Sumit Rathod

Shri Vile Parle Kelavani Mandal's Institute of Pharamcy Dhule · Pharmacology

The lipid endocannabinoid system has recently emerged as a novel therapeutic target for several inflammatory and tissue-damaging diseases, including those affecting the cardiovascular system. The primary targets of cannabinoids are cannabinoid type 1 (CB1) and 2 (CB2) receptors. The CB2 receptor is expressed in the cardiomyocytes. While the patholo...

Neuroinflammation is a complex biological process that typically originates as a protective response in the brain. This inflammatory process is triggered by the release of pro-inflammatory substances like cytokines, prostaglandins, and reactive oxygen and nitrogen species from stimulated endothelial and glial cells, including those with pro-inflamm...

The Endocannabinoid System (ECS) is a well-studied system that influences a variety of physiological activities. It is evident that the ECS plays a significant role in metabolic activities and also has some neuroprotective properties. In this review, we emphasize several plant-derived cannabinoids such as β-caryophyllene (BCP), Cannabichromene (CBC...

Background: Hairs are an important part of human beauty. The hair and scalp treatment primarily involves the use of shampoo for effective and smooth cleaning. The shampoo is not only a hair cosmetic that is used for the removal of oil, dust particles, dirt, dandruff, and environmental pollutant but it is also intended for maintaining the health and...

Earlier studies reported that long-term treatment with thymoquinone (TQ) at a high dose (20 mg/kg) exerts a cardioprotective effect against isoproterenol (ISO)-triggered myocardial infarction (MI) in rats. In the present study, we tested the hypothesis that TQ, as a potent molecule, can exhibit cardioprotective effects at the lower dose for a short...

Ghrelin is a peptide released by the endocrine cells of the stomach and the neurons in the arcuate nucleus of the hypothalamus. It modulates both peripheral and central functions. Although ghrelin has emerged as a potent stimulator of growth hormone release and as an orexigenic neuropeptide, the wealth of literature suggests its involvement in the...

Lysine, (S)-2,6,-diaminohexanoic acid, is a basic amino acid. Following ingestion, L-lysine is absorbed by the active transport process from the lumen of the small intestine into the enterocytes. L-lysine is a 5-HT4 antagonist that can increase and decrease ethanol intake when they are given intraperitoneal administration. 5-HT4 antagonist can bloc...

Kynurenic acid is a recognized broad-spectrum antagonist of excitatory amino acid receptors with a particularly high affinity for the glycine co-agonist site of the N-methyl-D-aspartate (NMDA) receptor complex. D- Cycloserine is a NMDA receptor partial agonist which facilitate in an initiation of nicotine withdrawal symptoms and dependence. Thus, t...

The aqueous and ethanolic exrracts of Cylista scariosa Roxb. leaves were evaluated for its psychopharmacological activities in several experimental models using swiss albino mice. Use of the elevated plus-maze test revealed that aqueous (100 mg/kg and 200 mg/kg, i.p) and ethanolic (50, 100 and 200 mg/kg, i.p) extracts of Cylista scariosa and standa...

Depression is a common, delibilitating, lifethreatning illness with a high incidence. Numerous antidepressant compounds are now available, which presumably act via different mechanisms involving the serotonergic, noradrenergic and dopaminergic systems. Mucuna pruriens a popular Indian medicinal plant is pharmacologically studied for its antidiabeti...

The present investigations were aimed to formulate the topical herbal analgesic and anti-inflammatory gel. Gels were formulated using different concentration of carbomer-940 and Na CMC as gelling agent and Boswellia serrata extract in 10% concentration. Before the formulation, the quality of raw material was standardized by their analysis including...

Diabetes mellitus is a serious illness with multiple complications and premature mortality, accounting for at least 10% of total health care expenditure in many countries. Bauhinia variegata Linn. grow in subtropical and tropical climate. The chemical constituents present in the plants are ß-sitosterol, luperol, kemferol-3-glucoside, tannins, carbo...

It is believed that drug-induced rewarding effects play an important role in the development of substance dependence. Recently, berberine was reported to inhibit the rewarding effects of drugs of abuse such as cocaine, morphine, and nicotine. Berberine is also demonstrated to modulate the activity of several neurotransmitter systems like, dopamine,...

Berberine ([C20H18NO4](+) ), one of the major constituents of the Chinese herb Rhizoma coptidis, is an isoquinoline alkaloid. Plethora of recent reports has indicated its ability to modulate several neurotransmitter systems, especially those implicated in ethanol dependence. Thus, the influence of berberine treatment on the development and expressi...