Stephanie A Cosentino

• Columbia University

Background: Prospective data show an increased risk of mortality in essential tremor (ET). Understanding the contributors to this increased mortality is of value. Methods: A total of 347 cases were enrolled in a prospective study of cognition in elders with ET (M baseline age = 79.6 years, M follow-up length = 2.7 years). At each visit, cases co...

Background Semantic memory refers to knowledge of attributes associated with common objects. Quantifying the strength of semantic association between successive ‘animal' fluency responses can be challenging. The current research assessed between‐group differences for ‘animal' fluency total output and selected verbal serial list learning, episodic m...

Background There is an urgent need for neuropsychological screening tests that are easily deployed and reliable. We have developed a digital neuropsychological screening protocol that is administered on a tablet, automatically scored using artificial intelligence, and requires approximately 10 minutes to administer. This tablet‐administered protoco...

Background Digital neuropsychological assessment easily captures behavior previously not obtainable by traditional pencil‐and‐paper tests. Verbal serial list learning tests are commonly used to assess for putative neurogenerative syndromes. Recognition test performance is often expressed compiling simple ‘yes/ no' responses, but fail to assess proc...

Background Age‐related changes in the systemic and cerebral vasculature adversely affect brain health and may contribute to neurodegeneration. However, the relationship between markers of systemic (arterial stiffness) and cerebral (flow pulsatility) vascular aging with neurodegeneration remains unclear. This study aimed to evaluate the associations...

Background Novel plasma markers are increasingly accepted as indicators of Alzheimer’s disease and related dementia (ADRD) pathophysiology. The extent to which these markers map with clinical symptoms of disease remains unclear. A proposed early clinical symptom of ADRD is subjective cognitive decline (SCD), the experience that cognition has declin...

Background Digital neuropsychological assessment easily captures behavior previously not obtainable by traditional pencil‐and‐paper tests. Verbal serial list learning tests are commonly used to assess for putative neurogenerative syndromes. Recognition test performance is often expressed compiling simple ‘yes/ no’ responses, but fail to assess proc...

Background Semantic memory refers to knowledge of attributes associated with common objects. Quantifying the strength of semantic association between successive ‘animal’ fluency responses can be challenging. The current research assessed between‐group differences for ‘animal’ fluency total output and selected verbal serial list learning, episodic m...

Background Cancer diagnosis is related to poor short‐term cognition, reflecting the condition, stress, and management. Less is known about long‐term relationships between time since cancer diagnosis and cognition. We evaluated the association between recency of cancer diagnosis and cognition. Method The National Health and Nutrition Examination Su...

Background Many studies have demonstrated an association between sleep and cognition in older adults. The Long Life Family Study (LLFS) has followed families enriched with longevity since 2006 and has shown that this cohort has slower rates of cognitive decline than their spouse controls and the general public. Understanding how sleep and cognition...

Neurodegenerative tauopathies are characterized by the deposition of distinct fibrillar tau assemblies, whose rigid core structures correlate with defined neuropathological phenotypes. Essential tremor (ET) is a progressive neurological disorder that, in some cases, is associated with cognitive impairment and tau accumulation. In this study, we exp...

Background Mild cognitive impairment, a precursor to Alzheimer’s disease and related disorders (ADRD), is widely underdiagnosed. Routine screenings are key for identifying older adults with emerging neurodegenerative disease. As women have increased risk of ADRD and often use their gynecologist as their primary care physician, the annual well woman...

Background Despite evidence that Alzheimer’s disease (AD) related pathological changes occur earlier in women than men, women are diagnosed later. To address this care disparity, the Evaluating Memory as Part of Women’s Routine Care (EMPOWER) program was established to integrate cognitive screening into routine gynecological well‐woman visits. Rece...

Lysophosphatidylcholines (LPC) are phospholipids involved in apoptosis and demyelination, among other functions. They have been linked to cancer, atherosclerosis, and neurodegeneration (with potential trade-offs) and explored as early markers of Alzheimer’s disease (AD) and accelerated aging. However, relationships between longitudinal changes in L...

Numerous studies demonstrate associations between sleep and cognition. This study includes a subset of 2344 participants from the Long Life Family Study, a cohort with slower overall rates of cognitive decline, and seeks to examine how sleep and cognition are related in this population. Our neuropsychological battery measured episodic, semantic, an...

