Subash Chandra Malik

Subash Chandra Malik
Karolinska Institutet | KI · Department of Geriatrics

Doctor of Philosophy
Post Doctoral Researcher

About

6
Publications
28,626
Reads
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81
Citations
Citations since 2017
5 Research Items
81 Citations
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Introduction
I am a post doctoral researcher at KI. I focus on understanding AD pathology using Super resolution microscopy. Wish you a great day.
Additional affiliations
July 2016 - January 2018
Pfizer
Position
  • Executive
September 2015 - July 2016
Pfizer
Position
  • Executive
July 2015 - September 2015
Hospira
Position
  • Executive
Education
August 2013 - June 2015
Indian Institute of Technology Kanpur
Field of study
  • Biological Sciences and Bioengineering
August 2009 - May 2013
College of Engineering and Technology, Bhubaneswar, Orissa
Field of study
  • Biotechnology

Publications

Publications (6)
Article
Full-text available
The limited ability of the central nervous system (CNS) to regenerate in adult mammals after injury or disease is a significant problem. Intriguingly, neural stem/progenitor cells (NSPCs) offer great promise for regenerating the CNS. Endogenous or transplanted NSPCs contribute to repair processes, but their differentiation and function are abnormal...
Article
Full-text available
Reactive astrocytes at the border of damaged neuronal tissue organize into a barrier surrounding the fibrotic lesion core, separating this central region of inflammation and fibrosis from healthy tissue. Astrocytes are essential to form the border and for wound repair but interfere with neuronal regeneration. However, the mechanisms driving these a...
Article
Full-text available
Stroke is the leading cause of adult disability. Endogenous neural stem/progenitor cells (NSPCs) originating from the subventricular zone (SVZ) contribute to the brain repair process. However, molecular mechanisms underlying CNS disease-induced SVZ NSPC-redirected migration to the lesion area are poorly understood. Here, we show that genetic deplet...
Article
The p75 neurotrophin receptor (p75NTR) functions at the molecular nexus of cell death, survival, and differentiation. In addition to its contribution to neurodegenerative diseases and nervous system injuries, recent studies have revealed unanticipated roles of p75NTR in liver repair, fibrinolysis, lung fibrosis, muscle regeneration, and metabolism....
Article
Full-text available
Neural stem/progenitor cells (NSPCs) originating from the subventricular zone (SVZ) contribute to brain repair during CNS disease. The microenvironment within the SVZ stem cell niche controls NSPC fate. However, extracellular factors within the niche that trigger astrogliogenesis over neurogenesis during CNS disease are unclear. Here, we show that...

Questions

Questions (12)
Question
It is awkward to ask such a silly question. But, practically, all the class of biomolecules are made up of elements and chemical reactions and bonds.
At some point in time, there has been a common ancestry from which there might have been a need of different classes of biomolecules.
Logically, evolution has its answers, but we can't reverse the way.
So, can we convert the carbohydrates into proteins or fats, or the other way?
Just to raise a thought among ourselves.
Question
Do plants conduct signal mechanism? And if they are conducting the signal through proteins or any biomolecule, do they conduct it in a specific channel like the neural network in the animal kingdom. I wonder, what they have in place of neurons? Some of us might actually think why do in the first place need them. They are not ruled by one king, like our brain.
Question
No doubt, we are going deeper into the research in each and every field. At the same time, do we lack sometimes a basic aim i.e. to help the society in which we live in. Through our research and scientific approach to solve one problem, there is a need to create this awareness that all we do is for others better life only. Now-a-days it is more likely personal and career motivated. This may lack the finest idea of creating science. Everyone like science due to its quality and helping nature. Aren't we forgetting something?
Question
Glycine is an achiral molecule. So can it show any kind of CD spectra in any kind of condition (either in far UV or in near UV)? Will it show the CD spectra in the form of a straight line or it will follow helical pattern?
Question
We have inherited something from our parents. It is encoded in our genes and we are expressing it. Can we change it during the course of time as we live on.
As is is always said, work hard and you will get results. Isn't it the stressed condition for our cells or is it the happy environment for the cells? Scientifically, more specific biologically?
What makes the cells and finally ourselves think that we are capable of doing something which we found difficult at some point of time.
Is IT EVOLUTION? Or, REALLY WE HAVE CHANGED OUR CODE WITH A MUCH SLOWER RATE?
Question
We have developed from a zygote, which eventually became a diploid cell. In that way, we are a cell. So strange, we have evolved and acquired distinguished features that we can not even count. Just think, we were once a cell.

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