Sunday Omilabu

Sunday Omilabu
College of Medicine University of Lagos · Medical Microbiology and Parasitology

Ph.D

About

224
Publications
34,499
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
2,586
Citations
Citations since 2016
63 Research Items
1590 Citations
2016201720182019202020212022050100150200250300
2016201720182019202020212022050100150200250300
2016201720182019202020212022050100150200250300
2016201720182019202020212022050100150200250300
Additional affiliations
August 1991 - present
College of Medicine, University of Lagos
Position
  • Managing Director
Description
  • Our laboratory has been involved with the teaching of medical virology and immunology to both medical and postgraduate students for over two decades. We also give diagnostic services to the Teaching hospital on viruses of public health importance.

Publications

Publications (224)
Article
Full-text available
Parkinson's disease (PD) is a neurodegenerative disorder characterized by both motor and non-motor features. The current treatment regimen for PD are dopamine enhancers which have been reported to worsen the disease prognosis after long term treatment, thus, the need for better treatment options. This study sought to investigate the protective acti...
Article
Full-text available
Molecular diagnostic testing has played a critical role in the global response to the novel Coronavirus disease (COVID-19) pandemic, since its first outbreak in late 2019. At the inception of the COVID-19 pandemic, nasopharyngeal swab sample analysis for COVID-19 diagnosis using the real-time polymerase chain reaction (RT-PCR) technique was the mos...
Article
Full-text available
Lassa Fever (LF) continues to be an endemic acute viral hemorrhagic fever (VHF) illness in Nigeria. Many suspected cases of LF infection have subsequently been confirmed negative and raises concerns as to what the diagnosis of such patients could be. Hence this study was to determine the causative agents of unconfirmed LF among initially suspected...
Article
Full-text available
Hepatitis C infection is a progressing and devastating live threatening health care problem in developing and developed countries worldwide caused by hepatitis C virus. The virus belongs to the family Flaviviridae and genus hepacivirus. Hepatitis C virus continues to be a disease burden in Nigeria and the world at large, and man is known to be its...
Article
Full-text available
The current resurgence and transmission dynamics of Lassa fever (LF) within an endemic community in Nigeria calls for concern. Lassa fever virus is known to be transmitted from rodents to humans as well as from human to human. This study aims to compare the knowledge, attitude/practices, and prevention of Community dwellers (CD) and Contacts of con...
Article
Full-text available
Background Lagos state is the industrial nerve centre of Nigeria and was the epicentre of the 2014 Ebola outbreak in Nigeria as it is now for the current Coronavirus Disease (COVID-19) outbreak. This paper describes how the lessons learned from the Ebola outbreak in 2014 informed the emergency preparedness of the State ahead of the COVID-19 outbrea...
Article
Full-text available
Nigeria, with a population of over 190 million people, is rated among the 10 countries with the highest burden of infectious and zoonotic diseases globally. In Nigeria, there exist a sub-optimal surveillance system to monitor and track priority zoonoses. We therefore conducted a prioritization of zoonotic diseases for the first time in Nigeria to g...
Article
Background The increasing trends of morbidity and mortality of Lassa fever is becoming more alarming in Nigeria. Information about immune response to the virus is limited. At exposure, the level of immunity plays a vital role in the vulnerability of individuals infected. Objective Investigating the immune status of health workers, infected cases a...
Article
Full-text available
Introduction In vitro studies have shown the efficacy of Ivermectin (IV) to inhibit the SARS - CoV- 2 viral replication, but questions remained as to In-vivo applications. We set out to explore the efficacy and safety of Ivermectin in persons infected with COVID19. Methods We conducted a translational proof of concept (PoC) randomized, double blin...
Article
Full-text available
A key element in containing the spread of the SARS-CoV-2 infection is quality diagnostics which is affected by several factors. We now report the comparative performance of five real-time diagnostic assays. Nasopharyngeal swab samples were obtained from persons seeking a diagnosis for SARS-CoV-2 infection in Lagos, Nigeria. The comparison was perfo...
Article
Full-text available
In an outbreak, effective detection of the aetiological agent(s) involved using molecular techniques is key to efficient diagnosis, early prevention and management of the spread. However, sequencing is necessary for mutation monitoring and tracking of clusters of transmission, development of diagnostics and for vaccines and drug development. Many s...
