
Sudhir KumarBoston University | BU · Department of Medicine
Sudhir Kumar
Doctor of Veterinary Medicine
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20
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Publications (20)
FOXD1+ derived stromal cells give rise to pericytes and fibroblasts that support the kidney vasculature and interstitium but are also major precursors of myofibroblasts. ZEB2 is a SMAD-interacting transcription factor that is expressed in developing kidney stromal progenitors. Here we show that Zeb2 is essential for normal FOXD1+ stromal progenitor...
Roundabout guidance receptor 2 (ROBO2) plays an important role during early kidney development. ROBO2 is expressed in podocytes, inhibits nephrin-induced actin polymerization, down-regulates nonmuscle myosin IIA activity, and destabilizes kidney podocyte adhesion. However, the role of ROBO2 during kidney injury, particularly in mature podocytes, is...
Background:
Increased levels of blood plasma urea were used as phenotypic parameter for establishing novel mouse models for kidney diseases on the genetic background of C3H inbred mice in the phenotype-driven Munich ENU mouse mutagenesis project. The phenotypically dominant mutant line HST014 was established and further analyzed.
Methods:
Analys...
The repulsive guidance cue SLIT2 and its receptor ROBO2 are required for kidney development and podocyte foot process structure, but the SLIT2/ROBO2 signaling mechanism regulating podocyte function is not known. Here we report that a potentially novel signaling pathway consisting of SLIT/ROBO Rho GTPase activating protein 1 (SRGAP1) and nonmuscle m...
Primary glomerulocystic kidney disease is a special form of renal cystic disorder characterized by Bowman's space dilatation in the absence of tubular cysts. ZEB2 is a SMAD-interacting transcription factor involved in Mowat-Wilson syndrome, a congenital disorder with an increased risk for kidney anomalies. Here we show that deletion of Zeb2 in mese...
During nephrogenesis, POU domain class 3 transcription factor 3 (POU3F3 aka BRN1) is critically involved in development of distinct nephron segments, including the thick ascending limb of the loop of Henle (TAL). Deficiency of POU3F3 in knock-out mice leads to underdevelopment of the TAL, lack of differentiation of TAL cells, and perinatal death du...
Exact p values of statistically analyzed* parameters of homozygous (HOM) and heterozygous (HET) Pou3f3L423P mutant mice and control (CON) mice at 12 days of age.
*Statistically significant differences between genotypes were determined by using a 1-way ANOVA with Gabriel’s post hoc test, differences between male and female mice of the identical geno...
Exact p values of statistically analyzed* parameters of homozygous (HOM) and heterozygous (HET) Pou3f3L423P mutant mice and control (CON) mice at 60 weeks of age.
UACR: Urine albumin-to-creatinine ratio. *Statistically significant differences between genotypes were determined by using a 1-way ANOVA with Gabriel’s post hoc test, differences between...
Increased levels of blood plasma urea were used as phenotypic parameter for establishing novel mouse models for kidney diseases on the genetic background of C3H inbred mice in the phenotype-driven Munich ENU mouse mutagenesis project. The phenotypically recessive mutant line HST011 was established and further analyzed. The causative mutation was de...
Time points of the phenotypic analyses for line Pou3f3L423P in the German Mouse Clinic (GMC).
(DOCX)
Murrah buffaloes (n=25) were used to explore the genetic polymorphism in DRB3 exon 2 by PCR-RFLP and to find out the association with mastitis. The gDNA was isolated from whole blood samples as per standard protocol and a 304 bp PCR was amplified. When 304 bp product of exon 2 of DRB3 gene was digested with RsaI, it revealed 10 alleles (a, b, c, f,...
Random amplified polymorphic DNA (RAPD) technique was used to characterize Murrah and Bhadawari breeds of buffalo. From the 9 random primers, a total of 84 bands were amplified between breeds and 51 of these (about 60.72%) were found to be polymorphic. In Murrah, overall percentage polymorphism of 56.36 was observed, while in Bhadawari it was 57.14...