Sudip Shrestha

• Consultant at Nepal Cancer Hospital and Research Center

Introduction Medication errors (MEs) are preventable incidents that can result in harm to patients. Therefore, it is essential for healthcare professionals (HCPs) to be well-informed about MEs. This study aims to assess the awareness levels of HCPs and the impact of educational intervention on their understanding of MEs. Methods Responses to a 17-...

Background Homologous recombinant repair (HRR) deficit and the associated sensitivity to poly (ADP-ribose) polymerase inhibitors (PARPi) has been well studied in breast, ovarian, prostate, and pancreatic cancers, but very little is known about it in other cancer types. Objectives We sought to understand the spectrum of HRR mutations in various can...

Background: The Distress Thermometer accompanied with Problems List is a commonly used screening tool for psychosocial distress. However, it’s cut-off score, performance and risk factors for psychosocial distress varies among studies. This is the first study conducted in Nepal to investigate the Distress Thermometer’s screening properties, its opti...

Purpose: Suicidal ideation (SI) and depressive symptoms are common in patients with cancer. A Distress Thermometer (DT) is an effective tool to screen depression and anxiety in such cohorts. We investigated the value of the DT for predicting SI and the prevalence and associated risk factors of SI in the study population. Methods: This cross-sect...

The tumor microenvironment is a result of dynamic interaction between different cellular and non-cellular components. In its essence it is not a solo performer, but an ensemble of performers that includes cancer cells, fibroblasts, myo-fibroblasts, endothelial cells and immune cells. The short review highlights important immune infiltrates within t...

Introduction Quality palliative care, which prioritizes comfort and symptom control, can reduce global suffering from non-communicable diseases, such as cancer. To address this need, the Nepalese Association of Palliative Care (NAPCare) created pain management guidelines (PMG) to support healthcare providers in assessing and treating serious pain....

We present two cases of 10 and 27 years old girls with recurrence of immature teratoma after an incomplete surgical staging. In both cases, there were huge abdominopelvic masses despite decrease in tumor markers with chemotherapy. Complete surgical resection of these masses was done, and histopathology showed only mature teratoma. In growing terato...

Pancreatic cancer is a highly lethal malignancy with symptoms such as abdominal pain, back pain, loss of appetite, bloating, weight loss, jaundice, nausea, vomiting, etc . It has a relatively late presentation, which makes its only potentially curative treatment, surgical resection, impractical for most patients. However, the prognosis is poor desp...

We present two cases of nine and twenty-seven years old girls with recurrence of immature teratoma after an incomplete surgical staging. In both cases, there were huge abdominopelvic masses despite decrease in tumor markers with chemotherapy. Complete surgical resection of these masses was done, and histopathology showed only mature teratoma.

Background One way to improve the delivery of oncology palliative care in low and middle-income countries (LMICs) is to leverage mobile technology to support healthcare providers in implementing pain management guidelines (PMG). However, PMG are often developed in higher-resourced settings and may not be appropriate for the resource and cultural co...

COVID-19 has emerged as a serious public health crisis of 21st century affecting millions of people around the world. First identified in Wuhan China, COVID-19 has spread globally claiming millions of human life and suffering. The Government of Nepal (GoN) has accelerated control measures through mass media, laboratory testing, quarantine, isolatio...

Background: The quality of life (QoL) of patients with lung cancer (LC) may be affected by disease-related limitations such as patients' functioning, the severity of symptoms, financial problems resulting along with the side effects of the treatment. The objective of this study was to translate LC-specific QoL questionnaire EORTC QLQ-LC29 into Nep...

Background: Antibiotic resistance (AMR) among Gram negative bacteria (GNB) has evolved into a greater medical crisis in recent years, compared to Gram positive bacteria; primarily with the emergence of carbapenem resistant GNBs. Of special concern are multidrug resistant organisms (MDRO) that are resistant to at least one agent in more than 2 famil...

A one-day workshop on proposal writing for research for health care professionals was organized by Hospital Research Board (HRB), Nepal Cancer Hospital and Research Center Pvt. Ltd, Harisiddhi, Lalitpur, Nepal on 2nd March 2019. The main aim of this workshop was to identify, motivate and prepare health care professionals for conducting research in...

