Sudam L. Kate

Sudam L. Kate
Sane Guruji Hospital, Hadapsar, Pune, India · Sickle Cell Department

MSc, PhD

About

42
Publications
4,750
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282
Citations
Citations since 2017
3 Research Items
83 Citations
2017201820192020202120222023051015
2017201820192020202120222023051015
2017201820192020202120222023051015
2017201820192020202120222023051015

Publications

Publications (42)
Article
Sickle cell disease (SCD) is a major medical problem in which mono-therapeutic interventions have so far shown only limited effectiveness. We studied the repurpose of genistein, which could prevent sickle hemoglobin from polymerizing under hypoxic conditions in this disease. Genistein an important nutraceutical molecule found in soybean. The presen...
Article
Sickle cell disease is an inherited disease caused by point mutation in hemoglobin (β-globin gene). Under oxygen saturation, sickle hemoglobin form polymers, leading to rigid erythrocytes. The transition of the blood vessels is altered and initiated by the adhesion of erythrocytes, neutrophils and endothelial cells. Sickle Hemoglobin (HbS) polymeri...
Article
Polymerization of Hemoglobin S is a major cause of morbidity and mortality in sickle cell disease, which leads to sickling and destruction of Red Blood Cell. Alizarin a bioactive compound from Rubia cordifolia is reported blood purifier. The present study investigates the potential of alizarin as an anti-sickling agent showing a significant decreas...
Article
Full-text available
Sickle cell disease is a major genetic disorder amongst Scheduled Caste (SC), Scheduled Tribe (ST), and Other Backward Communities (OBC) population groups of Maharashtra. We modified diagnosis technique and developed simple laboratory technology to identify carrier (Hb SS) and sufferer (Hb AS) suitable for field work. In order to find out prevalenc...
Article
Sickle-cell gene is known to protect against P. falciparum infection and provides a selective survival advantage in those areas where P. falciparum infection is endemic. This protection is not absolute and many other factors, inherited and acquired also contribute to the immunity against P. falciparum infection. We investigated incidence of splenom...
Article
The solubility test is evaluated against automated high-performance liquid chromatography (HPLC) and haemoglobin (Hb) electrophoresis for its efficacy in screening for the beta s gene in population groups in remote areas. Blood samples taken from 3246 individuals from the tribal populations of the Dhule and Gadchiroli districts of Maharashtra state...
Article
Five tribal populations (Hindu Mahadeo Koli, Vatankar, Madia Gond, Halbi, Pardhan) from different regions of Maharasthra with t total of n - 534 male and female individuals were typed for four serum protein polymorphisms (HP. TF. GC. PI). In addition to this the Hindu Mahadeo Koli samples could be also typed for the polymorphic blood group systems...
Article
Full-text available
Twenty four patients of classical marasmus and kwashiorkor along with equal number of healthy controls were selected for the study. Their serum amino acid patterns analysis revealed a mean ratio of glutamate to alanine in fasting samples of normal individuals to be 0.33, while it as 9.3 in kwashiorkor and 1.6 in marasmus. This differences in contro...
Article
Three tribal populations (Koli, Konkana, Pawara) from different regions of Maharashtra with a total of n=456 male and female individuals were typed for seven polymorphic blood group (A1A2B0, MNSs, RHESUS; Koli and Konkana only) and serum protein group systems (HP,GC, TF, PI). The genetic variability among these populations is considerable which can...
Article
The incidence of hepatitis B surface antigen (HBs Ag, Australia antigen) has been determined in three communities residing in an endemic malarial region in Western Maharashtra. A high incidence (5.92%) is found in the Marathas, a socially well-placed community, as compared to Nava-Buddhas (2.62%) and scheduled castes (1.63%) which are socially low-...
Article
