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Stéphane Doutreleau

Stéphane Doutreleau

MD, PhD

About

151
Publications
25,122
Reads
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3,043
Citations
Additional affiliations
May 2001 - August 2014
CHRU de Strasbourg
Position
  • MD, PhD
May 1991 - October 2014
University of Strasbourg
Position
  • Exercise physiology

Publications

Publications (151)
Article
Full-text available
Background There is a paucity of data on cardiovascular sequelae of asymptomatic/mildly symptomatic SARS-Cov-2 infections (COVID). Objectives The aim of this prospective study was to characterize the cardiovascular sequelae of asymptomatic/mildly symptomatic COVID-19 among high/elite-level athletes. Methods 950 athletes (779 professional French N...
Article
Left/right prefrontal cortex (PFC) activation is linked to positive/negative affects, respectively. Besides, larger left PFC oxygenation during exercise relates to higher cardiorespiratory fitness (CRF). High-intensity interval training (HIIT) is superior to moderate-intensity continuous training (MICT) in improving CRF. The influence of training o...
Article
Aims A unique Andean population lives in the highest city of the world (La Rinconada, 5,100 m, Peru) and frequently develops a maladaptive syndrome, termed chronic mountain sickness (CMS). Both extreme altitude and CMS are a challenge for the cardiovascular system. This study aims to evaluate cardiac remodelling and pulmonary circulation at rest an...
Article
Full-text available
It is well established that physical activity reduces all-cause mortality and can prolong life. Ultra-endurance running (UER) is an extreme sport that is becoming increasingly popular, and comprises running races above marathon distance, exceeding 6-hours, and/or running fixed distances on multiple days. Serious acute adverse events are rare but th...
Article
Full-text available
Purpose Both prolonged exercise and acute high-altitude exposure are known to induce cardiac changes. We sought to describe the cardiac responses to speed climbing at high-altitude, including left ventricular (LV) performance assessment using the myocardial work index (MWI), a new index derived from 2D speckle tracking echocardiography (STE). Meth...
Article
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Purpose The combined effects of acute hypoxia and exercise on cognition remain to be clarified. We investigated the effect of speed climbing to high altitude on reactivity and inhibitory control in elite climbers. Methods Eleven elite climbers performed a speed ascent of the Mont-Blanc (4810 m) and were evaluated pre- (at 1000 m) and immediately p...
Article
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Background Considering the potential greater cardiocirculatory effects of high intensity interval training (HIIT), we hypothesized that a 2-month supervised a high volume short interval HIIT would induce greater improvements in CRF and cardiometabolic risk and increase long-term maintenance compared to isocaloric moderate intensity continuous train...
Article
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Dear Editor, We really appreciate the Letter to the Editor by Jouffroy and colleagues [1], which added valuable information and discussion to our narrative review titled “Potential Long- Term Health Problems Associated with Ultra-Endurance Running” [2]. One of the primary aims of the paper was to “stimulate more open debate about the potential impl...
Article
High-altitude exposure results in a hyperventilatory-induced respiratory alkalosis followed by renal compensation (bicarbonaturia) to return arterial blood pH(a) toward sea-level values. However, acid-base balance has not been comprehensively examined in both lowlanders and indigenous populations - where the latter are thought to be fully adapted t...
Article
Résumé La fréquence des séjours en altitude (pour le travail, les loisirs, les voyages en avion ou en véhicule à moteur) justifie que soit posée la question de leur tolérance, en particulier chez des sujets porteurs de maladie respiratoire préexistante. La baisse de la pression barométrique, les variations de densité de l’air et les variations de t...
Article
A study to measure the composition of exhaled air was carried out in subjects living in the highest city in the world: La Rinconada in Peru. People living at high altitude have a strongly disturbed metabolism and have to deal with major physiological disturbances. It is very likely that these subjects develop a disturbance of their redox system. It...
Article
Full-text available
Several brands of water enriched with O2 (O2-waters) are commercially available and are advertised as wellness and fitness waters with claims of physiological and psychological benefits, including improvement in exercise performance. However, these claims are based, at best, on anecdotal evidence or on a limited number of unreliable studies. The pu...
