Sulagna Dutta

Sulagna Dutta
Mahsa University College | mahsa

PhD

About

119
Publications
91,340
Reads
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2,390
Citations
Additional affiliations
June 2020 - October 2020
Cleveland Clinic
Position
  • Research Mentor
January 2020 - present
Mahsa University College
Position
  • Project Manager
July 2019 - August 2019
Cleveland Clinic
Position
  • Research Intern
Education
April 2012 - November 2016
University of Calcutta
Field of study
  • Physiology (Immunology)
August 2009 - August 2011
University of Calcutta
Field of study
  • Physiology (Specialization in Immunology and Microbiology)
July 2009 - July 2011
Serampore College, University of Calcutta
Field of study
  • Physiology (Honors)

Publications

Publications (119)
Chapter
Toxic metals are potent reproductive disruptors inculcating adversities in male gonadal functioning at the pretesticular, testicular, and posttesticular levels. There are varied sources by which they get access to male reproductive organs. They either intrude into reproductive cells via different transporters mimicking essential metals or endogenou...
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Rabbit, a member of the Lagomorpha order, is the closest phylogenetic relative to humans, next to primates. It possesses greater acceptability as a laboratory mammal than primates in terms of husbandry, breeding ease, cost effectiveness, and legal ethical conveniences. Moreover, as a laboratory animal, the rabbit also owns its advantages over mice...
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Pregnancy, a challenging physiological state, requires shuffling of conventional immune work-sets. Strategies to tolerate the semi-allogenic fetus in normal human pregnancy are multivariate with perfect modulation of the immune cells. Pregnancy is marked by B cell lymphocytopenia accompanied by reduced responsiveness to infectious agents. Besides t...
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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the coronavirus disease 2019 (COVID-19) has been declared a pandemic by the World Health Organization (WHO) on 11th March 2020. Bulk of research on this virus are carried out to unveil its multivariate pathology. Surprisingly, men are reportedly more vulnerable to COVID-19 eve...
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Background The global prevalence of obesity has soared to a concerning height in the past few decades. Interestingly, the global decline in semen quality is a parallel occurrence that urges researchers to evaluate if obesity is among the most essential causatives of male infertility or subfertility. Main body Obesity may alter the synchronized wor...
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Background The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causing the coronavirus disease 2019 (COVID-19), has shown its persistent pandemic strength. This viral infectivity, kinetics, and the mechanisms of its actions in human body are still not completely understood. In addition, the infectivity and COVID-19 severity reportedly...
Article
Estrogens and progesterone, in unison and/or separately, synchronize the distinct events of blastocyst development, uterine priming and receptivity induction for implantation. In contrast to high implantation failure rates, the mechanistic concepts regarding the uterine receptivity for implantation still remain elusive. The present study aims to de...
Article
In article number 2100276, Gorain and co‐workers review the current strategies in breast cancer therapy. The research progress in delivering epigenetic agents using a nanotechnology platform can overcome solubility issues and unnecessary systemic exposure limitations. Thereby, specific, targeted, and efficient delivery can manage breast cancer cond...
Chapter
Idiopathic male infertility (IMI) refers to the condition where semen quality declines, but exact causatives are not identified. This occurs in almost 30–40% of infertile men. Traditional semen analyses are extensively used for determining semen quality, but these bear critical shortcomings such as poor reproducibility, subjectivity, and reduced pr...
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Male component is the major contributing factor in over half of all cases of infertility, with over 25% of infertile males having no recognised underlying cause of infertility. In around 40–50% of male infertility cases, oxidative stress (OS)-related processes have been found to be responsible for fertility impairment. Inflammation is a major stres...
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Nitric oxide (NO), a reactive nitrogen species, is a molecule of high physiological as well as pathological importance. Physiological mechanisms mediated by NO mainly include angiogenesis, growth, puberty and senescence. NO has vital roles in normal reproduction, including steroidogenesis, gametogenesis and the regulation of germ-cell apoptosis. In...
Article
The effects of chemosterilizing agents on the testes and sperm production and maturation are much less understood than their effects on the ovaries and oogenesis. It was discovered that sterilising male insects with ionising radiation caused the emergence of chromosome-wide or chromatid-specific dominant lethal mutations, which led to the developme...
