Sunday Adelakun

Sunday Adelakun
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Sunday verified their affiliation via an institutional email.
Verified
Sunday verified their affiliation via an institutional email.
Federal University of Technology | futa

Doctor of Philosophy
Lecturer/Biomedical/Psychiatry/Neurobehavioral and Aging Researcher

About

84
Publications
15,520
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675
Citations
Introduction
Adelakun Sunday works at the Department of Human Anatomy, Federal University of Technology, Akure, Ondo State. Adelakun research focused on Reproductive Biology, Neuroscience, and aging-related to low back pain due to intervertebral disc degeneration, Anatomy, and Biomedical research. The current project focused on Nutritional Dietary Supplements on Cisplatin-induced neurotoxicity in animal models and Low back pain induced by Annular puncture degeneration in a rabbit model.
Additional affiliations
October 2012 - September 2013
Ladoke Akintola University of Technology
Position
  • Reproductive and Neuro-endocriologist
Education
November 2019 - September 2023
Ladoke Akintola University of Technology
Field of study
  • Reproductive Anatomy, Teratology and endocrinology
September 2011 - December 2012
University of Lagos
Field of study
  • Anatomy (Forensic Anthropology)
February 2004 - December 2009
Ladoke Akintola University of Technology
Field of study
  • Reproductive Anatomy, Teratology and endocrinology

Publications

Publications (84)
Article
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This paper explores the overlapping dynamics of religion, politics, and cult-like behavior, focusing on the psychological, sociological, and cultural factors that contribute to their convergence. Religious and political systems, though distinct, often share mechanisms for mobilizing collective identity, fostering loyalty, and shaping belief systems...
Article
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The hippocampus, a major part of the limbic lobe, is divided into the Cornu Ammonis (CA1-CA4) and the dentate gyrus (DG) and plays major role in memory and learning. It has been determined that the leaves of Colocasia esculenta are rich in minerals, vitamins B complex, E, and ascorbic acid, as well as important amino acids. The study evaluated the...
Article
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Introduction The prefrontal cortex (PFC), crucial for cognition and memory, occupies a third of the cerebral cortex. This study investigated the protective effects of aqueous extract of Colocasia esculenta leaf (AECEL) against lipopolysaccharide (LPS)-induced PFC damage in mice. Methods 42 male Swiss albino mice (18–22 g) were divided into six gro...
Article
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Cisplatin (CP) has been used in clinical oncology but causes spermatogenesis damage. Isothiocyanato-4- methylsulfonylbutane (SFN) is a potent dietary bioactive agent that has been extensively studied for its effects on disease prevention. This study focused on the intervention of SFN on Germ cell apoptosis in CPinduced testicular toxicity and sp...
Preprint
Full-text available
Background The prefrontal-cortex (PFC) occupies about one-third of the total area of the cerebral cortex and it plays crucial role in Cognition and memory. This study evaluated the ameliorative effects of aqueous extract of Colocasia esculenta leaf (AECEL) on lipopolysaccharide-induced Prefrontal-cortex damage. Methods 42 Swiss male albino mice wi...
Article
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Vitamin B 12 is an essential water-soluble vitamin, commonly found in a variety of foods. The present study investigated the effect of Vitamin B 12 on tramadol-induced hepatorenal dysfunctionand DNA fragmentation in rats. Thirty-two (32) adult male Sprague-Dawley rats were randomized into four groups of eight (n = 8) rats each. Group A served as co...
Article
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Background: Sodium fluoride (NaF) causes testicular toxicity via an oxidative stress mechanism. Solanum aethiopicum (SAE) contains abundant antioxidant and androgenic properties. This study investigated the ameliorating potential of SAE extract against NaF-induced testicular damage in rats. Methods: Forty-eight (48) adult male Sprague Dawley rats (...
