
Sudesh GaidhaniCentral Council for Research in Ayurvedic Sciences · Department of Pharmacology
Sudesh Gaidhani
Master of Veterinary Science
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79
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Introduction
Ayurveda, Pharmacology, Pre-Clinical Safety/Toxicity, Veterinary Research
Skills and Expertise
Publications
Publications (79)
Background
In ayurvedic practice, the Guduchi ( Tinospora cordifolia (Willd.) Miers) stem is used as a Medhya drug for its beneficial effects on memory improvement.
Objectives
The current study was planned to explore the Medhya properties of the Guduchi stem extract by observing its ameliorating effect on AlCl3-induced neurotoxicity in rats that a...
The in-vitrocytotoxicity was studied in a pancreatic cell line (RIN5F) using streptozotocin-induced cellular damage. The Cytotoxic dose of aqueous and hydro-alcoholic extracts of Mimosa pudica root powder before and after streptozotocin treatment was studied and protein expression was explored. Both the extracts were subjected to metabolite analysi...
Cancer has evolved as a detrimental disorder alongside cardiovascular diseases. Plant-derived natural products have been the most successful source of potential anti-cancer drugs and for the isolation and characterization of novel compounds. Till now, only about 10% of the world's biodiversity has been assessed for biological activity and numerous...
Laghu vishagarbha taila (LVT) is a medicated oil preparation used in the Ayurvedic system of medicine and applied topically for the
treatment of painful musculoskeletal and inf lammatory disorders. It contains some mildly poisonous phytoconstituents which may
show untoward effects upon application. The present study evaluated the toxicity of LVT in...
Gokshuradi guggulu is an important classical polyherbal formulation used in Ayurvedic system of medicine for the treatment of various chronic diseases like kidney stones and diabetes. However, no scientific attempts were made to evaluate its oral toxicity. Hence, the present study evaluated the acute and 28 days repeated dose sub-acute oral toxicit...
Ayurveda has been divided in to eight major branches i.e. Ashtang Ayurveda which deals with prevention and promotion of health and cure of disease of a healthy individual. However, apart from Ashtangas other branches like Plant Ayurvedic medicine (Vrikshayurveda) and Ayurveda Veterinary medicine (Pashu Ayurveda) are not much popular among scientifi...
Background
Outbreak of Corona Virus Disease in late 2019 (COVID-19) has become a pandemic global Public health emergency. Since there is no approved anti-viral drug or vaccine declared for the disease and investigating existing drugs against the COVID-19.
Objective
AYUSH-64 is an Ayurvedic formulation, developed and patented by Central Council of...
The present study aimed to investigate the binding affinity of andrographolide and its derivative i.e., 14-deoxy-11,12-didehydroandrographolide with targets related to COVID-19 and their probable role in regulating multiple pathways in COVID-19 infection. SMILES of both compounds were retrieved from the PubChem database and predicted for probably r...
Ayurveda uniquely describes health as a state of mental and spiritual well-being apart from physical well-being. It has imparted an etiology of mental origin to various diseases. The basic memory functions are regarded to be a combination of the power of acquisition (Grahana), retention (Dharana), and recollection (Smarana).
Gut microbiota has tremendous potential to influence human physiology in terms of health and disease. Factors like improper diet, lifestyle and stress contribute in development of dysbiosis. Ayurveda emphasizes on the importance of mahasrotasa (GIT system) and its homeostasis in maintenance of health. Pharmacokinetic principles of Ayurvedic pharmac...
Aim
To evaluate the antidiabetic activity of hydroalcoholic extracts of Ficus gibbosa Blume (leaves and stem bark) in streptozotocin–nicotinamide induced diabetic rats.
Materials and methods
The animals were rendered diabetic by single intraperitoneal injections of nicotinamide (195 mg/kg body weight) followed by streptozotocin (65 mg/kg body weig...
