Stephan Jonas

University of Bonn | Uni Bonn · Institute for Digital Medicine

Lack of proper hand hygiene is a common source of hospital acquired infections. Training and evaluating efficiency in hand washing is therefore an important part of medical education. Here, we propose to use the Myo wearable armband to measure correctness of hand washing for mobile learning. Myo's sensors are designed in order to recognize the acti...

Objective: Morbidity and mortality due to preeclampsia in settings with limited resources often results from delayed diagnosis. The Congo Red Dot (CRD) test, a simple modality to assess the presence of misfolded proteins in urine, shows promise as a diagnostic and prognostic tool for preeclampsia. We propose an innovative mobile health (mHealth) s...

Birth defects affect 3% of children in the United States. Among the birth defects, congenital heart disease and craniofacial malformations are major causes of mortality and morbidity. Unfortunately, the genetic mechanisms underlying craniocardiac malformations remain largely uncharacterized. To address this, human genomic studies are identifying se...

Background Clinical and social trials create evidence that enables medical progress. However, the gathering of personal and patient data requires high security and privacy standards. Direct linking of personal information and medical data is commonly hidden through pseudonymization. While this makes unauthorized access to personal medical data more...

Ensuring data quality and protecting data are key requirements when working with health-related data. Re-identification risks of feature-rich data sets have led to the dissolution of the hard boundary between data protected by data protection laws (GDPR) and anonymized data sets. To solve this problem, the TrustNShare project is creating a transpar...

There is a growing consensus in the global health community that the use of communication technologies will be an essential factor in ensuring universal health coverage of the world’s population. New technologies can only be used profitably if their accuracy is sufficient. Therefore, we explore the feasibility of using Apple’s ARKit technology to a...

Background Virtual reality (VR) technologies are playing an increasingly important role in the diagnostics and treatment of mental disorders. Objective To systematically review the current evidence regarding the use of VR in the diagnostics and treatment of mental disorders. Data source Systematic literature searches via PubMed (last literature u...

Background: Postural imbalance can be adopted for the early detection of age-related diseases or monitoring the course of the disease treatment; especially in monitoring, frequent balance measurement is crucial. This is mainly done through regular in-person examinations by a physician currently. Feedback in between examinations is often missing....

Computer-vision-based frameworks enable markerless human motion capture on consumer-grade devices in real-time. They open up new possibilities for application, such as in the health and medical sector. So far, research on mobile solutions has been focused on 2-dimensional motion capture frameworks. 2D motion analysis is limited by the viewing angle...

Background Reliable and objective assessment of psychomotor skills in physiotherapy students’ education is essential for direct feedback and skill improvement. The aim of this study is to determine the interrater reliability in the assessment process of physiotherapy students and to analyse the assessment behaviour of the examiners. Methods Physio...

The aim of the present investigation was to assess if a mobile electroencephalography (EEG) setup can be used to track mental workload, which is an important aspect of learning performance and motivation and may thus represent a valuable source of information in the evaluation of cognitive training approaches. Twenty five healthy subjects performed...

Reducing passenger flow through highly frequented bottlenecks in public transportation networks is a well-known urban planning problem. This issue has become even more relevant since the outbreak of the SARS-CoV-2 pandemic and the necessity for minimum distances between passengers. We propose an approach that allows to dynamically navigate passenge...

Background: Mobile apps may encourage a lifestyle that avoids unhealthy behaviors, such as smoking or poor nutrition, which promotes cardiovascular diseases (CVD). Yet, little data is available on the utilization, perception, and long-term effects of such apps to prevent CVD. Objectives: To develop a mobile app concept to reduce the individual C...

Background: Physical activity helps improve the overall quality of life. The correct execution of physical activity is crucial both in sports as well as disease prevention and rehabilitation. Little to no automated commodity solutions for automated analysis and feedback exist. Objectives: Validation of the Apple ARKit framework as a solution for...

Human induced pluripotent stem cells (hiPSCs) are capable of differentiating into a variety of human tissue cells. They offer new opportunities for personalized medicine and drug screening. This requires large quantities of high quality hiPSCs, obtainable only via automated cultivation. One of the major requirements of an automated cultivation is a...

Ambient Assisted Living (AAL) is becoming crucial to help governments face the consequences of the emerging ageing population. It aims to motivate independent living of older adults at their place of residence by monitoring their activities in an unobtrusive way. However, challenges are still faced to develop a practical AAL system. One of those ch...

Dyslexia is a neurodevelopmental disorder characterized by severe and persistent reading difficulties despite normal intellectual functioning and appropriate schooling. To better understand the neural underpinnings of dyslexia, this study investigated the neurophysiological differences between normal readers (NR group, n = 4) and readers with dysle...

