Sukanta Kamila

Sukanta Kamila
Ulster University · School of Pharmacy and Pharmaceutical Science

PhD (Organic Chemistry)

About

84
Publications
8,113
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1,216
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Introduction
Ph.D in Organic Chemistry from Jadavpur University (IACS), W.B. India, Postdoc research from USA and UK, 75 publications so far, 5 Granted International Patents; currently working in Ulster University, UK. We have recently discovered a family of small molecules that shows promise in protecting brain cells against nerve-degenerative diseases such as Parkinson’s, Alzheimer’s and Huntington’s. Dallas-based biotech company EncephRx Inc is going to market the drug world wide.
Additional affiliations
July 2014 - present
Ulster University
Position
  • Research Associate
Description
  • Full time research
March 2010 - December 2013
Southern Methodist University
Position
  • Research Associate
Description
  • full time research, applying for grant, supervising grad & under-grad students.
March 2007 - March 2009
Robert Gordon University
Position
  • Postdoctoral Research
Description
  • Full time research.
Education
November 1998 - November 2003
April 1996 - July 1998
Vidyasagar University
Field of study
  • Organic Chemistry, Inorganic Chemistry, Physical Chemistry & Industrial Chemistry

Publications

Publications (84)
Article
Treatment options for patients with pancreatic cancer are limited and survival prospects have barely changed over the past 4 decades. Chemoradiation treatment (CRT) has been used as neoadjuvant therapy in patients with borderline resectable disease to reduce tumour burden and increase the proportion of patients eligible for surgery. Antimetabolite...
Article
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Purpose Chemoradiation therapy is the standard of care in muscle-invasive bladder cancer (MIBC). Although agents such as gemcitabine can enhance tumor radiosensitivity, their side effects can limit patient eligibility and treatment efficacy. This study investigates ultrasound and microbubbles for targeting gemcitabine delivery to reduce normal-tiss...
Article
In this study we compared three different microbubble-based approaches to the delivery of a widely used chemotherapy drug, gemcitabine: (i) co-administration of gemcitabine and microbubbles (Gem+MB); (ii) conjugates of microbubbles and gemcitabine-loaded liposomes (GemlipoMB); and (iii) microbubbles with gemcitabine directly bound to their surfaces...
Patent
Full-text available
The invention relates to microbubble complexes for use in methods of sonodynamic therapy which comprise a microbubble attached to or otherwise associated with one or more linking groups, each linking group being bound to at least one sonosensitising agent and at least one chemotherapeutic agent. It further relates to the microbubble complexes thems...
Article
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Recent pre-clinical studies have demonstrated the potential of combining chemotherapy and sonodynamic therapy for the treatment of pancreatic cancer. Oxygen-loaded magnetic microbubbles have been explored as a targeted delivery vehicle for this application. Despite preliminary positive results, a previous study identified a significant practical ch...
Article
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Mastectomy is a common surgical treatment used in the management of breast cancer but has associated physical and psychological consequences for the patient. Breast conservation surgery (BCS) is an alternative to mastectomy but is only possible when the tumour is of an appropriate size. Neo-adjuvant chemotherapy has been successfully used to downst...
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Phospholipid coated microbubbles are currently in widespread clinical use as ultrasound contrast agents and under investigation for therapeutic applications. Previous studies have demonstrated the importance of the coating nanostructure in determining microbubble stability and its dependence upon both composition and processing method. Whilst the i...
Article
Ultrasound, microbubbles, and magnetic nanoparticles have been used both separately and in varying combinations for targeted drug delivery. Recent studies have demonstrated the therapeutic benefit of magnetic microbubble (MMB) retention and acoustic targeting using separate devices. As a developmental step towards clinical implementation, a magneti...
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A ratiometric polymeric fluorescent probe for Zn(II) was developed comprising a Zn(II) responsive napthalimide sensing unit and a Zn(II) insensitive rhodamine based calibration fluorophore attached to a common poly(methyl methacrylate) backbone. The Zn(II) responsive unit was designed to operate according to the photoinduced electron transfer (PET)...
Article
Pancreatic cancer remains one of the most lethal forms of cancer with a 10-year survival of <1%. With little improvement in survival rates observed in the past 40 years, there is a significant need for new treatments or more effective strategies to deliver existing treatments. The antimetabolite gemcitabine (Gem) is the most widely used form of che...