Article
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Background: As a result of its many therapeutic properties, including its potent anti-hyperglycemic effect, the Spondias mombin plant is quickly gaining popularity as a local therapeutic agent for the treatment of many ailments. This work aimed at investigating the effects of co-administration of Spondias mombin and metformin in STZ-induced hypergl...
Article
The fructose-streptozotocin (FRU-STZ) diabetic model has been presented as a viable model of type2 diabetes but its impact on the testes and epididymis of Wistar rats is yet to be investigated. In this study, we probed the role of caffeic acid, a potent antioxidant, in FRU-STZ diabetic rats. Twenty normoglycemic rats were randomly divided into four...
Article
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Background Polycystic ovary syndrome (PCOS) is an endocrine disorder, affecting women of reproductive age. Ageratum conyzoïdes (AGC) is used traditionally in the treatment of fever, rheumatism, and ulcer. This study investigates the effects of AGC on ovarian-uterine in PCOS rats. Methods Female rats were randomized into four groups (n = 6). Group...
Article
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Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine and metabolic disorder, causes irregular menstrual cycles, dyslipidemia, excessive body weight, oxidative stress, hyperandrogenism, and infertility. This study focused on the impact of Cyperus esculentus (CES) on letrozole-induced PCOS in female Sprague-Dawley rats. Twenty (20) normal ra...
Article
Background This study examine the histochemical and histomorphological effect of 1-isothiocyanato-4-methyl sulfonyl butane (SFN) on cisplatin (CP) induced testicular alteration and cholesterol homeostasis. Materials and methods Ninety adult-male Sprague-Dawley rats were randomized into nine groups of ten (n = 10) rats each. Group A (control) recei...
Article
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Background 1-isothiocyanato-4-methyl-sulfonyl (SFN) butane is a naturally occurring compound from broccoli. Cisplatin (CP) reported has a standard chemotherapeutics agent. This study focused on the impact of SFN on cisplatin-induced testicular dysfunctions. Method Ninety adult-male Sprague-Dawley rats were randomly divided into nine groups of ten...
Article
Background Available evidence suggests that cimetidine is a reproductive toxicant that induces sexual and testicular dysfunction. Ocimum gratissimum (OG) is globally consumed for medicinal and nutritional purposes. To determine the modulating role of aqueous leaf extract of Ocimum gratissimum on cimetidine-induced gonado-toxicity, sexually mature m...
Article
Zinc (Zn) has proven to play a key role in spermatogenesis. The present study focused on the nutritional supplementation of Zn against cisplatin (CP)-induced spermatogonial and testicular dysfunctions. Thirty-two (32) mature male Sprague Dawley rats were randomized into four groups of eight (n = 8) rats each – Control group (received 2 ml of normal...
Article
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Introduction: Prenatal exposure to Marijuana (MJN) has been associated with various brain deficits. The main activity in marijuana, Δ9-Tetrahydrocannabinol (THC), crosses the placenta and affects fetal brain development. Despite this, marijuana remains a commonly abused substance among pregnant women. The current study examined the histological and...
Article
Background Death arising from hepato-renal related diseases is on the increase. Cyperus esculentus (CE) possesses antioxidants potentials. This study aim at investigating the effect of Cyperus esculentus on sodium fluoride (NaF)-induced hepato-renal toxicity in rats. Methods Twenty-four male rats weighting (10-12 weeks old, 200± 20g) randomized in...
Article
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Background Estradiol valerate (EV) is known to cause hypothalamic-pituitary dysregulation of the gonadotrophin-releasing hormone. This study focused on the impact of aqueous extract of Solanum melongena (SM) on EV-induced ovarian-pituitary dysfunction in female Sprague-Dawley rats. Methods Thirty-two healthy female Sprague Dawley rats weighing (8...
Article
This study aimed at the effect of vitamin B12 (VB12) on tramadol (TRM) induced pituitary-gonadal Axis toxicity. Thirty-two (32) adult male rats were randomized into four groups of eight (n = 8) rats each. Group A served as control was given 1 ml normal saline, group B received 50 mg /kg bwt TRM, group C received 0.5 mg/kg bwt VB12 and group D recei...