Background There is an urgent need for neuropsychological screening tests that are easily deployed and reliable. We have developed a digital neuropsychological screening protocol that is administered on a tablet, automatically scored using artificial intelligence, and requires approximately 10 minutes to administer. This tablet‐administered protoco...

Neurodegenerative tauopathies are characterized by the deposition of distinct fibrillar tau assemblies whose rigid core structures correlate with defined neuropathological phenotypes. Essential tremor (ET) is a progressive neurological disease associated with cognitive impairment and, in some cases, tau accumulation. Consequently, we explored the t...

Introduction: Essential tremor (ET) patients may exhibit a variety of non-motor features, including cognitive decline and depressive symptoms. Studies of several neurodegenerative diseases link depression to cognitive decline, suggesting depression is an early marker of dementia. We examined whether baseline depressive symptoms predict incident de...

Objective: Routine health care visits offer the opportunity to screen older adults for symptoms of Alzheimer's disease (AD). Many women see their gynecologist as their primary health care provider. Given this unique relationship, the Women's Preventive Services Initiative and the American College of Obstetrics and Gynecology advocate for integrated...

Introduction A rapid and reliable neuropsychological protocol is essential for the efficient assessment of neurocognitive constructs related to emergent neurodegenerative diseases. We developed an AI-assisted, digitally administered/scored neuropsychological protocol that can be remotely administered in ~10 min. This protocol assesses the requisite...

Introduction: Sleep disturbances have been associated with essential tremor (ET). However, their pathophysiological underpinnings remain unknown. In this exploratory study, we examined the association between subjective sleep disturbances and the presence of Lewy pathology (LP) on postmortem brain examination in ET cases. Methods: Fifty-two ET c...

Increasing appreciation of the phenotypic and biological overlap between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, alongside evolving biomarker evidence for a pre-symptomatic stage of disease and observations that this stage of disease might not always be clinically silent, is challenging traditional views of these disorders....

INTRODUCTION Late‐onset Alzheimer's disease (LOAD) has a strong genetic component. Participants in Long‐Life Family Study (LLFS) exhibit delayed onset of dementia, offering a unique opportunity to investigate LOAD genetics. METHODS We conducted a whole genome sequence analysis of 3475 LLFS members. Genetic associations were examined in six indepen...

Background and objectives We previously found a substantial familial aggregation of healthy aging phenotypes, including exceptional memory (EM) in long-lived persons. In the current study, we aim to assess whether long-lived families with EM and without EM (non-EM) differ in systemic inflammation status and trajectory. Methods The current study in...

Background Subjective Cognitive Decline (SCD) is increasingly recognized as a prodromal risk state for Alzheimer’s disease. However, relatively little is known about trajectories of SCD within cognitively normal older adults, or the factors that associate with SCD change in this group. In this study, we examine the extent to which specific psychiat...

Background Subjective cognitive decline (SCD) is a marker of Alzheimer’s disease and related dementia (ADRD) risk, as well as a reason why older adults seek medical help. However, whether the concept of SCD has utility in Latinx populations has been questioned because SCD’s inconsistent associations with cognition in this population. Measurement fa...

Background Studies have shown that mis‐identification of dementia in Medicare claims is quite common. We extend the literature by examining potential race/ethnic disparities in mis‐identification of dementia in Medicare claims in a diverse cohort of older adults who underwent careful clinical assessment. Method Participants were enrolled the Washi...

Background Risk tolerance, a crucial component of decision‐making, has been shown to be highly domain‐specific (Blais, 2006). Nevertheless, when risk‐taking behavior is studied in the context of aging, it is almost exclusively examined using behavioral economics tasks which focus on financial risk‐taking behavior, neglecting other important domains...

Background Older adults with essential tremor (ET) are at increased risk for Alzheimer’s disease (AD) and related disorders. Examining cognitive trajectories within this population will enable better identification of individuals who evidence accelerated rates of change. Here we examine how variability in baseline cognitive performance affects traj...

Background There is growing evidence that patients with Essential Tremor (ET) are at higher risk for Mild Cognitive Impairment (MCI) and dementia than controls. ET is a quite heterogeneous disorder, including not only motor symptoms, but sleep deficits as some of its non‐motor characteristics. The aim of the current research was to investigate the...

Background Subjective Cognitive Decline (SCD) is being recognized as one of the earliest clinical signs of Alzheimer’s disease (AD). However, SCD is susceptible to a range of task factors (e.g., how SCD is measured) and person factors (e.g., mood). Currently, there is rising concern about the COVID‐19 pandemic’s impact on memory and mood. The purpo...