Background: IT systems in the healthcare field can have a marked sociotechnical impact: they modify communication habits, alter clinical processes and may have serious ethical implications. The introduction of such systems involves very different groups of stakeholders because of the inherent multi-professionalism in medicine and the role of patie...

Development of mobile sensors brings new opportunities to medical research. In particular, mobile electroencephalography (EEG) devices can be potentially used in low cost screening for epilepsy and other neurological and psychiatric disorders. The necessary condition for such applications is thoughtful validation in the specific medical context. As...

This approach uses the strong advantages a Delhi study has, identifies the disadvantages of traditional Delphi techniques and aims to introduce and evaluate a modified approach called 360-Degree Delphi. Key aspects of 360-Degree Delphi are tested by applying the approach to the needs and requirements analysis of a system for managing patients’ adva...

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Introduction Staphylococci are the most commonly identified pathogens in bloodstream infections. Identification of Staphylococcus aureus in blood culture (SAB) requires a prompt and adequate clinical management. The detection of coagulase-negative staphylococci (CoNS), however, corresponds to contamination in about 75% of the cases. Nevertheless, a...

This approach uses the strong advantages a Delhi study has, identifies the disadvantages of traditional Delphi techniques and aims to introduce and evaluate a modified approach called 360-Degree Delphi. Key aspects of 360-Degree Delphi are tested by applying the approach to the needs and requirements analysis of a system for managing patients’ adva...

The authors wish to make the following erratum to this paper [...]

Intensive development of e-learning methods still struggles with domains where feedback on manual and physical skills is necessary, for example, crafts or physiotherapy movements. Most of such training is currently done exclusively through direct teacher-student interaction. The traditional approach minimizes the possibilities for remote learning,...

Electroencephalography (EEG) is a core element in the diagnosis of epilepsy syndromes and can help to monitor antiseizure treatment. Mobile EEG (mEEG) devices are increasingly available on the consumer market and may offer easier access to EEG recordings especially in rural or resource-poor areas. The usefulness of consumer-grade devices for clinic...

Congenital heart disease (CHD) is a significant cause of mortality in infants and adults. Currently human genomic analysis has identified a number of candidate genes in these patients. These genes span diverse categories of gene function suggesting that despite the similarity in cardiac lesion, the underlying pathophysiology may be different. In fa...

Establishing connections between changes in linear DNA sequences and complex downstream mesoscopic pathology remains a major challenge in biology. Herein, we report a novel, multi-modal and multiscale imaging approach for comprehensive assessment of cardiovascular physiology in Drosophila melanogaster We employed high-speed angiography, optical coh...

This approach uses the strong advantages a Delhi study has, identifies the disadvantages of traditional Delphi techniques and aims to introduce and evaluate a modified approach called 360-Degree Delphi. Key aspects of 360-Degree Delphi are tested by applying the approach to the needs and requirements analysis of a system for managing patients’ adva...

Cerebrospinal fluid (CSF) flow in the brain ventricles is critical for brain development. Altered CSF flow dynamics have been implicated in congenital hydrocephalus (CH) characterized by the potentially lethal expansion of cerebral ventricles if not treated. CH is the most common neurosurgical indication in children effecting 1 per 1000 infants. Cu...

Background Efficient planning of hospital bed usage is a necessary condition to minimize the hospital costs. In the presented work we deal with the problem of occupancy forecasting in the scale of several months, with a focus on personnel’s holiday planning. Methods We construct a model based on a set of recursive neural networks, which performs a...

Speaker attribution and labeling of single channel, multi speaker audio files is an area of active research, since the underlying problems have not been solved satisfactorily yet. This especially holds true for non-standard voices and speech, such as children and impaired speakers. Being able to perform speaker labelling of pathological speech woul...

In this manuscript we propose a novel method to compare simultaneously recorded electroencephalography (EEG) signals from different devices. Although standard methods like correlation and spectral analysis give quantitative answers to this question, these methods often penalize certain artifacts such as eye blinking too strongly. In our analysis we...

Functional magnetic resonance imaging (fMRI) and scalp electroencephalography (EEG) are non-invasive brain imaging techniques. fMRI offers millimeter-accurate spatial resolution and second-accurate temporal resolution. In contrast, EEG’s spatial resolution is limited while its temporal resolution is in the millisecond range. These complimentary cha...

The Newcastle-Ottawa scale (NOS) is one of many scales used to judge the quality of observational studies in systematic reviews. It was criticized for its arbitrary definitions of quality items in a commentary in 2010 in this journal. That commentary was cited 1,250 times through December 2016. We examined the citation history of this commentary in...