Article
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Background: Cisplatin (CN) is considered a cytotoxic agent and DNA synthesis inhibitor. D-Ribose-L-Cysteine (DRLC) is an active ingredient of riboceine, helps cells to produce glutathione on body demand. Aim: Current study focused on ameliorating potential and fertility-enhancing activities of D-Ribose–L-Cysteine in cisplatin-induced oligoasthenote...
Article
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Background Cisplatin (CN) is considered as a cytotoxic agent and DNA synthesis inhibitor. D-Ribose-l-Cysteine (DRLC) is an active ingredient of riboceine, help cells to produce glutathione on body demand. Aim Current study focused on ameliorating potential and fertility enhancing activities of D-Ribose–l-Cysteine in cisplatin induced oligoasthenot...
Article
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Objective: Reproductive toxicity has been greatly linked with Highly Active Antiretroviral Therapy (HAART) use. This study investigated the effects of Moringa oleifera Leaf Extract (MOE) on HAART-induced testicular toxicity in adult male Wistar rats. Methods: Twenty adult male Wistar rats (150-200 g) were assigned into four groups (n=5). Group A...
Article
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Background The novel coronavirus disease (COVID-19), declared a global pandemic by the World Health Organization (WHO) on March 11, 2020, has constituted one of the most serious health challenges of the century, globally. The causative organism was initially named the 2019 novel coronavirus (2019 nCoV) but has subsequently been renamed Severe Acute...
Article
Background : Mercury chloride (HgCl2) is known to cause reproductive dysfunction. The negative effects may be ameliorated with the use of certain antioxidants. Present study focused on impact of D-Ribose-L-Cysteine (DRLC) on mercury chloride-induced testicular toxicity in male rats. Materials and methods : Forty-eight (48) adult male Sprague-Dawle...
Article
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Objective: Reproductive toxicity is an important health challenge, mostly associated with exposure to several environmental toxicants. Arsenic is a ubiquitous toxic compound naturally present in the environment. This study was carried out to evaluate the dietary supplements of D-Ribose-L-Cysteine against sodium arsenate-induced testicular toxicity...
Article
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Transfluthrin is a fast-acting insecticide used in household and hygiene products, mainly against flying insects, such as mosquito and flies, and in agriculture material pests. Its uses in these areas have not been without health risk to humans and the ecosystem. Therefore, the current study was designed to investigate the effect of smoke emanating...
Article
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Study design: Symptomatic disk degeneration is characterized by early pathological changes in the morphological, biochemical, and biomechanical properties of the intervertebral disc (IVD). Several methods that can be used to resolve this condition are being researched. Purpose: The present study was designed to examine the preventive and restora...
Article
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Diabetes mellitus is becoming an important public health challenge worldwide and especially in developing nations. About 8.8 percent of the world adult population has been reported to have diabetes. Glutamine-fructose-6-phosphate amidotransferase 1 (GFAT1) catalyses the first committed step in the pathway for biosynthesis of hexosamines in mammals,...
Article
The prevalence of low back pain associated with disc degeneration reduced quality of life with socio-economic impact. This study is aimed at investigating the histomorphometric and antioxidant response of Brassica oleracea extract in annular puncture-induced intervertebral disc degeneration using a rabbit model. Fifteen (15) New Zealand white rabbi...
Article
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Tetrapleura tetraptera (TT) has been used as a spice, dietary supplement and medicine for various ailments. This study evaluate influence of Tetrapleura tetraptera extract on testis and copulatory behavior in sexually mature male rats. Thirty-two male and sixty-four virgin female rats weighing 150-200g were used for this study. Male rats randomly d...
Article
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D-ribose-L-cysteine is a pro-drug that is derived from L-cysteine which is reported to upsurge the cellular levels of glutathione. Diabetes mellitus is a metabolic disease that causes oxidative imbalance resulting in an impairment of the steroidogenic function and reproductive dysfunctions. This study is to investigate the potency of D-ribose-L-cys...