Preprint
Full-text available
Introduction: In vitro studies have shown the efficacy of Ivermectin (IV) to inhibit the SARS - CoV- 2 viral replication, but questions remained as to In-vivo applications. We set out to explore the efficacy and safety of Ivermectin in persons infected with COVID19. Methods: We conducted a translational proof of concept (PoC) randomized, double bli...
Conference Paper
Full-text available
Background of the Study: A total of about 1.5 million people died from tuberculosis (TB) including 251,000 living with HIV in 2018 with a large proportion from sub-Saharan Africa. In Nigeria, the burden of influenza virus in tuberculosis and HIV patients is unknown. Aim: This study investigated influenza virus in tuberculosis and HIV patients atten...
Article
Full-text available
Influenza virus is a major cause of infections in animals and human resulting in an annual 3 to 5 million cases of severe illness, and 290 000 to 650 000 deaths worldwide. It can spread from pigs to man and from man to pigs. Pigs have receptors that can allow human and avian influenza viruses to mix and produce new subtypes capable of causing pande...
Article
Full-text available
Background: In April 2020, a community-based active case search surveillance system of coronavirus disease 2019 (COVID-19) was developed by the emergency outbreak committee in Lagos State. This followed the evidence of community transmission of coronavirus disease in the twenty Local Government Areas in Lagos State. This study assessed the value o...
Article
Full-text available
Introduction: Lassa virus (LASV), the causative agent of Lassa fever (LF), an endemic acute viral haemorrhagic illness in Nigeria, is transmitted by direct contact with the rodent, contaminated food or household items. Person-to-person transmission also occurs and sexual transmission has been reported. Thus, this study investigated the presence of...
Technical Report
Full-text available
This is a report of the Nigerian Institute of Medical Research's effort in providing the genomic RNA sequence of the index case of SARS-CoV-2 imported by an Italian male aged 44 years. Disclaimer: I am hosting this report on behalf of all my colleagues both in and outside NIMR who contributed to this landmark endeavor.
Article
Full-text available
Background: Parvovirus B19 (B19) has tropism for cells of the erythroid lineage, which may lead to transient inhibition of erythropoiesis. Several studies and case reports suggested that B19 infection may contribute significantly to severe chronic anemia in HIV infected persons. Objective: To detect parvovirus B19 DNA in treatment-naïve HIV pati...
Article
Full-text available
Background: Plasmodium falciparum-resistance to sulphadoxine-pyrimethamine (SP) has been largely reported among pregnant women. However, the profile of resistance markers to SP dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) in the general population are varied and not frequently monitored. Currently, SP is used as partner drug...
Article
The COVID-19 pandemic is currently causing widespread infection and deaths around the world. Since the identification of the first case in Nigeria in February 2020, the number of confirmed cases has risen to over 9,800. Although pregnant women are not necessarily more susceptible to infection by the virus, changes to their immune system in pregnanc...
Article
Full-text available
Introduction: Success in curtailing the pandemic coronavirus disease (COVID-19) depends largely on a sound understanding of the epidemiologic and clinical profile of cases in a population as well as the case management approach. This study documents the presenting characteristics, treatment modalities and outcomes of the first 32 COVID-19 patients...
Article
Full-text available
Introduction: Early detection of emerging influenza virus variant is a key factor in the WHO influenza Global strategies for prevention and control. Rapid, accurate, inexpensive and portable detection systems are needed for influenza virus diagnosis and surveillance. Such a detection system should easily identify all the subtypes of influenza virus...
Article
Introduction: The diagnosis of Lassa fever is crucial to confirm cases, as well as to control/prevent nosocomial and community-based transmission and initiation of treatment, which is still limited in the country. Thus, we aimed at providing some information on the laboratory detection of Lassa from suspected cases in Nigeria. Methods: This was...
Article
Full-text available
Background: The changing epidemiology of the Lassa virus from endemic areas to other parts of West Africa has been reported. However, there has been no documented Lassa fever transmission chains in the Benin Republic. Two outbreaks of Lassa fever (November 2014 and January 2016) in the Benin Republic were characterised by a high number of deaths (m...