Background: Sleep disorders have a prevalence of up to 50% and are commonly diagnosed using polysomnography. However, polysomnography requires trained staff and specific equipment in a laboratory setting, which are expensive and limited resources are available. Mobile and wearable devices such as fitness wristbands can perform limited sleep monito...

BACKGROUND Mobile health (mHealth) is a fast-growing professional sector. As of 2016, there are more than 259,000 mHealth apps available internationally. However, while mHealth apps are growing in acceptance, relatively little attention and limited effort have been invested to establish their scientific integrity through statistical validation. Thi...

Background Mobile health (mHealth) is a fast-growing professional sector. As of 2016, there were more than 259,000 mHealth apps available internationally. Although mHealth apps are growing in acceptance, relatively little attention and limited efforts have been invested to establish their scientific integrity through statistical validation. This pa...

Background: Manual skills teaching, such as physiotherapy education, requires immediate teacher feedback for the students during the learning process, which to date can only be performed by expert trainers. Objectives: A machine-learning system trained only on correct performances to classify and score performed movements, to identify sources of...

Long term EEG examinations, for example during epilepsy diagnosis, can be performed more efficiently with support of automated abnormality detection. Currently, these methods are usually developed based on one specific database, which limits the possibilities of generalizations. Here, we present a machine learning solution for detection of interict...

Long term EEG examinations, for example during epilepsy diagnosis, can be performed more efficiently with support of automated abnormality detection. Currently, these methods are usually developed based on one specific database, which limits the possibilities of generalizations. Here, we present a machine learning solution for detection of interict...

Learners nowadays are described as technology-savvy. Being "digital natives" accustomed to technology, students use mobile devices for learning engagement. As a supplement to classroom experience, their use of educational applications (apps) allows them to access information anytime and anywhere, thus making apps convenient instruments for both the...

Learners nowadays are described as technology-savvy. Being "digital natives" accustomed to technology, students use mobile devices for learning engagement. As a supplement to classroom experience, their use of educational applications (apps) allows them to access information anytime and anywhere, thus making apps convenient instruments for both the...

A novel approach for positioning using smartphones and image processing techniques is developed. Using structure from motion, 3D reconstructions of given tracks are created and stored as sparse point clouds. Query images are matched later to these 3D models. High computational costs of image matching and limited storage require compressing point cl...

Objective: For long-term electrocardiography (ECG) recordings, accurate R-wave detection is essential. Several algorithms have been proposed but not yet compared on large, noisy, or pathological data, since manual ground-truth establishment is impossible on such large data. Methods: We apply the simultaneous truth and performance level estimatio...

Myocardial infarction represents the most investigated pathology. Heart tissues are histologically assayed on a routine base in clinical laboratories. However, the lack of a standard operation procedure for e.g. calculating the size of the infarcted area of myocardium, may lead to an increased errors' interval, with little correlation between resul...

In this paper, we propose a novel approach to eLearning that makes use of smart wearable sensors. Traditional eLearning supports the remote and mobile learning of mostly theoretical knowledge. Here we discuss the possibilities of eLearning to support the training of manual skills. We employ forearm armbands with inertial measurement units and surfa...

Background: Language reflects the state of one's mental health and personal characteristics. It also reveals preoccupations with a particular schema, thus possibly providing insights into psychological conditions. Using text or lexical analysis in exploring depression, negative schemas and self-focusing tendencies may be depicted. As mobile techno...

In recent years the need for informal home care in European countries is growing quickly due to increased life expectancy and demographic change. Informal caregivers have to overcome many obstacles ranging from a lack of adequate training to misjudging their physical and psychological abilities. The aim of this project is to create a low cost weara...

The etiology of craniofacial defects is incompletely understood. The ability to obtain large amounts of gene sequence data from families affected by craniofacial defects is opening up new ways to understand molecular genetic etiological factors. One important link between gene sequence data and clinical relevance is biological research into candida...

Gamification is used in clinical context in the health care education. Furthermore, it has shown great promises to improve the performance of the health care staff in their daily routine. In this work we focus on the medication sorting task, which is performed manually in hospitals. This task is very error prone and needs to be performed daily. Nev...

Gamification is used in clinical context in the health care education. Furthermore, it has shown great promises to improve the performance of the health care staff in their daily routine. In this work we focus on the medication sorting task, which is performed manually in hospitals. This task is very error prone and needs to be performed daily. Nev...

In recent years the need for informal home care in European countries is growing quickly due to increased life expectancy and demographic change. Informal caregivers have to overcome many obstacles ranging from a lack of adequate training to misjudging their physical and psychological abilities. The aim of this project is to create a low cost weara...