Sung Won Kim

Grains are the most important food consumed globally, yet their yield can be severely impacted by pest infestations. Addressing this issue, scientists and researchers strive to enhance the yield-to-seed ratio through effective pest detection methods. Traditional approaches often rely on preprocessed datasets, but there is a growing need for solutio...

When the trachea is excessively damaged because of diseases, accidents, or surgery, it is difficult to achieve both mucosal reconstruction and structural stability using current technologies. Here, a biomimetic tracheal graft (BTG) is developed through a hybrid process of 3D printing and electrospinning using polycaprolactone (PCL)polymer. First, a...

Background and Objectives: Endothelial cells are essential to various therapeutic strategies for cardiovascular diseases. Developing efficient methods to generate large quantities of well-defined endothelial cells could improve cardiovascular treatment. This study explored the impact of lab-on-a-chip technology on the endothelial differentiation po...

Vehicular Internet of Things (V-IoT) systems will be critical in advancing intelligent transportation networks because of the easy communication they make possible between vehicles, roadside infrastructure, and other network entities. Integrating adaptive IoT-based communication models will increase resource utilization and allow multiple communica...

Uncrewed Aerial Vehicles (UAVs) are frequently utilized in several domains such as transportation, distribution, monitoring, and aviation. A significant security vulnerability is the Global Positioning System (GPS) Spoofing attack, wherein the assailant deceives the GPS receiver by transmitting counterfeit signals, thereby gaining control of the UA...

Mild head trauma often leads to long-term cognitive and neurological deficits. PLX3397, an inhibitor of colony-stimulating factor 1 receptor (CSF1R), offers promise as a therapeutic agent for traumatic brain injury (TBI) by targeting neuro-inflammation. Stem cell-based approaches are widely studied for neurological disorders. The objective of this...

This study aimed to investigate the therapeutic effect of human nasal turbinate-derived stem cells (hNTSCs) on mice with rheumatoid arthritis (RA) and identify hNTSC gene signatures with therapeutic effects on RA. hNTSCs were obtained from 20 healthy controls (HCs) who had undergone nasal turbinate surgery. Collagen-induced arthritis (CIA) mice wer...

The mainstream adoption of Internet of Things (IoT) devices for health and lifestyle tracking has revolutionized health monitoring systems. Sixth-generation (6G) cellular networks enable IoT healthcare services to reduce the pressures on already resource-constrained facilities, leveraging enhanced ultra-reliable low-latency communication (eURLLC) t...

Background Endoscopic endonasal transsphenoidal surgery is widely used to resect pituitary adenomas, yet its impact on olfactory function after resection of the posterosuperior nasal septum remains a concern. To optimize surgical techniques to preserve olfactory function, it is essential to understand the relationship between the extent of septal r...

Background and Objectives: Current craniofacial reconstruction surgical methods have limitations because they involve facial deformation. The craniofacial region includes many areas where the mucosa, exposed to air, is closely adjacent to bone, with the maxilla being a prominent example of this structure. Therefore, this study explored whether huma...

Background and Objectives: This study aimed to investigate the influence of a respiratory mucosa-on-a-chip on the respiratory epithelial differentiation potential of human nasal inferior turbinate-derived stem cells (hNTSCs). Materials and Methods: After isolating hNTSCs from five patients, we divided the samples from the patients into the study gr...

Every year, about 1.19 million people are killed in traffic accidents; hence, the United Nations has a goal of halving the number of road traffic deaths and injuries by 2030. In line with this objective, technological innovations in telecommunication, particularly brought about by the rise of 5G networks, have contributed to the development of mode...

Background and Objectives: Empty nose syndrome (ENS) is a debilitating condition that often results from traumatic or iatrogenic causes, such as nasal surgery. There are various conservative and surgical treatments for ENS, but their effectiveness remains uncertain. Therefore, the development of animal models that accurately mimic human ENS is esse...