Article
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Background: Sleep disordered breathing (SDB) is a frequent disorder with serious adverse health consequences in people with Down syndrome (DS). This study aims to evaluate and classify sleep and physical activity (PA) characteristics in adults with DS. Methods: Forty participants with DS wore an accelerometer for seven consecutive days to measur...
Article
Résumé L’hypoxie hypobare, caractéristique de l’environnement d’altitude, a des conséquences physiologiques importantes sur les systèmes cardio-vasculaire et respiratoire, qui sont fortement stimulés pour maintenir au mieux un apport en oxygène le plus adéquat possible. Ce processus dynamique d’acclimatation est influencé à la fois par le niveau d’...
Conference Paper
Full-text available
Background. Physical activity is a cornerstone for the management of obesity. Owing to, in part, lower pleasure, this population however perform very little exercise.[1] From a physiopsychological standpoint, left and right prefrontal cortex (PFC) activation are thought to be related to positive and negative affects, respectively.[2] Moreover, larg...
Article
Background Excessive ventilation (V̇E) and abnormal gas exchange during exercise are features of chronic thromboembolic pulmonary hypertension (CTEPH). In selected CTEPH patients, balloon pulmonary angioplasty (BPA) improves symptoms and exercise capacity. How BPA affects exercise hyperventilation and gas exchange is poorly understood. Methods In...
Article
Champigneulle, Benoit, Ivan Hancco, Richard Renan, Stéphane Doutreleau, Emeric Stauffer, Aurélien Pichon, Julien V. Brugniaux, Hélène Péré, Pierre Bouzat, David Veyer, and Samuel Verges. High-altitude environment and COVID-19: SARS-CoV-2 seropositivity in the highest city in the world. High Alt Med Biol. 22: 000-000, 2021. Background: A reduced cor...
Article
Full-text available
Participation in ultra-endurance running (UER) events continues to grow across ages, including youth athletes. The 50- and 100-km are the most popular distances among youth athletes. Most youth athletes are between 16–18 years; however, some runners younger than 12 years have successfully completed UER events. Parents, athletes, coaches, race direc...
Article
Significance: Oxygenation is one of the skin tissue physiological properties to follow for patient care management. Furthermore, long-term monitoring of such parameters is needed at the patient bed as well as outside the hospital. Diffuse reflectance spectroscopy has been widely used for this purpose. Aim: The aim of the study is to propose a lo...
Article
Background Appropriate advice for the practice of sport in patients with a cardiomyopathy is a challenging issue. Recent evolution towards more comprehensive and tailored recommendations may facilitate the clinical practice. However, neither their application in real life has been evaluated nor the concordance within clinicians. Methods We submitt...
Article
Full-text available
Purpose: A decision tree based on a clinico-physiological score (SHAI score) has been developed to detect subjects susceptible to Severe High Altitude Illness (SHAI). We aimed to validate this decision tree, to rationalize the prescription of acetazolamide (ACZ) and to specify the rule for a progressive acclimatization. Methods: Data were obtain...
Article
Introduction Living in high altitude is challenging for the cardiovascular system, and some of highlanders develop a chronic mountain sickness (CMS). Only few data are available above the altitude of 4380 m. La Rinconada is the highest mining city in the world at an altitude of 5100 m. Objective To describe heart remodeling and pulmonary hemodynam...
Article
Little is known about hemostasis modifications induced by chronic hypoxic exposure in high-altitude residents, especially in those who develop excessive erythrocytosis (EE, i.e. hemoglobin concentration ≥ 21 g·dL-1 in male and ≥ 19 g·dL-1 in female). The aim of this preliminary study was to assess coagulation alterations in highlanders with or with...
Article
BACKGROUND Sleep‐disordered breathing is associated with a poor prognosis (mortality) in patients with ischemic cardiomyopathy. The understanding of mechanisms linking intermittent hypoxia (IH), the key feature of sleep‐disordered breathing, to ischemic cardiomyopathy progression is crucial for identifying specific actionable therapeutic targets. T...
Article
Full-text available
Background While millions of people are living permanently at high altitude (>2,500 m) worldwide, the mechanisms underlying their tolerance to chronic hypoxia and those responsible for the occurrence of chronic mountain sickness (CMS) remain to be elucidated. Excessive erythrocytosis (EE) is thought to be the main mechanism responsible for CMS symp...