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Infertility and conception complications have long been major global health concerns1, and these continue to be significant clinical problems affecting 8% to 10% of couples globally and 7% to 15% of couples in the United States2-6. Infertility has also been common among the Indian population (4-6%, as per the 1981 census)4. In the causation of infe...
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Coronavirus disease 2019 (COVID-19) involves a complex pathogenesis and with the evolving novel variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the long-term impacts of the unceasing COVID-19 pandemic are mostly uncertain. Evidence indicates deleterious impact of this disease upon male reproductive health. It is concer...
Article
Breast cancer (BC), the most common cancer in women, is incurable due to metastatic spread to distant organs. Existence of epigenetic dysregulation had been shown to contribute to the progression and even metastasize through the transition from epithelial to mesenchymal. Behind failure strategies of conventional treatments, fruitful outcomes of epi...
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American Center for Reproductive Medicine Reasearch Collaborators-2018
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Viral infections have been a part of human existence to date, though viruses have posed a huge threat with various outbreaks lately. These threats are associated with reproductive health challenges, especially male infertility. The prime focus of this review is to highlight the mechanisms associated with viral infection-induced male infertility/sub...
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Few peculiarities have been observed in the aetiology of coronavirus disease 2019 (COVID-19), one such being its greater prevalence in men than women partly due to the higher expressions of angiotensin-converting enzyme-2 (ACE2) in the male reproductive tissues. Recent scientific reports are in line with some of the evidence-based hypotheses in the...
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The pathophysiology of male infertility involves various interlinked endogenous pathways. About 50% of the cases of infertility in men are idiopathic, and oxidative stress (OS) reportedly serves as a central mechanism in impairing male fertility parameters. The endogenous antioxidant system operates to conserve the seminal redox homeostasis require...
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Male infertility is approaching a concerning prevalence worldwide, and inflicts various impacts on the affected couple. The hormonal assessment is a vital component of male fertility evaluation as endocrine disorders are markedly reversible causatives of male infertility. Precise hormonal regulations are prerequisites to maintain normal male fertil...
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Male infertility is referred to as the lack of ability of the male to impregnate his fertile female partner even after 12 months of unprotected, frequent sexual contact. It affects anywhere from 9 percent to 15.8percent of the general population. Male infertility can be treated with a variety of conventional methods, but the effectiveness of this t...
Article
Immunological infertility contributes significantly to the etiology of idiopathic male infertility. Shielding the spermatogenic cells from systemic immune responses is fundamental to secure normal production of spermatozoa. The body’s immune system is tuned with the host self-components since the early postnatal period, while sperm first develops d...
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Human reproductive system involve a number of intricate complex interconnected physiological metabolic pathways and metabolites with involvement of overall health of different body organs. Overall health alterations mediated physiological conditions such as obesity, diabetes etc. bring about additional variations in expression and presence of metab...
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Untainted environment promotes health, but the last few decades experienced steep upsurge in environmental contaminants posing detrimental physiological impact. The responsible factors mainly include the exponential growth of human population, havoc rise in industrialization, poorly planned urbanization, and slapdash environment management. Environ...
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Adropin is a novel peptide hormone with multidimensional functionalities awaiting to be unveiled completely. This hormone is encoded by the 'energy homeostasis-associated' (Enho) gene. It is primarily produced by the liver, while to some extent by the brain, circulatory system and numerous other peripheral tissues. In the twelve years of its discov...
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Adipokines, mostly produced by white adipose tissues, have been established to be endocrine factors which are also essential in energy homeostasis. More recently, their contribution in fertility regulation has been recommended. Resistin as well as visfatin are unique adipocyte-derived signaling chemicals whose expressions enhance in advanced obesit...
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Orexins are hypothalamus-derived neuropeptides with versatile functions. The most explored domains of orexins’ functions are their influence on the central nervous system (CNS) implicated in the regulation of sleep/wakefulness cycle, food intake behavior, energy homeostasis, and cognitive processes. Orexins reportedly bear two isoforms, orexin-A...