The cyclic adenosine monophosphate (cAMP) cascade is thought to play an important role in regulating alcohol-dependent behaviors, with potentially opposite effects following acute versus chronic administration. Phosphodiesterase 4 (PDE4) is the primary brain enzyme that metabolizes cAMP, thereby terminating its signal. Radioligand binding to PDE4 s...

This study proposed an optimized histogel construction method for histological analysis by applying lung cancer patient-derived organoids (PDOs) to the developed histo-pillar strip. Previously, there is the cultured PDOs damage problem during the histogel construction due to forced detachment of the Matrigel spots from the 96-well plate bottom. To...

Background: Accurate identification of eosinophilic chronic rhinosinusitis is essentialg because its treatment and prognosis substantially differ from other subtypes. Methods: This retrospective observational study included 640 patients who underwent endoscopic sinus surgery for chronic rhinosinusitis in a single tertiary center from January 202...

C]Carfentanil ([¹¹C]CFN) is the only selective carbon-11 labeled radiotracer currently available for positron emission tomography (PET) imaging of mu opioid receptors (MORs). Though used extensively in clinical research, [¹¹C]CFN has not been thoroughly characterized as a tool for preclinical PET imaging. As we were occasionally observing severe vi...

Objectives: Patients with empty nose syndrome usually suffer from paradoxical nasal congestion, nasal dryness, epistaxis and suffocation. Conservative management is general option for the empty nose syndrome. However, there are several patients who continually complain of symptoms. If symptoms persist, surgical options are considered. Therefore, w...

Pyroptosis represents a type of cell death mechanism notable for its cell membrane disruption and the subsequent release of proinflammatory cytokines. The Nod-like receptor family pyrin domain containing inflammasome 3 (NLRP3) plays a critical role in the pyroptosis mechanism associated with various diseases resulting from particulate matter (PM) e...

Secondary atrophic rhinitis (AR), a consequence of mucosal damage during nasal surgeries, significantly impairs patient quality of life. The lack of effective, lasting treatments underscores the need for alternative therapeutic strategies. A major impediment in advancing research is the scarcity of studies focused on secondary AR. Our study address...

Patient-derived organoids (PDOs) are valuable in predicting response to cancer therapy. PDOs are ideal models for precision oncologists. However, their practical application in guiding timely clinical decisions remains challenging. This study focused on patients with advanced EGFR-mutated non-small cell lung cancer and employed a cancer organoid-ba...

Purpose This study investigated the impact of aeroallergens on the development and progression of chronic rhinosinusitis (CRS), with a focus on the specific associations between aeroallergens and CRS according to allergen type, number, and extent of sensitization. Methods The medical records of 256 CRS patients were retrospectively analyzed. All w...

Objectives This study aimed to determine the efficacy of hypoglossal nerve stimulation (HGS) in the treatment of obstructive sleep apnea. Data Sources PubMed, Cochrane database, Embase, Web of Science, SCOPUS, and Google Scholar. Review Methods Five databases were reviewed to identify relevant studies that measured polysomnography parameters such...

Objectives This study assessed the impact of cryoablation of the posterior nasal nerve on symptoms of rhinitis in individuals with allergic rhinitis (AR) and non‐allergic rhinitis (NAR). Data Sources PubMed, SCOPUS, Embase, Web of Science, and Cochrane databases for studies published up to June 2023. Review Methods Studies that evaluated the qual...

Background: Recently, cancer organoid-based drug sensitivity tests have been studied to predict patient responses to anticancer drugs. The area under curve (AUC) or IC50 value of the dose-response curve (DRC) is used to differentiate between sensitive and resistant patient's groups. This study proposes a multi-parameter analysis method (cancer org...

Objective We investigated the anatomical and dental factors associated with unilateral maxillary sinus fungal ball (MSFB). Also, we evaluated the effect of combinations of those factors on the incidence of MSFB. Methods Three hundred patients were divided into MSFB, normal, and chronic rhinosinusitis (CRS) groups. We reviewed paranasal computed to...