Blood samples of 1,266 individuals were collected from three caste populations; Nava Budha (Mahar), Maratha, and a mixed group of Scheduled castes from each of three districts of Maharashtra, Nagpur, Akola, and Thane. The samples were tested for 12 enzyme systems, viz., AcPh, AK, CA-I, CA-II, Est-D, LDH, MDH, Oxidase, PGM-1, PGM-2, 6-PGD, and PHI....
Article
2,258 newborns delivered at the Sassoon General Hospitals, Pune, during 1980-81 were screened for inborn errors of metabolism. One case of cystinuria (0.04%), one of alcaptonuria (0.04%) and two cases of mucopolysaccharidosis (0.08%) were detected. The importance of screening of newborns, in particular the high risk ones, has been discussed.
Article
In this paper the effect of age, Hb types and G-6-PD deficiency on height, weight and skinfold thickness among 1720 subjects belonging to Nava-Budha, Maratha and a mixed Scheduled caste of Maharashtra, India, have been examined using two models of analysis of variance. In the first model the factors used for explaining the variation are communities...
Article
The present paper reports results of analysis of 14 genetic marker systems-ABO, MN, Rh, Hp, Tf, Cp, Alb, AcPH, PGM, LDH, MDH, Est-D, Hb and G-6-PD studied on a number of subjects of 9 endogamous groups of Maharashtra: Bhils, Katkaris and Pawaras, (all tribal groups); Deshastha Rigvedi and Chitpavan (two Brahmin groups); Nava Budhas (a scheduled cas...
Article
Genetic distance analysis based on 16 biochemical markers, following Nei's distance measure has been performed on nine endogamous groups of Maharashtra: Nava Budha, Maratha, Deshastha Rigvedi Brahmin, Chitpavan Brahmin, Chandrasenya Kayastha Prabhu, Parsis, Bhil, Pawara and Katkari. The distances between these groups are small as compared to the wi...
Article
The term colour blindness is generally used to describe the lack of sensitivity to colours. Although there are instances of total colour blindness, in most cases the people confuse red or green, and this defect is an X-linked trait. This colour vision anomaly is widely used as a genetic marker in the study of human variation, and is frequently cite...
Article
Full-text available
Over 900 individuals from ten endogamous groups in the Indian states of Maharashtra and West Bengal were studied for G-6-PD deficiency and haemoglobin variants. The incidence of G-6-PD varied from nil to 17.3%, while that of Hb-S varied from nil to 22.3%. In general, the tribal populations of Maharashtra are characterized by the presence of a high...
Article
Full-text available
The distribution of placental alkaline phosphatase and lactate dehydrogenase types in 635 placentas from various endogamous groups of Maharashtra have been studied by starch gel electrophoresis. In the case of alkaline phosphatase, 6 common phenotypes and 6 rare phenotypes (F2I1, S1S2, S2S3, I1S2, F1S2, F1I2) are encountered. The highest frequency...
Article
A Sindhi family with psoriasis and abnormal haemoglobin Hb D in some of the members of the family isreported. The significance of this finding as an added genetic marker of psoriasis is discussed.
Article
A Sindhi family with psoriasis and abnormal hemoglobin HbD in some of the members of the family is reported. The significance of this finding as an added genetic marker of psoriasis is discussed.
Article
Full-text available
Forty five cases of Turner syndrome diag- nosed in the Genetics Clinic, between January 1986 and December 1993, were analyzed. The most commonly observed karyotype was 45, X (44.4%), followed by 45, X/46, XX mosakhm (24.4%). Less frequently demonstrated karyo- types were 45, X/46, X, i (Xq) mosaicism and 46, X, i (Xq) (13.3%). Mosaicism for chromo-...
Article
The zygosity of 39 pairs of like sexed twins was determined by analysis of blood groups, physical appearance and dermatoglyphics. There were 25 monozygous and 14 dizygous twin pairs. The study of blood groups proved to be superior to other methods of determining zygosity.
Article
Full-text available
Incidence of colourblindness among 1501 (945 males and 656 females) persons belonging to four nomadic Mendelian isolates, the Nandiwallas of Maharashtra, India, has been reported. Out of the four groups, three lacked the gene for colourblindness, while in one group the incidence was rather low (0·3 per cent). Our findings support the differential s...

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