The tubers of Amorphophallus paeoniifolius (Elephant foot yam), principally consumed as crop food and vegetables, are used in ethno-medicinal practices in mitigation of constipation and piles. Hence, present study evaluated the effect of tubers of A. paeoniifolius and its active constituents glucomannan and betulinic acid on experimentally-induced...
Trayodashang guggulu is an important Ayurvedicpolyherbal formulation containing babula (stem barkof Acacia nilotica), ashwagandha (roots of Withaniasomnifera), hapusa (fruits of Juniperuscommunis), guduchi (stem of Tinosporacordifolia), shatavari (roots of Aspargusrecemosus), gokshuara (fruits of Tribulusterrestris), vradadaru (roots of Argyeria ne...
Nothapodytes nimmoniana is a natural source of camptothecin, a known anticancer drug. Stem and leaf extracts of Nothapodytes nimmoniana were studied to assess its in vitro action on cancer progression events in a cervical cancer cell line, the HeLa. As a well-studied ideal model system, the HeLa has been chosen and the effects of extracts on cancer...
Ayurveda, the traditional system of Indian medicine is the first and foremost life care system based upon philosophical framework providing medical care to humans, animals, and plants. But, the classical texts of Ayurveda are rarely studied in-depth to find out their contemporary relevance either due to lack of information or negligence towards our...
Background:
Aarogyavardhini Vati is a classical Ayurvedic herbomineral formulation. It contains mercury and copper compounds as principal minerals along with other minerals and herbal ingredients. Aarogyavardhini Vati is indicated in chronic liver ailments. However, safety concerns are often raised regarding the use of mercury containing ayurvedic...
Through Golden Triangle Partnership Scheme (GTP)
coordinated by CCRAS – Ministry of AYUSH generated evidences on quality
(chemical characterization) and safety profiles of eight most commonly used
metal and mineral based medicines in clinical practice in collaboration with
CSIR and ICMR. The research outcome comprising information on four
formulati...
Through Golden Triangle Partnership Scheme (GTP)
coordinated by CCRAS – Ministry of AYUSH generated evidences on quality
(chemical characterization) and safety profiles of eight most commonly used
metal and mineral based medicines in clinical practice in collaboration with
CSIR and ICMR. The research outcome comprising information on four
formulati...
Through Golden Triangle Partnership Scheme (GTP)
coordinated by CCRAS – Ministry of AYUSH generated evidences on quality
(chemical characterization) and safety profiles of eight most commonly used
metal and mineral based medicines in clinical practice in collaboration with
CSIR and ICMR. The research outcome comprising information on four
formulati...
Thyroid disorders have been one among the most challenging and most common endocrine disorders that we confront worldwide. Major thyroid disorders include hypothyroidism, hyperthyroidism, goiter/iodine deficiency, Hashimoto’s thyroiditis, and thyroid cancer. Among these, hypothyroidism is arguably the most challenging as its multifarious clinical p...
Aim
The study was designed to develop and standardize a novel polyherbal formulation (PHF) for augmenting milk production in healthy dairy cattle.
Materials and methods
Five raw plant drugs, viz., tubers of Asparagus racemosus Willd. (Shatavari), whole plant of Eclipta alba (L.) Hassk. ( Bhringraj ), seeds of Trigonella foenum-graecum L. (Methika)...
Background: Central Council for Research in Ayurvedic Sciences (CCRAS) is actively involved in the scientific process of
drug development adopting prevalent guidelines such as good
clinical practices guidelines for Ayurveda, Siddha, Unani (ASU)
drugs (GCP-ASU), Ministry of AYUSH and National ethical
guidelines for Bio-medical Research (ICMR), WHO g...
Background:
Premna integrifolia Linn. is a medicinal plant of an Ayurvedic importance and proved to have an anti-inflammatory, anti-diabetic, anti-microbial and hypo-lipidemic activity. Glutathione (GSH) redox status is an important parameter to assess the antioxidant activity of any neutraceuticals.
Objective:
In order to assess the anti-oxidan...
