as their roots frequently contain a purple-red dye used in the cosmetic industry. Furthermore, dried roots of Arnebia euchroma, A. guttata, and Lithospermum erythrorhizon, which have been designate...
Article
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Prunus africana is an endangered medicinal plant and hence new propagation methods are urgently required to increase its population. Unfortunately, propagation through seeds is challenging due to its long flowering cycle and recalcitrant seeds. We developed a protocol for micropropagation using nodal segment explants. A woody plant medium supplemen...
Article
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Scrophulariae Radix, derived from the dried roots of Scrophularia ningpoensis Hemsl. or S. buergeriana Miq, is a traditional herbal medicine used in Asia to treat rheumatism, arthritis, and pharyngalgia. However, the effects of Scrophularia buergeriana, S. koraeinsis, and S. takesimensis on osteoclast formation and bone resorption remain unclear. I...
Article
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To guarantee the safety and efficacy of herbal medicines, accurate identification and quality evaluation are crucial. The ripe dried seeds of Cuscuta australis R.Br. and C. chinensis Lam. are known as Cuscutae Semen (CS) and are widely consumed in Northeast Asia; however, the seeds of other species can be misidentified as CS owing to morphological...
Article
Somatic chromosome numbers were determined for 15 taxa belonging to six genera of Caryo-phyllaceae in South Korea, Pseudostellaria (three species), Stellaria (three species), Dianthus (one species), Gypsophila (one species), Lychnis (two species) and Silene (five species), and were compared with previously reported chromosome numbers for each genus...
Article
Adulterants in processed food and herbal medicines reduce their safety, quality control, or pharmacological efficacy. Four mistletoe species, including Viscum coloratum, inhabit Korea. Leaves and branches of V. coloratum, defined as edible or medicinal mistletoe species in Korean, are used to prepare Korean herbal medicines as well as leached tea....
Article
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Dimocarpus longan, Litchi chinensis, and Nephelium lappaceum are commercially valuable subtropical and tropical fruits of the Sapindaceae family. Arillus and seeds of the three species have very similar morphologies; however, the arillus of D. longan is used as the herbal medicine Longan Arillus and seeds of L. chinensis are used as Litchi Semen in...
Article
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The various database management system has been developed for storing, processing, and retrieving taxonomic data. In this paper, we present an order-family code, which is decimals, an 11-digit number. The order-family code contains phylogenetic relationships between each order and family and to help their database establishing effectively. To prese...
Article
Microsatellite markers were newly isolated for Sarcandra glabra (Chloranthaceae), an ecologically important species in the evergreen broad-leaved forests of East Asia. On the Korean Peninsula, S. glabra is endangered, being extremely restricted to a few habitats on Jeju Island, which is the northern edge of their distribution range with evolutionar...
Article
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A comparative study of the leaf micromorphology of Korean Piperales, including medicinal materials, was performed through light microscopy and scanning electron microscopy, to evaluate their taxonomic significance. Piperales possessed both amphistomatic and hypostomatic leaves. The epidermal area ranged from 38 to 5077 μm2, and the stomatal area ra...
Article
Full-text available
Herbal medicines have been traditionally used a lot in Northeast Asia, e.g., South and North Korea, China, Japan, and Taiwan. In particular, various rosaceous plants are widely used for medicinal purposes among countries. However, the original rosaceous species, which are registered in pharmacopoeia standards, are sometimes different and confuse. I...
Article
Full-text available
Cynanchum L. in the subfamily Asclepiadoideae (Apocynaceae) includes four recognized species on the Korean peninsula, two of which are native to South Korea. However, the species ranges in South Korea are poorly defined. During a field survey, we discovered C. thesioides, previously unrecorded in South Korea, in Gimpo-si, Gyeonggi-do, and found an...
Article
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The purpose of this investigation is to analyze for the Korean patent application trends of health functional foods based on the medicinal plant resources. An electronic search for health functional foods was conducted in WIPSON DB (https://www.wipson.com). Korean patents that were registered between January 1, 2008, and October 14, 2019, were sele...
Article
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Trichosanthes is a genus in Cucurbitaceae comprising 90–100 species. Trichosanthes species are valuable as herbaceous medicinal ingredients. The fruits, seeds, and roots of species such as T. kirilowii and T. rosthornii are used in Korean traditional herbal medicines. T. rosthornii is only found in China, whereas in South Korea two varieties, T. ki...
Article
Full-text available
Disporum sessile roots are used as a medicinal herb. To ensure the accurate identification of D. sessile, we sequenced its chloroplast genome using the Illumina MiSeq platform. Results showed that the chloroplast genome of D. sessile is 159,102 bp in size, with a large single-copy (LSC) region (85,456 bp), a small single-copy (SSC) region (17,108 b...
Article
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Background: Scrophularia buergeriana Miq. (Scrophulariaceae) (SB) has been used as an oriental medicine for the treatment of inflammatory diseases, such as neuritis and pharyngolaryngitis. Purpose: We explored the therapeutic effects of S. buergeriana ethanol extract (SBE) on airway inflammation in ovalbumin (OVA)-induced asthmatic mice and lipo...
