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The Zn2+ stored in the secretory vesicles of glutamatergic neurons is coreleased with glutamate upon stimulation, resulting in the elevation of extracellular Zn2+ concentration (). This elevation of regulates the neurotransmission and facilitates the fibrilization of amyloid‐β (Aβ). However, the exact surrounding neurons under (patho)physiological...
Silicon nanowire field-effect transistors modified with specific aptamers can directly detect the minute dopamine and neuropeptide Y released from cells. The binding of these molecules to the aptamers results in a conductance change of the transistor biosensor and illustrates the differential releasing mechanisms of these molecules stored in variou...
We report the synthesis of size controlled ZnO and rare-earth doped ZnO nanorods in the sub-10 nm diameter regime. The preferential growth of the nanostructures along the polar c-axis leads to the formation of wurtzite phase ZnO nanorods. The anisotropic growth is the manifestation of 'oriented attachment' kinetics. Photoluminescence measurements r...
My doctoral research dealt with the preparation of silica nanostructures, their photoluminescence and an explorative study of a potential application of such nanostructures, functionalized with fluorophores. The motivation for this study is threefolds: Such nanostructures can be prepared by the soft chemical method of reverse micelle mediated sol-gel method (RMSG). The mechanism of the blue PL of such nanostructures and especially, the effect of simple chemical inputs on this PL is not well understood. Finally the surface of silica is covered with silanol (≡ Si-OH) groups, which can be functionalized using simple silanol chemistry. These properties are more pronounced with silica nanostructures having large surface area. Presence of large number of surface silanol groups in silica nanostructures renders them for easy surface fictionalization and their colloidal dispersion. This aspect has been exploited in the field of drug delivery and development of sensors