Article
Lead (Pb) exposure induces oxidative stress causing an imbalance in antioxidant enzymes, cognitive impairments, and neurodegeneration. This study investigated the neuroprotective and antioxidant properties of sulphoraphane (SFN) on Pb-induced neurotoxicity of adult Wistar rats. Forty animals (150 ± 20 g) were divided into four groups (n=10): Group...
Article
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Background: The exposure of male individuals to an environmental toxicant is regarded as a channel that results in reduced sperm counts and infertility. Objective: This study investigated the ameliorative response of Sulforaphane (SFN) on Aluminum trichloride (AlCl 3) induced testicular toxicity in adult male Wistar rats. Materials and Methods: A t...
Article
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Low back pain is a musculoskeletal disorder implicated in disc degeneration. Grape seed extracts (GSEs) is a natural flavonoids rich compound with antioxidants and anti-inflammatory properties. This study is aimed at investigating the inhibitory and anabolic response of GSE on annular punctured induced disc degeneration in the rabbit model. Twenty-...
Article
Objective Chronic exposure to fluoride causes tissue damage induced by oxidative imbalance, Cyperus esculentus (CE) possess anti-inflammatory and immunostimulatory properties. This study focused on Salutary role of Cyperus esculentus in sodium fluoride (NaF) induced testicular degeneration and sperm quality deteriorations. Methods Sexually mature...
Article
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Mismatches between children’s anthropometric measures and classroom furniture dimensions can cause musculoskeletal disorders and affect performance in classroom activities. The aim of this study was to survey the anthropometric mea sures of primary school children in Akure South Local Government and to evaluate the level of match/mismatch between...
Article
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Background Solanum melongena (SM) is commonly known as the garden egg fruit or eggplant. It can be eaten fresh or cooked and has a large history of consumption in West Africa. This study focused on interventions of aqueous extract of SM (garden eggs) fruits on Mercury chloride (HgCl2) induced testicular toxicity in adult male Wistar rats. Methods...
Article
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Children spend most of their school time in classrooms and in sitting positions; therefore, the use of ill-fitted classroom furniture can cause discomfort and irritation, and predispose users to musculoskeletal disorders. The aim of this study was to survey the anthropometric measures of selected secondary school children in Akure, Nigeria, and to...
Article
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Prolonged exposure to aluminum through occupational hazards or food/water intake has been linked to the occurrence of Alzheimer’s disease (AD). This study aimed at investigating the neuroprotective effects of Gallic Acid (GA) against aluminum-chloride induced AD in adult Wistar rats. Twenty eight (28) adult Wistar rats were divided into four groups...
Article
This study aimed at investigating the preventive and rejuvenating capacity of 1-isothiocyanato-4-(methylsulfinyl) butanein annular punctured intervertebral disc degeneration in rabbit model.Twentyfive New Zealand white rabbits (1.5 to 3.0 kg each) underwent annular puncture.Group 1 received 50 mg/kg of phosphate-buffered saline orally for 8 weeks (...
Article
Male reproductive function is clearly impaired in diabetes. This study investigates the responses to the bioactive component of Crassocephalum crepidioides (C. crepidioides) on histomorphology, spermatogenesis and steroidogenesis in Streptozotocin induced Diabetic Male Rats. Eighteen (18) male diabetic and twelve non diabetic male rats were divided...
Article
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Exposure to cadmium and consumption of herbal alcoholic beverages (HAB) is rising in Nigeria, thereby leading to the increase in the risk of neurodegenerative disorders. Preventing the damages caused by these exposures will be a valuable approach in managing neurodegenerative disorders associated with this exposure. In folkloric medicine moringa ol...