Article
Background: While severe intermittent hypoxia (IH) is well known to induce deleterious cardiometabolic consequences, moderate IH may induce positive effects in obese individuals. The present study aimed to evaluate the effect of two hypoxic conditioning programs on cardiovascular and metabolic health status of overweight or obese individuals. Met...
Conference Paper
The development of wearable devices for healthcare monitoring is of primary interest, in particular for homecare applications. But it is challenging to develop an evaluation framework to test and optimize such a device by following a non-invasive protocol. As well established reference devices do exist for capnometry, we propose a protocol to evalu...
Article
Full-text available
Key points: Highlanders developed unique adaptative mechanisms to chronic hypoxic exposure, including substantial haemoglobin and haematocrit increases. A significant proportion of populations living permanently at high altitude developed however maladaptive features known as chronic mountain sickness (CMS). This study aimed to assess the effects...
Article
Introduction: Nitric oxide (NO) precursor supplementation has been shown to increase NO bioavailability and can potentially improve vascular function and exercise performance. It remains unclear whether the combination of NO precursor supplementation and exercise training has synergic effects on exercise performance. This study aims to assess the...
Article
Full-text available
Purpose: Ultramarathon running includes two main types of events: single (SSR) and multi-stage races (MSR). Direct comparison of neuromuscular fatigue and recovery following SSR vs MSR race of comparable distance and elevation have never been performed. The aim of this study was to assess neuromuscular fatigue and recovery following two ultramarat...
Article
Introduction: Combining exercise training with hypoxic exposure has been recently proposed as a new therapeutic strategy to improve health status of obese individuals. Whether hypoxic exercise training (HET) provides greater benefits regarding body composition and cardiometabolic parameters than normoxic exercise training (NET) remains however unc...
Article
Introduction: Cardiac insufficiency affects nearly 2% of the population with increased morbidity/mortality despite advances in therapeutic management. The sleep apnoea syndrome (SAS) is a risk factor for, and cause of aggravation of, myocardial dysfunction. Background: SAS is found in 70% of patients with chronic cardiac failure, 65% of patients...
Article
Moderate intensity continuous exercise (MICE) improves fat oxidation. High-intensity intermittent exercise (HIIE) is thought to have a greater potential for fat oxidation but it might be too demanding in the long term for patients. We hypothesized that an initial bout of HIIE could maximize fat oxidation during MICE. Eighteen healthy participants p...
Article
Increased nitric oxide (NO) bioavailability may improve exercise performance and vascular function. It remains unclear whether older adults who experience a decreased NO bioavailability may benefit from chronic NO precursor supplementation. This randomised, double-blind, trial aims to assess the effect of chronic NO precursor intake on vascular fun...
Article
New findings: What is the central question of this study? What is the effect of acute NO precursor intake on vascular function, muscle and cerebral oxygenation and peripheral and central neuromuscular fatigue during knee-extension exercise? What is the main finding and its importance? Acute NO precursor ingestion increases the plasma concentration...
Article
Background The new North American guidelines for participation in competitive sport in patients with coronary artery disease (CAD) are less restrictive than previous guidelines. Aim To evaluate the incidence of major adverse cardiac events (MACE) in men with CAD who practise intensive physical activity after a stenting procedure. MACE included in-...
Article
Physical performance relies on the concerted action of myriad responses, many of which are under circadian clock control. Little is known, however, regarding the time-dependent effect on exercise performance at the molecular level. We found that both mice and humans exhibit daytime variance in exercise capacity between the early and late part of th...
Article
Objectif Le sous diagnostic du SAOS est responsable d’une morbidité per-opératoire et son aggravation est potentiellement un facteur d’arythmies cardiaques post-opératoires. Étudier l’impact du SAOS sur les évènements cardiaques rythmiques après chirurgie sous anesthésie générale (AG). Méthodes Étude monocentrique cas témoins prospective non rando...
Article
Full-text available
Purpose The aim of this study was to assess the acute cardiorespiratory as well as muscle and cerebral tissue oxygenation responses to submaximal constant-load (CL) and high-intensity interval (HII) cycling exercise performed in normoxia and in hypoxia at similar intensity, reproducing whole-body endurance exercise training sessions as performed in...
