Stephan Grabbe

Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Univerity of Mainz Medical Center · Dermatology

Zusammenfassung Das Basalzellkarzinom ist der häufigste maligne Tumor der hellhäutigen Bevölkerung mit weiterhin steigender Inzidenz. Ein Update der S2k‐Leitlinie unter Beteiligung aller mit dem Krankheitsbild vertrauten Fachgesellschaften sowie vorangegangener Literaturrecherche ist für die Qualität der Versorgung der betroffenen Patienten von hoh...

Cationic, core‐crosslinked nanogel particles are prepared from synthetic biodegradable materials. These fully hydrophilic nanogels offer superior customizability compared to common lipid nanoparticles, thereby circumventing intrinsic immune stimulatory properties. Electrostatic loading allows for complexation of nucleic acids including the immune s...

Basal cell carcinoma is the most common malignant tumor in the fair‐skinned population and its incidence continues to rise. An update of the S2k guideline with the participation of all specialist societies familiar with the clinical picture and previous literature research is of great importance for the quality of care for affected patients. In add...

Zusammenfassung Hintergrund Die weltweite Inzidenz von Hautkrebs ist in den letzten Jahren kontinuierlich gestiegen. Patienten benötigen daher Informationen über die Diagnose und Behandlungsmöglichkeiten. Gleichzeitig müssen sie lernen, mit den wahrgenommenen Konsequenzen der Diagnose umzugehen. Im Jahr 2015 hat die Bundesregierung das Recht auf e...

Zusammenfassung Hintergrund Aktinische Keratosen (AK) zeigen eine steigende Inzidenz und haben als häufigste (prä)kanzeröse Läsionen der hellhäutigen Bevölkerung einen enormen Behandlungsbedarf. Um die Adhärenz zu erhöhen, ist die Erhebung von therapiebezogenen Bewertungen der verschiedenen Behandlungsarten durch die Patienten von großer Bedeutung...

Background IκBζ, a rather unknown co-regulator of NF-κB, is mostly inducibly expressed and can either activate or repress a specific subset of NF-κB target genes. While its role as a transcriptional regulator of various cytokines and chemokines in immune cells has been revealed, IκBζ’s function in solid cancer remains unclear. Methods We investiga...

Gaining spatial control over innate immune activation is of great relevance during vaccine delivery and anticancer therapy, where one aims at activating immune cells at draining lymphoid tissue while avoiding systemic off‐target innate immune activation. Lipid‐polymer amphiphiles show high tendency to drain to lymphoid tissue upon local administrat...

Background The global incidence of skin cancer has steadily increased in recent years. Accordingly, patients require information on diagnosis and treatment options while dealing with the perceived impact of the diagnosis. In 2015, the German government enacted legislation under the Social Code (SGB V, § 27b), granting patients the right to obtain a...

The present study demonstrates that albumin-coated drug nanocrystals represent a highly efficacious novel approach for the controlled intracellular release of drugs with limited solubility in immune cells.

Mycosis fungoides (MF) is the most common entity of Cutaneous T cell lymphomas (CTCL) and is characterized by the presence of clonal malignant T cells in the skin. The role of the skin microbiome for MF development and progression are currently poorly understood. Using shotgun metagenomic profiling, real-time qPCR, and T cell receptor sequencing, w...

Chemotherapy poses both physical and psychological challenges for patients, prompting many to seek answers independently through online resources. This study investigates German Google search behavior regarding chemotherapy-related terms using Google AdWords data from September 2018 to September 2022 to gain insights into patient concerns and needs...

Background Actinic keratoses (AK) are increasing in incidence and represent the most common (pre‐)cancerous lesion in the fair‐skinned population, with a high unmet medical need. In order to increase treatment adherence, it is very important to assess patients' therapy‐related evaluations of different treatment options. Patients and methods 100 pa...

Background: Lichen planopilaris (LPP) is an inflammatory cicatricial alopecia characterized by an irreversible destruction of the hair follicle resulting in its permeant destruction. The clinical presentation of LPP is a progressive patchy scarring alopecia. A variety of systemic agents is used to treat LPP with varying success. The aim of this ret...

Nannizzia incurvata is a geophilic dermatophyte that is rarely detected in Germany. We report on a 17-year-old traveler returning from Indonesia in whom Nannizzia incurvata was isolated as the causative agent of tinea corporis. Targeted, local antimycotic therapy and clinical follow-up was recommended. This report shows the importance of a detailed...