Article
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The brain is vulnerable to oxidative damage due to its high oxygen consumption. This Study investigate the effects of cadmium on the lateral geniculate body of developing male wistar rats and ameliorative potential of Moringa oleifera seed oil and walnut oil extracts. Seven groups of five animals each were used in this experiment. Group A received...
Article
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Objectives: The aim of this study was to investigate the antioxidant effect of aqueous Lawsonia inermis leaf extract on aluminum-induced oxidative stress and the histology of the pituitary gland of adult Wistar rats. Methods: Thirty-five adult male Wistar rats weighing between 100-196g and 15 mice of the same weight range were included in the st...
Article
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Background: Cadmium is a human carcinogen element and one of the most toxic pollutants in the environment. Present study aims at histomorphological study of some of the effects of Moringa oleifera oil and cashew (Anarcardium occidentale) nuts oil on Cadmium-induced liver damage in wistar rats. Methods: Thirty-five Wistar rats (80-180 g) were random...
Article
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p>Background: Cadmium (Cd) has been reported to cause distinct neurotoxic effects in adult and newborn animals. This study was designed to investigate some of the effects caused by cadmium on the lateral geniculate body of adult male wistar rats and the ameliorative properties of antioxidants present in Moringa oleifera seed oil and walnut oil extr...
Article
Objective: To determine the role of aqueous crude leaf extract of Seneciobiafrae (SB) combined with Zinc (Zn) on Testicular function of Adult Male Sprague dawley Rats. Materials and methods: Twenty-four adult males praguedawley Rats weighing 180-200g, aged 10-12 weeks, were randomized into four groups (A,B,C,D) of six rats each (n = 6) and were giv...
Article
Effects of Ageratum conyzoides (AC) on hormonal and biochemical assay in male diabetic rats were examined. Twenty four adult male wistar rats divided into four groups of six rats (n=6) each, Nondaibetic control received 2 ml/kg bw distilled water, Diabetic control given distilled water as placebo, Diabetic rats treated subcutaneously with 5 units/k...
Article
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Objective: Cisplatin has been established to cause reproductive dysfunction; Cochlospermum planchonii is globally used in folklore medicine and has numerous therapeutic benefits. This study focused on fertility enhancing activities of Cochlospermum planchonii (Cp) on cisplatin-induced reproductive dysfunctions. Materials and methods: Total of 30 ma...
Article
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Objective: To determine the impact of walnut oil on nitrite-induced testicular toxicity in Sprague-Dawley (SD) rats. Available evidence suggests that walnut oil contains high levels of important unsaturated fatty acids including alpha-linolenic acid (ALA) and omega-3; nitrite is a reproductive toxicant that causes the loss of germ cells in the sem...
Article
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Objective: The current study focused on the pro-fertility potential of Senecio biafrae (Sb) extract and vitamin C in Male Sprague Dawley (SD) rats with tetracycline-induced infertility. Methods: A total of 36 male and 36 female adult SD rats were used for this investigation. The male rats randomly assigned to Group A (controls) were given normal...
Article
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Objective: The present study focused on histomorphology, sperm quality, hormonal profile and hematological parameters in adult male Sprague-Dawley rats following the administration of aqueous crude extract of Solanum nigrum by gastric gavage. Methods: Fourty healthy male adult (12-14 weeks old) Sprague-Dawley rats weighing 200-220g were randomly...
Article
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Globally mercury (Hg) has been reported as one of heavy metal of known toxicity, noted for inducing public health disasters. Present study examines the therapeutics potentials of Ocimum basilicum on mercury chloride (HgCl2) induced hepatotoxicity in Wistar rats. Thirty adult Wistar rats randomly divided into six groups (A-F) of five rats each. Grou...
Article
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Background: Available evidence shows that cadmium nitrate (CdN) is locally used in Africa as a supplement in the preparation of herbal mixture. This study focused on histomorphological and biochemical assessment of testicular parameters following oral administration of CdN in adult male wistar rats. Materials and Methods: Twenty (n=20) adult male w...