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Adipokines are peptides produced mainly by the fat tissue adipocytes and their levels are sensitive to alterations in metabolic state. While there is little known about the impact of adipokines on male reproductive control, both animal-based experimental data and clinical research suggest that they can influence numerous male fertility indices. Che...
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Irisin is a novel skeletal muscle- and adipose tissue-secreted peptide. It is conventionally regarded as an adipomyokine and is a cleaved fragment of Fibronectin type III domain-containing protein 5 (FNDC5). It is involved in the browning of white adipose tissue, glucose tolerance, and reversing of metabolic disruptions. Fertility is closely linked...
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Inflammation is among the core causatives of male infertility. Despite male infertility being a serious global issue, “bits and pieces” of its complex etiopathology still remain missing. During inflammation, levels of proinflammatory mediators in the male reproductive tract are greater than usual. According to epidemiological research, in numerous...
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Objective: Anemia bears a high global prevalence with about 1.6 billion people living with this affliction. Malaysia carries the burden of 13.8% anemia prevalence which urges for extensive research directed to its prediction and amelioration. This is the first study that aims to (a) propose simple non-invasive predictive anthropometric markers and...
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Polycystic ovarian syndrome (PCOS) is the most common cause of anovulatory fertility problems in women of reproductive age, with a prevalence as high as 40% to 75%. There are different treatment modalities for increasing the chance of pregnancy in PCOS patients. Since most of the PCOS patients suffer from ovulatory problems, therapeutic efforts are...
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One of the most prevalent serum adipokines, adiponectin, is well-known for its function in regulating insulin sensitivity and preventing the metabolic syndrome from developing. Adiponectin is expressed in numerous components of the testis and studies claim that adiponectin may have positive paracrine effects on testicular functions. Adiponectin, on...
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Male infertility undeniably is a serious global issue affecting one in every 20 men and about 50% of overall infertility cases are contributed by male factor(s). Despite the declining trend of male fecundity and overwhelming prevalence of men infertility, there are very subtle efforts made to address the yet unknown underlying causatives for the de...
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Women perhaps are more exposed to coronavirus disease 2019 (COVID-19), caused by the novel coronavirus (CoV) called as the severe acute respiratory syndrome-CoV-2 (SARS-CoV-2), as compared to men, due to their greater contribution in healthcare and social services. Globally, around 70% of health and social service providers constitute of female. Th...
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Objective: To evaluate the clinical efficacy and safety profile of a novel-designed isosceles-configured (SUN Teeth™) toothbrush in comparison to a standard reference toothbrush with end-rounded bristles (approved by the American Dental Association [ADA]). Methods: The sample size was determined using the G-Power-software, version 3.1.2 and, acc...
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Background Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has turned into a global pandemic with multitudinous health impacts. Main body In light of the higher vulnerability of men to COVID-19 than women, there is rising concerns on the impact of SARS-CoV-2 infection on male fertili...
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Objective: Oxidative stress (OS) plays a key role in the etiology of unexplained male infertility. Coenzyme Q10 (CoQ10) is a potent antioxidant that may improve semen quality and OS in infertile men with idiopathic oligoasthenoteratospermia (OAT), but the underlying mechanism is unknown. Therefore, the present study was undertaken to investigate t...
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Male infertility has a complex etiopathology, which mostly remains elusive. Although research has claimed that oxidative stress (OS) is the most likely underlying mechanism of idiopathic male infertility, the specific treatment of OS-mediated male infertility requires further investigation. Coenzyme Q10 (CoQ10), a vitamin-like substance, has been f...
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Climate change is an incessant global phenomenon and has turned contentious in the present century. Malaysia, a developing Asian country, has also undergone significant vicissitudes in climate, which has been projected with significant deviations in forthcoming decades. As per the available studies, climate changes may impact on the fertility, eith...
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Purpose: Polycystic ovarian syndrome (PCOS) is most commonly presented with insulin resistance (IR). Simple anthropometric indices may serve as surrogate markers of these conditions with population-based cut-off values. The present study suggests the cut-off values of waist-to-height ratio (WHtR) and body mass index (BMI) in early prediction of PCO...
