Sudha Rao

Genotypic Technology and Dhitiomics

Introduction The present-day Zoroastrian-Parsis have roots in ancient pastoralist migrations from circumpolar regions leading to their settlement on the Eurasian Steppes and later, as Indo-Iranians in the Fertile Crescent. After migrating from the Persian province of Pars to India, the Zoroastrians from Pars (“Parsis”) practiced endogamy, thereby p...

The present-day Zoroastrian-Parsis have roots in ancient pastoralist migrations from circumpolar regions ¹ leading to their settlement on the Eurasian Steppes ² and later, as Indo Iranians in the Fertile Crescent ³ . From then, the Achaemenids (550 - 331 BC), and later the Sassanids (224 BC - 642 AD) established the mighty Persian Empires ² . The A...

Background: There are several techniques to analyse copy number variation in both research and clinical settings, such as whole genome amplification (sWGA), SNP arrays and one of the most commonly used techniques, array based comparative genomic hybridization (aCGH). In the latter, copy number comparison is obtained between differentially labelled...

Disease associated chromosomal rearrangements often have break points located within disease causing genes or in their vicinity. The purpose of this study is to characterize a balanced reciprocal translocation in a girl with intellectual disability and seizures by positional cloning and whole genome sequencing. The translocation was identification...

Disease associated chromosomal rearrangements often have break points located within the disease gene or in its vicinity. In order to identify the disease gene, characterization of the breakpoints is a promising start. Here we report the characterization of a balanced reciprocal translocation 46,X,t(X;20)(q12;p13) in a girl with seizures by both po...

Malarial parasite P. falciparum, an apicomplexan protozoan has a 23.3 MB nuclear genome and encodes ~ 5600 transcripts.The genetic diversity of the parasite within and across geographical zones is a challenge to gene expression studies which are essential for understanding of disease process, outcome and developing markers for diagnostics and progn...

Agilent 15K cross strain P. falciparum gene expression microarray probe annotation.

Transcripts detected in this study represented by probes specific only to HB3 strain.

var gene transcripts detected in this study. var genes transcripts detected for all the 3 representing strain is included in three separate excel sheets. Details about the var genes represented by specific probe in the array and detection status of each var gene in the three strains are included.

rifins gene transcripts detected in this study. Details about the rifin genes of the two strains i.e. 3D7 and HB3 represented by specific probe in the array and detection status of each rifin genes in the two strains are included.

stevor gene transcripts detected in this study. Details about the stevor genes of the two strains i.e. 3D7 and HB3 represented by specific probe in the array and detection status of each stevor gene in the two strains are included.

Supporting information contains supplementary figures S1-S4 and supplementary tables S1 and S10-S12.

3D7 transcripts detected in this study.

3D7 Transcripts not detected in this study although represented by specific probes.

List of differentially regulated genes between two clusters.

This study describes a molecular analysis of partial trisomy 14q and partial trisomy 12p in a 5-year-old male child presenting with dysmorphic features, congenital heart disease and global developmental delay. Chromosomal analysis of the patient with GTG bands revealed a 47,XY,+der(14)t(12;14)(p13;q22)mat karyotype; the mother's karyotype was 46,XX...

Abstract: Mitochondrial sequencing applications include mutation frequency estimation for population mapping, human migration pattern, population divergence and Forensics analysis. Mitochondrial gene mutations are also implied in aging, tumor suppression or susceptibility to diseases like cancers, neurodegenerative diseases, muscle disorders and in...

Herbal remedies are increasingly being recognised in recent years as alternative medicine for a number of diseases including cancer. L., commonly known as turmeric is used as a culinary spice in India and in many Asian countries has been attributed to lower incidences of gastrointestinal cancers. Curcumin, a secondary metabolite isolated from the r...

Pathway table. The table lists the enzyme annotations from which pathway were determined. (XLS)

KOG table. The table lists the KOG annotations from which KOG terms were determined. (XLS)

SSR information Cultivar C. This file provides SSR information for sample C (XLS)

Final table. The table lists the best annotation for each transcript. (XLS)

SNP filtering criteria. The file provides criteria used for filtering SNPs. (DOC)

BLAST against Curcuma longa nucleotide sequences. The table lists the best hit for each RT, with similarity to Curcuma longa ESTs. (XLS)

Swiss-Prot table. The table lists the Swiss-Prot annotations from which Gene Ontology terms were determined. (XLS)

SSR information Cultivar A. This file provides SSR information for sample A. (XLS)

BLAST against ESTs from ArREST. The table lists the hits for each RT, with similarity to ArREST ESTs. (ODS)

Pfam table. The table lists the pfam annotations from which domains were determined. (XLS)

SSR information Cultivar B. This file provides SSR information for sample B (XLS)

Background Phyto-remedies for diabetic control are popular among patients with Type II Diabetes mellitus (DM), in addition to other diabetic control measures. A number of plant species are known to possess diabetic control properties. Costus pictus D. Don is popularly known as “Insulin Plant” in Southern India whose leaves have been reported to inc...

SNPs. The tab delimited table lists the SNPs obtained after aligning the reads back to the transcripts.

SSRs. The tab delimited table lists the SSRs identified using MISA.

PlantCyc Enzyme Annotations. The tab delimited table lists the pathway annotations from PlantCyc enzymes annotation.

Pfam Annotations. The tab delimited table lists the annotations from Pfam protein domains.

SNP filtering criteria. The file provides criteria used for filtering SNPs.

Other Secondary Metabolite Annotations. The document shows the percentage distribution of other secondary metabolite pathway related transcripts observed from PlantCyc enzymes annotation.

Final Annotation table. The final tab delimited table lists the best annotation assigned to transcripts after picking the best annotation from individual databases.

Venn diagram depicting sharing of transcripts annotated by six different databases. The Venn diagram shows transcripts unique to each database and which are shared amongst different databases.

Swiss-Prot Annotations. The tab delimited table lists the Swiss-Prot annotations leading to Gene Ontology term classifications.

KOG Annotations. The tab delimited table lists the annotations from Cluster of Orthologous Groups leading to KOG classifications.

Supplementary data for Validation of assembled transcripts of C. pictus.

Similarity search among other anti-diabetic plant resources. The file provides results of similarity search of the transcripts against GenBank nucleotide sequences from other anti-diabetic plants.

Cancer of the esophagus is of two main types, each with distinct etiological and pathological characteristics. Esophageal squamous cell carcinoma (ESCC) is predominant type of esophageal cancers worldwide comprising almost 95% of cases. While ESCC is prevalent in the developing world, esophageal adenocarcinoma is commonly seen in the developed coun...

The Rpb4/Rpb7 subcomplex of yeast RNA polymerase II (Pol II) has counterparts in all multisubunit RNA polymerases from archaebacteria to higher eukaryotes. The Rpb4/7 subcomplex in Saccharomyces cerevisiae is unique in that it easily dissociates from the core, unlike the case in other organisms. The relative levels of Rpb4 and Rpb7 in yeasts affect...

Neurogenesis proceeds throughout life in the higher vocal center (HVC) of the adult songbird neostriatum. Testosterone induces neuronal addition and endothelial division in HVC. We asked if testosterone-induced angiogenesis might contribute importantly to HVC neuronal recruitment. Testosterone upregulated both VEGF and its endothelial receptor, VEG...