Premna integrifolia Linn. is a medicinal plant used in "Dhasamula" drug preparation of Ayurvedic systems of medicine in the treatment of various ailments like bronchitis, dyspepsia, liver disorders, piles, constipation, hyperlipidemia and fever. The anti-atherosclerotic activity of hydroalcoholic extract (HAE) of root bark of P. integrifolia was ev...
A 12 month old male Swiss albino mouse reared in the Laboratory Animal Housing Facility, Regional Ayurveda Institute for Drug Development, Gwalior, India, was found to have a growth on the right fl ank region. The animal was euthanized and necropsied. Post-mortem examination revealed well demarcated subcutaneous mass with whitish cut surface which...
Objective:
Kanchnar guggulu is a compound Ayurvedic formulation used in clinical practice for the treatment of benign and malignant tumors. The present study investigates its cytotoxic and antiproliferative activities.
Methods:
The hydro-alcoholic (50%) extract of kanchnar guggulu was prepared. Its antimitotic activity was assessed in an Allium...
Ayurvedic drugs are multicomponent mixtures from the same chemical or different classes of chemical compounds. A detailed evaluation on the pharmacological responses of these multicomponent drugs is the key area for understanding their pharmacological and toxicological profiles. In a critical evaluation of pharmacological responses, it is essential...
Purpose: The present paper was aimed to study an in-vitro and in-vivo antioxidant activities of hydro alcoholic extracts (HAE) of root bark of P. integrifolia. Methods: The hydro alcoholic extract was subjected to various in-vitro assays such as DPPH, nitric oxide scavenging activity, reducing power assay, superoxide anion radical scavenging and ir...
India is one among such countries that enjoys great antiquity of health practices backed by a strong base of its indigenous traditional knowledge (TK). The TK on medical and health sciences is systematically documented in dedicated compen-dia, such as Charaka Samhita, Sushruta Samhita, Ashtang Samgraha, etc., and also as supplementary health inform...
Premna integrifolia L. is an important medicinal herb contains apparent therapeutic properties. The present study focused on P. integrifolia L. root bark used in phytochemical and pharmacognostical evaluvation.
Aim
Hyperlipidemia has been ranked as one of the greatest risk factors contributing to prevalence and severity of coronary heart diseases. The present study has been taken up to evaluate hypolipidemic activity of hydro alcoholic extract of Cardiospermum halicacabum L. leaf, as this plant is widely used by the local healers of South India for treatm...
Context:
Makaradhwaja is a KupipakwaRasayana. Since it contains two heavy metals, namely mercury and gold, it is essential to evaluate its safety. Hence, the present study was undertaken with an objective to evaluate toxicity and target organ of toxicity of Makaradhwaja if so.
Aims:
The objective was to evaluate toxicological profile, the target...
Aim: This study focuses on the documentation and critical evaluation of the presence of botanical nootropics in Ayurveda based on the available classical literature in Ayurveda. The study also entails the terminology used for different memory and cognitive functions in the classical texts of Ayurveda.
Background: The process of memory (smriti) an...
Context: Amorphophallus paeoniifolius tuber is an important constituent of Ayurvedic system of medicine. The tuber of this plant has high medicinal value and is consumed as a food. It is associated with acridity (itchy sensation in mouth and throat) upon oral consumption and presence of high oxalates raphides.
Aims: To evaluate the acute and suba...
Context: This work had as outcome to deal with the part of the population of Seropédica, Rio de Janeiro those who use the public health system and use alternative medicinal plants for the treatment of illness.
Aims: To evaluate the potential medicinal uses of local plants traditionally used in curing/treatment different diseases and illnesses, and...
Premna integrifolia Linn. is a medicinal plant used in “Dhasamula” drug preparation of Ayurvedic systems of medicine in the treatment of various ailments like bronchitis, dyspepsia, liver disorders, piles, constipation, hyperlipidemia and fever. The anti-atherosclerotic activity of hydroalcoholic extract (HAE) of root bark of P. integrifolia was ev...