Conference Paper
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Background: Since the past few decades, the global decline in male fertility has been a persistent concern. Male infertility accounts for half of the world's estimated infertility occurrences. In recent years, there has been a lack of interventions on fertility parameters in Malaysian men despite evidence of reduced fertility rates in Malaysia. In...
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Climate change has always been a major factor affecting health and the economy of the world. In the 21st century these effects have become more pronounced. Over the next decades, researchers expect significant environmental vicissitudes such as rising annual temperatures, increasing sea levels, rainfall fluctuations and extreme weather events in Ma...
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Pandemics are regarded as large-scale outbreaks of infectious disease that has the potential to significantly increase morbidity and mortality over a wide geographical area, which is accompanied by economic, social and political disruption. The likelihood of pandemic, especially caused by viral infectious diseases has increased over the past few ye...
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In 2020, the COVID‐19 pandemic led to the suspension of the annual Summer Internship at the American Center for Reproductive Medicine (ACRM). To transit it into an online format, an inaugural 6‐week 2020 ACRM Online Mentorship Program was developed focusing on five core pillars of andrology research: scientific writing, scientific methodology, plag...
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Background: Salivary factors modulate the balanced dynamic mineralization process of the dental enamel. Salivary proteins such as statherin and acidic proline-rich proteins (PRPs) protect oral surfaces by regulating oral calcium homeostasis and remineralization of enamel. Thus, they possibly play vital roles in dental caries. Aim: The present st...
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Men show higher vulnerability to severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection (COVID-19) and present with depleted testosterone levels. Reports pertaining to high luteinizing hormone (LH), while diminished levels of in COVID-19 patients negate the hypothalamic–pituitary–testicular (HPT) axis mediated lowering of testostero...
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The study explores the possible roles played by the salivary proteins like statherin acidic proline-rich proteins (aPRP) in dental caries formation.
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Mulberries are popular edible fruits found in abundance in Asia, and their uses as traditional medicine date back to ancient eras. These fruits have been found to contain a great variety of nutritive components, namely, amino acids, essential fatty acids, vitamins, and minerals. Mulberries are also rich in bioactive compounds, such as rutin, anthoc...
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The last four decades has witnessed some of the deadliest viral pandemics with far-reaching consequences. These include the Human Immunodeficiency Virus (HIV) (1981), Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) (2002), Influenza A virus subtype H1N1 (A/H1N1) (2009), Middle East Respiratory Syndrome Coronavirus (MERS-CoV) (2012), Ebola...
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Rabbit strains find immense application in biomedical research with every strain having their discrete advantage in the specific research endeavor. Acceptability of rabbit strains as laboratory animals owes to their breeding ease, availability, cost-effectiveness, ethical conveniences, larger size compared to rats and mice, and responsiveness. With...
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Infertility is a subject of worldwide concern as it affects approximately 15% of couples. Among the prime contributors of infertility, urogenital bacterial infections have lately gained much clinical importance. Staphylococcal species are commensal bacteria and major human pathogens mediating an array of reproductive tract infections. Emerging evid...
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Adrenaline and noradrenaline are important catecholamines of the biological system, responsible for the regulation of major functions of the body via their action on the brain. This noradrenaline is the chief neurotransmitter of the sympathetic nervous system, whereas adrenaline is an important metabolic hormone, known to play a vital role in the c...
Chapter
Histamine is an important monoamine consisting of an imidazole ring, which is connected to the amino group by an ethylene group. It is biosynthesized through histidine decarboxylase-catalysed decarboxylation of the amino acid L-histidine. It acts through four different G-protein-coupled receptors in different locations of the body to exert its phar...
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Obesity is a “multi-metabolic and hormonal disease state” that primarily results from an imbalanced physiological energy homeostasis. There is a wide range of factors that play role in the causation of obesity, which can be exogenous or endogenous. Despite significant advances in research to develop knowledge over the development and progression of...
Article
Male infertility has a complex etiology, and many times, the cause is unknown. While routine semen analysis provides an overview of basic semen parameters, such as sperm concentration, motility, viability and morphology, a significant overlap of these parameters has been reported in fertile and infertile men. Moreover, conventional semen parameters...
