Sudha K Ganesh

• MD
• Managing Director at Sankara Nethralaya

Purpose To report the clinical pattern of surgically induced necrotizing scleritis (SINS) in a tertiary eye care center in Southern India. Methods Retrospective analysis of all SINS cases visiting the uveitis clinic of a tertiary eye institute between January 2009 and April 2019. Results In total, 15 patients with a median age of 65 (IQR:52–70) y...

Purpose: To evaluate the spectrum of uveitis occurring after 60 years of age in elderly patients who presented to a tertiary care eye center in India. Methods: Retrospective study of patients who visited a tertiary eye care institute between January 2010 and July 2020. Result: Eighty-seven patients developed uveitis after 60 years, with only 44.8...

Purpose: To describe a cohort of patients with retinal vasoproliferative tumours (RVPT) seen in the uveitis clinic of a single tertiary eye care institute in India. Methods: Retrospective Chart Review. Results: In our study of 17 patients with 18 eyes affected by RVPTs, 94.1% showed unilateral involvement, one patient had bilateral RVPTs, and...

In modern warfare, ocular injuries are quite common. These injuries can carry high morbidity, which can in turn determine an injured person’s future independence and employability. It has been observed that soldiers who sustain eye injuries during warfare often become unfit for further continuation of military service and also for many civilian occ...

Purpose: This study aimed to describe visual outcomes in cases of pediatric uveitis in an Indian population and to analyze various factors affecting these outcomes. Methods: Single-center, retrospective chart review of 277 cases of uveitis in patients under the age of 18 years. Variables assessed included age and sex distribution, anatomical loc...

The aim of this series is to report challenges faced in diagnosis of three cases of recurrent or atypical uveitis not responding to conventional treatment. A high index of suspicion, aided by newer techniques, such as cytology, immunohistochemistry, flow cytometry of ocular fluids, and contrast-enhanced magnetic resonance imaging, may be necessary...

Purpose: To evaluate the role of swept-source optical coherence tomography (SS-OCT) in the management of acute Vogt-Koyanagi-Harada's (VKH) disease. Methods: Retrospective analysis of SS-OCT images of acute VKH patients between January 2015 and February 2020 in a tertiary eye care hospital. Results: We studied 34 eyes of 17 patients with acute...

PurposeTo describe the clinical profile of HLA B-27-associated uveitis in Indian population.Method We conducted a retrospective review of medical records of 431 eyes of 255 consecutive patients with HLA B-27-associated uveitis, presented to our institute between 2012 and 2017.ResultThe study observed a male preponderance (75.7%) and the mean age of...

Quick Response Code: Purpose: To evaluate clinical profile of patients with uveitis who developed central serous chorioretinopathy (CSC). Methods: Retrospective case series of consecutive patients of uveitis with CSC managed at a tertiary eye care center in India between 1994 and 2014. The data about clinical features, investigations, treatment, an...

Aim: To look at markers to differentiate ocular sarcoidosis from ocular tuberculosis in a high TB endemic population. Materials & methods: Retrospective multicenter study involving seven tertiary eyecare centers in India between July 2016 to December 2016. Demographic, clinical and laboratory data were retrieved from respective hospital database...

Viral anterior uveitis (VAU) needs to be suspected in anterior uveitis (AU) associated with elevated intraocular pressure, corneal involvement, and iris atrophic changes. Common etiologies of VAU include herpes simplex, varicella‑zoster, cytomegalovirus, and rubella virus. Clinical presentations can vary from granulomatous AU with corneal involveme...

Purpose To report the clinical profile of cataract and its surgical management in a scleritis cohort from India. Methods We conducted a retrospective review of medical records of 39 eyes of 32 consecutive patients with scleritis who underwent cataract surgery in a tertiary eye care institute. Results The mean age at presentation was 50.9 ± 11.1 y...

Purpose: To examine the clinical profile of sympathetic ophthalmia among the pediatric age group. Methods: Retrospective review of patients 18 years and younger with sympathetic ophthalmia seen in a tertiary eye care center between 1997 and 2017. Results: Of 20 patients included in the study, 70% were male. The most common inciting event for s...

Purpose: To standardize a nomenclature system for defining clinical phenotypes, and outcome measures for reporting clinical and research data in patients with ocular tuberculosis (OTB). Methods: Uveitis experts initially administered and further deliberated the survey in an open meeting to determine and propose the preferred nomenclature for terms...

Paradoxical reactions following initiation of anti-tubercular therapy have been documented most often in extrapulmonary tuberculosis. A combination of factors such as delayed hypersensitivity, decreased suppressor mechanisms, and an increased response to mycobacterial antigens mediated by the host's immune system have been implicated in the develop...

PRēCIS:: Phacotrabeculectomy with adjunctive Mitomycin C is a good option for the management of coexisting cataract and glaucoma. Strict pre-operative control of inflammation and close follow-up are essential in the management of eyes with uveitic glaucoma. Purpose: To compare the outcomes of phacotrabeculectomy with adjunctive antimetabolites in...

