Suiyang Liao

• Doctor of Philosophy
• PostDoc Position at University of British Columbia

When formulating mRNA into lipid nanoparticles (LNP), various copy numbers of mRNA are encapsulated, leading to a distribution of mRNA loading levels within the LNPs. It is unclear whether the mRNA loading level affects the functional delivery of the message. Here we show that depending on the mRNA loading level, LNPs exhibit distinct mass densitie...

Self-amplifying RNA (saRNA) vectors are a next-generation RNA technology that extends the expression of heterologous genes. Clinical trials have shown the dose-sparing capacity of saRNA vectors in a vaccine context compared with conventional messenger RNA. However, saRNA vectors have historically been based on a limited number of alphaviruses, and...

The current rapid advancement in ribonucleic acid (RNA) therapeutics research depends on innovations in drug delivery, especially the development of a lipid-nanoparticle (LNP)-based system. The conventional LNP formulation typically contains four components, including an ionizable cationic lipid, a phospholipid, cholesterol or a cholesterol derivat...

When formulating mRNA into lipid nanoparticles (LNP), various copy numbers of mRNA are encapsulated, leading to a distribution of mRNA loading levels within LNPs. It is unclear if the mRNA loading level affects the functional delivery of the message. Here we show that depending on the mRNA loading level, LNPs exhibit distinct mass densities and can...

Vaccination is one of the most successful measures in modern medicine to combat diseases, especially infectious diseases, and saves millions of lives every year. Vaccine design and development remains critical and involves many aspects, including the choice of platform, antigen, adjuvant, and route of administration. Topical vaccination, defined he...

Most nanoparticles’ parameters affect their interactions with cells. To date, all the parameters studied are basically static (e.g., size, shape, ligands, charge). This is unfortunate, as proteins have structural dynamics that most nanoparticles do not possess. Here we study single-chain polymeric nanoparticles (SCPNs), whose structure undergoes dy...

Polymers when self-cross-linked into single-chain nanoparticles bear some resemblance to folded proteins; yet proteins have clear energy landscapes that determine precisely folded structures, while single-chain polymer nanoparticles (SCNPs) have more undefined structures. There have been initial reports showing that some structural parameters in SC...

MALDI-TOF is used to quantify the atomic composition and describe the phase segragation of the surface of AuAg nanoparticles.

Accurate nanoparticle size determination is essential across various research domains, with many functionalities in nanoscience and biomedical research being size-dependent. Although electron microscopy is capable of resolving a single particle down to the sub-nm scale, the reliable representation of entire populations is plagued by challenges in p...

SnO2 nanofibers show wide applications in many advancing areas, such as gas sensors and semiconductors. The traditional methods of fabricating SnO 2 nanofibers include electrospinning, hydrothermal synthesis etc. In this work, SnO 2 nanofibers were prepared by blow spinning, which is a convenient and high-efficient method. Meanwhile, a 3D sponge na...

Accurate nanoparticle (NP) size determination is essential across research domains, with many functions in nanoscience and biomedical research being size-dependent. Although transmission electron microscopy (TEM) is capable of resolving a single NP down to the sub-nm scale, the reliable representation of entire populations is plagued by challenges...

Protein drugs have great potential as targeted therapies, yet their application suffers from several drawbacks, such as instability, short half‐life, and adverse immune responses. Thus, protein delivery approaches based on stimuli‐responsive nanocarriers can provide effective strategies for selectively enhancing the availability and activation of p...

Nonspecific protein adhesion to nanoparticle (NP) has been proven to have important implications in nanomedicine. However, there are only a few examples of careful studies relating protein binding thermodynamics to NP physicochemical features. In particular, a systematic investigation of how NP/protein binding parameters scale with size for sub-10...

In the field of flexible electronics, elastomeric substrates take the place of their rigid counterparts and boost fascinating uses such as solar cells, electronic skins, and flexible displays. Nano-level dimensions lead to novel properties of materials, which is the case in nanofibers with a large aspect ratio and a high surface–volume ratio. Resea...

In this study, we report draw-spinning method that can produce aligned polymer ultrathin fibers with diameter down to 200 nm. Apart from creating perfectly aligned fibers, this method can draw fibers at a high speed and can thus reorient molecular chains. Tensile tests show that nylon 66 fiber bundles fabricated by draw-spinning exhibit >400% elong...

Ultrathin metal fibers can serve as highly conducting and flexible current and heat transport channels, which are essential for numerous applications ranging from flexible electronics to energy conversion. Although industrial production of metal fibers with diameters of down to 2 μm is feasible, continuous production of high-quality and low-cost na...

Transparent conductive film (TCF) has found widespread use in displays, solar cells and sensors. Indium tin oxide (ITO) is currently the most widely used transparent electrode because of low sheet resistance and high transparency. However, major problem of ITO is the lacking of flexibility, which totally limits its applications for complex conditio...

Conducting metal nanowires can be assembled into thin films for flexible electronics and optoelectronics applications including transparent electrodes, nanocircuits, and electronic skin, however, the junction resistances and low aspect ratios still limit its performance. Herein we reports high-quality silver nanofibers (AgNFs) synthesized by a gas-...

Transparent electrodes are essential components for optoelectronic devices suchas displays and thin-film solar cells. Traditionally, the deposition of transparentconducting layers and the sealing of the device are separate steps. Here wereport on a highly transparent, conductive, and flexible “tape”, which can beobtained by transferring silver nano...