Sung Hyun Kim

Asan Medical Center | AMC · Department of Ophthalmology

Recently, high-rise residential buildings in Korea have adopted slender shear walls with irregular section shapes, such as T-shape, H-shape, and C-shape. In the seismic design of the slender shear walls, the transverse reinforcement for lateral confinement should be provided in the boundary elements to increase deformation capacity and subsequent d...

This paper focuses on addressing the local stabilization and disturbance attenuation problems arising in the IT-2 T-S fuzzy control system within a limited operating region, by introducing an improved adaptive memory-based event-triggered mechanism (AMETM). In contrast to recent works, the proposed method eliminates the necessity for the previous i...

CT‐P13, a biosimilar of infliximab, is used to treat inflammatory diseases that arise from immune system complications, resulting in excessive and persistent inflammation. The subcutaneous (SC) formulation of CT‐P13 overcomes the drawback of prolonged administration associated with the intravenous (IV) infliximab biosimilar, necessitating autoinjec...

Purpose: Several studies have evaluated the impact of sarcopenic obesity (SO) on postoperative complications, including postoperative pancreatic fistula (POPF), in patients undergoing pancreatoduodenectomy (PD). Previous studies have shown that SO increases POPF, but it remains unclear whether SO increases postoperative complications. In this stud...

At the core of molecular biology lies the intricate interplay between sequence, structure, and function. Single-molecule techniques provide in-depth dynamic insights into structure and function, but laborious assays impede functional screening of large sequence libraries. We introduce high-throughput Single-molecule Parallel Analysis for Rapid eXpl...

Background Sarcomatoid change is rarely seen in epithelial malignancy that can be observed in diverse organs. Although a sarcomatoid change in combined hepatocellular-cholangiocarcinoma (cHCC-CC) is assumed to be a poor prognostic factor, this issue has not been studied due to its rare incidence. In this study, we aimed to identify the oncological...

PURPOSE To explore the predictive potential of serial computed tomography (CT) radiology reports for pancreatic cancer survival using natural language processing (NLP). METHODS Deep-transfer-learning–based NLP models were retrospectively trained and tested with serial, free-text CT reports, and survival information of consecutive patients diagnose...

This paper presents a novel method for designing event-triggered dissipative observer-based control for discrete-time Takagi-Sugeno fuzzy singular systems, addressing admissibility, dissipativity, observer-based control, and event-triggered data challenges simultaneously. The distinctive strength of our method lies in its one-step design framework,...

Understanding the structure of biomolecules is vital for deciphering their roles in biological systems. Single-molecule techniques have emerged as alternatives to conventional ensemble structure analysis methods for uncovering new biology in molecular dynamics and interaction studies, yet only limited structural information could be obtained experi...

A bstract We study the expected sensitivity to the mixing between sterile and tau neutrinos directly from the tau neutrino disappearance in the high-energy fixed target experiment. Here, the beam energy is large enough to produce tau neutrinos at the target with large luminosity. During their propagation to the detector, tau neutrinos may oscillate...

Background Sleep has been known to affect childhood development. Sleep disturbance is likely more common in children with developmental delay (DD) than in typical development. There are few studies on the correlation between sleep disturbance and developmental features in children with DD. Therefore, this study aimed to evaluate the associations be...

Background: An evaluation of the persistence of symptoms following COVID-19 in economically active young and middle-aged adults is crucial due to its significant socioeconomic impact resulting from compromised work performance. Methods: A prospective, multicenter study at 12 South Korean hospitals from January to December 2022 involved telephone in...

Background Pancreatic neuroendocrine tumors (PNETs) represent 1–2% of pancreatic tumors, with recent guidelines recommending active surveillance for non-functioning PNETs (NF-PNETs) smaller than 2 cm. However, the management of multiple NF-PNETs, as well as the influence of tumor number on prognosis, remains under-researched. Methods This retrospe...

Background: The trastuzumab biosimilar CT-P6 is approved for human epidermal growth factor receptor 2 (HER2)-positive early breast cancer (EBC), metastatic breast cancer (MBC), and metastatic gastric cancer (MGC). The objective of this post-marketing surveillance (PMS) study was to evaluate the real-world safety and effectiveness of CT-P6 in patie...

Simple Summary Our study aimed to compare the operative and survival outcomes between radical antegrade modular pancreatosplenectomy (RAMPS) and conventional distal pancreatosplenctomy (cDPS), and identify prognostic factors for left-sided pancreatic cancer. We performed a retrospective propensity score match (PSM) analysis from 333 patients who un...

Background Several guidelines exist for minimally invasive pancreatoduodenectomy (MIPD) regarding its prerequisites and learning curve. However, these guidelines are based on the experience of the pioneers of MIPD; minimal data exist on the experience of the next generation of surgeons. The aim of this study was to compare the two surgeon types (ve...