Purpose: To report a case series of pediatric inflammatory choroidal neovascularization (CNV) seen at referral uveitis clinic. Methods: Records of pediatric patients with uveitis and inflammatory CNV between January 2000 and December 2012 were analyzed. Results: Ten eyes of seven patients were included. Mean age 12.6 years, mean follow-up 89.6 mont...

Purpose: To describe clinical manifestations, management and visual outcome in postsurgical sympathetic ophthalmia (SO). Methods: Retrospective study. Results: Mean age of the patients was 41.1 years, and males were affected 1.8 times than the female. Vitrectomy and scleral buckling were the most common inciting surgeries followed by cataract...

Purpose: To report the clinical profile of a series of antineutrophil cytoplasmic antibody (ANCA)-associated scleritis in Indian population. Methods: : We conducted a retrospective review of medical records of 33 eyes of 26 consecutive patients with scleritis, who tested positive for either antibody to proteinase 3 [anti-PR3/cytoplasmic antineut...

Objective: To analyze the demographic profile, treatment, and visual outcome of the patients with sympathetic ophthalmia (SO) in a multicenter collaborative retrospective cohort study. Methods: Medical records of the patients with SO from UK, Singapore, India were reviewed for history of ocular trauma or surgery and subsequent development of uveiti...

Purpose: To describe the clinical pattern of scleritis in patients ≤16 years of age at a tertiary care eye hospital in India. Methods: The medical records of 24 eyes of 20 children with scleritis were included in this retrospective study. Collected data included age, subsets of uveitis, best corrected visual acuities (BCVA), detailed laboratory...

Purpose: To describe clinical findings and outcomes for ocular toxoplasmosis in an international multicenter collaborative study. Methods: Retrospective analysis of 190 patients diagnosed with ocular toxoplasmosis from three study sites (Brazil, India, and Singapore). Results: There were 93 (48.9%) females with a mean age of 32.8 years. The most co...

Purpose: To describe the clinical pattern of uveitis in patients with retinitis pigmentosa (RP) at a tertiary care eye hospital over a period of 30 years. Methods: The medical records of 32 eyes of 22 patients of RP with uveitis were included in this study. Collected data included age, subsets of uveitis, best corrected visual acuities (BCVA), deta...

Purpose: To describe the clinical pattern of uveitis in patients with retinitis pigmentosa (RP) at a tertiary care eye hospital over a period of 30 years. Methods: The medical records of 32 eyes of 22 patients of RP with uveitis were included in this study. Collected data included age, subsets of uveitis, best corrected visual acuities (BCVA), deta...

Purpose: To report pattern of uveitic patients with hypotony in Indian population. Methods: Retrospective medical record review of 30 eyes of 21 consecutive patients with uveitic hypotony. Patient demographics, ocular findings and systemic association were recorded. Results: Mean age of the patients was 29.5 years (range 7-71 years) and 80.9%(...

Background Multiple choroidal granulomas are a rare presentation of tuberculosis. Choroidal granulomas in immunocompetent patients can pose difficulty in diagnosis as in most cases systemic examination may not reveal any evidence of tuberculosis. We report a case of bilateral multiple choroidal granulomas with systemic vasculitis-like features and...

To analyze the profile, etiology, complications, medical and surgical management, and visual outcome among pediatric uveitis patients seen at a referral uveitis clinic in India. Retrospective cohort study, tertiary hospital setting. Records between January 2007 and April 2010 were reviewed for patients with uveitis who were 0-18 years of age. Uveit...

Purpose To evaluate the reliability of clinical grading of vitreous haze using a new 9-step ordinal scale versus the existing 6-step ordinal scale. Design Evaluation of diagnostic test (interobserver agreement study). Participants A total of 119 consecutive patients (204 uveitic eyes) presenting for uveitis subspecialty care on the study day at 1...

The tuberculin skin test, used to detect latent systemic tuberculosis (TB), has its limitations. The utility of interferon-gamma assays, found useful in the diagnosis of latent TB, is still unestablished in tubercular uveitis. We present the results of QuantiFERON(®)-TB Gold (QFT-G) test and its relevance in the diagnosis and management of suspecte...

To evaluate the role of high-resolution computerized tomography (HRCT) of the chest as a diagnostic tool in granulomatous uveitis. Observational case series. Fifty-eight consecutive patients were evaluated with chest HRCT based on clinical diagnosis of granulomatous uveitis, which was further classified using SUN classification as anterior, interme...

Posterior uveitic entities are varied entities that are infective or non-infective in etiology. They can affect the adjacent structures such as the retina, vitreous, optic nerve head and retinal blood vessels. Thorough clinical evaluation gives a clue to the diagnosis while ancillary investigations and laboratory tests assist in confirming the diag...

To evaluate outcomes of phacoemulsification cataract surgery with intraocular lens (IOL) implantation in children and adults with juvenile idiopathic arthritis-associated uveitis. Charts of 7 patients (10 eyes) with juvenile idiopathic arthritis-associated uveitis who had phacoemulsification cataract surgery between December 2002 and March 2005 wer...