Background Despite the fact that women are more likely to develop Alzheimer’s disease (AD) than men, and develop pathological changes at an earlier age, women often receive diagnoses later. This disparity is possibly due to women’s verbal memory advantage, and the fact that verbal memory tests are often the gold‐standard for diagnostics. Further, a...

Background Genetic risk factors have been explored extensively for late onset Alzheimer’s Disease (LOAD). The largest meta‐analysis GWAS studies to date (Bellenguez et al., 2022) identified 83 single nucleotide polymorphisms (SNPs) associated with LOAD in the general population. The Long Life Family Study (LLFS) is aimed to identify factors associa...

Background Alzheimer’s disease (AD) exhibits substantial variability in its initial presentation and rate of progression. Our goal was to understand AD progression well enough to create a calculator that uses presented clinical features to estimate the length of time from initial presentation to major disease outcomes in individual patients with AD...

Objective Although health problems are often a natural consequence of aging, many older adults struggle to manage their health care problems. Health literacy refers to the ability to access, process, and use health information to make appropriate decisions to promote good overall health. Low levels of health literacy are associated with a host of n...

Objective Alzheimer’s disease (AD) is expected to affect over 7 million older Americans by 2025. Development of fast and inexpensive screening measures for routine screening is critical for identifying those suffering from the earliest stages of AD including Mild Cognitive Impairment (MCI) and Subjective Cognitive Decline (SCD). Here we assess the...

Objective Subjective Cognitive Decline (SCD), the perception of deteriorating cognition in the absence of apparent impairment on objective testing, has gained momentum in recent literature as a risk marker for AD. Traditional neuropsychological assessments, while typically inclusive of a word list learning task, often do not include a comparable fi...

Objective The current research framework recommends using biomarkers to further understand Alzheimer’s disease (AD) pathogenesis, including other contributing factors like cerebrovascular disease. In longitudinal studies of people with neuropathological examination after death, baseline loneliness was associated with lower cognition, faster cogniti...

Objective An individual with dementia suffers from cognitive decline affecting not only memory but at least one of the other domains, such as personality, praxis, abstract thought, language, executive functioning, attention, and social skills. Further, the severity of the decline must be significant enough to interfere with daily functions. It is c...

Objective Cognitive tests requiring spoken responses, such as paragraph recall, are rich in cognitive-related information that is not captured using traditional scoring methods. This study aimed to determine if linguistic features embedded in spoken responses may differentiate between individuals who are and are not cognitively impaired. Participa...

Objective The Biber Figure Learning Test (BFLT) is a serial figure learning assessment previously been shown to be sensitive to various biomarkers of the aging brain. BFLT is an extensive assessment requiring about 30 minutes for administration. In this study, we investigated BFLT’s associations with subjective cognitive decline (SCD), an early mar...

Objective Subjective cognitive decline (SCD) is increasingly being considered one of the earliest clinical signs of Alzheimer’s Disease (AD). Certain characteristics of early life, such as childhood socioeconomic status (SES), have been associated with late life cognitive performance. Here we examine the extent to which childhood SES predicts SCD....

Objective Historically, assessment of financial decision making (FDM) has largely relied on self- or informant-reports, and paper-and-pencil tests. However, subjective report is prone to under/over-estimation biases, and most available tests probe increasingly outdated tasks such as writing checks and checkbook management. Advances in technology ha...

Although the connection between type 2 diabetes (T2D) and dementia is known, it is less clear whether this relationship extends to cognitive decline. Our aim was to examine whether baseline fasting plasma glucose, insulin, HOMA-IR, and HbA1c, and T2D status predict cognitive decline in a multicenter cohort study of families with a clustering of exc...

Objective The COVID-19 pandemic increased utilization of remote assessment to allow clinicians and researchers to continue valuable work while maintaining quarantine guidelines. With guidelines relaxing, researchers have returned to in-person assessment. Information is needed regarding the effect of remote assessments on test-retest reliability. CO...

Objective Subjective Cognitive Decline (SCD) is the self-reported experience of one’s own declining cognition prior to objective impairment on clinical neuropsychological testing. While SCD is a promising marker of preclinical Alzheimer’s disease (AD), information is needed to determine which cognitive complaints reflect typical aging versus prodro...