Objective s To conduct a systematic review and meta‐analysis of published articles to assess the impact of inferior turbinate/meatus augmentation in patients diagnosed with empty nose syndrome (ENS). Data Sources PubMed, Cochrane database, Embase, Web of Science, SCOPUS, and Google Scholar. Review Methods Six databases were searched to December 2...

This study investigated the influence of hypoxic culture conditions on human nasal inferior turbinate-derived stem cells (hNTSCs), a subtype of mesenchymal stem cells (MSCs). It aimed to discern how hypoxia affected hNTSC characteristics, proliferation, and differentiation potential compared to hNTSCs cultured under normal oxygen levels. After obta...

Purpose This systematic review and meta-analysis evaluates the effect of TRNP on rhinitis-related symptoms. Methods We reviewed studies retrieved from PubMed, SCOPUS, Embase, the Web of Science, and the Cochrane database to June 2023. Studies that evaluated quality-of-life and rhinitis-related symptom scores before and after treatment were analyze...

Background and Objectives: Through a comprehensive meta-analysis of the pertinent literature, this study evaluated the utility and efficacy of perioperative infraorbital and/or infratrochlear nerve blocks in reducing postoperative pain and related morbidities in patients undergoing septorhinoplasty. Materials and Methods: We reviewed studies retrie...

Continuous positive airway pressure (CPAP) is the primary therapeutic modality for obstructive sleep apnea (OSA) management. However, despite efforts to encourage patients to comply with CPAP usage, long-term adherence remains low. Consequently, surgical intervention for OSA is considered a secondary option for patients who exhibit non-compliance w...

Objectives To evaluate the association between statin use and chronic rhinosinusitis (CRS). Design and Setting Systematic review and meta‐analysis. The methodological quality of studies was assessed using the Newcastle–Ottawa scale. Participants Patients with CRS. Main Outcome Measures Pooled odds ratios (ORs) with 95% confidence interval (CIs)...

Background: Organoids are self-organized three-dimensional culture systems and have the advantages of both in vitro and in vivo experiments. However, each organoid has a different degree of self-organization, and methods such as immunofluorescence staining are required for confirmation. Therefore, we established a system to select organoids with h...

Background and Objectives: We compared pain levels, cardiovascular parameters, and complications according to whether patients underwent nasal packing with non-absorbable or biodegradable materials.Methods: Patients who underwent septoplasty from May 2015 to April 2020 were retrospectively reviewed. Numeric rating scale (NRS) scores for pain, blood...

Objectives We compared the lengths of a nasoseptal flap (NSF) and skull base according to race, age, and sex. Methods We performed paranasal sinus computed tomography in 19,961 adult patients between 2003 and 2022. The race of the patients was East Asian (n = 71), Caucasian (n = 71), or Middle Eastern (n = 71). The expected lengths of the NSF and...

Background and Objectives: This study was performed to investigate the utility of high-resolution computed tomography (HRCT) for the initial localization of cerebrospinal fluid rhinorrhea. Methods: HRCT data regarding the point of cerebrospinal fluid leakage (as confirmed in the operating room), collected up to December 2022, were extracted from fi...

Objectives: Minimally invasive and remote surgical approaches for thyroid tumors have been developed primarily for cosmetic benefit. However, conventional meta-analysis could not provide comparative data between new techniques. This network meta-analysis would be able to provide data for clinicians and patients to compare cosmetic satisfaction and...

Objectives We assessed the effect of tranexamic acid on postoperative bleeding, and any adverse effects, in patients undergoing head-and-neck surgery. Methods We searched databases (PubMed, SCOPUS, Embase, the Web of Science, Google Scholar, and the Cochrane database) from their dates of inception to August 31, 2021. We analyzed studies that compa...