Retrospective analysis of the clinical features, investigative profile, response to treatment, and final visual outcome in histopathologically confirmed cases of sarcoid uveitis. Retrospective case series analysis was done of 15 eyes of 9 patients seen between July 1999 and August 2003 with biopsy-proven sarcoid uveitis. There were 3 were males and...

Juvenile idiopathic arthritis (JIA) associated uveitis is one of the most common causes of visual morbidity in children. We report the systemic, clinical and investigational features of a cohort of all cases of JIA associated uveitis seen at our referral uveitis clinic between 1988 and 2004. Retrospective case series All patients of JIA seen at the...

To describe the role of triple agent immunosuppression in severe recalcitrant cases of Vogt-Koyanagi-Harada syndrome. Retrospective chart review of five cases of Vogt-Koyanagi-Harada syndrome. All cases were treated with oral prednisolone, azathioprine, and cyclosporine in combination, and rapid remission was observed in all patients. The synergist...

We report a case of necrotizing scleritis following diode cyclo-photocoagulation (CPC). A-64-year-old-Asian Indian male presented with pseudophakic corneal decompensation with secondary angle closure glaucoma that was uncontrolled with maximum medical therapy. Trans-scleral diode CPC was performed in the inferior 180-degree section using a standard...

Detailed outline of clinical cases of uveitis and scleritis

To analyze the results of cataract surgery in patients with sympathetic ophthalmia. Sankara Nethralaya, Medical Research Foundation, Chennai, India. This study comprised 66 patients (132 eyes) with sympathetic ophthalmia seen at the uveitis referral clinic between January 1990 and July 2001; 42 eyes (31.8%) had cataract. Cataract surgery was perfor...

To analyze the results of phacoemulsification cataract surgery with implantation of posterior chamber intraocular lenses (IOLs) of different biomaterials in eyes with pars planitis. Medical and Vision Research Foundations, Sankara Nethralaya, Chennai, India. The records of 86 patients (100 eyes) with pars planitis who had phacoemulsification with I...

To describe the development of Fuchs' heterochromic iridocyclitis (FHI) following bilateral ocular toxoplasmosis in an Asian Indian female. Case report of a patient with bilateral ocular toxoplasmosis who developed bilateral Fuchs' heterochromic iridocyclitis. Features characteristic of bilateral Fuchs' heterochromic iridocyclitis developed followi...

To evaluate the outcomes of cataract surgery in patients with Vogt-Koyanagi-Harada's (VKH) syndrome. Medical Research Foundation, Sankara Nethralaya, Chennai, India. Methods: Fifty-nine eyes of 39 patients with VKH syndrome who had cataract surgery between May 1985 and June 2001 were retrospectively analyzed. Extracapsular cataract extraction (ECCE...

To report a case of ocular filariasis due to Wuchereria bancrofti manifesting as panuveitis. Observational case report. A 30-year-old, healthy, Asian, Indian male presented with decreased vision and panuveitis with secondary glaucoma in the right eye. Careful slit-lamp examination revealed multiple, tiny, motile larvae in the anterior chamber. Indi...

To describe the occurrence of peripapillary choroidal atrophy and experience with triple-agent immunosuppression in three cases of sympathetic ophthalmia. Retrospective chart review of three cases of sympathetic ophthalmia with peripapillary choroidal atrophy. Three patients with sympathetic ophthalmia were managed with steroid pulse therapy and tr...

Vogt-Koyanagi-Harada (VKH) disease is known to have varied manifestations in different ethnic groups. In order to analyze the clinical profile of VKH cases in the Indian population, we studied 87 consecutive cases of VKH disease treated in an uveitis clinic in South India between 1985 and 1996. Retrospective analysis and review of charts of consecu...

The authors analyzed the results of cataract surgery performed on patients with intermediate uveitis from January 1990 through January 1997. Fifty-two eyes of 44 patients with intermediate uveitis underwent cataract surgery during this period. These patients were evaluated with respect to duration of intermediate uveitis, treatment regimen, intraop...

Posterior scleritis is relatively uncommon and is often misdiagnosed due to its protean manifestations. We report eight cases of posterior scleritis to analyse the clinical profile, ultrasonographic and computed tomography (CT) scan features of this rare disorder. Fundus findings included serous retinal detachment, choroidal folds, retinal folds, s...

This report describes a retrospective study of all new patients in our uveitis clinic between January 1992 and December 1994, undertaken to identify the pattern of uveitis in the Indian subcontinent. A standard clinical protocol, and the naming-meshing system with tailored laboratory investigations were used to arrive at a final uveitic diagnosis....

The pattern of uveitis changes over time with the emergence or identification of new uveitic entities. The aim of this prospective study was to obtain a correct incidence pattern and aetiology of uveitis cases seen in a uveitis clinic. We studied all new uveitic cases seen in a-one year period. A standard clinical protocol was followed for each cas...

T he management of patients with chronic non infectious uveitis is usually complicated by factors such as the tendency of the inflammation to remain active or to progress despite treatment with maximum tolerable dose of steroids. Many treatment regimens incorporating either a cytotoxic agent or cyclosporine A in addition to steroids have been prove...