Sundaresan Neelakantan

Sri Sathya Sai Institute of Higher Learning · Department of Chemistry

Point-of-care (POC) diagnostic platforms are globally employed in modern smart technologies to detect events or changes in the analyte concentration and provide qualitative and quantitative information in biosensing. Surface plasmon-coupled emission (SPCE) technology has emerged as an effective POC diagnostic tool for developing robust biosensing f...

Antibiotic resistance is rapidly exacerbating the unceasing rise in nosocomial infections caused by drug-resistant bacterial pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), carbapenem-resistant Enterobacteriaceae (CRE) and vancomycin-resistant Enterococcus (VRE). Therefore, there is a dire need for new therapeutic agents that...

Photoplasmonic platforms are being demonstrated as excellent means for bridging nanochemistry and biosensing approaches at advanced interfaces, thereby augmenting the sensitivity and quantification of the desired analytes. Although resonantly coupled electromagnetic waves at the surface plasmon-coupled emission (SPCE) interface are investigated wit...

Hydrogen energy production through water electrolysis is envisaged as one of the most promising, sustainable, and viable alternate sources to cater to the incessant demands of renewable energy storage. Germane to our effort in this field, we report easily synthesizable and very cost-effective isoperthiocyanic acid (IPA) molecular complexes as elect...

The search for an environment friendly, sustainable and cost-effective catalyst used in electrochemical water splitting via the hydrogen evolution reaction (HER) has generated considerable interest in renewable energy research worldwide. In the current study, we report cost-effective and easily synthesizable 2-thioureidobenzothiazole (BTT) metal co...

In the current communication, we report the role of sodium do-decyl sulphate (SDS) as the corrosion inhibition enhancer for 2-thioureidobenzoxazole (BOT) on mild steel (MS) in 2M Hydrochloric acid electrolyte. Though, 2-thioureidobenzoxazole shows limited inhibition due of the presence of oxygen atom, addition of small quantity of SDS enhances the...

Hybrid molecules in the recent years have gained significant importance in drug research as promising therapeutic agents. We report a novel combination of two such bioactive scaffolds (benzoxazole and 4-thiazolidinone- B-T hybrids) as inhibitors of SARS-CoV-2. The study uses an in-silico approach to identify the potential of B-T hybrids as possible...

Corrosion Inhibition potential of three 2-thioureidobenzheteroazoles, namely, 2-thioureidobenzoxazole(BOT),2-thioureidobenzimidazole(BIT),2-thioureidobenzothiazole (BTT) compounds were predicted theoretically using quantum chemical calculations on type CS 1084 carbon steel in 2 M HCl at 25 °C. DFT calculations indicated that BTT showed better inhib...

Advancements in business management have taken place through diverse fields. One such contributing area has been imitation of sustainable and successful systems and processes from nature, called bio-mimicry. Research has been done to develop bio-mimetic management frameworks. Successful bio-mimetic solutions have been implemented in industry to pro...

In this article, we report intermolecular interactions in terms of the effect of benzfused heterocyclic compounds, i.e., 2‐thioureidobenzimidazole and 2‐thioureidobenzoxazole (0.00, 0.01, and 0.05 mol kg−1), on the micellization behavior of sodium dodecylsulphate (SDS) (1–52 mmol kg−1) in dimethylsulphoxide (DMSO) at different temperatures (293.15–...

The knowledge about the characteristics of drug – bio-surfactants system is crucial in pharmacology which helps to design better pharmaceutical formulations. The descriptions of the modulation in drug (metformin hydrochloride) – bio-surfactants (sodium cholate and sodium deoxycholate) mixture, in solution micellar phase has been accessed by means o...

Multi drug resistant (MDR) pathogens pose a serious threat to public health since they can easily render most potent drugs ineffective. Efflux pump inhibitors (EPI) can be used to counter the MDR phenotypes arising due to increased efflux. In the present study, a series of dithiazole thione derivatives were synthesized and checked for its antibacte...

A one-pot, cost-effective system for sensing fluoride ions using quinizarin as a novel chromophore is reported. Quinizarin complexes with Al(III) to form a self-organized turn-on fluorescence system in methanol. In the presence of fluoride ions, this system undergoes a subsequent ligand swap reaction with the fluoride ion and consequently the fluor...

The subject of the study is the structure and conformation of 1″,4″-Dispiro-cyclohexane-6,6′-bis(benzothiazoline), a dispiro compound that has a cyclohexyl ring flanked by two benzothiazoline rings on either side. Using single crystal X-ray diffraction measurements, Infra-red absorption, and Raman spectroscopy techniques, it is found that the centr...