Article
Full-text available
Objective To assess polymorphism in Kelch 13 gene of Plasmodium falciparum isolates in Lagos, Nigeria. Methods 195 Plasmodium falciparum‐positive dried blood spots collected from individuals that accessed diagnostic care at some health facilities and during community surveys across several Local Government Areas of Lagos State, Nigeria, were inves...
Presentation
Full-text available
Background: Many studies have reported on outbreaks of Lassa fever, but there are very few reports on the clinico-epidemiological profile and case notification dynamics of Lassa fever in West Africa. We describe the clinico-epidemiological profile, case notifications, and outcomes of Lassa fever in Ebonyi State, Nigeria over a ten-year period (2005...
Article
Full-text available
Hepatitis E virus genotype 1 (HEV-1) is associated with large epidemics. Notably, HEV subtype 1e (HEV-1e) has caused HEV outbreaks in sub-Saharan Africa. We report here the second full-length genome sequence of an HEV-1e strain (NG/17-0503) from a recent outbreak in Nigeria in 2017. It shares 94.2% identity with an HEV-1e strain from Chad.
Poster
Full-text available
Objectives : Despite regular occurrence of influenza epidemics in the tropical and subtropical regions, there is less monitoring of the pattern of viral spread in these regions especially in sub-Saharan Africa including Nigeria. This prompted our investigation to perform gene sequencing and phylogenetic evolutionary relatedness on influenza viral i...
Article
Full-text available
Introduction: Ebola virus (EBOV) has been shown to persist in some body fluids of Ebola Virus Disease (EVD) survivors with implication for future transmission particularly in Nigeria where EVD was experienced for the first time in 2014. Thus, this paper was aimed at providing information on the duration of persistence of EBOV in Nigeria. Materials...
Article
Full-text available
Introduction: The co–infection of Human immunodeficiency virus (HIV), Hepatitis B and C viruses remains a public health problem particularly in resource limited setting like Nigeria. Studies on these co–infections have been done principally among adult and pregnant women with limited information on the pediatric population. The study aims at docume...
Article
Introduction: Intracellular α-synuclein (α-syn)-rich protein aggregates called Lewy bodies (LB) and neuronal death are present in nearly all cases of sporadic Parkinson disease (PD). It is widely believed that LB appears early in the disease and spreads in synaptically coupled brain networks, driving neuronal dysfunction and death. Objective: This...
Article
Full-text available
The co-infection of different influenza A virus enable viral gene re-assortments especially in pigs that serve as mixing vessel with the possibility of emergence of novel subtypes. Such re-assortants pose serious public health threat, as epitomised by the emergence of pandemic influenza in 2009. In Nigeria, there is mixture of animal species and hi...
Chapter
Full-text available
Dengue fever is the world’s fastest spreading mosquito borne viral infection prevalent throughout the subtropical and tropical regions and in 128 countries including all African regions. Dengue virus (DV) poses a serious global public health threat on 3.9 billion people causing 100 to 200 million morbidity and 30,000 mortality annually. The major c...
Poster
Full-text available
Influenza A viruses in pigs have been scarcely investigated in Africa, with rare viral detection prior to 2009. The spread of pandemic H1N1/2009 changed the epidemiology of swine influenza due to frequent human-to-swine transmissions. New reassortants are emerging with a combination of genes from swine influenza and pandemic H1N1/2009 strains. This...
Poster
Full-text available
Cytomegalovirus (CMV) and Rubella virus remain the commonest viral infection in pregnancy and the leading cause of congenital deformities especially in developing countries. According to the World Health Organisation, CMV has a high global prevalence of 50- 90% in all human populations while more than 100,000 children are born annually with Congeni...
Article
Full-text available
Introduction: Global travel is an efficient route of transmission for highly infectious pathogens and increases the chances of such pathogens moving from high disease-endemic areas to new regions. We describe the rapid and safe identification of the first imported case of Ebola virus disease in a traveler to Lagos, Nigeria, using conventional reve...
Article
Full-text available
Containment limited the 2014 Nigerian Ebola virus (EBOV) disease outbreak to 20 reported cases and 8 fatalities. We present here clinical data and contact information for at least 19 case patients, and full-length EBOV genome sequences for 12 of the 20. The detailed contact data permits nearly complete reconstruction of the transmission tree for th...