Ethnopharmacological relevance:
The leaves of Chenopodium album Linn. are traditionally used for correction of kidney diseases and urinary stones. The present work investigated the effect of methanolic and aqueous extracts of leaves of Chenopodium album on experimentally induced urolithiasis in rats to substantiate its traditional use as antilithi...
Background: Chandraprabha vati is a classical Ayurvedic formulation, markedly used for mitigation of Prameha, which correlates in many ways with obesity, metabolic syndrome and diabetes mellitus.
Objective: The present study was aimed to investigate effect of Chandraprabha vati in experimentally-induced hyperglycemia and lipid profile alterations....
Aim: The flowers of Bombax ceiba are traditionally used as home remedy in the treatment of jaundice and spleen enlargement. The present work investigated the effect of aqueous extract of flowers of Bombax ceiba (BCAE) on experimentally induced hepatotoxicity in rats to substantiate its traditional use as hepatoprotective agent.
Methods: Hepatotoxic...
Aim:
The tuber of Amorphophallus paeoniifolius (Family-Araceae), commonly called suran or jimikand, has medicinal and food value. It is used in ethnomedicinal practices for correction of gastrointestinal disturbances such as constipation and hemorrhoids. The present study evaluated the effect of A. paeoniifolius tuber on gastrointestinal motor fun...
The leaves of Chenopodium album Linn. are traditionally used in treatment of jaundice and spleen enlargement. The present work investigated the effect of aqueous extract of leaves of Chenopodium album on experimentally induced hepatotoxicity in rats to substantiate the traditional use in liver diseases. The hepatotoxicity was induced in rats by car...
In the present study the antioxidant activity of alcoholic extract of Premna tomentosa L. root (AT) and hepatoprotective activity of alcoholic extract of aerial parts Premna tomentosa L. by inducing hepatic injury with D-galactosamine hydrochloride in rats was carried out. The lyophilized alcoholic extract of Premna tomentosa ranging from concentra...
Abstract
Objectives: This study was conducted to estimate No Observed Effect Level (NOEL) or no observed adverse effect level of
Swarna Bhasma an Ayurvedic classical preparation of gold in Wistar rats. Materials and Methods: Swarna Bhasma was
prepared as per classical Ayurvedic text and analyzed for physicochemical properties. A total of 40 Wistar...
Ayurvedic herbo-mineral drugs have specified different
methods of preparation and operational procedures. These drugs are required in
lesser doses, cause no distaste unlike herbal drugs and are faster in action, With
tremendous expansion in the use of Ayurveda worldwide, safety and efficacy
as well as quality control have become important concerns....
The protective effect of methanolic extract of Lantana camara L. leaves (LCME) was evaluated at doses of 200 and 400 mg/kg against 1,2–dimethyl hydrazine (DMH) induced colon cancer in rat model. Animals were divided into six groups (n=10), i.e. Normal Control, DMH (20mg/kg), DMH + LCME (200 mg/kg), DMH + LCME (400mg/kg), LCME (200mg/kg) and LCME (4...
http://archive.is/RIMDS
Trivanga Bhasma, a metallic preparation containing Bhasmas of Naga (lead), Vanga (tin) and Yashada (zinc), was studied for repeated dose toxicity in Swiss albino mice to estimate No Observed Effect Level (NOEL) or No Observed Adverse Effect Level (NOAEL). A total of 80 Swiss albino mice of either sex with an average body weight of 28-30 g were equa...
A 12-week-old Swiss Albino mouse was presented with unilateral (left) testicular enlargement of approximately 1.5 cm in diameter and the right testicle mildly reduced in size and weight. Histopathology evaluation revealed three distinct neoplasms in the left testicle: choriocarcinoma, yolk sac carcinoma, and embryonal carcinoma. Teratoma was diagno...