Objective: To assess the prognostic utilities of various risk factors for laryngeal squamous cell carcinoma. Methods: Six databases were searched to January 2022. Hazard ratios for overall survival and disease-free survival were collected and study characteristics were recorded. The risk of bias was evaluated using the Newcastle–Ottawa scale. Resul...

Objectives: To compare the effect of steroid-impregnated spacers to conventional management after endoscopic sinus surgery (ESS) in patients with chronic rhinosinusitis (CRS). Methods: Six databases were searched from inception until November 2022. Sixteen studies were found that compared the improvement of chronic sinusitis-related symptoms and...

Background: Risk stratification systems for evaluating thyroid nodules on ultrasound use varying approaches to classify levels of suspicion for malignancy, leading to variable performance. Objective: To perform a network meta-analysis comparing the diagnostic performance for detection of thyroid cancer of six risk stratification systems used to eva...

Objectives: We assessed the pain control efficacies and associated morbidities of drugs administered locally (around the tonsils) in pediatric patients undergoing a tonsillectomy. Methods: Randomized controlled trials up to April 2022 were retrieved from six databases. The treatment networks featured six interventions (ropivacaine, bupivacaine,...

Device to Device (D2D) communication is expected to be an essential part of 5G cellular networks. D2D communication enables close-proximity devices to establish a direct communication session. D2D communication offers many advantages, such as reduced latency, high data rates, range extension, and cellular offloading. The first step to establishing...

Background: There have been reports investigating the use of olfactory training in olfactory dysfunction after COVID-19. Objective: We evaluated the effect of olfactory training on the olfactory dysfunction of patients infected with COVID-19. Methods: We searched PubMed, EMBASE, the Web of Science, the Cochrane database, SCOPUS, and Google Sch...

Objectives: We assessed the effects and safety of endoscopic septoplasty in patients with nasal septal deviations (NSD), compared with those of conventional septoplasty. Design and setting: Systematic review and meta-analysis. Participants: Patients who have undergone various endoscopic septoplasty procedure, such as hemitransfixion incision,...

Adult stem cell-based therapeutic approaches have great potential in regenerative medicine because of their immunoregulatory properties and multidifferentiation capacity. Nevertheless, the outcomes of stem cell‑based therapies to date have shown inconsistent efficacy owing to donor variation, thwarting the expectation of clinical effects. However,...

Background Cells in the human body experience different growth environments and conditions, such as compressive pressure and oxygen concentrations, depending on the type and location of the tissue. Thus, a culture device that emulates the environment inside the body is required to study cells outside the body. Methods A blanket-type cell culture d...

International mobile union (IMU) present new verticals for IMT‐2030 paradigm. The Beyond‐5G (B5G) is expected to support IMT‐2030 communication paradigm. The 3rd generation partnership project (3GPP) introduced narrowband internet‐of‐thing (NB‐IoT), a low power wide are (LPWA) technology to support ultra‐massive machine type communication (umMTC) w...

To enable massive-scale connectivity with low latency and efficient resource usage for massive machine type communications, the grant free access scheme has been proposed, which allows users to communicate with low signaling overhead and without the need for any prior resource allocation procedure. Due to the sporadic nature of packet transmission...

Non-invasive diagnostic tools that facilitate visualization of potentially malignant oral lesions and cancers have been introduced. Oral lesions detected by optical coherence tomography (OCT) were compared to reference results based on histological findings. The diagnostic odds ratio (DOR), along with summary receiver operating characteristic curve...

Mesenchymal stem cells (MSCs) are increasingly used as regenerative therapies for patients in the preclinical and clinical phases of various diseases. However, the main limitations of such therapies include functional heterogeneity and the lack of appropriate quality control (QC) methods for functional screening of MSC lines; thus, clinical outcome...

Background and Objectives: Understanding the anatomical variation in the sphenoid sinus is important to fully expose the sellar floor and clivus. Materials and Methods: The Onodi cell and intersphenoid sinus septation based on preoperative paranasal sinus computed tomography (PNS CT) and the surgical records of 877 patients who underwent the endosc...

