Stephan Hruby

Stephan Hruby
Tauernclinic Zell am See · Urology

Priv.Doz.,Dr.,FEBU

About

79
Publications
5,943
Reads
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1,025
Citations
Citations since 2016
17 Research Items
525 Citations
2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080
Additional affiliations
March 2010 - present
Paracelsus Medical University Salzburg
Position
  • Vice Chairman

Publications

Publications (79)
Article
Importance: DCVAC/PCa is an active cellular immunotherapy designed to initiate an immune response against prostate cancer. Objective: To evaluate the efficacy and safety of DCVAC/PCa plus chemotherapy followed by DCVAC/PCa maintenance treatment in patients with metastatic castration-resistant prostate cancer (mCRPC). Design, setting, and partic...
Article
p>Use of α-blockers for medical expulsive therapy (MET) has been the subject of huge debate in urology. Moreover, there have been a number of randomized controlled trials with differing results. We conducted a systematic review and meta-analysis of randomized controlled trials investigating the efficacy of α-blockers for MET. This review confirms t...
Article
Introduction: Kidney stone disease (KSD) affects millions of people worldwide and has an increasing incidence. Social media (SoMe) and search engines are both gaining in usage, whilst also being used by patients to research their conditions and aid in managing them. With this in mind, many authors have expressed the belief that SoMe and search eng...
Article
Aim: To assess the ability of apparent diffusion coefficient (ADC) measurements obtained by MRI to predict disease-specific survival (DSS) in patients with bladder cancer and compare it with established clinico-pathological prognostic factors. Material and methods: The ethical review board approved this cross-sectional study. Patients with suspe...
Article
Full-text available
Use of α-blockers for medical expulsive therapy (MET) has been the subject of huge debate in Urology. Moreover, there have been a number of randomised controlled trials (RCTs) with differing results. We conducted a systematic review and meta-analysis of RCTs investigating the efficacy α-blockers for MET. This review confirms there is a role for α-b...
Article
Objective: To assess prostate cancer (PCa) detection and prediction by combining the in-bore magnetic resonance imaging-guided transrectal targeted prostate biopsy (MRGB) with prostate-specific antigen (PSA) parameters and the Prostate Health Index (PHI) in case of negative 12-core standard biopsy. Materials and methods: A total of 112 men (2014...
Article
Objective To investigate the efficacy and safety of the adjustable transobturator male system (ATOMS) in males with stress urinary incontinence (SUI) after transurethral resection of the prostate (TURP). Materials and methods From a large international prospectively administrated ATOMS-register we identified 49 patients with an ATOMS device due to...
Article
Full-text available
Purpose To retrospectively evaluate whether prone CT scanning is superior to supine scanning for correct localization of distal urinary calculi in patients with acute flank pain. Methods Consecutively performed unenhanced CT scans in patients with acute flank pain were retrospectively analyzed in 150 patients in supine and another 150 patients in...
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Full-text available
Purpose This is a prospective multicentric comparative study evaluating the performance of XenX—a new dual-purpose device for the prevention of stone fragments migration during ureteroscopic lithotripsy (URS). Methods Between March 2014 and January 2015, 41 patients undertaking URS + XenX were matched with 41 patients undergoing standard URS. Pati...
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Purpose: To prospectively assess anxiety and depression in patients undergoing diagnostic cystoscopy. Methods: Patients presenting for outpatient diagnostic cystoscopy were recruited from four European urological departments. Anxiety and depression were assessed with the 'Hospital Anxiety and Depression Scale' (HADS) before cystoscopy and after...
Article
Context: Extended pelvic lymph node dissection (ePLND) is the gold standard for detecting lymph node (LN) metastases in prostate cancer (PCa). The benefit of sentinel node biopsy (SNB), which is the first draining LN as assessed by imaging of locally injected tracers, remains controversial. Objective: To assess the diagnostic accuracy of SNB in...
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Full-text available
Due to the urgent need for new prostate cancer (PCa) therapies, the role of androgen receptor (AR) interacting proteins should be investigated. In this study we aimed to address whether the AR coactivator nuclear receptor coactivator 1 (NCOA1) is involved in PCa progression. Therefore, we tested the effect of long-term NCOA1 knockdown on processes...
Article
Purpose: This is a prospective multicentric comparative study evaluating the performance of XenX-a new dual-purpose device for the prevention of stone fragments migration during ureteroscopic lithotripsy (URS). Methods: Between March 2014 and January 2015, 41 patients undertaking URS + XenX were matched with 41 patients undergoing standard URS....
Article
In recent years, new therapeutic options have brought improvements in the treatment of metastatic, castration-resistant prostate cancer. Targeted Hormone Therapy (THT) represents a novel therapeutic component for which recent studies have shown a maximum benefit in the time between failure of androgen deprivation therapy (patient is metastatic and...