Background The collagen-rich tumor stroma plays a crucial role in biliary tract cancer (BTC). Circulating collagen turnover markers of type I collagen (reC1M), type III collagen (PRO-C3), type IV collagen (C4G), type VIII collagen (PRO-C8), type XI collagen (PRO-C11), type XVII collagen (PRO-C17) and type VIII collage (TUM) may be used as potential...

Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer and the third leading cause for cancer‐related death worldwide. The tumor is difficult‐to‐treat due to its inherent resistance to chemotherapy. Antistromal therapy is a novel therapeutic approach, targeting cancer‐associated fibroblasts (CAF) in the tumor microenvironm...

Zusammenfassung Hintergrund und Ziele Hidradenitis suppurativa (HS)/Acne inversa (Ai) ist eine chronische, stark beeinträchtigende Erkrankung mit begrenzten Therapiemöglichkeiten. Die gerätebasierte LAight‐Therapie wurde 2017 in Europa zugelassen. Ziel dieser Studie war es, die Auswirkungen einer Real‐World‐Versorgung mit der LAight‐Therapie auf d...

Transcutaneous delivery systems bear several advantages over conventional needle-based injections. Considering the low bioavailability and poor water-solubility of imiquimod, a manufacturing process has been developed to incorporate imiquimod as suspended nanocrystals in different formulations. In this study, three formulations - fast-dissolving mi...

Sexual health, a critical aspect of overall well-being, is often compromised in individuals with chronic disorders. Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that mainly affects intertriginous areas, potentially impacting sexual health as a result of its specific symptoms and psychosocial burden. This cross-sectional st...

The growth pattern of oropharyngeal squamous cell carcinomas (OPSCC) varies from compact tumor cell aggregates to diffusely infiltrating tumor cell-clusters. The influence of the growth pattern on local tumor control and survival has been studied mainly for surgically treated oral cavity carcinomas on a visual basis. In this study, we used multiple...

Background and objectives Hidradenitis suppurativa (HS)/Acne inversa (Ai) is a chronic debilitating disease with limited therapy options. The device‐based LAight therapy was approved in Europe in 2017. The aim of this study was to evaluate the effect of real‐world care with at least one treatment with LAight therapy on disease activity and burden i...

KH-type splicing regulatory protein (KSRP) is a single-stranded nucleic acid-binding protein with multiple functions. It is known to bind AU-rich motifs within the 3′-untranslated region of mRNA species, which in many cases encode dynamically regulated proteins like cytokines. In the present study, we investigated the role of KSRP for the immunophe...

Integrin receptors are heterodimeric surface receptors that play multiple roles regarding cell–cell communication, signaling, and migration. The four members of the β2 integrin subfamily are composed of an alternative α (CD11a–d) subunit, which determines the specific receptor properties, and a constant β (CD18) subunit. This review aims to present...

Introduction: Hidradenitis suppurativa (HS) is a chronic inflammatory disorder of the pilosebaceous unit, often affecting and deforming intimate regions. HS is associated with severe pain, pruritus, and constant, purulent, malodorous discharge expected to impair sexual health of patients. Methods: We performed a cross-sectional, multicentric stu...

Background Systemic inflammation with elevated inflammatory cytokines is a hallmark in patients with cirrhosis and the main driver of decompensation. There is insufficient data on whether inflammatory cytokine levels differ between hepatic and jugular veins, which may have implications for further immunological studies. Methods Blood from the hepa...

Background Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease affecting approximately 1% of the population. The patient journey through the German health care system leads to high disease burden and substantial treatment costs. The EsmAiL study showed that an innovative, interprofessional, multimodal care-concept reduces disease a...

Background Hidradenitis suppurativa (HS) is an inflammatory disease of the inverse skin regions with an age peak at around 40 years and an estimated prevalence of 1%. Nodules and abscesses can develop into fistules and scarring, which cause severe pain. HS is a progressive, life‐defining disease that leads to physical limitations, inability to work...

Zusammenfassung Aktinische Keratosen (AK) sind häufige Hautveränderungen bei hellhäutigen Menschen mit dem Potenzial, in ein kutanes Plattenepithelkarzinom (PEK) überzugehen. Beide Erkrankungen können mit erheblicher Morbidität verbunden sein und stellen eine große Krankheitslast insbesondere in der älteren Bevölkerung dar. Um einen evidenzbasierte...

