• Home
  • Sukhen Das Mandal
Sukhen Das Mandal

Sukhen Das Mandal
Ghani Khan Choudhury Institute of Engineering And Technology

Doctor of Philosophy

About

12
Publications
2,084
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
198
Citations

Publications

Publications (12)
Article
Post-transcriptional regulation of gene expression plays a major role in determining the cellular proteome in health and disease. Post-transcriptional control mechanisms are disrupted in many cancers, contributing to multiple processes of tumorigenesis. RNA-binding proteins (RBPs), the main post-transcriptional regulators, often show altered expres...
Article
Full-text available
Quorum-sensing mechanisms that sense the density of immune cells at the site of inflammation to initiate inflammation resolution have recently been demonstrated as a major determinant of the inflammatory response. We observed a density-dependent increase in expression of the inflammatory tumor suppressor protein programmed cell death 4 (PDCD4) in m...
Article
N6-methyladenosine (m⁶A), the most prevalent epitranscriptomic modification in eukaryotes, is enriched in 3′-untranslated regions (3′UTRs) of mRNAs. As 3′UTRs are major binding sites of RNA-binding proteins (RBPs) and microRNAs (miRNAs), m⁶A-dependent local RNA structure change may alter the accessibility of RBPs and miRNAs to their target sites an...
Article
Full-text available
Expression of tumor suppressor p53 is regulated at multiple levels, disruption of which often leads to cancer. We have adopted an approach combining computational systems modeling with experimental validation to elucidate the translation regulatory network that controls p53 expression post DNA damage. The RNA-binding protein HuR activates p53 mRNA...
Article
Riboswitches are cis-regulatory non-coding genomic segments that control the expression of downstream genes by undergoing conformational change upon ligand binding. We present a comprehensive database of prokaryotic riboswitches that allows the user to search for riboswitches using multiple criteria, extract information about riboswitch location an...
Article
Full-text available
Hepatitis E virus (HEV) is a pathogen that is transmitted by the fecal-oral route. Owing to the lack of an efficient laboratory model, the life cycle of the virus is poorly understood. During the course of infection, interactions between the viral and host proteins play essential roles, a clear understanding of which is essential to decode the life...
Article
Full-text available
Background Myc is an essential gene having multiple functions such as in cell growth, differentiation, apoptosis, genomic stability, angiogenesis, and disease biology. A large number of researchers dedicated to Myc biology are generating a substantial amount of data in normal and cancer cells/tissues including Burkitt’s lymphoma and ovarian cancer....
Article
Full-text available
PPIMpred is a web server that allows high-throughput screening of small molecules for targeting specific protein–protein interactions, namely Mdm2/P53, Bcl2/Bak and c-Myc/Max. Three different kernels of support vector machine (SVM), namely, linear, polynomial and radial basis function (RBF), and two other machine learning techniques including Naive...
Article
Full-text available
Pluripotency is a unique property of stem cells that allows them to differentiate into all types of adult cells or maintain the self-renewal property. PluriPred predicts whether a protein is involved in pluripotency from primary protein sequence using manually curated pluripotent proteins as training datasets. Machine learning techniques (MLTs) suc...

Network

Cited By