Article
Objectives: To demonstrate the feasibility of our novel NOTES-assisted approach with medium-term follow-up. Patients and methods: From March 2012, we included all patients who presented to our clinic with symptomatic or complicated retentive bladder diverticula secondary to long-standing infravesical obstruction. After managing the primary cause...
Article
To prospectively assess women's pain during rigid and flexible diagnostic cystoscopy and afterwards during a one-week follow-up. Prospective, multi-institutional trial analyzing numeric rating scales (NRS) of women undergoing diagnostic cystoscopy. Pain categories: no (0 points), mild (1-3), moderate (4-6) and severe pain (7-10). Assessing of pain...
Article
The aim of this study was to evaluate the impact of hours worked by a urologist before performing ureteroscopy on its safety and efficacy. Patients treated at a single institution from January 2010 to December 2013 were analyzed. The study assessed patient, stone and surgical parameters, stone-free rates and intraoperative complications performed i...
Article
In external beam radiation (EBRT) of the prostate, the rectum is the dose-limiting organ at risk, and sparing of the anterior rectal wall is a prerequisite for safe delivery of doses beyond 70Gy. Spatial sparing of the rectum can be achieved by introducing a spacer material into the retroprostatic space, thus separating the anterior rectal wall fro...
Article
In this study we investigated if visualisation of the drainage system of the prostate by free Indocyanin Green (ICG) leads to identification of all or even more lymph node metastases detected by superextended PLND in an intermediate and high risk prostate cancer patient population. 38 consecutive men with intermediate and high risk prostate cancer...
Article
70 Background: Recently we have introduced fluorescence by means of Indocyanin Green(ICG) in addition to radio-guided dissection using Technetium 99(Tc99) for laparoscopic pelvic sentinel node dissection (Urology 2012). Hence we could show that ICG alone gave equal results compared to TC99. Since ICG visualizes the complete drainage system we have...
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Full-text available
Spontaneous, nontraumatic retroperitoneal hemorrhage or Wunderlich syndrome (WS) is a rare but potential life-threatening condition. In most patients a bleeding renal neoplasm is the cause of the retroperitoneal hematoma. The management of this condition includes a conservative approach in the hemodynamically stable patients and active treatment in...
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Metastatic renal cell carcinoma (mRCC) has been one of the most treatment-resistant cancers because of its unpredictable clinical course, resistance to chemo- and radiotherapy, and the limited response to immunotherapy and targeted agents. We present a case of long-term survival, that is, 28 years, after primary diagnosis (longest survival in the l...
Article
Abstract Introduction: To analyse the life-prevalence and the incidence of clinical symptoms of the RLRV diagnosed incidentally over 10 years by computed tomography. Material and Methods: 7929 consecutive patients (out- and in-patients) were studied with multidetector computed tomography from January 2000 to April 2011. We retrospectively reviewed...
Article
Purpose To evaluate functional outcomes and morbidity rates after laparoscopic adenomectomy (LA) and Eraser laser enucleation of the prostate (ELEP). Materials and methods Forty patients with lower urinary tract symptoms suggesting bladder outlet obstruction, with a prostate heavier than 70 g on transrectal ultrasound, were selected to undergo l...
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Full-text available
Open, laparoscopic and robot-assisted approaches are all feasible in partial nephrectomy and every procedure has its own pros and cons. Nowadays, open nephron-sparing surgery is the gold standard treatment of T1 renal cell cancer. In experienced centers, the laparoscopic or robot-assisted approach is a viable alternative. Advances in surgery and im...
Article
Hemodynamically stable patients with renal injury can be managed conservatively. Anatomy typically leads to physiologic confinement of urinomas or renal hematomas to the interfascial planes of the retroperitoneum. In the presented case there was unusual reperfusion 14 days after a successful embolization of a renal pseudoaneurysm, at this time 28 d...
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Aim: To determine the status quo in respect of various diode lasers and present the techniques in use, their results and complications. We assess how these compare with transurethral resection of the prostate and other types of laser in randomized controlled trials (RCTs). When adequate RCTs were not available, case studies and reports were evalua...
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Full-text available
Inguinoscrotal hernias containing urinary bladder are very rare. There are only a few cases described with perforation in the scrotum. This illness is a severe and should be kept in mind with any patient complaining of a scrotal hernia. We report a case of bladder perforation caused by inguinoscrotal hernia with incarceration and severe sepsis in a...
Article
Treatment of renal stones using flexible ureteroscopy (fURS) is increasingly common despite the poor evidence in literature supporting its use and indications. With this study, we wanted to investigate the current use and indication of fURS for the treatment of renal stones in the clinical practice across the European countries. A survey was conduc...