Article
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Magnetically responsive microbubbles (MagMBs), consisting of an oxygen gas core and a phospholipid coating functionalised with Rose Bengal (RB) and/or 5-fluorouracil (5-FU), were assessed as a delivery vehicle for the targeted treatment of pancreatic cancer using combined antimetabolite and sonodynamic therapy (SDT). MagMBs delivering the combined...
Article
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A new class of iodinated cyanine dyes have been prepared for use in NIR excited photodynamic therapy (PDT) and demonstrated improved efficacy in two pancreatic cell lines as well as excellent tumour control in a murine model of the disease.
Article
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The interest in Quantum Dots as a class of nanomaterials has grown considerably since their discovery by Ekimov and Efros in the early 1980s. Although this early work focussed primarily on CdSe-based nanocrystals, the field has now expanded to include various classes of nanoparticles with different types of core, shell or passivation chemistry. Suc...
Article
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In this manuscript we describe the preparation of an oxygen-loaded microbubble (O2MB) platform for the targeted treatment of pancreatic cancer using both sonodynamic therapy (SDT) and antimetabolite therapy. O2MB were prepared with either the sensitiser Rose Bengal (O2MB-RB) or the antimetabolite 5-fluorouracil (O2MB-5FU) attached to the microbubbl...
Article
Full-text available
A new sensitiser (4) for use in photodynamic therapy (PDT) has been developed to enable control ROS production as a function of pH. This pH dependent PDT behaviour was tested in HeLa cells and in SCID mice bearing human xenograft pancreatic cancer (BxPC-3) tumours.
Patent
Full-text available
The present invention provides methods of making and using 5-(2-(indol-3-yl)-2-oXoethylidene)-3-phenyl-2-thioxothia Zolidin-4-one derivatives having HIV-1 or J SP-l inhibitory activity.
Article
Full-text available
Luminescent sensors and switches continue to play a key role in shaping our understanding of key biochemical processes, assist in the diagnosis of disease and contribute to the design of new drugs and therapies. Similarly, their contribution to the environment cannot be understated as they offer a portable means to undertake field testing for hazar...
Patent
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The present invention provides oxazine compounds, method of using and method of making oxazine compounds and its pharmaceutical use.
Article
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Luminescent sensors and switches continue to play a Q3 key role in shaping our understanding of key biochemical processes, assist in the diagnosis of disease and contribute to the design of new drugs and therapies. Please check this proof carefully. Our staff will not read it in detail after you have returned it. Translation errors between word-pro...
Article
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The pathogenic mechanism(s) contributing to loss of dopamine neurons in Parkinson's disease (PD) remain obscure. Leucine-rich repeat kinase 2 (LRRK2) mutations are linked, as a causative gene, to PD. LRRK2 mutations are estimated to account for 10 % of familial and between 1 % and 3 % of sporadic PD. LRRK2 proximate single nucleotide polymorphisms...
Article
Full-text available
The synthesis of a variety of novel 5-substituted titled compounds containing a priviledged rhodanine scaffold is described. The synthesis involves a microwave (MW) assisted Knoevenagel condensation of 3-(2-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-2-thioxothiazolidin-4-one with suitably substituted aromatic aldehydes. However...
Patent
Full-text available
The present invention provides oxazine compounds, method of using and method of making oxazine compounds and its pharmaceutical use.
Patent
Full-text available
The present invention provides oxazine compounds, method of using and method of making oxazine compounds and its pharmaceutical use.
Article
Full-text available
N-Phenyl-4-(6-phenylimidazo[2,1-b]thiazol-5-yl)thiazol-2-amines (6a-q) have been synthesized by the Hantzsch thiazole reaction of 2-chloro-1-(6-phenylimidazo[2,1-b]thiazol-5-yl)ethanones (4a-e) with suitably substituted thioureas using microwave heating. The ethanones (4a-e) were prepared by the reaction of 6-phenylimidazo[2,1-b]thiazoles (3a-e) wi...
Article
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Pyridobenzimidazoles 6a-iwere synthesized in very good to excellent yields (81-96%) by the condensation of substituted N-phenyl-o-phenylenediamines 4a-d with indole/benzo[b]thiophene-3-aldehydes 5a-t inmethoxyethanol under reflux conditions. The diamines 4a-d were prepared byfirst treating 2-chloro-3-nitropyridine (1)with suitably substituted anili...