Objective Historically, psychiatric conditions and neurodegenerative diseases have been considered differential diagnoses in older adults with cognitive impairment. However, recent evidence has shown that neuropsychiatric symptoms may be prodromal for neurodegenerative disease. Subjective Cognitive Decline (SCD) is a potential marker for pre-clinic...

Our previous work identified linguistic markers from paragraph recall that predicted cognitive impairment. However, many features were related to psychological constructs, and mood disorders, such as depression, are also associated with cognitive impairment. Therefore, we aimed to identify linguistic markers that are associated with depression and...

Early detection of Alzheimer’s disease is needed but cognitive screeners, used widely in research and clinical settings, suffer from poor sensitivity and specificity. Acoustic features of speech are altered in Alzheimer’s disease and may aid detection of cognitive impairment. We sought to test whether acoustic metrics from a cognitive screener diff...

Objective Research has indicated that racial and ethnic minoritized groups in the United States are disproportionately affected by dementia (e.g., Alzheimer’s disease), and seek help (HS) later in the disease course, if at all. It has also been posited that individuals from different ethno-racial groups have divergent perceptions of the aging proce...

Introduction Screening for neurocognitive impairment and psychological distress in ambulatory primary and specialty care medical settings is an increasing necessity. The Core Cognitive Evaluation™ (CCE) is administered/scored using an iPad, requires approximately 8 min, assesses 3- word free recall and clock drawing to command and copy, asks questi...

Background We investigated whether aspects of subjective cognitive aging, including awareness of age-related gains and losses in cognition (AARC-gains, AARC-losses) and subjective cognitive decline (SCD), predict change in objective cognitive function as measured by verbal reasoning (VR) and working memory (WM). Methods We used longitudinal data f...

Background Misidentification of dementia in Medicare claims is quite common. Objective We examined potential race/ethnic disparities in misidentification of dementia in Medicare claims in a diverse cohort of older adults who underwent careful clinical assessment. Methods Participants were enrolled in the Washington Heights-Inwood Columbia Aging P...

Subjective cognitive decline (SCD), a potential early marker for neurodegenerative disease such as Alzheimer’s disease, is common among older adults. Although it is often regarded as a personal health concern, most individuals with SCD do not seek help from a health care professional. Help-seeking (HS) is a complex, individualized process with sign...

Background and objectives: Neuropsychiatric symptoms (NPS), including psychotic symptoms (hallucinations, illusions, delusions), agitation/aggression, and depressed mood, are common in individuals with Alzheimer's disease (AD) and predict poorer outcomes, including faster disease progression. We aimed to evaluate associations between NPS and cogni...

Objective: Disparities in Alzheimer disease (AD) and differences in help seeking (HS) across sociodemographic groups warrant public health concern. Research addressing such disparities must shift toward the earliest clinical manifestations of AD to optimize diagnosis, intervention and care planning. Subjective cognitive decline (SCD), a risk state...

Background The major aims of the three Predictors Studies have been to further our understanding of Alzheimer’s disease (AD) progression sufficiently to predict the length of time from disease onset to major disease outcomes in individual patients with AD. Objectives To validate a longitudinal Grade of Membership (L-GoM) prediction algorithm devel...

Background Although Alzheimer’s Disease (AD) and Lewy Body Disease (LBD) have distinct underlying pathologies, the clinical differentiation of these disorders remains challenging, particularly AD versus mixed AD/LBD. Previous studies have shown that patients with mixed AD/DLB can have lower total output phonemic fluency than patients with AD. Exami...

Background Older adults are increasingly experiencing financial loss, with annual costs estimated to be about $2.9 billion. The risk of experiencing financial loss is magnified in those with neurodegenerative conditions, including Alzheimer’s disease (AD) and Frontotemporal Dementia (FTD). However, limited information exists on the frequency and am...

Background Although essential tremor (ET) patients have greater odds of mild cognitive impairment (MCI) and dementia than age-matched controls, the functional consequences of these enhanced odds are unknown. We examined associations between cognitive diagnosis and the occurrence of near falls, falls, use of a walking aid or a home health aide, non-...

Background: Cognitive impairment is a feature of essential tremor (ET). There are no studies of the genetic drivers of this association. We examined whether the microtubule-associated protein tau (MAPT) H1 haplotype is associated with cognitive performance in ET. Methods: ET cases genotyped for the MAPT H1 and H2 haplotypes completed a battery o...

Background: Although essential tremor (ET) is associated with cognitive decline, we know little about how specific cognitive changes predict significant events in patients' lives. We examined the relations of attention, executive function, language, memory, and visuospatial performance to the occurrence of near falls, falls, walking aid use, home...