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Background: The three-parent assisted reproductive technique may increase oocyte competence. Objective: In this case-control study, the suitability of germinal vesicle transfer (GVT), synchronous ooplasmic transfer (sOT), asynchronous ooplasmic transfer using cryopreserved MII oocyte (caOT), and asynchronous ooplasmic transfer using waste MII oo...
Article
Alongside an increasing prevalence of couple and male infertility, evidence suggests there is a global declining trend in male fertility parameters over the past few decades. This may, at least in part, be explained through detrimental lifestyle practices and exposures. These include alcohol and tobacco consumption, use of recreational drugs (e.g.,...
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Disruption of semen quality in cases of testicular and accessory gland infections, owe to altered spermatogenesis, sperm maturation and/or transport. The impact depends on the intensity, duration of progression, mediators of the inflammatory process and individual susceptibility to the infection. Interactions among the mediators with immunological...
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Worldwide concern regarding the growing incidence of male infertility is taking a toll on research to unveil numerous factors affecting male reproductive functions. Infection or inflammation in the reproductive tract either via pathogenic intrusion or systemic diseases, reportedly are closely associated with deterioration in male fertility paramete...
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Male reproductive tract inflammation/infection possibly has a direct association with the occurrence of male infertility. Semen quality has been reported to be markedly reduced in conditions of male reproductive tract inflammation owing to functional or anatomical alterations in the reproductive tract such as accessory glands dysfunctions, obstruct...
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Oxidative stress (OS), occurring as a result of redox imbalance, have been considered a leading cause of male infertility. Redox imbalance is mediated by excessive production of reactive oxygen species (ROS) exceeding the antioxidant capacity. In seminal plasma, the main contributor of ROS are the infiltrated and resident leukocytes, although modes...
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Studies in the last few decades have explained the role of different factors in the induction of obesity and related complications, such as obesity-induced male infertility. Among these factors, the endocrine and inflammatory factors are the major contributors that lead to male reproductive issues in obese men. However, the exact mechanism by which...
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Male infertility is a multifactorial condition which in some cases are presented with unidentifiable underlying causes. Men with idiopathic or non-curable oligoasthenoteratozoospermia as well as with unexplained infertility may be provided with non-hormonal medical treatment which includes the use of anti-inflammatory, antioxidants, fibrinolytic co...
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Male reproductive system is immunoprivileged and has special immune microenvironment to protect the testicular cells including the germ cells. A wide range of microorganisms are identified that can infect male reproductive tissues via hematogenous dissemination as well as male genitourinary tract, and severely impair reproductive functions. Testis...
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Aim: To compare the effects of conventional and camouflage syringe in reducing anxiety and pain levels during maxillary dental procedures in paediatric patients. Study design: Children between 4 and 14 years who attended Dental Clinic, MAHSA University, Malaysia and required local anesthesia, were randomly selected for the present study with due co...
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Erectile dysfunction (ED) is one of the most common sexual dysfunctions, which may be defined as persistent or recurrent inability of sufficient penile erection during sexual performance1 . It is a major global men’s health problem affecting more than 150 million individuals and is expected to still increase significantly owing to poor lifestyle fa...
Chapter
The prevalence of obesity has increased at soaring rates in the last 35 years with greater than a third of the US population being afflicted with the condition. Concurrent reduction in male fecundity in terms of declining semen quality is another major global concern. A growing body of research has indicated the potential role of obesity in the det...
Chapter
Oxygen, in its diatomic form, is essentially reduced to sustain cellular respiration and survival. This reduction leads to generation of highly reactive oxygen metabolites or reactive oxygen species (ROS), which influence various cellular functions. Endogenous ROS generation in male reproductive tissue and its seminal concentration possess both phy...
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Purpose: Oxidative stress and sperm DNA fragmentation (SDF) are potential contributing factors for idiopathic male infertility. Coenzyme Q10 (CoQ10) have been reported to be effective in the treatment of idiopathic male infertility, in general, owing to its antioxidant properties. Thus, the present study intends to investigate the effects of CoQ10...