Article
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Objective : Arnebiae Radix, the roots of Arnebia euchroma (Royle) Johnst. or A. guttata Bunge, is a well-known traditional herbal medicine in East Asia. In the Korean Pharmacopoeia, three authentic species, including two Arnebia and Lithospermum erythrorhizon Sieb. et Zucc. have recognized as a Lithospermi Radix. But, the morphological and taxonomi...
Article
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Scanning electron microscope/energy-dispersive X-ray spectroscopy (SEM/EDX) is a rapid, non-destructive, and multi-elemental analytical technique used for the elemental analysis and chemical characterization of the selected surface of the sample. In this study, the elemental concentration ratios of four cicada's exuviae including Cicadidae Periostr...
Article
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Previous studies have suggested that exuviae can be used for the identification of cicada species, but the precise characteristics that differ among species have not been determined. Thus, we performed the first comparative analyses of the leg morphology, ultrastructure, and mitochondrial DNA sequences of exuviae of four dominant cicada species in...
Article
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Achyranthes bidentata Blume is an important herbal medicine. However, little genetic information about Achyranthes is available. To facilitate species identification, we sequenced its complete chloroplast genome using the Illumina MiSeq platform. The data show that the chloroplast genome of A. bidentata is 151,441 bp in size and comprises an 83,890...
Article
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The genus Cuscuta (Convolvulaceae) comprises well-known parasitic plants. Cuscuta species are scientifically valuable, as their life style causes extensive crop damage. Furthermore, dried seeds of C. chinensis are used as a Korean traditional herbal medicine. Despite the importance of Cuscuta species, it is difficult to distinguish these plants by...
Article
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Cicadidae Periostracum, the exuviae of Cryptotympana atrata (Fabricius, 1775), is well-known traditional medicine in Korea. The present study aims to describe in detail by using stereoscope and scanning electron microscope for discriminating authentic of Cicadidae Periostracum in the markets. Moreover, we present here the morphological differences...
Article
Both the contents of fatty acids and the ratios of unsaturated to saturated fatty acids are important parameters for determining the nutritional values of oils. Thus, we herein evaluated the fatty acids present in the seed oils of Lepidium apetalum Willdenow, Descurainia sophia (L.) Webb ex Prantl, and Draba nemorosa L. as sources of Lepidii seu De...
Article
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The genus Angelica (Apiaceae) comprises valuable herbal medicines. In this study, we determined the complete chloroplast (CP) genome sequence of A. polymorpha and compared it with that of Ligusticum officinale (GenBank accession no. NC039760). The CP genomes of A. polymorpha and L. officinale were 148,430 and 147,127 bp in length, respectively, wit...
Article
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Lepidii seu Descurainiae Semen, the dried ripe seeds of Descurainia sophia (L.) Webb ex Prantl or Lepidium apetalum Willd., is used widely as a traditional herbal medicine in Northeast Asia. However, seeds of a number of other species have been misidentified as Lepidii seu Descurainiae Semen, and are therefore misused because of morphological simil...
Article
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BACKGROUND To ensure the safety, quality, and therapeutic efficacy of processed foods and herbal medicines, it is important to identify and discriminate economically motivated adulterants. Z. schinifolium is sold at a higher price than other Zanthoxylum species and frequently adulterated with closely related Zanthoxylum species because of its high...
Article
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The accurate identification of plant species is of great concern for the quality control of herbal medicines. The Korean Pharmacopoeia and the Pharmacopoeia of the People's Republic of China define Angelicae Dahuricae Radix (Baek-Ji in Korean and Bai-zhi in Chinese) as the dried roots of Angelica dahurica or A. dahurica var. formosana belonging to...
Article
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Objectives : Pharbitidis Semen, the seeds of Ipomoea nil (L.) Roth or I. purpurea (L.) Roth, is well-known traditional herbal medicine in Korea. But it is often marketed as a different seed or mixtures of its closely related species. Thus, the present study aims to provide external and micromorphological characters and identification key by using s...
Article
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Dried roots of Dipsacus asper (Caprifoliaceae) are used as important traditional herbal medicines in Korea. However, the roots are often used as a mixture or contaminated with Dipsacus japonicus in Korean herbal markets. Furthermore, the dried roots of Phlomoides umbrosa (Lamiaceae) are used indiscriminately with those of D. asper, with the confusi...
Article
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Ipomoea L. is the largest genus within the Convolvulaceae and contains 600–700 species. Ipomoea species (morning glories) are economically valuable as horticultural species and scientifically valuable as ecological model plants to investigate mating systems, molecular evolution, and both plant–herbivore and plant–parasite interactions. Furthermore,...
Article
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Cnidium officinale (Ligusticum officinale) is an important herbal medicine. To facilitate species identification, we determined the complete chloroplast genome of C. officinale using the Illumina MiSeq platform. The genome was 148,518 bp in length, comprising a large single copy (LSC) region of 93,977 bp, a small single copy (SSC) region of 17,607...