Sumithra Sankararaman

Sumithra Sankararaman
Washington University in St. Louis | WUSTL , Wash U · Department of Genetics

PhD

About

18
Publications
4,800
Reads
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325
Citations
Additional affiliations
June 2007 - December 2008
Indian Institute of Science
Position
  • PostDoc Position
May 2005 - December 2006
Washington University in St. Louis
Position
  • PostDoc Position
October 2003 - May 2005
University of Illinois at Chicago
Position
  • PostDoc Position

Publications

Publications (18)
Article
Full-text available
Sex can be an important determinant of cancer phenotype, and exploring sex-biased tumor biology holds promise for identifying novel therapeutic targets and new approaches to cancer treatment. In an established isogenic murine model of glioblastoma (GBM), we discovered correlated transcriptome-wide sex differences in gene expression, H3K27ac marks,...
Preprint
Sex can be an important determinant of cancer phenotype, and exploring sex-biased tumor biology holds promise for identifying novel therapeutic targets and new approaches to cancer treatment. In an established isogenic murine model of glioblastoma, we discovered correlated transcriptome-wide sex differences in gene expression, H3K27ac marks, large...
Conference Paper
p>Sex can be an important determinant of cancer phenotype and exploring sex-specific tumor biology holds promise for identifying novel therapeutic targets and new approaches to cancer treatment. In an established model of glioblastoma, we discovered transcriptome-wide sexual dimorphism in gene-expression that was concordant with sex differences in...
Article
Full-text available
Molecular and behavioral responses to opioids are thought to be primarily mediated by neurons, although there is accumulating evidence that other cell types play a prominent role in drug addiction. To investigate cell-type-specific opioid responses, we performed single-cell RNA sequencing (scRNA-seq) of the nucleus accumbens of mice following acute...
Preprint
Full-text available
Molecular and behavioral responses to opioids are thought to be primarily mediated by neurons, although there is accumulating evidence that other cell types also play a role in drug addiction. To investigate cell-type-specific opioid responses, we performed single-cell RNA sequencing of the nucleus accumbens of mice following acute morphine treatme...
Article
Molecular and behavioral responses to opioids are thought to be primarily mediated by neurons, although there is accumulating evidence that other cell types play a prominent role in drug addiction. To investigate cell-type-specific opioid responses, we performed single-cell RNA sequencing (scRNA-seq) of the nucleus accumbens of mice following acute...
Article
Full-text available
Glioblastoma (GBM) is among the most aggressive and frequent forms of adult brain cancer with a very poor survival rate despite decades of research and a myriad of clinical trials. Similar to other tumors, such as bladder and lung cancer, GBM is reported to have a higher incidence in males than females. This consistent sex difference in incidence d...
Article
Full-text available
The piggyBac (PB) transposon has been used in a number of biological applications. The insertion of PB transposons into the genome can disrupt genes or regulatory regions, impacting cellular function, so for many experiments it is important that PB transposition is tightly controlled. Here, we systematically characterize three methods for the post-...
Article
Full-text available
We formulate the thin-film hydrodynamics of a suspension of polar self-driven particles and show that it is prone to several instabilities through the interplay of activity, polarity, and the existence of a free surface. Our approach extends, to self-propelling systems, the work of Ben Amar and Cummings [Phys. Fluids 13 1160 (2001)10.1063/1.1359748...
Article
We propose a hydrodynamic model for pattern formation in mixtures of molecular motors and microtubules. Our model invokes a vector field describing the local microtubule orientation, and two scalar density fields associated to molecular motors which either attach to and move along the microtubule, or diffuse within the solvent. We present results f...
Article
We solve a model for the equilibrium folding of DNA via the formation of randomly placed (nonspecific) loops. We find that the loop rearrangement entropy drives a significant reduction in loop size as more loops form. The reduction of the most probable loop size occurs over a wide range of forces and is enhanced by interloop cooperativity, indicati...
Article
We study the formation of loops along a DNA molecule under applied tension, as might occur in single-DNA micromanipulation experiments with proteins which are able to simultaneously bind two DNA sites. We consider the case of "bare" DNA in the loop, which forms a "teardrop" shape, and the case where a single DNA-bending protein produces a "kink" in...
Article
We model the stable self-organized patterns obtained in the nonequilibrium steady states of mixtures of molecular motors and microtubules. In experiments [Nédélec et al., Nature (London) 389, 305 (1997); Surrey et al., Science 292, 1167 (2001)] performed in a quasi-two-dimensional geometry, microtubules are oriented by complexes of motor proteins....
Article
We model the effects of confinement on the stable self-organized patterns obtained in the non-equilibrium steady states of mixtures of molecular motors and microtubules. In experiments [Nedelec et al. Nature, 389, 305 (1997); Surrey et al., Science, 292, 1167 (2001)] performed in a quasi-two-dimensional confined geometry, microtubules are oriented...
Article
We investigate the classical ground-state configurations of a collection of skyrmions in the limit of vanishing Lánde g factor. We show that in this limit, the skyrmions which are large and overlapping, behave qualitatively differently from small skyrmions. We investigate the system in various regimes of spin stiffness. We find that in all regimes,...
Article
We study the linearized hydrodynamics of a two-component fluid membrane near a repulsive wall, using a model that incorporates curvature-concentration coupling as well as hydrodynamic interactions. This model is a simplified version of a recently proposed one [J.-B. Manneville et al., Phys. Rev. E 64, 021908 (2001)] for nonequilibrium force centers...
Article
We investigate the existence of spiral ordering in the planar spin orientation of skyrmions localised on a face centered rectangular lattice (FCRL). We use the non-linear sigma model (NLSM) to numerically calculate the minimum energy configurations of this lattice around the $\nu=1$ quantum Hall ground state. Our variational ansatz contains an angl...