Data
Lassa virus (LASV) causes a deadly haemorrhagic fever in humans, killing several thousand people in West Africa annually. For 40 years, the Natal multimammate rat, Mastomys natalensis, has been assumed to be the sole host of LASV. We found evidence that LASV is also hosted by other rodent species: the African wood mouse Hylomyscus pamfi in Nigeria,...
Article
Full-text available
Lassa virus (LASV) causes a deadly haemorrhagic fever in humans, killing several thousand people in West Africa annually. For 40 years, the Natal multimammate rat, Mastomys natalensis, has been assumed to be the sole host of LASV. We found evidence that LASV is also hosted by other rodent species: the African wood mouse Hylomyscus pamfi in Nigeria,...
Article
Full-text available
The first epidemic of Ebola haemorrhagic disease in West Africa is the largest and longest Ebola epidemic till date, where the outbreak notably involved three countries with distant spread to other countries. It has caused significant mortality, with reported case fatality rates of up to 70%. Data and relevant information were extracted from the re...
Article
Full-text available
The mechanism of action of the extracts on the replicative cycle of the viruses revealed that Citrus paridisi could be a prophylactic agent of measles infection (Table 5) having prevented attachment/entry of the virus to the cell, thus acting as an attachment/entry inhibitor of measles virus. The same plant material could also be used for treatment...
Article
Full-text available
Human immunodeficiency virus (HIV) may influence hepatitis C virus (HCV) disease through immunosuppression. The aim of this study was to determine the sero-prevalence of HCV in HIV sero-positive children in Lagos, Nigeria. 132 blood samples of children aged 1-15 years were collected at the HIV clinics of Lagos University Teaching Hospital (LUTH) an...
Article
Full-text available
Objective: This hospital-based retrospective cohort study was undertaken with a view to determine the epidemiological trend of measles in Lagos State, Nigeria Methods: Medical records of clinically diagnosed measles patients from nine referral public hospitals in Lagos State between 1998 and 2007 were retrieved, transcribed and reviewed. Data were...
Technical Report
Full-text available
This technical document provides an assessment tool for biosafety level 3 (BSL-3) laboratories as well as relevant regulations and information sources related to design, construction, maintenance, safety and biosafety operation operation of BSL3.
Article
Full-text available
The objectives were to determine the seroprevalence of hepatitis B virus (HBV) infection and assess the major risk factors among Nigerian pregnant women. This was a cross-sectional descriptive study carried out among pregnant women at the antenatal clinic of a Tertiary Hospital in Lagos, Nigeria. A total number of 150 consenting pregnant women were...
Presentation
Full-text available
ABSTRACT Background: Many studies have reported on outbreaks of Lassa fever, but there are very few reports on the clinico-epidemiological profile and case notification dynamics of Lassa fever in West Africa. We describe the clinico-epidemiological profile, case notifications, and outcomes of Lassa fever in Ebonyi State, Nigeria over a ten-year per...
Article
BACKGROUND: Although there have been a lot of research done on Avian Influenza in the world, there are still visible indications in the Nigerian poultry farming system that the bio-security measures are not adhered to strictly. Hence, it is of great importance to identify the circulating strains of Avian Influenza virus in Nigeria, so as to prevent...
Article
Full-text available
In 2014, Ebola virus (EBOV) was identified as the etiological agent of a large and still expanding outbreak of Ebola virus disease (EVD) in West Africa and a much more confined EVD outbreak in Middle Africa. Epidemiological and evolutionary analyses confirmed that all cases of both outbreaks are connected to a single introduction each of EBOV into...
Article
Full-text available
Sequence determination of complete or coding-complete genomes of viruses is becoming common practice for supporting the work of epidemiologists, ecologists, virologists, and taxonomists. Sequencing duration and costs are rapidly decreasing, sequencing hardware is under modification for use by non-experts, and software is constantly being improved t...
Article
Full-text available
Background: Hepacare(®) is a herbal formulation used to treat patients with sickle-cell anaemia complicated with jaundice, also recommended as a protective agent against liver damage due to chronic ingestion of alcohol. Methods: In vitro antioxidant properties of Hepacare(®) was determined using 1, 1- diphenyl-2-picryl-hydrazyl (DPPH), total ant...