Background Little is known regarding healthcare expenditures for patients with dementia with Lewy bodies (DLB) during the end of life. Objective This study estimated Medicare expenditures during the last 5 years of life in a decedent sample of patients who were clinically diagnosed with Alzheimer’s disease (AD) or DLB and had autopsy confirmed dia...

We conducted a genome-wide association study of Digit Symbol Substitution Test scores administered in 4207 family members of the Long Life Family Study (LLFS). Genotype data were imputed to the HRC panel of 64,940 haplotypes resulting in ∼15M genetic variants with a quality score > 0.7. The results were replicated using genetic data imputed to the...

Cognitive tests that require a spoken response, such as paragraph recall, are rich in cognitive‐related information that is not captured using traditional scoring methods. This study aimed to determine whether linguistic features embedded in spoken responses can differentiate between individuals who are and are not cognitively impaired. We used lin...

Early help seeking (HS) among patients with emerging Alzheimer’s disease and related dementias (AD/ADRD) can have considerable implications for treatment course, access to clinical trials, lifestyle, and future quality of life. Previous studies in older adults suggest cognitive impairment itself does not lead people to seek help; rather, HS appears...

Background: Routine healthcare visits offer the opportunity to screen older adults for cognitive changes that accompany the earliest clinical stages of Alzheimer's disease (AD) including Mild Cognitive Impairment (MCI) and Subjective Cognitive Decline (SCD). It is well-established that women are at increased risk for AD and that many women see the...

Memory Complaints (MCs) are a risk factor for dementia, but research in this area has largely been limited to non-Latinx White adults. Previous studies have shown that Latinx/Hispanic individuals are at higher risk for Alzheimer’s Disease and Related Disorders (ADRD). The mechanisms underlying this disparity in ADRD are multidimensional and can inc...

Clinical differentiation of Alzheimer’s disease (AD) versus Lewy Body Disease (LBD; including mixed AD‐LBD) is challenging, as both diseases overlap in cognitive symptoms. This can lead to misdiagnosis with detrimental consequences to the patient’s health. While autopsy‐based studies reveal that visuoconstruction tends to be more preserved in AD ve...

Frontotemporal degeneration (FTD) is an umbrella term encompassing a range of rare neurodegenerative disorders that cause progressive decline or changes in cognition, language, behavior, and personality. The FTD Insights Survey was created with the aim of gathering information on the lived experience of FTD. Here we present a subset of survey data...

Caregivers identify the need for continuous supervision of Alzheimer’s disease patients while awake as a “milestone” functional change that has a profound impact on the lives of the caregiver and patient. The specific predictors of this important functional change are not known. We determined specific cognitive, neuropsychiatric, and motor symptoms...

Background Impaired awareness of ability is common in dementia and has important clinical implications. Evidence from different clinical groups has shown that awareness can vary according to whether evaluation refers to self or other performance. Objective The present study aimed to investigate awareness for self- and other-performance in Alzheime...

Background The major aims of the three Predictors Studies have been to further our understanding of Alzheimer’s disease (AD) progression sufficient to predict the length of time from disease onset to major disease outcomes in individual patients with AD. Objectives To validate a longitudinal Grade of Membership (L-GoM) prediction algorithm develop...

Frontotemporal degeneration (FTD) is an umbrella term encompassing a range of rare neurodegenerative disorders that cause progressive declines in cognition, behavior, and personality. Hearing directly from individuals living with FTD and their care partners is critical in optimizing care, identifying meaningful clinical trial endpoints, and improvi...

Background Essential tremor (ET) is among the most common movement disorders in adults. While ET is diagnosed and primarily characterized by the presence of tremor, it also can impact cognition, sleep, mood, and motor functioning more broadly. The manifestations of ET can have various consequences, including difficulty with activities of daily livi...

Objective: While subjective cognitive decline (SCD) is gaining ground as a "preclinical" risk state for Alzheimer disease, its utility depends on our understanding of the factors linked to SCD. Rarely examined sociocultural factors including perceptions of aging may relate to the subjective experience of cognitive aging. Identifying such associati...

Objective Given the association between essential tremor (ET) and higher rates of cognitive decline, assessing this decline is an important element of research and clinical care. The Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) are two broad, brief measures that are widely used to monitor cognitive impairment in...