Background Adjuvant therapy with immune-checkpoint inhibitors (CPI) or BRAF/MEK-directed targeted therapy (TT) improves recurrence-free survival (RFS) for patients with advanced, BRAFV600-mutant (BRAFmut) resected melanoma.1–6 However, 40% of these patients will develop distant metastasis (DM) within 5 years, which require systemic treatments.2 5 L...

For successful therapeutic interventions in cancer immunotherapy, strong antigen-specific immune responses are required. To this end, immunostimulating cues must be combined with antigens to simultaneously arrive at antigen-presenting cells and initiate cellular immune responses. Recently, imidazoquinolines have shown their vast potential as small...

Zusammenfassung Aktinische Keratosen (AK) sind häufige Hautveränderungen bei hellhäutigen Menschen mit dem Potenzial, in ein kutanes Plattenepithelkarzinom (PEK) überzugehen. Beide Erkrankungen können mit erheblicher Morbidität verbunden sein und stellen eine große Krankheitslast insbesondere in der älteren Bevölkerung dar. Um eine evidenzbasierte...

Actinic keratosis (AK) are common lesions in light‐skinned individuals that can potentially progress to cutaneous squamous cell carcinoma (cSCC). Both conditions may be associated with significant morbidity and constitute a major disease burden, especially among the elderly. To establish an evidence‐based framework for clinical decision making, the...

Actinic keratosis (AK) are common lesions in light‐skinned individuals that can potentially progress to cutaneous squamous cell carcinoma (cSCC). Both conditions may be associated with significant morbidity and constitute a major disease burden, especially among the elderly. To establish an evidence‐based framework for clinical decision making, the...

Selected patients with early-stage melanoma have a “hidden high risk” of poor oncologic outcomes. They might benefit from clinical trials, and ultimately, if warranted by trial results, judicious everyday use of adjuvant therapy. A promising tool to identify these individuals is the immunoprint® assay. This immunohistochemical 7-biomarker prognosti...

Introduction Transcutaneous immunization (TCI) is a non-invasive vaccination method promoting strong cellular immune responses, crucial for the immunological rejection of cancer. Previously, we reported on the combined application of the TLR7 agonist imiquimod (IMQ) together with the anti-psoriatic drug dithranol as novel TCI platform DIVA (dithran...

Background Adjuvant therapy with immune-checkpoint inhibitors (CPI) or BRAF/MEK-directed targeted therapy (TT) improves recurrence-free survival (RFS) for patients with advanced, BRAFV600-mutant (BRAFmut) resected melanoma. However, 40% of these patients will develop distant metastases (DM) within 5 years, which require systemic therapy. Little dat...

Background: Hidradenitis suppurativa affects approximately 1% of the population. Objective: Highlighting the relevance of self-management-competency as a new therapeutic target. Method: 258 patients from the ‘Epidemiology and Care in Acne inversa (EpiCAi)’ project were included in the study. Disease burden was measured by patient-rated questionnair...

Aging attenuates the overall responsiveness of the immune system to eradicate pathogens. The increased production of pro-inflammatory cytokines by innate immune cells under basal conditions, termed inflammaging, contributes to impaired innate immune responsiveness towards pathogen-mediated stimulation and limits antigen-presenting activity. Adaptiv...

Background: Merkel cell carcinoma (MCC) is an immunogenic but aggressive skin cancer. Even after complete resection and radiation, relapse rates are high. PD-1 and PD-L1 checkpoint inhibitors showed clinical benefit in advanced MCC. We aimed to assess efficacy and safety of adjuvant immune checkpoint inhibition in completely resected MCC (ie, a se...

Background: Cutaneous T cell lymphomas (CTCL) are a heterogeneous group of non-Hodgkin lymphomas that are characterized by the presence of clonal malignant T cells in the skin, with Mycosis fungoides (MF) being the most common entity. The role of the skin microbiome for MF development and progression are currently poorly understood. Methods: We use...

Extracellular acidification profoundly influences anti-tumor immunity but the molecular details of this immune evasion mechanism are not well understood. Here we demonstrate that tumor-associated macrophages (TAM) are capable of sensing H+ ions in a G protein-coupled receptor (GPR)65-dependent manner. This sensing induces a functional polarization...

Background: Hidradenitis suppurativa is an inflammatory disease of the inverse skin regions that occurs particularly in young women and affects approximately 1% of the population. Outpatient care is often inadequate and usually cannot prevent progression. Objective: The aim of the EsmAiL trial was to evaluate whether an innovative care concept c...