Pelvic malalignment leads to general imbalance and adversely affects leg length. Timely and accurate diagnosis of pelvic alignment in patients is crucial to prevent additional complications arising from delayed treatment. Currently, doctors typically assess pelvic alignment either manually or through radiography. This study aimed to develop and ass...

(1) Background: The aim of this study was to compare the survival benefit of radical ante-grade-modular pancreato-splenectomy (RAMPS) with conventional distal pancreato-splenectomy (cDPS) in left-sided pancreatic cancer. (2) Methods: A retrospective propensity score matching (PSM) analysis was conducted on 333 patients who underwent RAMPS or cDPS f...

Proteins are the primary functional actors of the cell. While proteoform diversity is known to be highly biologically relevant, current protein analysis methods are of limited use for distinguishing proteoforms. Mass spectrometric methods, in particular, often provide only ambiguous information on post-translational modification sites, and sequence...

Accurate localization and delivery of biomolecules is pivotal for building tools to understand biology. The interactions of biomolecules with atomically flat 2D surfaces offer a means to realize both the localization and delivery, yet experimental utilization of such interactions has remained elusive. By combining single-molecule detection methods...

INTRODUCTION CT-P13 subcutaneous (SC) infliximab formulation demonstrated superiority over placebo in maintenance therapy in Crohn's disease (CD) and Ulcerative Colitis (UC) patients in two parallel 54 weeks studies (LIBERTY-CD and LIBERTY-UC). We performed a post-hoc subgroup analysis comparing patients treated with CT-P13 SC with and without comb...

INTRODUCTION Dose escalation of IV infliximab is an option for inflammatory bowel disease (IBD) patients who lose response after induction therapy. However, as yet, there is limited data for CT-P13 subcutaneous (SC) infliximab (CT-P13 SC) dose escalation in IBD patients. AIMS & METHODS The aim of the post hoc analysis was to evaluate the efficacy,...

Background Parthanatos represents a critical molecular aspect of Parkinson's disease, wherein AIMP2 aberrantly activates PARP-1 through direct physical interaction. Although AIMP2 ought to be a therapeutic target for the disease, regrettably, it is deemed undruggable due to its non-enzymatic nature and predominant localization within the tRNA synth...

Photovoltaic (PV) technology enables the conversion of solar energy into electricity. Si-based PV modules, which currently represent more than 90% of the global PV market, are expected to be in...

This paper focuses on addressing the problem of reference tracking control for dual-active bridge DC–DC converters through a combination of sampled-data and linear parameter varying (LPV) control approaches. For this purpose, we formulate an error state-space model for dual-active bridge DC–DC converters as an LPV system with input saturation and s...

Background Alzheimer’s disease (AD), a common form of dementia, is caused in part by the aggregation and accumulation in the brain of amyloid ß (Aß), a product of the proteolytic cleavage of amyloid precursor protein (APP) in endosomes. Trafficking of APP, such as surface‐intracellular recycling, is an early critical step required for Aβ generation...

Background Commercial anti-CD19 chimeric antigen receptor T-cell therapies (CART19) are efficacious against advanced B-cell non-Hodgkin lymphoma (NHL); however, most patients ultimately relapse. Several mechanisms contribute to this failure, including CD19-negative escape and CAR T dysfunction. All four commercial CART19 products utilize the FMC63...

Molecularly imprinted polymers (MIPs) have garnered significant attention as a promising material for engineering specific biological receptors with superior chemical complementarity to target molecules. In this study, we present an electrochemical biosensing platform incorporating MIP films for the selective detection of the interleukin-1β (IL-1β)...

Noninvasive ultrasonic inspection of sludge accumulated inside fluid-flow pipes is important to avoid a catastrophic pipeline failure. Although an earlier ultrasonic inspection method is applicable to both metal and plastic pipes, it can be applied only when the height of the accumulated sludge inside a plastic pipe is larger than about 1/5 of the...

Background In the 8th edition of the American Joint Committee on Cancer, the nodal staging of intrahepatic cholangiocarcinoma (ICC) is classified as N0 and N1 in accordance with lymph node (LN) metastases. Recently, several studies have reported that the number of metastatic LNs is associated with prognosis in patients with ICC. However, the majori...

Background Long-term oxygen therapy (LTOT) improves the survival of patients with hypoxemia due to chronic respiratory diseases. The clinical outcomes of LTOT are strongly associated with patient adherence. To improve the adherence of patients, physicians have focused on the efficacy of LTOT. However, poor adherence may stem from patients’ percepti...

Background Sleep has been known to affect childhood development. Sleep disturbance is likely to be more common in children with developmental delay (DD) than in children with normal development. There are few studies on the correlation between sleep disturbance and developmental aspects in children with DD. Therefore, this study aimed to evaluate t...