Article
Résumé L’épreuve d’effort fait-elle encore partie des examens utiles dans la détection des cardiopathies à risque chez des sujets sportifs ? Doit-on continuer à l’utiliser comme examen de surveillance chez des patients sportifs coronariens ? Les méta-analyses, considérant un sous-décalage ST de plus de 1 mm comme critère de positivité, soulignent l...
Article
Full-text available
In this study, we hypothesized that adding CO2 to an inhaled hypoxic gas mixture will limit the rise of pulmonary artery pressure (PAP) induced by a moderate exercise. Eight 20-year-old males performed four constant-load exercise tests on cycle at 40% of maximal oxygen consumption in four conditions: ambient air, normobaric hypoxia (12.5% O2), inha...
Article
Full-text available
Aims Cardiovascular events occurring during physical activity are becoming a public health problem. Besides medical exams screening for cardiac abnormalities, better prevention could make such accidents less frequent. This study assessed the lack of awareness of cardiovascular risk factors and behaviors in the general sporting population. Methods...
Article
Maximal aerobic capacity is a strong health predictor and peak oxygen consumption ( V ′ O 2 peak ) is considered a reflection of total body health. No systematic reviews or meta-analyses to date have synthesised the existing data regarding V ′ O 2 peak in patients with obstructive sleep apnoea (OSA). A systematic review of English and French articl...
Data
Funnel spot for studies reporting steps per day.
Article
Full-text available
A systematic review of English and French articles using Pubmed/Medline and Embase included studies assessing objective physical activity levels of obstructive sleep apnea (OSA) patients and exploring the effects of exercise training on OSA severity, body mass index (BMI), sleepiness, and cardiorespiratory fitness [peak oxygen consumption (VO2peak)...
Article
Full-text available
Central nervous system diseases are among the most disabling in the world. Neuroprotection and brain recovery from either acute or chronic neurodegeneration still represent a challenge in neurology and neurorehabilitation as pharmacology treatments are often insufficiently effective. Conditioning the central nervous system has been proposed as a po...
Article
Full-text available
Nitric oxide (NO) is implicated in vasomotor control mechanisms altering the diameter of the vessels under various physiological and pathological conditions. There are two main NO production pathways, one NO synthase (NOS) independent (nitrate-nitrite-NO) and the other is NOS dependent (citrulline-arginine-NO). The objective of the study was to eva...
Article
This study assessed the effects of aging on cardiorespiratory and tissue oxygenation responses to hypoxia both at rest and during incremental maximal exercise. Sixteen young (20 - 30 years) and 15older (60 - 70 years) healthy subjects performed two maximal incremental cycling tests in normoxia and hypoxia (inspiratory oxygen fraction: 12%). Cardior...
Article
Background: Cardiovascular events related to high-intensity sport practice are rare but dramatic. Coronary artery disease (CAD) is the leading cause of these events after the age of 35 years. The value of a maximal exercise test (ET) for detection of athletes at risk remains a matter of debate. Aim: The aim of this prospective multicentre study...
Article
Background: Eccentric exercise training has been shown to improve muscle force strength without excessive cardiovascular stress. Such an exercise modality deserves to be tested in pulmonary arterial hypertension. Aim: We aimed to assess the effects of an eccentric training modality on cardiac function and survival in an experimental monocrotalin...
Article
Full-text available
Objective: Hypoxic exposure can be used as a therapeutic tool by inducing various cardiovascular, neuromuscular, and metabolic adaptations. Hypoxic conditioning strategies have been evaluated in patients with chronic diseases using either sustained (SH) or intermittent (IH) hypoxic sessions. Whether hypoxic conditioning via SH or IH may induce diff...
Article
We measured the effects of adding CO2 to an inhaled hypoxic gas mixture on cardio-respiratory parameters during maximal exercise. Eight young males performed four incremental maximal exercise tests on cycle under ambient air, hypoxia (FIO2 0.125), inhaled CO2 (FICO2 0.045), and combination of hypoxia and inhaled CO2. The highest ventilation (VE) an...
Article
Full-text available
Background: Echocardiography (ECHO) plays a key role in both the diagnosis and prognosis of pulmonary hypertension (PH). Many equations have been published to assess right heart hemodynamics using ECHO. The objective of this study was to test the accuracy and precision of different echocardiographic equations in comparison with the right heart cat...