Article
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2-(Alkyl-1-yl)-1H-imidazol-5(4H)-ones 5a-n were synthesized via nucleophilic substitution of the methylsulfanyl group of the corresponding 2-(methylthio)-1H-imidazol-5(4H)-ones 3a-c with suitably substituted secondary amines. The starting 2-thioxo- imidazolidin-4-ones 2a,2b were prepared by condensation of thiohydantoin and benzo[b]-thiophene-3-car...
Article
Full-text available
Pyridobenzimidazoles 6a-i were synthesized in very good to excellent yields (81-96 %) by the condensation of substituted N-phenyl-o-phenylenediamines 4a-d with indole/benzo[b]thiophene-3-aldehydes 5a-t in methoxyethanol under reflux conditions. The diamines 4a-d were prepd. by first treating 2-chloro-3-nitropyridine (1) with suitably substituted an...
Article
Full-text available
Condensation of 1,2-phenylenediamine with a variety of indole-based oxoacetaldehydes, prepd. from the corresponding acid chlorides in presence of HSnBu3, furnished 2-(1H-indol-3-yl)quinoxalines. In addn., 1,2-phenylenediamines substituted with a strong electron-withdrawing group at the para position, provided 6-substituted (1H-indol-3-yl)quinoxalin...
Article
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CdSe/ZnS quantum dots functionalised with [Carboxymethyl-(4-mercapto-phenyl)-amino]-acetate displayed selectivity for Zn 2+ion when tested against a range of other commonly available metal ions in buffered aqueous solution (pH 7.0 ± 0.1). The probe displayed an enhancement in its fluorescence intensity upon addition of Zn2+attributed to a cancella...
Article
Full-text available
Condensation of 1,2-phenylenediamine with a variety of indole based aldehydes, prepared from the corresponding acid chloride in presence of HSnBu3, furnishes (1H-indol-3-yl)quinoxalines. In addition, 1,2-phenylenediamines substituted with a strong electron-withdrawing group at the para position, provides 6-substituted (1H-indol-3-yl)quinoxalines. S...
Article
Full-text available
Condensation of 1,2-phenylenediamine with a variety of indole based aldehydes, prepared from the corresponding acid chloride in presence of HSnBu(3). furnishes (1H-indol-3-yl)quinoxalines. In addition, 1,2-phenylenediamines substituted with a strong electron-withdrawing group at the para position, provides 6-substituted (1H-indol-3-yl)quinoxalines....
Article
Full-text available
CdSe/ZnS quantum dots functionalized with [carboxymethyl-(4-mercapto-phenyl)-amino]-acetate displayed selectivity for Zn2+ ion when tested against a range of other commonly available metal ions in buffered aq. soln. (pH 7.0 ±0.1). The probe displayed an enhancement in its fluorescence intensity upon addn. of Zn2+ attributed to a cancellation of a p...
Article
Full-text available
The photophys. properties of a range of fluorescent sensors with β-aminobisphosphonate receptors were studied. The compds. were designed according to the fluorophore-spacer-receptor format of photoinduced electron transfer-based sensors. The sensors displayed unusual fluorescence intensity-pH profiles that were attributed to a receptor-fluorophore...
Article
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A wide variety of titled compounds, several of which have neuro-protecting properties has been prepared in yields ranging between 70 to 90%. The compounds were identified by 1 HNMR, 13 C NMR, 1D and 2D NOE analysis, and HRMS. An investigation of the effect of certain 5-substitutuents on the E to Z ratios in DMSO-d 6 was carried out. The 5-nitro and...
Article
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Neurodegenerative diseases are a major health problem particularly among the elderly. Drugs to prevent or slow down the death of neurons are urgently needed but are currently unavailable. We previously reported that the c-Raf inhibitor, GW5074 {5-iodo-3-[(3',5'-dibromo-4'-hydroxyphenyl) methylene]-2-indolinone}, is protective in tissue culture and...
Article
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Commercially available CdSe-ZnS Quantum Dots (QDs) have been modified by exchanging the hydrophobic surface ligands with (2-mercaptoethyl)-trimethylammonium chloride. The resulting water soluble conjugate was titrated with solutions of adenosine triphosphate (ATP), adenosine diphosphate, adenosine monophosphate, guanosine triphosphate (GTP), guanos...
Article
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A CdSe-ZnS quantum dot (QD) has been surface functionalised with 1-(2-mercapto-ethyl)-3-phenyl-thiourea in the fluorophore-spacer-receptor format typical of Photoinduced Electron Transfer (PET) based organic dye sensors. The resulting QD conjugate was tested for selectivity toward the tetrabutylammonium salts of fluoride, chloride, bromide, hydroge...