Background: To assess the diagnostic utility of middle meatal culture (MMC) in patients with acute and chronic sinusitis; Methods: Six databases were thoroughly reviewed up to March 2022. Sensitivity, specificity, and negative and positive predictive values were extracted. Methodological quality was evaluated using the QUADAS-2 instrument; Results...

Objectives The authors applied surgical techniques acquired during the use of endoscopic combined transseptal/transnasal approach to reduce approach-related morbidity and improve sinonasal outcomes. Study Design This is a retrospective cohort study of a prospectively collected database. Setting The study setting involves a tertiary referral center....

As one of the nine subtypes of adrenergic receptors (ARs) in the brain, α2C-ARs play essential roles in emotion and memory, and are implicated in neuropsychiatric disorders, including depression, Alzheimer's disease, substance use disorder, and schizophrenia. A recently developed α2C-AR specific positron emission tomography (PET) radiotracer, [¹¹C]...

Objective We explored the clinical significances of the relationships among sphenoid sinus aeration, intersphenoid sinus septum (ISS), and internal carotid artery (ICA). Methods We retrospectively reviewed the preoperative paranasal sinus computed tomography scans and the medical charts of 490 patients who were treated by the endoscopic endonasal...

Investigating prior methodologies, it has come to our knowledge that in smart cities, a disaster management system needs an autonomous reasoning mechanism to efficiently enhance the situation awareness of disaster sites and reduce its after-effects. Disasters are unavoidable events that occur at anytime and anywhere. Timely response to hazardous si...

Background and Objectives: YouTube is a widely used web site. In general, many people search for medical information on YouTube. We evaluated the septoplasty and turbinoplasty videos on YouTube from an expert’s point of view.Methods: We used “septoplasty,” “turbinoplasty,” and “septoplasty turbinoplasty” to search YouTube. Of the 150 videos, we eve...

Amyloid-β (Aβ)-peptide production or deposition in the neuropathology of Alzheimer’s disease (AD) was shown to be caused by chronic inflammation that may be induced by infection, but the role of pathogenic-bacteria-related AD-associated Aβ is not yet clearly understood. In this study, we validated the hypothesis that there is a correlation between...

The major cause of the increasing world mortality rate is cardiovascular disease (CVD), killing 17.9 million people annually. Current techniques are costly, challenging to operate on, and an expert is needed to confirm the diagnosis results. Phonocardiogram (PCG) signals are heart sound recordings of heart rhythms and have many advantages over trad...

Objectives: To assess the predictive value of various risk factors for pharyngocutaneous fistula (PCF) after total laryngectomy. Methods: The characteristics of each study were collected from six databases up to January of 2022. Risk for bias was assessed using the QUADAS-2 tool. Results: A total of 58 studies in 9845 patients were included in...

A great deal of research has focused on small‐scale robots for biomedical applications and minimally invasive delivery of therapeutics (e.g., cells, drugs, and genes) to a target area. Conventional fabrication methods, such as two‐photon polymerization, can be used to build sophisticated micro‐ and nanorobots, but the long fabrication cycle for a s...

Objectives To assess the diagnostic utility of smartphone-based measurement in detecting moderate to severe obstructive sleep apnea syndrome (OSAS). Methods Six databases were thoroughly reviewed. Random-effect models were used to estimate the summary sensitivity, specificity, negative predictive value, positive predictive value, diagnostic odds r...

In this paper, we propose an agent-based approach for the evaluation of Multiple Unmanned Autonomous Vehicle (MUAV) wildfire monitoring systems for remote and hard-to-reach areas. Emerging environmental factors are causing a higher number of wildfires and keeping these fires in check is becoming a global challenge. MUAV deployment for the monitorin...