Objective: The leaves of Holoptelea integrifolia are used in the treatment of diabetes and lipid disorders. The present study demonstrates the influence of the aqueous extract of leaves of Holoptelea integrifolia (HIAE) on the lipid profile in normal and Tyloxapol-induced hyperlipidemic rats. Materials and Methods: The vehicle, the aqueous extract...
This study presents validation and quality assessment of Rasamanikya, a light, micro fine powder, prepared by processing Patra Haratala, in which powder of Shodhita Haratala (Orpiment- As 2S 3), sandwiched between two Abhraka (white mica) sheets, is heated for a while to obtain a specific pharmaceutical preparation. Analysis of Rasamanikya was perf...
A unilateral non-metastatic embryonal carcinoma and teratoma of the testis was observed in a 12-week-old Swiss Albino mouse at the end of a 28-day repeated dose toxicity study. The teratocarcinoma almost completely replaced the parenchyma of the left testis. The tumor was composed of sheets and rosettes of primitive embryonal cells, anaplastic cell...
Aim: To study the anticonvulsant activity of Amorphophallus paeoniifolius. Materials and Methods: Petroleum ether extracts of Amorphophallus paeoniifolius at the dose of 200, 300, 400 mg/kg were used for the effects on the onset of convulsion in Isoniazid (INH) induced mice model. Diazepam at the dose of 4 mg/kg was used as the standard drug. Resul...
Night blindness, which is also referred to as Nyctalopia is the lack of normal night vision following the adjustment period. It is most often caused by vitamin A deficiency and retinal dystrophies. Revelation of veiled knowledge about single ophthalmic plant drugs indicated in “Night blindness” scattered elsewhere in ancient and medieval Ayurvedic...
Pharmacology), CCRAS 61-65, Institutional area, Opposite 'D' block, JANAKPURI, New Delhi. The present study was conducted to evaluate the anti-inflammatory, analgesic and anti-arthritic activities of Mahanarayana tailam (MT) in laboratory animals. Carrageenan induced rat paw oedema, Freund's adjuvant induced arthritis in rats and Eddy's hot plate i...
Collecting blood from Lab animals is necessary for a wide variety of scientific studies, and there are a number of efficient methods available. It is important to remember that blood collection can stress the animals, and may have an impact on the outcome of research data. Potential adverse affects viz. Hypovolemic shock, anemia, stress, haemorrhag...
Renal cell carcinoma (RCC) is the most common malignant tumor of the kidney, and the incidence is increasing very rapidly across all population groups. Accumulation of hypoxia-induced factors and the over-expression of vascular endothelial growth factor (VEGF) are the most important predisposing factors for the progression of the disease. Angiogene...
This study was conducted to estimate the heavy metal profile and determine the safety of Mahayograj guggulu, an Ayurvedic herbo-mineral preparation.
Mahayograj guggulu, manufactured by Shree Baidynath Ayurved Bhawan Pvt. Ltd., Gwalior Road, Jhansi - 284 003 (of batch number-07 and manufacturing date October 2004) was procured from the local market....
The hydro-alcoholic extracts of five Ayurvedic medicinal plants, pericarp of Terminalia chebula, rhizome of Acorus calamus, stem bark of Bauhinia variegate, whole plant of Phyllanthus amarus, root of Glycyrrhiza glabra were evaluated for their antiproliferative activity on fourteen cancer cell lines. These plant extracts were tested by sulforhodami...
Mahasudarshan Ghan Vati is a classical preparation of fourty five ingredients, it has been in use since long as an antipyretic in Ayurvedic practice. The drug was screened for its safety/toxicity studies in acute and chronic models in albino rats. The limits of all the four heavy metal content are found to be within the permissible limits. No morta...
Navratna rasa, an ayurvedic proprietary medicine based on classical formulation has been in use since long for general debility, rickets and calcium deficiency in Ayurvedic practices. The drug was screened for its safety/toxicity studies in acute and chronic models. No mortality and behavioral changes were observed during the course of acute toxici...