Introduction: Essential tremor (ET) is a clinically heterogeneous disease characterized by motor and non-motor features, including cognitive impairment. In a cross-sectional analysis, we determined whether the presence and severity of motor features of ET are associated with cognitive performance. Methods: Participants enrolled in a study that u...

Amyotrophic lateral sclerosis (ALS), when viewed as a biological entity rather than a clinical syndrome, likely evolves along a continuum, with the initial clinically silent phase eventually evolving into clinically manifest ALS. Since motor neuron degeneration is incremental and cumulative over time, it stands to reason that the clinical syndrome...

Neuropsychological assessment using the Boston Process Approach (BPA) suggests that an analysis of the strategy or the process by which tasks and neuropsychological tests are completed, and the errors made during test completion convey much information regarding underlying brain and cognition and are as important as overall summary scores. Research...

Essential Tremor (ET), by definition, is a disorder of movement. Yet over the years, epidemiologic, clinical, pathologic, and neuroimaging studies have converged to reveal a cognitive side of ET. The cognitive symptoms in ET are heterogeneous and are likely to reflect heterogeneous underlying mechanisms. In this chapter, we review and synthesize a...

Introduction Essential tremor (ET), a common movement disorder, is characterized by motor, cognitive and psychiatric symptoms. Depressed mood, a symptom of ET, has historically been viewed as a psychological response to disability. However, depressive symptoms are emerging as a predictor of cognitive decline across several clinical populations. We...

At present, no research criteria exist for the diagnosis of prodromal behavioural variant frontotemporal dementia (bvFTD), though early detection is of high research importance. Thus, we sought to develop and validate a proposed set of research criteria for prodromal bvFTD, termed ‘mild behavioural and/or cognitive impairment in bvFTD’ (MBCI-FTD)....

Objective Subjective cognitive decline (SCD) has emerged as one of the first manifestations of Alzheimer’s disease (AD). However, discrepancies in its relationship with tests of memory and other cognitive abilities have hindered SCD’s diagnostic utility. Inter-individual heterogeneity in metamemory, or memory awareness, and the use of clinical meas...

The Trail Making Test (TMT) is a neuropsychological test used to assess cognitive dysfunction. The TMT consists of two parts: TMT‐A requires connecting numbers 1 to 25 sequentially; TMT‐B requires connecting numbers 1 to 12 and letters A to L sequentially, alternating between numbers and letters. We propose using a digitally recorded version of TMT...

Objective: Amyotrophic lateral sclerosis (ALS) is a multi-system disorder characterized primarily by motor neuron degeneration, but may be accompanied by cognitive dysfunction. Statistically appropriate criteria for establishing cognitive impairment (CI) in ALS are lacking. We evaluate quantile regression (QR), that accounts for age and education,...

We conducted a genome-wide association study (GWAS) of Digit Symbol Substitution Test (DSST) scores administered in 4207 family members of the Long Life Family Study (LLFS). Genotype data were imputed to the HRC panel of 64,940 haplotypes resulting in ~15M genetic variants with quality score > 0.7. The results were replicated using genetic data imp...

Financial decision-making (FDM) and awareness of the integrity of one's FDM abilities (or financial awareness) are both critical for preventing financial mistakes. We examined the white matter correlates of these constructs and hypothesized that the tracts connecting the temporal–frontal regions would be most strongly correlated with both FDM and f...

Extreme longevity is associated with resilience to Alzheimer’s disease. A major goal of centenarian studies is therefore to identify factors associated with maintaining cognitive function throughout life. Over the past year, two studies of centenarians and their offspring (age 60-110+ years) have pivoted from in-home assessments of cognitive and ph...

Background: A recent consensus statement introduced the term “ET plus”. Although investigators have quantified the prevalence of ET plus in cross-sectional studies, patients with ET plus have not been tracked longitudinally; hence, there is no understanding of its stability over time. Methods: We present prospective, longitudinal phenotypic data on...

Background Perceived physical fatigability is highly prevalent in older adults and associated with mobility decline and other health consequences. We examined the prognostic value of perceived physical fatigability as an independent predictor of risk of death among older adults. Methods Participants (N = 2,906), mean age 73.5 [SD, 10.4] years, 54....

Identifying genes underlying memory function will help characterize cognitively resilient and high‐risk declining subpopulations contributing to precision medicine strategies. We estimated episodic memory trajectories in 35,245 ethnically diverse older adults representing eight independent cohorts. We conducted apolipoprotein E (APOE)‐stratified ge...