Background Effective anti-tumor immune responses are mediated by T cells and require organized, spatially coordinated interactions within the tumor microenvironment (TME). Understanding coordinated T-cell-behavior and deciphering mechanisms of radiotherapy resistance mediated by tumor stem cells will advance risk stratification of oropharyngeal can...

Background Despite the availability of effective systemic therapies, a significant number of advanced melanoma patients develops brain metastases. This study investigated differences in incidence and time to diagnosis of brain metastasis and survival outcomes dependent on the type of first-line therapy. Methods Patients with metastatic, non-resect...

The approval of immune-checkpoint inhibitors (CPI) and mitogen activated protein kinase inhibitors (MAPKi) in recent years significantly improved the treatment management and survival of patients with advanced malignant melanoma. CPI aim to counteract receptor-mediated inhibitory effects of tumor cells and immunomodulatory cell types on effector T...

Hidradenitis suppurativa (HS), a chronic inflammatory disorder of the apocrine-bearing skin, presents with deep seated inflamed nodules, abscesses, draining sinus tracts, and scarring with a profound impact on quality of life. In this review of Pubmed, EMBASE, and Cochrane Central databases, we focus on the role of hormonal therapies in the treatme...

Regulatory T cells (Treg) are essential for the maintenance of peripheral tolerance. Treg dysfunction results in diverse inflammatory and autoimmune diseases with life-threatening consequences. β2-integrins (CD11a-d/CD18) play important roles in the migration of leukocytes into inflamed tissues and cell signaling. Of all β2-integrins, T cells, incl...

Seborrheic keratosis (SK) is the most common benign epidermal tumor in clinical dermatological practice. This review summarizes current knowledge about the clinical and histological appearance, epidemiology, pathogenesis, and treatment of SK. There are different subtypes of SK based on clinical presentation and histologic findings. Several factors,...

Complaint management related to pharmaceutical products is essential to protect the health of the public. It involves recording/ documentation, assessment, investigation, and review of com plaints concerning quality defects of the pharmaceutical product with a potential recall of the affected batch(es) or withdrawal of the product from the market....

Complaint management related to pharmaceutical products is essential to protect the health of the public. It involves recording/ documentation, assessment, investigation, and review of com plaints concerning quality defects of the pharmaceutical product with a potential recall of the affected batch(es) or withdrawal of the product from the market....

Merkel cell carcinoma (MCC, ICD-O M8247/3) is a rare, malignant, primary skin tumor with epithelial and neuroendocrine differentiation. The tumor cells share many morphologic, immunohistochemical, and ultrastructural features with cutaneous Merkel cells. Nevertheless, the cell of origin of MCC is unclear. MCC appears clinically as a reddish to purp...

Zusammenfassung Die seborrhoische Keratose (SK) ist der häufigste gutartige epidermale Tumor in der klinisch‐dermatologischen Praxis. Diese Übersicht fasst den Kenntnisstand zu Klinik, Histologie, Epidemiologie, Pathogenese und Therapie von SK zusammen. Anhand des klinischen und histologischen Bildes unterscheidet man verschiedene Typen der SK. Es...

Zusammenfassung Das Merkelzellkarzinom (MCC, ICD‐O M8247/3) ist ein seltener, maligner, primärer Hauttumor mit epithelialer und neuroendokriner Differenzierung. Die Tumorzellen teilen viele morphologische, immunhistochemische und ultrastrukturelle Eigenschaften mit den Merkel‐Zellen der Haut. Die Ursprungszelle (cell of origin) des MCC ist dennoch...

The present article exemplifies the application of the concept of quality by design (QbD) for the systematic development of a nanoparticulate imiquimod (IMQ) emulsion gel formulation as an investigational medicinal product (IMP) for evaluation in an academic phase-I/II clinical trial for the treatment of actinic keratosis (AK) against the comparato...

Background and objectives: Hidradenitis suppurativa (HS) differs widely with respect to its clinical presentation. Literature imposes different phenotypes potentially implying different treatment modalities. The aim of this study is to develop a validated scheme that enables HS patients to identify their own lesion types. Patients and methods: T...

Hintergrund: Die Acne inversa (Ai) unterscheidet sich stark in ihrer klinischen Ausprägung. In der Literatur werden verschiedene Phänotypen beschrieben, die möglicherweise unterschiedliche Behandlungsmodalitäten erfordern. Ziel dieser Studie ist es, ein validiertes Schema zu entwickeln, das es Ai-Patienten ermöglicht, ihre eigenen Läsionstypen zu i...