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5
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Introduction
Current institution
Additional affiliations
June 2020 - present
Education
August 2013 - July 2019
July 2008 - July 2010
Publications
Publications (5)
Mycobacterium tuberculosis HddA enzyme phosphorylates the M7P substrate and converts it to M7PP product in GDP-D-α-D-heptose biosynthetic pathway. For structural and functional studies on MtbHddA, we have purified the enzyme, which eluted as a monomer from size exclusion column. Purified MtbHddA had ATPase activity. The SAXS analysis supported glob...
M. tuberculosis GmhA enzyme catalyzes the isomerization of D-sedoheptulose 7-phosphate into D-glycero-D-α-manno-heptose-7-phosphate in GDP-D-glycero-α-D-manno-heptose biosynthetic pathway. The D-glycero-α-D-manno-heptose is a major constituent of lipopolysaccharide and contributes to virulence and antibiotic resistance to mycobacteria. In current s...
The M. tuberculosis GmhB protein converts the D-glycero-α-D-manno-heptose 1,7-bisphosphate
(GMB) intermediate into D-glycero-α-D-manno-heptose 1-phosphate by removing the phosphate
group at the C-7 position. To understand the structure and substrate binding mechanism, the
MtbGmhB was purified which elutes as monomer on gel filtration column. The sm...
Mycobacterium tuberculosis decaprenylphosphoryl-β-d-ribose oxidase (MtbDprE1) acts in concert with decaprenylphosphoryl-β-d-ribose 2-epimerase (MtbDprE2) and catalyzes the epimerization of DPR into DPA. DPA is the sole precursor for synthesis of arabinogalactan and lipoarabinomannan in the mycobacterial cell wall. MtbDprE1 is a unique antimalarial...