The continuous rise in opioid overdoses in the United States is predominantly driven by very potent synthetic opioids, mostly fentanyl and its derivatives (fentanyls). Although naloxone (NLX) has been shown to effectively reverse overdoses by conventional opioids, there may be a need for higher or repeated doses of NLX to revert overdoses from high...

Impressive technological advancements over the past decades commenced significant advantages in the maritime industry sector and elevated commercial, operational, and financial benefits. However, technological development introduces several novel risks that pose serious and potential threats to the maritime industry and considerably impact the mari...

Objectives: The aim of this study was to evaluate the differences in clinical and laboratory features between eosinophilic chronic rhinosinusitis (ECRS) and non-ECRS and to compare diagnostic criteria for ECRS. Methods: We compared clinical features and/or laboratory findings classified as ECRS and non-ECRS according to various diagnostic criter...

Purpose To investigate the long-term safety and efficacy of a 3D-printed bioresorbable polycaprolactone (PCL) nasal implant for nasal septal deformity reconstruction. Methods Fourteen patients who had undergone nasal septum reconstruction surgery using 3D-printed PCL nasal septal implants were enrolled. The primary outcome was the change in total...

Purpose To investigate the effects of nasal surgery including endoscopic sinus surgery (ESS) and/or septoplasty on Eustachian tube dysfunction (ETD) symptoms using the Eustachian Tube Dysfunction Questionnaire 7 (ETDQ-7). Methods Patients who underwent ESS and/or septoplasty between April 2020 and October 2021 were retrospective reviewed. The pati...

The aim of this study was to validate the use of human brain organoids (hBOs) to investigate the therapeutic potential and mechanism of human-neural-crest-derived nasal turbinate stem cells (hNTSCs) in models of Alzheimer’s disease (AD). We generated hBOs from human induced pluripotent stem cells, investigated their characteristics according to neu...

PurposeTo evaluate the diagnostic accuracy of near-infrared autofluorescence-based identification in the identification of parathyroid glands during thyroidectomy or parathyroidectomy.Methods The clinical studies were retrieved from PubMed, the Cochrane Central Register of Controlled Trials, Embase, Web of Science, SCOPUS, and Google Scholar. The s...

Objectives: To assess the effect of topical steroids on acute-onset olfactory dysfunction in patients infected with COVID-19. Design and setting: Systematic review and meta-analysis of cohort studies. Participants: Patients infected with COVID-19. Main outcome measures: PubMed, Embase, the Web of Science, SCOPUS, Cochrane database, and Googl...

The rapid increase in heterogeneous data traffic with the ongoing development of self-organizing and self-sustaining networks exposes the limitations of the fifth generation (5G) system, which was originally aimed at enabling the realization of the Internet of Everything. This study presents flexible design agreements of beyond 5G (B5G) from the cu...

Cardiac diseases constitute a major root of global mortality and they are likely to persist. Electrocardiogram (ECG) is widely opted in clinics to detect countless heart illnesses. Numerous artifacts interfere with the ECG signal, and their elimination is vital to allow medical specialists to acquire valuable statistics from the ECG. The utmost art...

Objectives: We estimated volume changes in the posterior bony wall of the sphenoid sinus, as well as alterations in nasal function (including olfactory function and subjective symptoms), after sphenoid mucosal repositioning using the endoscopic endonasal transsphenoidal approach (EETSA). Methods: During 2010 and 2021, 13 patients underwent sphen...

Objectives: We hypothesized that ultrasonography for salivary gland stone detection would have a diagnostic accuracy similar to that confirmed by sialendoscopy, sialography, or surgery. Therefore, we evaluated the diagnostic characteristics of ultrasonography in terms of submandibular and parotid stone detection compared to confirmatory methods....

Background Recent studies have attempted to verify the predictive capability of the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) for cervical necrotizing fasciitis (CNF). Methods The two authors independently reviewed six databases (PubMed, Cochrane, Embase, Web of Science, SCOPUS and Google Scholar databases were searched). Seven...