Article
Unlabelled: BACKGROUND/AIMS/OBJECTIVES: To describe the depth of the laser coagulation zone in vivo based on histological examinations and the functional outcome of a 1,318-nm diode laser for enucleation in benign prostatic enlargement (BPE). Methods: A total of 20 patients with BPE were treated by laser Eraser® enucleation of the prostate (ELEP...
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Full-text available
Mid-urethral tapes are largely used to manage stress urinary incontinence (SUI). In certain cases, however, this procedure results in bothersome complications that lead to complete resection. We present the case of an 85-year-old woman who presented with ongoing suprapubic pain, hematuria, vaginal bleeding and recurrent urinary tract infections. Th...
Article
Objective: The purpose of this review is to provide an overview of the possibilities and drawbacks of the various possibilities of renal parenchymal cooling during laparoscopic partial nephrectomy and also give an outlook into future developments. Methods: In January 2012 a PubMed Search using the search terms "partial nephrectomy, cooling," fol...
Article
Purpose of review: Transurethral resection of the prostate has long been held as the gold standard for treatment of benign prostatic hyperplasia (BPH); however, there have been significant innovations in other less invasive alternative treatments for BPH in recent years. Our purpose is to present emerging surgical treatment modalities which have b...
Article
Objective To discuss the contemporary management of urinary tract endometriosis and report our experience concerning laparoscopic treatment of intrinsic urinary tract endometriosis. Methods We performed a retrospective, multicenter study of data collected from March 2006 to March 2011. Ten women were referred from gynecology, seven with ureteral i...
Article
Objective: To investigate the feasibility of visualizing lymphatic drainage of the prostate using indocyanine green. The results were compared with standard radio-guided sentinel lymph node dissection and validated by extended pelvic lymph node dissection. Methods: From March 2010 to October 2011, (99m)Tc-labelled colloid (18 hours before surger...
Article
BACKGROUND: Eraser, a 1318-nm diode laser, has been used for 15 yr for resection of lung metastases. It was recently introduced in urology for small kidney tumors and for the treatment of benign prostatic obstruction. OBJECTIVE: To demonstrate on video our technique of Eraser laser enucleation of the prostate (ELEP) and report our experience. DESIG...
Article
Retrograde ureteral access after cross-trigonal ureteral reimplantation can be challenging. We present our experience with retrograde ureteral catheterization and flexible ureteroscopy after Cohen cross-trigonal reimplantation in patients presenting with ureteral stones. Cystoscopy is performed and a Tiemann ureteral catheter is inserted into the i...
Article
The correlation between an increased body mass index and testicular germ cell cancer has been a topical subject matter of literature. The thesis examines whether for patients with germ cell cancer of the testis the relation between the body cross section and the muscle mass at a particular spot at the abdomen is dislocated toward muscle hypertrophy...
Article
Decompression of peripheral nerves at different anatomic sites leads to long-lasting improvement of nerve function. For the pudendal nerve such compression sites have also been described, however, indication for surgical decompression at the dorsal nerve canal, and outcome measures have not been presented. In the following work, we review the detai...
Article
Entrapment neuropathies of the pudendal nerve are uncommon and therefore often overlooked or misdiagnosed clinical entities. Detailed relationships of this nerve as it exits the pelvis through the urogenital diaphragm and enters the mobile part of the penis have not yet been delineated. It was the purpose of this work to investigate the relationshi...
Article
To investigate the relations of the pudendal nerve in this complex anatomic region and determine possible entrapment sites that are accessible for surgical decompression. Entrapment neuropathies of the pudendal nerve are an uncommon and, therefore, often overlooked or misdiagnosed clinical entity. The detailed relations of this nerve as it exits th...
Article
We evaluated pathological features of prostate cancer detected on repeat prostate biopsy in men with a serum total prostate-specific antigen (PSA) level between 4 and 10 ng/ml who were diagnosed with benign prostatic tissue after an initial biopsy and compared them to those cancers detected on initial prostate biopsy. In this prospective European p...
Article
To evaluate pretreatment serum prostate-specific antigen (PSA) as an outcome predictor of targeted microwave thermotherapy. Seventy-one patients with lower urinary tract symptoms of benign prostatic hyperplasia underwent targeted transurethral microwave thermotherapy using the Targis system. Outcomes 12 months after treatment were evaluated by the...
Article
ber die Behandlung des klinisch lokalisierten Prostatakarzinom wird nach wie vor viel diskutiert. Die Behandlungsmglichkeiten erstrecken sich von den agressiven kurativen Therapien bis zur engmaschigen Kontrolle ohne in die Krankheit einzugreifen (“Watchfull Waiting”). Normalerweise wird jungen Patienten mit einer Lebenserwartung von mehr als 10 Ja...