Steven T. G. Street

Steven T. G. Street
University of Victoria | UVIC · Department of Chemistry

Doctor of Philosophy

About

15
Publications
1,232
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276
Citations
Introduction
Exploring the biomedical applications of precision polymer nanofibers at the University of Victoria.

Publications

Publications (15)
Article
Full-text available
Selective G-quadruplex ligands offer great promise for the development of anti-cancer therapies. A new class of cationic naphthalene diimide ligands that selectively bind to the hybrid form of the human telomeric G-quadruplex in K+ buffer are described here. We demonstrate that an imidazolium-bearing mannoside-conjugate is the most selective ligand...
Article
Full-text available
Fiber-like block copolymer (BCP) micelles offer considerable potential for a variety of applications, however, uniform sam-ples of controlled length and with spatially tailored chemistry have not been accessible. Recently, a seeded growth method, termed ‘living’ crystallization-driven self-assembly (CDSA), has been developed to allow the formation...
Preprint
p>A facile imide coupling strategy for the one-step preparation of G‑quadruplex ligands with varied core chemistries is described. The G‑quadruplex stabilization, anticancer and antiparasitic activity of a library of nine compounds was examined, identifying a nanomolar inhibitor of T. brucei with 78‑fold selectivity over MRC5 cells, and strong stab...
Article
Full-text available
Polymer-based nanoparticles show substantial promise in the treatment and diagnosis of cancer and other diseases. Herein we report an exploration of the cellular uptake of tailored, low dispersity segmented 1D nanoparticles which were prepared from an amphiphilic block copolymer, poly(dihexylfluorene)-b-poly(ethyleneglycol) (PDHF13-b-PEG227), with...
Article
Naphthalene diimide (NDI) is a central scaffold that has been commonly used in the design of G-quadruplex (G4) ligands. Previous work revealed notable anticancer activity of a disubstituted N-methylpiperazine propyl NDI G4 ligand . Here, we explored structure-activity relationship studies around ligand bis-N,Ń-2,7-bis(3-(4-methylpiperazin-1-yl)prop...
Article
We describe the development of a modular, functionalizable platform for biocompatible core-shell block copolymer nanofibers of controlled length (22 nm-1.3 μm) and low dispersity produced via living crystallization-driven self-assembly (CDSA). The nanofibers possessed a crystalline poly(fluorenetrimethylenecarbonate) (PFTMC) core and a basic poly(2...
Article
The rapid increase in antibiotic resistant strains of bacteria has led to an urgent need to develop new methods of treating bacterial infections. Antibacterial polymeric nanoparticles are of interest for their more general mechanism of action which involves targeting anionic bacterial membrane structures with cationic functional groups. In this wor...
Article
Full-text available
A facile imide coupling strategy for the one‐step preparation of G‐quadruplex ligands with varied core chemistries is described. The G‐quadruplex stabilization of a library of nine compounds was examined using FRET melting experiments, and CD, UV‐Vis, fluorescence and NMR titrations, identifying several compounds that were capable of stabilizing G‐...
Article
Transient electronic and vibrational absorption spectroscopies have been used to investigate whether UV-induced electron-driven proton transfer (EDPT) mechanisms are active in a chemically modified adenine-thymine (A•T) DNA base pair. To enhance the fraction of biologically relevant Watson-Crick (WC) hydrogen-bonding motifs, and eliminate undesired...
Article
Selective G-quadruplex ligands offer great promise for the development of anti-cancer therapies. A novel series of divalent cationic naphthalene diimide ligands that selectively bind to the hybrid form of the human telomeric G-quadruplex in K⁺ buffer are described herein. It is demonstrated that an imidazolium-bearing mannoside conjugate is the mos...
Article
Full-text available
We report several ruthenium catalysts incorporating mixed donor phosphine-amine ligands for the upgrade of ethanol to the advanced biofuel n-butanol, which show high selectivity (≥90%) at good (up to 31%) conversion. In situ formation of catalysts from mixtures of [RuCl2(η6-p-cymene)]2 and 2-(diphenylphosphino)ethylamine (1) shows enhanced activity...
Article
Transmembrane anion carriers (anionophores) have potential for biological activity, including the treatment of channelopathies such as cystic fibrosis. A new family of anionophores has been synthesized, in which three thiourea groups are mounted on a cyclohexane-based scaffold. Though conceptually related to earlier polycyclic systems, these molecu...
Article
Transmembrane anion carriers (anionophores) have potential for biological activity, including the treatment of channelopathies such as cystic fibrosis. A new family of anionophores has been synthesized, in which three thiourea groups are mounted on a cyclohexane-based scaffold. Though conceptually related to earlier polycyclic systems, these molecu...

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