Article
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A novel β-aminobisphosphonate receptor has been combined with naphthalene in the fluorophore–spacer–receptor format of a typical photoinduced electron transfer (PET) based sensor. The sensor was synthesised in two steps by first reacting aminomethylnaphthalene with diethyl vinylphosphonate to produce the parent tetraester, followed by deprotection...
Article
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A series of new 2-alkyl/arylbenzothiazoles has been synthesized on the basis of the potent and selective in vitro anti-tumor properties of 2-(3,4-diethoxyphenyl)-5-fluorobenzothiazole. The synthesis of benzothiazole analogs was achieved via microwave irradiation of a 1:1 mixture of o-aminothiophenol and alkyl/aryl acylacetonitriles at temperature o...
Article
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Thiazolines were synthesized in a one-pot reaction in excellent yield using a newly developed methodology. Ketonitriles were directly condensed with cysteamine (2-amino-thioalcohol) via microwave irradiation at 210°C for 10 minutes under solvent free conditions and without any solid support. All the compounds were characterized by 1H nmr, 13C nmr s...
Article
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A series of 2-alkyl/aryl-4H-benzo[1,4]thiazine-3-ones have been synthesized by microwave irradiation of ethyl-2-bromo-2-alkyl/aryl acetate and 2-amino thiophenol in the presence of 1,8-diazabicyclo-[5.4.0]undec-7-ene and N-methylpiperidine. All compounds were characterized by 1H NMR, 13C NMR and elemental analyses, and by X-ray crystallography in t...
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2‐Aryl‐substituted nitriles were prepared in good to excellent yields in a one‐pot reaction by the reaction of benzyne, generated using neutral conditions from (phenyl)[o‐(trimethylsilyl)‐phenyl]iodonium triflate, and 2‐lithionitriles. 3‐Keto nitriles substituted at the 2‐position were obtained in good yields when these reactions were trapped with...
Article
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(Z)-Hetarylmethylene and (Z)-substituted benzylidene derivs. of 4H-benzo[1,4]thiazine-3-thiones were prepd. by the reaction of 4H-benzo[1,4]thiazine-3-thiones with various aldehydes. Subsequent treatment of the thiazine-3-thiones with di-Me acetylenedicarboxylate and various arynes gave the corresponding di-Me 4-aryl-4,10-dihydrothiopyrano[3,2- b]b...
Article
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Biocatalytic enantioselective hydrolysis of beta-hydroxy nitriles to corresponding (S)-enriched beta-hydroxy carboxylic acids has been achieved for the first time by an isolated nitrilase bll6402 from Bradyrhizobium japonicum USDA110. This offers a new "green" approach to optically pure beta-hydroxy nitriles and beta-hydroxy carboxylic acids. The o...
Article
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Treatment of cyclic tert-trihalomethylcarbinols with CrCl(2) in THF/HMPA in the presence of aryl or aliphatic aldehydes initiates a cascade sequence of one carbon ring expansion-olefination affording conjugated exocyclic ketones. Acyclic tert-trihalomethylcarbinols undergo a comparable cascade of one carbon homologation-olefination.
Article
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Substituted quinoxalin-2-ones have been prepared in high yields in a one-pot reaction in which a 1:1 mixture of 1,2-diaminobenzene and appropriate ethyl 2-bromoalkyl/aryl acetate is subjected to microwave irradiation in presence of DBU at 190 °C for 6 min A possible mechanism is presented.{A figure is presented}.
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4,4‐Dialkyl and 4,4‐diaryl‐4H‐benzo[d][1,3]oxathiin‐2‐ones were synthesized by the reaction of 2‐(mercapto‐phenyl)‐dialkyl‐ (or diaryl)‐methanol with CDI in excellent yield. The 2‐(mercaptophenyl)‐dialkyl‐ (or diaryl)‐methanols were prepared by the reaction of commercially available methylthiosalicylate with an appropriate alkyl or aryl Grignard re...
Article
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4 A series of 2-alkyl/aryl-4H-benzo[1,4]thiazine-3-ones have been synthesized by microwave irradiation of ethyl-2-bromo-2-alkyl/aryl acetate and 2-amino thiophenol in the presence of 1,8-diazabicyclo-[5.4.0]undec-7-ene and N-methylpiperidine. All compounds were characterized by 1 H NMR, 13 C NMR and elemental analyses, and by X-ray crystallography...