Clinicopathologic profile of Lymphoma

Introduction: Contaminated hands are associated with increase in healthcare associated infections (HCAIs). Effective hand hygiene (HH) plays a vital role, especially in critical areas such as the ICU. Improvement of HH practice is therefore, the primary objective of IPC program for which the World Health Organization (WHO) recommends a multi-modal...

The aim of this study was to address the problems associated with polypharmacy in elderly cancer patients and to highlight the role of pharmacists in such cases in resource‐limited settings. A narrative review of existing literature was performed to summarize the evidence regarding the impact of polypharmacy in elderly cancer patients and the pharm...

Drug and Therapeutics Committees (DTCs) serve as an assembly place to join and bond with diverse stakeholders of hospitals to improve the utilization of the medicinal fortes. DTCs are a key inclusion to promote the rational use of medications. DTCs are, however, operative in only a limited number of hospitals in Nepal. DTC was begun at the oncology...

An access to adequate and safe blood transfusion services is an essential measure of basic healthcare systems. The main purpose of hemovigilance is to enhance the quality and safety of the blood transfusion chains, which are implemented for improving the quality of the blood transfusion chain processes, especially focusing on blood safety. Globally...

85 Background: The purpose of the new ASCO resource-stratified guideline on global palliative care (Osman H, Shrestha S, Temin S, et al, Palliative Care in the Global Setting: ASCO Resource-Stratified Practice Guideline, JGO, 2018) is to provide expert guidance to clinicians and policymakers on implementing palliative care in resource-constrained s...

A novel mutation in the MLH1 gene likely to be pathogenic for Lynch syndrome was discovered in a proband with a family history of colon cancer. Immunohistochemistry showed negative expression of PMS2 and MLH1 in the resected tumor sample. The mutation lies at the highly conserved C-terminus of the MLH1 protein, the region through which it dimerizes...

Purpose The purpose of this new resource-stratified guideline is to provide expert guidance to clinicians and policymakers on implementing palliative care of patients with cancer and their caregivers in resource-constrained settings and is intended to complement the Integration of Palliative Care Into Standard Oncology Care: American Society of Cli...

The clinical pharmacist's part is emerging as a key extension to the human services care team bringing about enhanced patient care in the world. The main objective of this article is to highlight the role of clinical pharmacist in an oncology setting of Nepal. An enrollment of clinical pharmacist in an oncology hospital or in oncology settings can...

Cancer is on the rise, and is known to cause significant impact on the health and socio-economics of a nation. Advancement in modern therapy has changed the way cancer is controlled and has brought significant benefits to the patients. However, Adverse Drugs Reactions of cancer chemotherapy is common, that can lead to disability and even death. The...

Objective The main objective of this study was to identify the problems of Nepalese breast cancer survivors living in an urban area who had completed their treatment for at least 6 months. Methods A cross-sectional descriptive study was conducted to assess the problems of breast cancer survivors who were registered at the Nepal Cancer Support Grou...

The treatment of breast cancer is multidisciplinary and different modalities can lead to different problems. A cross sectional, comparative study was done to compare problems of breast cancer survivors with that of women without cancer. Ninety women were included with 45 in each group. The participants in the breast cancer survivor group completed...

Introduction: There is no published data in Nepal regarding the use of gefitinib in patients with non-small cell lung cancer (NSCLC). Therefore, a retrospective analysis was conducted to evaluate the response and toxicity profile of Gefitinib alone in patients with advanced NSCLC and unknown epidermal growth factor receptor (EGFR) status. Methods...

Over the last few years, Nepali and international colleagues have been collaborating in the development of palliative care services in Nepal. The program continues to move forward amid the considerable social and political difficulties facing Nepal. Although a number of individuals and organizations have been involved, the partnership between the I...

This is a retrospective study of histologically proven cases of carcinoma of the gall bladder presenting to Bhaktapur Cancer Hospital and Om Hospital and Research center, Nepal, over a period of four years, from January 1999 to December 2003. The aim of this study was to review outcome of management and staging of cancer of gall bladder presenting...