This paper investigates the local stability and stabilization criteria of sampled-data control systems, taking into account actuator saturation and peak-bounded exogenous disturbances. Specifically, this study introduces two innovations to extend the maximum upper bound of the sampling interval: two novel time integrals of the weighted state deriva...

Accurate localization of biomolecules is pivotal for understanding biological processes. Utilizing the atomically flat surface of 2D materials offers a promising route to achieve this without the need for tethering or constraining. Here we comprehensively investigate the binding and diffusion of DNA on hexagonal boron nitride (hBN) surfaces. Our fi...

Hybridizing single‐walled carbon nanotubes (SWCNTs) with π‐conjugated organic small molecules (π‐OSMs) offers a promising approach for producing high‐performance thermoelectric (TE) materials through the facile optimization of the molecular geometry and energy levels of π‐OSMs. Designing a twisted molecular structure for the π‐OSM with the highest...

Understanding the structure of biomolecules is vital for deciphering their characteristics and roles in biological systems. While current structural analysis techniques like nuclear magnetic resonance and X-ray crystallography excel in many aspects, they fall short in capturing comprehensive single-molecule information. To address this limitation a...

Proteins are the primary functional actors of the cell. Hence, their identification is pivotal to advance our understanding of cell biology and disease. Current protein analysis methods are of limited use for distinguishing proteoforms. In particular, mass spectrometric methods often provide only ambiguous information on post-translational modifica...

The triage process in emergency departments (EDs) relies on the subjective assessment of medical practitioners, making it unreliable in certain aspects. There is a need for a more accurate and objective algorithm to determine the urgency of patients. This paper explores the application of advanced data-synthesis algorithms, machine learning (ML) al...

Nowadays, as wafer sizes continue to increase in the solar industry, the use of half-cut cells has gained attention as a means of increasing the current output by reducing resistive losses. The laser scribing technology cannot increase the output power, as the laser process can cause losses due to laser-induced damages. Therefore, laser scribing lo...

Pancreatic hamartoma is a benign tumor of the pancreas with an extremely low incidence and is commonly diagnosed by pathologic examination after surgery. This report describes the case of a 57-year-old female who was referred for the evaluation of a pancreatic mass and an adrenal incidentaloma. Further imaging studies suggested pancreatic neuroendo...

This paper presents a new method to design an event-triggered dissipative observer-based control for discrete-time Takagi-Sugeno fuzzy singular systems by handling admissibility, dissipativity, observer-based control, and event-triggered data problems all in one. In particular, the proposed method has the advantage of being able to realize a one-st...

Background Although many formulas for predicting postoperative pancreatic fistula (POPF) have been introduced, POPF is generally predicted during pancreatic surgery due to pancreatic texture. This study was designed to verify the correlation between Hounsfield units (HU) and pancreatic texture and to suggest a fistula risk score (FRS) that can be u...

Background: The Phase 3 IKEMA study (NCT03275285) demonstrated isatuximab (Isa) in combination with carfilzomib (K) and dexamethasone (d) significantly improved progression-free survival (PFS) in patients with relapsed multiple myeloma (MM) compared with Kd. A post-hoc analysis of East Asian patients in IKEMA evaluated the efficacy and safety of I...

Background: Although the importance of sleep problems has been increasingly emphasized due to the effects on children's development and children's and families' daytime behaviors, physical health, and quality of life, they have been overlooked in clinical practice. However, there have been few studies on the effects of rehabilitation on sleep prob...

Cladosporium species are cosmopolitan fungi, characterized by olivaceous or dark colonies with coronate conidiogenous loci and conidial hila with a central convex dome surrounded by a raised periclinal rim. Cladosporium species have also been discovered in marine environments. Although many studies have been performed on the application of marine o...

e13025 Background: CT-P6 is a biosimilar trastuzumab product approved in many countries worldwide, including the European Union and the United States. This study aims to confirm the safety and effectiveness of CT-P6 in routine clinical practice settings for the approved indications of HER2-positive metastatic breast cancer (MBC), early breast cance...

Abstract Plasmonic nanostructured metals have many advantages for applications in high‐performance surface‐enhanced Raman scattering (SERS) spectroscopy. In particular, unique designing nanostructures with bicontinuous ligaments surrounded by cylindrical voids with tunable dense pores from a few to hundreds of nanometers can be utilized for the hig...

This paper aims to investigate the problem of local nonquadratic stabilization and disturbance attenuation for Takagi–Sugeno (T–S) fuzzy systems under the limited operating region of premise variables. To derive less conservative local stabilization conditions, this paper first proposes a parameterized linear matrix inequality (PLMI) formulation me...

Accurate lung nodule segmentation is crucial for early-stage lung cancer diagnosis, as it can substantially enhance patient survival rates. Computed tomography (CT) images are widely employed for early diagnosis in lung nodule analysis. However, the heterogeneity of lung nodules, size diversity, and the complexity of the surrounding environment pos...