Density (ρ), speed of sound (u), and viscosity (η) measurements of amino acids l-glutamine and l-histidine in aqueous solutions of metformin hydrochloride (an antidiabetic drug) (0.01, 0.07, and 0.13 mol·kg–1) were carried out in the concentration range (0.02–0.20 mol·kg–1) at 293.15, 298.15, 303.15, 308.15, and 313.15 K. The experimental data has...

The ligand, 1-(1H-benzimidazol-2-yl)guanidine (GBI) gives two absorbance peaks at 245 nm and 295 nm respectively. GBI complexes with mercury(II) to form a white coloured complex. The analytical parameters such as effect of pH, reagent dosage, reaction time, effect of mercuric ion concentration, effect of interfering ions have been studied. The rang...

In the title compound, C8H9N4S⁺·Cl⁻·H2O, the cation is approximately planar, with a dihedral angle of 7.71 (8)° between the mean planes of the benzo­imidazole ring system and the thio­urea unit. In the crystal, cations, anions and water molecules of crystallization are linked by O—H⋯Cl, N—H⋯O, N—H⋯Cl and N—H⋯S hydrogen bonds into a three-dimensiona...

In the title compound, C6H6BrNO, the Br atom is displaced from the pyridine ring mean plane by 0.0948 (3) Å, while the hydroxyl O atom and the methyl C atom are displaced by 0.0173 (19) and 0.015 (3) Å, respectively. In the crystal, mol­ecules are linked via O—H⋯N hydrogen bonds, forming chains propagating along the a-axis direction. These chains a...

Indigo and Tyrian purple are two dyes which have captured the imagination of the common man as well as the gentry from the very beginning of human civilization. Their story is like a multi-coloured yarn, with strands from chemistry, history, culture and politics. Their popularity is reflected by the fact that their stories are very well documented...

From the very beginning of civilization, humans have used chemicals from Nature – most of them comparatively small organic molecules now designated as secondary metabolites – for a variety of purposes such as pigments and dyes, arrow and fish poisons and olfactory stimulants. It is no wonder that many eminent chemists were attracted to these materi...

Among the most colourful objects found in Nature are bird feathers and butterfly wings. Their beauty is more obvious when a bird or a butterfly is in flight as the colour of the pigments present in wings and feathers is accentuated by refraction and reflection of incident light by the nanokeratinoid structural elements in the feather. Thus, when a...

The paper studies sustainable supply chain management from the perspective of protein biosynthesis, which is one of the most fundamental supply chains present in every organism. After providing a review of literature, the study explains the protein biosynthesis process. The paper then analyzes sustainable supply chains using a biomimetic perspectiv...

A one pot signaling system for fluoride ion in aqueous and non-aqueous media. The study focuses on Quinizarin (1) metal complexes, aluminum in particular, as a fluorometric fluoride sensor

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Integrated value systems are management systems which provide value to the user or consumer. While supply chains help firms attain a competitive edge, it is integrated value systems that make the advantage sustain under intense competitive conditions. In this paper, lessons for integrated value systems have been developed using a bio-mimetic framew...

Advancements in business management have taken place through diverse fields. One such contributing area has been imitation of sustainable and successful systems and processes from nature, called bio-mimicry. Research has been done to develop bio-mimetic management frameworks. Successful bio-mimetic solutions have been implemented in industry to pro...

2-Thioureidobenzoxazole (1) was synthesized using 5-amino-3H-1,2,4-dithiazole-3-thione and 2-aminophenol and characterized by X-ray crystallography. The molecule of 1 is essentially planar due to π conjugation and an intramolecular N–H⋯N hydrogen bond also contributes towards its planarity. The crystal lattice is built up of stacks of dimers of 1 g...

New and efficient one pot syntheses of 2-thioureidobenzimidazole (V), 2-thioureidobenzoxazole (VI), and 2-thioureidobenzothiazole (VII) have been developed. The target compounds were obtained in good yields by condensing the title synthon commonly known as isoperthiocyanic acid (I) with 1,2-diaminobenzene (II), 2-aminophenol (III), and 2-aminothiop...

Indigo and Tyrian purple are two dyes which have captured the imagination of the common man as well as the gentry from the very beginning of human civilization. Their story is like a multi-coloured yarn, with strands from chemistry, history, culture and politics. Their popularity is reflected by the fact that their stories are very well documented...