Article
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Eco-friendly direct solvent-free reactions of 2-aminothiophenol and arom. or aliph. b-keto esters with microwave irradn. produced 2-substituted benzothiazoles in excellent yield. Expts. that compared microwave irradn. to conventional heating methods showed that the former gives the 2-substituted benzothiazoles faster and in higher yields. The forma...
Article
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(Z)-Hetarylmethylene and (Z)-substituted benzylidene derivatives of 4H-benzo[1,4]thiazine-3-thiones were prepared by the reaction of 4H-benzo[1,4]thiazine-3-thiones with various aldehydes. Subsequent treatment of the thiazine-3-thiones with dimethyl acetylenedicarboxylate and various arynes gave the corresponding dimethyl-4-aryl-4,10-dihydrothiopyr...
Article
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Thioaurones were prepared one pot in high yield by the treatment of N,N-diethyl-2-(methylsulfanyl)arylamides with LDA and an aromatic aldehyde through directed ortho-metalation. Heating the thioaurones derived from cinnamaldehyde above 200 ºC resulted in [1]benzothieno[3,2-b]pyrans. Treatment of N,N-diethyl-2-(methylsulfanyl)benzamide and crotonald...
Article
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Z)-Hetarylmethylene and (Z)-substituted benzylidene derivatives of 4H-benzo[1,4]thiazine-3-thiones were prepared by the reaction of 4H-benzo[1,4]thiazine-3-thiones with various aldehydes. Subsequent treatment of the thiazine-3-thiones with dimethyl acetylenedicarboxylate and various arynes gave the corresponding dimethyl-4-aryl-4,10-dihydrothiopyra...
Article
Full-text available
Thioaurones were prepared one pot in high yield by the treatment of N,N-diethyl-2-(methylsulfanyl)arylamides with LDA and an aromatic aldehyde through directed ortho-metalation. Heating the thioaurones derived from cinnamaldehyde above 200 ºC resulted in [1]benzothieno[3,2-b]pyrans. Treatment of N,N-diethyl-2-(methylsulfanyl)benzamide and crotonald...
Article
Full-text available
Eco-friendly direct solvent-free reactions of o-aminothiophenol and aromatic or aliphatic β-keto esters with microwave irradiation produced 2-substituted benzothiazoles in excellent yield. Experiments that compared microwave irradiation to conventional heating methods showed that the former gives the 2-substituted benzothiazoles faster and in highe...
Article
Full-text available
The titled compds., e.g., I, were prepd. by the reaction of 4H-benzo[1,4]-oxazin-3-thiones with di-Me acetylenedicarboxylate. The 3-thione intermediates were obtained by treating 4-methyl-4H-benzo[1,4]oxazin-3-ones with P2S5 followed by piperidine-mediated condensation of the resulting 4-methyl-4H-benzo[1,4]oxazin-3-thiones with various arom. and h...
Article
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Benzothiopyrano[2,3-b]indoles were prepared by the cyclization of 1,3-dihydroindole-2-thiones with varions dienophiles. The 1,3-dihydroindole-2- thiones were readily synthesized by the reaction of oxindole with P2S5 followed by a piperidine-mediated condensation of the resulting thioindole with a suitable aromatic aldehyde.
Article
The reaction of 2-methylthiophenol with sodium hydride and N,N-diethylcarbamoyl chloride in THF afforded N,Ndiethylthiocarbamic acid S-o-tolyl ester in good yield. The ester was subsequently treated with LDA and various arom. aldehydes to provide 3-substituted derivs. of (alkyliden-1-yl)-3H-benzo[b]thiophen-2-ones, e.g., I. The Z isomer was formed...
Article
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The reaction of 2-methylthiophenol with sodium hydride and N,N-diethylcarbamyl chloride in THF afforded N,N-diethylthiocarbamic acid S-o-tolyl ester in 97% yield. The ester was subsequently treated with LDA and various aromatic aldehydes to provide new 3-substituted derivatives of (alkyliden-1-yl)-3H-benzo[b]thiophen-2-ones. The Z isomer was formed...
Article
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A short and efficient synthesis of condensed 1,4-oxathiin-2-ones from easily available phenols is described. The key step in this synthesis is a hitherto unreported anionic rearrangement under directed metalation conditions. The rearrangement occurs after side chain deprotonation of a methyl sulfanyl group by an O-carbamate directed metalating grou...